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Cited by 204Probiotics and Fermented FoodsExercise and Physiological ResponsesThermoregulation and physiological responses

Effects of probiotics supplementation on gastrointestinal permeability, inflammation and exercise performance in the heat

Open access
Shing, Cecilia M., Peake, Jonathan M., Lim, Chin Leong, Briskey, David, Walsh, Neil P., Fortes, Matthew B., Ahuja, Kiran D. K., Vitetta, Luis·2014·European Journal of Applied Physiology
DOI 10.1007/s00421-013-2748-y
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Abstract

Purpose This study aimed to investigate the effects of multi-strain probiotics supplementation on gastrointestinal permeability, systemic markers of inflammation and running performance when exercising in the heat.Methods Ten male runners were randomized to 4 weeks of daily supplementation with a probiotics capsule (45 billion CFU of Lactobacillus, Bifidobacterium and Streptococcus strains) or placebo, separated by a washout period (double-blind, cross-over trial). After each treatment, the runners exercised to fatigue at 80% of their ventilatory threshold at 35 °C and 40% humidity. To assess gastrointestinal permeability, runners ingested lactulose and rhamnose before exercise and post-exercise urine was collected to measure sugar concentrations. Venous blood samples were collected before, immediately after and 1 h after exercise, and core temperature was monitored during exercise.Results Probiotics supplementation significantly increased run time to fatigue (min:s 37:44 ± 2:42 versus 33:00 ± 2:27; P = 0.03, d = 0.54). Average core temperature during exercise was similar between trials (probiotic 38.1 ± 0.2 °C, placebo 38.1 ± 0.1 °C; P = 0.77, d = 0.13). Serum lipopolysaccharide concentration increased post-exercise (P < 0.001), while there was a moderate to large reduction in pre-exercise (d = 0.70) and post-exercise (d = 1.24) concentration following probiotics supplementation. Plasma concentrations of IL-6, IL-10 and IL-1ra increased after exercise (P < 0.01), but there was no significant difference between trials (P > 0.05). There was a small to moderate reduction (d = 0.35) in urine lactulose:rhamnose and a small reduction (d = 0.25) in symptoms of gastrointestinal discomfort following probiotics supplementation (both P = 0.25).Conclusion Four weeks of supplementation with a multi-strain probiotic increased running time to fatigue in the heat. Further studies are required to elucidate the exact mechanisms for this performance benefit.

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  • In ten male runners, 4 weeks of multi-strain probiotics improved time to fatigue while running in the heat.

    “In another study researching the effect of multi-strain probiotics Shing et al. [46] found 4 weeks of supplementation improved time to fatigue while running in the heat for ten male runners.”

    From International Society of Sports Nutrition Position Stand: Probiotics (2019) · cites this paper as [46]

  • Four weeks of multi-strain probiotic supplementation had no significant effect on lactulose:rhamnose ratio, urinary claudin-3, or serum LPS in male runners exercising in the heat.

    “There was no significant effect on lactulose:rhamnose ratio, urinary claudin-3 or serum LPS and it is possible that 4 weeks may not have been sufficient to detect changes.”

    From International Society of Sports Nutrition Position Stand: Probiotics (2019) · cites this paper as [46]

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Authors
Shing, C. M., Peake, J. M., Lim, C. L., Briskey, D., Walsh, N. P., Fortes, M. B., Ahuja, K. D. K., & Vitetta, L.
Affiliations
  • University of Tasmania (AU)
  • Queensland University of Technology (AU)
  • National University of Singapore (SG)
  • The University of Queensland (AU)
  • Bangor University (GB)
Corresponding author
Shing, Cecilia M.
ORCID
Venue
European Journal of Applied Physiology
Publisher
Springer Science and Business Media LLC
Published
2013-10-23
Volume
114
Issue
1
Pages
93-103
ISSN
  • 0020-9376 (ISSN-L)
  • 1439-6319
  • 1439-6327
DOI
10.1007/s00421-013-2748-y
OpenAlex
W1601403942
Cited by
204
References
45
Citations by year
2026: 14 · 2025: 18 · 2024: 22 · 2023: 17 · 2022: 27 · 2021: 19 · 2020: 23 · 2019: 20 · 2018: 20 · 2017: 11 · 2016: 5 · 2015: 3 · 2014: 5
FWCI
6.45
Type
journal article
Language
en
Open access
Licence
Locations
  • European Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • eCite Digital Repository (University of Tasmania) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • Faculty of Health; Institute of Health and Biomedical Innovation
Funders
  • National Health and Medical Research Council
  • National Medical Research Council
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
Keywords
multi-strain probiotics, gastrointestinal permeability, exercise in the heat, running performance, systemic inflammation, lipopolysaccharide, interleukins, core body temperature, gastrointestinal discomfort, Lactobacillus, Bifidobacterium, Streptococcus
MeSH terms
Adult, Double-Blind Method, Hot Temperature, Humans, Inflammation, Intestinal Absorption, Male, Running, Cytokines, Exercise Tolerance, Cross-Over Studies, Probiotics, Gastrointestinal Tract

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