The DOI matches its Crossref record; 127 of the 129 references it cites were found in a registry or an index.
Excitatory signal flow and connectivity in a cortical column: focus on barrel cortex.
Abstract
A basic feature of the neocortex is its organization in functional, vertically oriented columns, recurring modules of signal processing and a system of transcolumnar long-range horizontal connections. These columns, together with their network of neurons, present in all sensory cortices, are the cellular substrate for sensory perception in the brain. Cortical columns contain thousands of neurons and span all cortical layers. They receive input from other cortical areas and subcortical brain regions and in turn their neurons provide output to various areas of the brain. The modular concept presumes that the neuronal network in a cortical column performs basic signal transformations, which are then integrated with the activity in other networks and more extended brain areas. To understand how sensory signals from the periphery are transformed into electrical activity in the neocortex it is essential to elucidate the spatial-temporal dynamics of cortical signal processing and the underlying neuronal 'microcircuits'. In the last decade the 'barrel' field in the rodent somatosensory cortex, which processes sensory information arriving from the mysticial vibrissae, has become a quite attractive model system because here the columnar structure is clearly visible. In the neocortex and in particular the barrel cortex, numerous neuronal connections within or between cortical layers have been studied both at the functional and structural level. Besides similarities, clear differences with respect to both physiology and morphology of synaptic transmission and connectivity were found. It is therefore necessary to investigate each neuronal connection individually, in order to develop a realistic model of neuronal connectivity and organization of a cortical column. This review attempts to summarize recent advances in the study of individual microcircuits and their functional relevance within the framework of a cortical column, with emphasis on excitatory signal flow.
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“For example, L4 spiny neurons in the barrel cortex of the mouse are characterized by mainly vertically-oriented, predominantly intra-columnar, axons that target layer 2/3 pyramidal cells [46].”
From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [46]
In the citing paper
“The projections from layer 3 to layer 5 are confined to the same column [46].”
From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [46]
In the citing paper
“It is known that layer 2/3 pyramidal cell axons have two distinct projection fields: one horizontal (the long range axon collaterals), and one vertical [46].”
From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [46]
Citations
Cites
Receptive fields, binocular interaction and functional architecture in the cat’s visual cortex
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Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
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Self-citationInterneurons of the hippocampus
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NEURONAL CIRCUITS OF THE NEOCORTEX
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Highly nonrandom features of synaptic connectivity in local cortical circuits
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2 of the 129 references couldn’t be matched to a known paper.
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Amaral, D. G., Schumann, C. M., & Nordahl, C. W. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2007.12.005 · Cited by 1,492
The Functional Organization of the Barrel Cortex
Petersen, C. C. H. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.017 · Cited by 732
Synaptic mechanisms for plasticity in neocortex
Feldman, D. E. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135516 · Cited by 704
Long-Range Neuronal Circuits Underlying the Interaction between Sensory and Motor Cortex
Mao, T., Kusefoglu, D., Hooks, B. M., Huber, D., Petreanu, L., & Svoboda, K. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.029 · Cited by 538
Active properties of neocortical pyramidal neuron dendrites
Major, G., Larkum, M. E., & Schiller, J. (2013) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150343 · Cited by 443
Metadata
- Authors
- Lübke, J., & Feldmeyer, D.
- Affiliations
- Forschungszentrum Jülich (DE)
- Corresponding author
- Feldmeyer, Dirk
- Venue
- Brain Structure and Function
- Published
- 2007-06-01
- Volume
- 212
- Issue
- 1
- Pages
- 3-17
- ISSN
- 1863-2653 (ISSN-L)
- 1863-2661
- OpenAlex
- W1990931283
- Cited by
- 233
- References
- 129
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 11 · 2023: 4 · 2022: 13 · 2021: 9 · 2020: 9 · 2019: 11 · 2018: 9 · 2017: 14 · 2016: 8 · 2015: 16 · 2014: 15 · 2013: 19 · 2012: 15
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Brain Structure and Function (publishedVersion)
- PubMed (publishedVersion)
- JuSER (Forschungszentrum Jülich) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- barrel cortex, cortical columns, neuronal connectivity, microcircuits, somatosensory cortex, synaptic transmission, horizontal connections, sensory signal processing
- MeSH terms
- Afferent Pathways, Animals, Humans, Nerve Net, Neural Pathways, Synaptic Transmission, Neurons, Afferent, Sensory Receptor Cells, Somatosensory Cortex, Pyramidal Cells, Ventral Thalamic Nuclei
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