Cited by 233Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchVisual perception and processing mechanisms

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Excitatory signal flow and connectivity in a cortical column: focus on barrel cortex.

Lübke, Joachim, Feldmeyer, Dirk·2007·Brain Structure and Function

DOI 10.1007/s00429-007-0144-2

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Abstract

A basic feature of the neocortex is its organization in functional, vertically oriented columns, recurring modules of signal processing and a system of transcolumnar long-range horizontal connections. These columns, together with their network of neurons, present in all sensory cortices, are the cellular substrate for sensory perception in the brain. Cortical columns contain thousands of neurons and span all cortical layers. They receive input from other cortical areas and subcortical brain regions and in turn their neurons provide output to various areas of the brain. The modular concept presumes that the neuronal network in a cortical column performs basic signal transformations, which are then integrated with the activity in other networks and more extended brain areas. To understand how sensory signals from the periphery are transformed into electrical activity in the neocortex it is essential to elucidate the spatial-temporal dynamics of cortical signal processing and the underlying neuronal 'microcircuits'. In the last decade the 'barrel' field in the rodent somatosensory cortex, which processes sensory information arriving from the mysticial vibrissae, has become a quite attractive model system because here the columnar structure is clearly visible. In the neocortex and in particular the barrel cortex, numerous neuronal connections within or between cortical layers have been studied both at the functional and structural level. Besides similarities, clear differences with respect to both physiology and morphology of synaptic transmission and connectivity were found. It is therefore necessary to investigate each neuronal connection individually, in order to develop a realistic model of neuronal connectivity and organization of a cortical column. This review attempts to summarize recent advances in the study of individual microcircuits and their functional relevance within the framework of a cortical column, with emphasis on excitatory signal flow.

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Self-citation
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BackgroundMethod
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Authors: Lübke, J., & Feldmeyer, D.
Affiliations: Forschungszentrum Jülich (DE)
Corresponding author: Feldmeyer, Dirk
ORCID: Lübke, Joachim
Feldmeyer, Dirk
Venue: Brain Structure and Function
Publisher: Springer Science and Business Media LLC
Published: 2007-06-01
Volume: 212
Issue: 1
Pages: 3-17
ISSN: 1863-2653 (ISSN-L)
1863-2661
DOI: 10.1007/s00429-007-0144-2
OpenAlex: W1990931283
Cited by: 233
References: 129
Citations by year: 2026: 4 · 2025: 9 · 2024: 11 · 2023: 4 · 2022: 13 · 2021: 9 · 2020: 9 · 2019: 11 · 2018: 9 · 2017: 14 · 2016: 8 · 2015: 16 · 2014: 15 · 2013: 19 · 2012: 15
FWCI: 1.06
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Brain Structure and Function (publishedVersion)
PubMed (publishedVersion)
JuSER (Forschungszentrum Jülich) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Keywords: barrel cortex, cortical columns, neuronal connectivity, microcircuits, somatosensory cortex, synaptic transmission, horizontal connections, sensory signal processing
MeSH terms: Afferent Pathways, Animals, Humans, Nerve Net, Neural Pathways, Synaptic Transmission, Neurons, Afferent, Sensory Receptor Cells, Somatosensory Cortex, Pyramidal Cells, Ventral Thalamic Nuclei

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Excitatory signal flow and connectivity in a cortical column: focus on barrel cortex.

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