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Saliency, switching, attention and control: a network model of insula function
Open accessAbstract
The insula is a brain structure implicated in disparate cognitive, affective, and regulatory functions, including interoceptive awareness, emotional responses, and empathic processes. While classically considered a limbic region, recent evidence from network analysis suggests a critical role for the insula, particularly the anterior division, in high-level cognitive control and attentional processes. The crucial insight and view we present here is of the anterior insula as an integral hub in mediating dynamic interactions between other large-scale brain networks involved in externally oriented attention and internally oriented or self-related cognition. The model we present postulates that the insula is sensitive to salient events, and that its core function is to mark such events for additional processing and initiate appropriate control signals. The anterior insula and the anterior cingulate cortex form a “salience network” that functions to segregate the most relevant among internal and extrapersonal stimuli in order to guide behavior. Within the framework of our network model, the disparate functions ascribed to the insula can be conceptualized by a few basic mechanisms: (1) bottom–up detection of salient events, (2) switching between other large-scale networks to facilitate access to attention and working memory resources when a salient event is detected, (3) interaction of the anterior and posterior insula to modulate autonomic reactivity to salient stimuli, and (4) strong functional coupling with the anterior cingulate cortex that facilitates rapid access to the motor system. In this manner, with the insula as its integral hub, the salience network assists target brain regions in the generation of appropriate behavioral responses to salient stimuli. We suggest that this framework provides a parsimonious account of insula function in neurotypical adults, and may provide novel insights into the neural basis of disorders of affective and social cognition.
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“As part of the viscerosensory cortex, the anterior insula plays a pivotal role in appraising an interoceptive inference based on incoming raw interoceptive and exteroceptive input (Seeley et al., 2007; Menon and Uddin, 2010; Zaki et al., 2012; Wager et al., 2015).”
From How Processing of Sensory Information From the Internal and External Worlds Shape the Perception and Engagement With the World in the Aftermath of Trauma: Implications for PTSD (2021) · cites this paper as Menon and Uddin, 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Here, the insula helps direct information to lateralized frontoparietal networks in the brain that involve the dorsolateral prefrontal cortex and the posterior parietal cortex in order to facilitate multisensory integration (Menon and Uddin, 2010; Figure 4).”
From How Processing of Sensory Information From the Internal and External Worlds Shape the Perception and Engagement With the World in the Aftermath of Trauma: Implications for PTSD (2021) · cites this paper as Menon and Uddin, 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Developing an awareness of an emotional feeling underlying a sensory experience may aid in its translation to the central executive network, which plays a role in identifying the contextual meaning of an emotional feeling (Seeley et al., 2007; Menon and Uddin, 2010; Wager et al., 2015).”
From How Processing of Sensory Information From the Internal and External Worlds Shape the Perception and Engagement With the World in the Aftermath of Trauma: Implications for PTSD (2021) · cites this paper as Menon and Uddin, 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, while both insula and dACC are components of the SN, they subserve different functions, with insula more related to internal somatic function and monitoring task performance (Eckert et al. 2009;Menon and Uddin 2010;Cai et al. 2014), while the dACC is”
From Brain Activity and Functional Connectivity Associated with Hypnosis (2016) · cites this paper as Menon and Uddin 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“the insula is involved in the processing of body control and experience, emotion, empathy, and time through its extensive connections to cortical and subcortical limbic structures (Menon and Uddin 2010;Cai et al. 2014).”
From Brain Activity and Functional Connectivity Associated with Hypnosis (2016) · cites this paper as Menon and Uddin 2010
Experimental — accuracy not yet measured
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“Salience Network (SN): Crucial for detecting relevant internal and external stimuli and switching between the DMN and CCN/CEN, dysfunction in the SN (often involving the dorsal anterior cingulate cortex (dACC) and insula) has been linked to fatigue, aPective symptoms, and cognitive diPiculties post-concussion 12 13 .”
From Functional MRI Guided Accelerated Intermittent Theta Burst Stimulation for Chronic Post-Concussive Syndrome: A Feasibility and Efficacy Study (2025) · cites this paper as [12]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Here, the insula plays a putative role in engaging large-scale neural systems by translating incoming sensory information to intrinsic cortical connectivity networks that assist in modulating and contextualizing incoming salient sensory information to guide behavioral responses (Menon and Uddin, 2010; Seeley et al., 2007).”
From How Processing of Sensory Information From the Internal and External Worlds Shape the Perception and Engagement With the World in the Aftermath of Trauma: Implications for PTSD (2021) · cites this paper as Menon and Uddin, 2010
The cited source says what the claim attributes to it.
In the citing paper
“The insular cortex has reciprocal connections to the ACC and can facilitate cognitive control by acting as the switch between the central-executive network and the default mode network DMN (Cole and Schneider, 2007; Sridharan et al., 2008; Menon and Uddin, 2010).”
From Mindfulness, Interoception, and the Body: A Contemporary Perspective (2019) · cites this paper as Menon and Uddin, 2010
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In the citing paper
“The anterior insula node of the salience network, in particular, is crucial for bottom-up detection of salient events and switching between other large-scale networks to facilitate access to attention and working memory resources. 25”
From 20 years of the default mode network: A review and synthesis. (2023) · cites this paper as [25]
The cited source says what the claim attributes to it.
In the citing paper
“The SN governs our attention to the external and internal world (Menon and Uddin, 2010), and as such, integrates sensory, emotional and cognitive information to facilitate optimal communication, social behavior and self-awareness (Menon, 2015).”
From Distinct functional connectivities predict clinical response with emotion regulation therapy (2017) · cites this paper as Menon and Uddin, 2010
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In the citing paper
“The anterior insula is associated with the integration of interoception and cognition (Menon and Uddin, 2010), and the right anterior VLPFC with reflexive reorienting and response inhibition (Levy and Wagner, 2011).”
From Neural correlates of emotion acceptance vs worry or suppression in generalized anxiety disorder (2017) · cites this paper as Menon and Uddin, 2010
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In the citing paper
“Notably, suppression of the DMN and engagement of cognitive control networks during task performance are thought to be controlled by a common mechanism, with the salience network playing a crucial role.”
From 20 years of the default mode network: A review and synthesis. (2023) · cites this paper as [25]
The cited source says what the claim attributes to it.
In the citing paper
“as well as empathic perception of pain in others, (Menon and Uddin 2010;Gu et al. 2012)”
From Brain Activity and Functional Connectivity Associated with Hypnosis (2016) · cites this paper as Menon and Uddin 2010
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“While decreases have been for MPFC and ACC in depression [74], but also social anxiety [75] or Alzheimer disease [76], a recent study in bipolar depression rather indicated an increase in MPFC ReHo [74].”
From State and training effects of mindfulness meditation on brain networks reflect neuronal mechanisms of its antidepressant effect (2016) · cites this paper as [74]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“The rationale for applying TMS, and specifically iTBS, to PCS stems from converging evidence suggesting that persistent post-concussive symptoms are associated with disruptions in largescale functional brain networks.”
From Functional MRI Guided Accelerated Intermittent Theta Burst Stimulation for Chronic Post-Concussive Syndrome: A Feasibility and Efficacy Study (2025) · cites this paper as [12]
Experimental — accuracy not yet measuredIn the citing paper
“The right aINS has previously been identified as a critical node for suppressing DN activity and reallocating attentional resources to salient events.244,245”
From The default network and self-generated thought: component processes, dynamic control, and clinical relevance (2014) · cites this paper as [244]
In the citing paper
“Detected hub nodes were located within the CON (i.e., the left dACC), the salience network (53) (i.e., the right anterior insula, right intraparietal sulcus, and bilateral dACC), and the motor network (i.e., bilateral pre- and post-central gyri).”
From Impact of Childhood Trauma on Executive Function in Adolescence—Mediating Functional Brain Networks and Prediction of High-Risk Drinking (2020) · cites this paper as [53]
In the citing paper
“Together these distributed brain networks integrate bottom-up attention with top-down control and generate appropriate behavioral responses to salient stimuli, thereby contributing to behavioral regulation and sound executive function (51–57).”
From Impact of Childhood Trauma on Executive Function in Adolescence—Mediating Functional Brain Networks and Prediction of High-Risk Drinking (2020) · cites this paper as [53]
In the citing paper
“As such, the SN has been proposed to play a key role in cognitive control (Ham et al., 2013), i.e., switching brain activity between introspective, ruminative functions of the default-mode network and externally focused, task-based functions of the central executive network (Menon and Uddin, 2010).”
From Cortico-striatal-thalamic loop circuits of the salience network: A central pathway in psychiatric disease and treatment (2016) · cites this paper as Menon and Uddin, 2010
In the citing paper
“It is activated in a wide variety of cognitive and emotional tasks (Dosenbach et al., 2006) and forms the important salience network in resting state literature (Menon and Uddin, 2010).”
From Cognitive flexibility in adolescence: Neural and behavioral mechanisms of reward prediction error processing in adaptive decision making during development (2015) · cites this paper as Menon and Uddin, 2010
In the citing paper
“Indeed, activity in the AIC is a common feature in studies of cognitive control and inhibitory processing [7, 46–50] and reward sensitivity [8, 9].”
From The role of the anterior insula in adolescent decision making (2014) · cites this paper as [8]
In the citing paper
“The SN dynamically switches between the ECN and DMN, which are generally anticorrelated, following detection of relevant stimulation or condition”
From The Insula: A Brain Stimulation Target for the Treatment of Addiction (2019) · cites this paper as Menon and Uddin, 2010
In the citing paper
“These include automatic salience evaluation, [ 4 9 8 _ T D $ D I F F ] inhibition/interruption of ongoing activity[ 4 9 9 _ T D $ D I F F ] , alerting, salience-driven switching, and reflexive orienting [40,43,47,48].”
From Anxiety and Threat-Related Attention: Cognitive-Motivational Framework and Treatment (2018) · cites this paper as [48]
In the citing paper
“In addition, over-reactive threat salience-driven switching may cause excessive threat-prioritisation in cognitive system functioning (attention, working memory), and resultant anxiety [48].”
From Anxiety and Threat-Related Attention: Cognitive-Motivational Framework and Treatment (2018) · cites this paper as [48]
In the citing paper
“The adaptive value of this inhibitory mechanism in salient, emotional situations may be to prepare for immediate action in the external world [39].”
From On the interaction of social affect and cognition: empathy, compassion and theory of mind (2018) · cites this paper as [39]
In the citing paper
“These regions are interconnected with the ventral striatum and form core components of the brain's incentive salience system (Menon and Uddin, 2010).”
From Neural networks involved in adolescent reward processing: an activation likelihood estimation meta-analysis of functional neuroimaging studies (2015) · cites this paper as Menon and Uddin, 2010
In the citing paper
“The insula is a critical component of the brain's salience network (Craig, 2009; Menon and Uddin, 2010) and participates in interoceptive awareness, the representation of physiological states associated with risk (Xue et al., 2010), and integration of such states with behavior during risky contexts that are characterized by uncertainty (Singer et al., 2009).”
From Neural networks involved in adolescent reward processing: an activation likelihood estimation meta-analysis of functional neuroimaging studies (2015) · cites this paper as Menon and Uddin, 2010
In the citing paper
“The anterior cingulate, frequently co-activated with the anterior insula (Menon and Uddin, 2010) may play a role in integrating emotion and motivational signals pertaining to contextual salience with executive control systems (Pessoa, 2009) so that adaptive behavioral responses can be formulated and executed.”
From Neural networks involved in adolescent reward processing: an activation likelihood estimation meta-analysis of functional neuroimaging studies (2015) · cites this paper as Menon and Uddin, 2010
In the citing paper
“The SORT not only activates brain regions involved in semantic memory recall, which include bilateral inferior frontal gyrus (including Broca's area), left DLPFC, left middle temporal gyrus, bilateral angular gyrus, and PCC [Assaf et al., 2006;Binder et al., 2009], but also activates salience-related regions, including dorsal anterior cingulate cortex (dACC), pre-SMA [Assaf et al., 2006] and”
From Specific default mode subnetworks support mentalizing as revealed through opposing network recruitment by social and semantic FMRI tasks: Mentalizing and Default-Mode Subnetworks (2015) · cites this paper as Menon and Uddin, 2010
In the citing paper
“SN also plays a role in adaptive switching between the central executive network (CEN), involved in focused attentional states, and the default mode network (DMN), active during introspective self-referential thought and social emotional processes ( Amodio and Frith, 2006 ; Sridharan et al., 2008 ; Menon and Uddin, 2010 ; Spreng and Grady, 2010 ; Menon, 2015 ).”
From The brain-body disconnect: A somatic sensory basis for trauma-related disorders (2022) · cites this paper as Menon and Uddin, 2010
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Cites
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504136102 · Cited by 8,553
Dissociable intrinsic connectivity networks for salience processing and executive control
Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426
Self-citationSpontaneous fluctuations in brain activity observed with functional magnetic resonance imaging
Fox, M. D., & Raichle, M. E. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2201 · Cited by 6,700
How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657 · cited 6×
“Descending pathways from the dorsal posterior insula have been described which terminate in the brainstem parabrachial nuclei, constituting a mechanism for cortical control of brainstem homeostatic systems (Craig 2002).”
InfluentialFunctional connectivity in the resting brain: a network analysis of the default mode hypothesis
Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0135058100 · Cited by 6,358
Self-citationHow do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
Consistent resting-state networks across healthy subjects
Damoiseaux, J. S., Rombouts, S. A. R. B., Barkhof, F., Scheltens, P., Stam, C. J., Smith, S. M., & Beckmann, C. F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601417103 · Cited by 4,326
Binder, J. R., Desai, R. H., Graves, W. W., & Conant, L. L. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp055 · Cited by 4,060
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Hodge, R. D., Miller, J. A., Novotny, M. A., Kalmbach, B. E., Ting, J. T., Bakken, T. E., Aevermann, B. D., Barkan, E. R., Berkowitz-Cerasano, M. L., Cobbs, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14952-3 · Cited by 95
Cholinergic Denervation Patterns Across Cognitive Domains in Parkinson's Disease
van der Zee, S., Müller, M. L. T. M., Kanel, P., van Laar, T., & Bohnen, N. I. (2020) · Movement Disorders · doi:10.1002/mds.28360 · Cited by 96
Regression dynamic causal modeling for resting‐state fMRI
Frässle, S., Harrison, S. J., Heinzle, J., Clementz, B. A., Tamminga, C. A., Sweeney, J. A., Gershon, E. S., Keshavan, M. S., Pearlson, G. D., Powers, A. R., et al. (2021) · Human Brain Mapping · doi:10.1002/hbm.25357 · Cited by 92
Gradients of neurotransmitter receptor expression in the macaque cortex
Froudist‐Walsh, S., Xu, T., Niu, M., Rapan, L., Zhao, L., Margulies, D. S., Zilles, K., Wang, X., & Palomero‐Gallagher, N. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01351-2 · Cited by 103
Karim, H. T., Andreescu, C., Tudorascu, D., Smagula, S. F., Butters, M. A., Karp, J. F., Reynolds, C., & Aizenstein, H. J. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.55 · Cited by 95
Koenigsberg, H., Denny, B. T., Fan, J., Liu, X., Guerreri, S., Mayson, S., Rimsky, L., New, A., Goodman, M., & Siever, L. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13070852 · Cited by 87
Altered Gray Matter Structural Covariance Networks in Early Stages of Alzheimer's Disease
Montembeault, M., Rouleau, I., Provost, J.-S., & Brambati, S. M. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv105 · Cited by 94
Frequency dependent hub role of the dorsal and ventral right anterior insula
Wang, Y., Zhu, L., Zou, Q., Cui, Q., Liao, W., Duan, X., Biswal, B. B., & Chen, H. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.10.004 · Cited by 95
Next-generation neural mass and field modeling
Byrne, Á., O’Dea, R. D., Forrester, M., Ross, J., & Coombes, S. (2019) · Journal of Neurophysiology · doi:10.1152/jn.00406.2019 · Cited by 101
Reducing the Cognitive Footprint of Brain Tumor Surgery
Dadario, N. B., Brahimaj, B. C., Yeung, J. T., & Sughrue, M. E. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.711646 · Cited by 93
Functional Connectivity of the Brain Across Rodents and Humans
Xu, N., LaGrow, T. J., Anumba, N., Lee, A., Zhang, X., Yousefi, B., Bassil, Y., Clavijo, P. G., Sharghi, V. K., Maltbie, E. A., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.816331 · Cited by 100
Neuroimaging in schizophrenia: A review article
Dabiri, M., Firouzabadi, F. D., Yang, K., Barker, P. B., Lee, R. R., & Yousem, D. M. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1042814 · Cited by 104
Kronemer, S. I., Aksen, M., Ding, J. Z., Ryu, J. H., Xin, Q., Ding, Z., Prince, J. S., Kwon, H., Khalaf, A. F., Forman, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35117-4 · Cited by 95
Sidlauskaite, J., Sonuga-Barke, E. J. S., Roeyers, H., & Wiersema, J. R. (2015) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-015-0630-0 · Cited by 99
Altered salience network connectivity predicts macronutrient intake after sleep deprivation
Fang, Z., Spaeth, A. M., Ma, N., Zhu, S., Hu, S., Goel, N., Detre, J. A., Dinges, D. F., & Rao, H. (2015) · Scientific Reports · doi:10.1038/srep08215 · Cited by 94
Maesawa, S., Bagarinao, E., Fujii, M., Futamura, M., Motomura, K., Watanabe, H., Mori, D., Sobue, G., & Wakabayashi, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118072 · Cited by 96
Tsuchida, A., & Fellows, L. K. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr370 · Cited by 103
Neuroimaging Correlates of Resilience to Traumatic Events—A Comprehensive Review
Bolsinger, J., Seifritz, E., Kleim, B., & Manoliu, A. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00693 · Cited by 102
Toenders, Y. J., van Velzen, L. S., Heideman, I. Z., Harrison, B. J., Davey, C. G., & Schmaal, L. (2019) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2019.100700 · Cited by 93
Jauhar, S., Fortea, L., Solanes, A., Albajes‐Eizagirre, A., McKenna, P. J., & Raduà, J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0255292 · Cited by 103
A brain atlas of axonal and synaptic delays based on modelling of cortico-cortical evoked potentials
Lemaréchal, J.-D., Jedynak, M., Trébaul, L., Boyer, A., Tadel, F., Bhattacharjee, M., Deman, P., Tuyisenge, V., Ayoubian, L., Hugues, E., et al. (2021) · Brain · doi:10.1093/brain/awab362 · Cited by 114
Ganesan, S., Beyer, E., Moffat, B. A., Dam, N. T. V., Lorenzetti, V., & Zalesky, A. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104846 · Cited by 95
Intrinsic connectivity networks from childhood to late adolescence: Effects of age and sex
Solé‐Padullés, C., Castro‐Fornieles, J., de la Serna, E., Calvo, R. M., Baeza, I., Moyá, J., Lázaro, L., Rosa, M., Bargalló, N., & Sugranyes, G. (2015) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2015.11.004 · Cited by 94
Affective neural response to restricted interests in autism spectrum disorders
Cascio, C. J., Foss‐Feig, J. H., Heacock, J., Schauder, K. B., Loring, W. A., Rogers, B. P., Pryweller, J. R., Newsom, C. R., Cockhren, J., Cao, A., et al. (2014) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12147 · Cited by 93
Strawn, J. R., Cotton, S., Luberto, C. M., Patino, L. R., Stahl, L., Weber, W. A., Eliassen, J. C., Sears, R. W., & DelBello, M. P. (2016) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2015.0054 · Cited by 95
Functional connectivity and cognitive impairment in migraine with and without aura
Buono, V. L., Bonanno, L., Corallo, F., Pisani, L. R., Presti, R. L., Grugno, R., Lorenzo, G. D., Bramanti, P., & Marino, S. (2017) · The Journal of Headache and Pain · doi:10.1186/s10194-017-0782-6 · Cited by 96
Kesler, S. R., Rao, A., Blayney, D. W., Oakley-Girvan, I. A., Karuturi, M. S., & Palesh, O. G. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00555 · Cited by 96
Danckert, J. A., Mugon, J., Struk, A. A., & Eastwood, J. D. (2018) · Springer eBooks · doi:10.1007/978-3-319-77619-4_6 · Cited by 99
Guo, X., Duan, X., Suckling, J., Chen, H., Liao, W., Cui, Q., & Chen, H. (2018) · Human Brain Mapping · doi:10.1002/hbm.24447 · Cited by 93
Lawrence, K. E., Hernandez, L. M., Bowman, H. C., Padgaonkar, N. T., Fuster, E., Jack, A., Aylward, E., Gaab, N., Horn, J. D. V., Bernier, R., et al. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa105 · Cited by 89
Schurz, M., Maliske, L., & Kanske, P. (2020) · Cortex · doi:10.1016/j.cortex.2020.05.006 · Cited by 110
Foundations of Human Consciousness: Imaging the Twilight Zone
Scheinin, A., Kantonen, O., Alkire, M. T., Långsjö, J., Kallionpää, R., Kaisti, K. K., Radek, L., Johansson, J. J., Sandman, N., Nyman, M. J., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0775-20.2020 · Cited by 98
Bao, W., Gao, Y., Cao, L., Li, H., Liu, J., Liang, K., Hu, X., Zhang, L., Hu, X., Gong, Q., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.017 · Cited by 92
Eckert, U., Metzger, C. D., Buchmann, J. E., Kaufmann, J., Osoba, A., Li, M., Safron, A., Liao, W., Steiner, J. H., Bogerts, B., et al. (2011) · Human Brain Mapping · doi:10.1002/hbm.21389 · Cited by 93
Investigating interoception and body awareness in adults with and without autism spectrum disorder
Fiene, L., & Brownlow, C. (2015) · Autism Research · doi:10.1002/aur.1486 · Cited by 91
Hong, J., Kilpatrick, L. A., Labus, J. S., Gupta, A., Katibian, D., Ashe-McNalley, C., Stains, J., Heendeniya, N., Smith, S. R., Tillisch, K., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1683-14.2014 · Cited by 96
Auditory cortex is implicated in tinnitus distress: a voxel-based morphometry study
Schecklmann, M., Lehner, A., Poeppl, T. B., Kreuzer, P. M., Rupprecht, R., Rackl, J., Burger, J., Frank, E., Hajak, G., Langguth, B., et al. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0520-z · Cited by 92
Wang, J., Khosrowabadi, R., Ng, K. K., Hong, Z., Chong, J. S. X., Wang, Y., Chen, C.-Y., Hilal, S., Venketasubramanian, N., Wong, T. Y., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00404 · Cited by 92
Nicholson, A. A., Harricharan, S., Densmore, M., Neufeld, R. W. J., Ros, T., McKinnon, M. C., Frewen, P., Théberge, J., Jetly, R., Pedlar, D., et al. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102262 · Cited by 100
Abnormalities in structural covariance of cortical gyrification in schizophrenia
Palaniyappan, L. K., Park, B., Balain, V., Dangi, R., & Liddle, P. F. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0772-2 · Cited by 94
Andreescu, C., Sheu, L. K., Tudorascu, D., Gross, J. J., Walker, S. E., Banihashemi, L., & Aizenstein, H. J. (2014) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2014.05.003 · Cited by 102
Aging is associated with changes in the neural circuits underlying empathy
Chen, Y.-C., Chen, C.-C., Decety, J., & Cheng, Y. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.10.080 · Cited by 94
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Mestres-Missé, A., Turner, R., & Friederici, A. D. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.05.021 · Cited by 91
Joo, S. H., Lim, H. K., & Lee, C. U. (2016) · Psychiatry Investigation · doi:10.4306/pi.2016.13.1.1 · Cited by 94
Wang, J., Wang, Y., Wu, X., Huang, H., Jia, Y., Zhong, S., Wu, X., Zhao, L., He, Y., Huang, L., et al. (2018) · Brain Imaging and Behavior · doi:10.1007/s11682-018-9978-x · Cited by 93
Moreno-López, L., Ioannidis, K., Askelund, A. D., Smith, A., Schueler, K., & van Harmelen, A. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.12.008 · Cited by 98
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Tremblay, C., Abbasi, N., Zeighami, Y., Yau, Y. H. C., Dadar, M., Rahayel, S., & Dagher, A. (2020) · Brain · doi:10.1093/brain/awaa234 · Cited by 91
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Ha, O., & Lim, S.-L. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1265074 · Cited by 105
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Cocchi, L., Halford, G. S., Zalesky, A., Harding, I. H., Ramm, B. J., Cutmore, T. R. H., Shum, D., & Mattingley, J. B. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht075 · Cited by 94
Jolles, D., Ashkenazi, S., Kochalka, J., Evans, T. M., Richardson, J. L., Rosenberg‐Lee, M., Zhao, H., Supekar, K., Chen, T., & Menon, V. (2016) · Developmental Science · doi:10.1111/desc.12399 · Cited by 98
Self-citationNeurocognitive mechanisms of the “testing effect”: A review
van den Broek, G. S. E., Takashima, A., Wiklund‐Hörnqvist, C., Wirebring, L. K., Segers, E., Verhoeven, L. T. W., & Nyberg, L. H. (2016) · Trends in Neuroscience and Education · doi:10.1016/j.tine.2016.05.001 · Cited by 101
Wiebking, C., de Greck, M., Duncan, N. W., Tempelmann, C., Bajbouj, M., & Northoff, G. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00082 · Cited by 90
I keep a close watch on this heart of mine: increased interoception in insomnia
Wei, Y., Ramautar, J. R., Colombo, M. A., Stoffers, D., Gómez-Herrero, G., van der Meijden, W. P., te Lindert, B. H. W., van der Werf, Y. D., & Van Someren, E. J. W. (2016) · Sleep · doi:10.5665/sleep.6308 · Cited by 90
Janes, A. C., Farmer, S. L., Peechatka, A. L., Frederick, B. B., & Lukas, S. E. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.9 · Cited by 90
Naçi, L., Cusack, R., Jia, V. Z., & Owen, A. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5577-12.2013 · Cited by 89
Dynamics of brain activity underlying working memory for music in a naturalistic condition
Burunat, I., Alluri, V., Toiviainen, P., Numminen, J., & Brattico, E. (2014) · Cortex · doi:10.1016/j.cortex.2014.04.012 · Cited by 95
Brain connectivity and psychiatric comorbidity in adolescents with Internet gaming disorder
Han, D. H., Kim, S. M., Bae, S., Renshaw, P. F., & Anderson, J. S. (2015) · Addiction Biology · doi:10.1111/adb.12347 · Cited by 95
Default Mode and Executive Networks Areas: Association with the Serial Order in Divergent Thinking
Heinonen, J., Numminen, J., Hlushchuk, Y., Antell, H., Taatila, V. P., & Suomala, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162234 · Cited by 95
Brain networks underlying novel metaphor production
Beaty, R. E., Silvia, P. J., & Benedek, M. (2016) · Brain and Cognition · doi:10.1016/j.bandc.2016.12.004 · Cited by 91
Fractional amplitude of low-frequency fluctuations (fALFF) in post-stroke depression
Egorova, N., Veldsman, M., Cumming, T. B., & Brodtmann, A. G. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.07.014 · Cited by 92
Toward a brain theory of meditation
Raffone, A., Marzetti, L., Gratta, C. D., Perrucci, M. G., Romani, G. L., & Pizzella, V. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2018.10.028 · Cited by 94
Nguyen, V. T., Breakspear, M. J., Hu, X., & Guo, C. C. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.08.078 · Cited by 90
Auditory change detection in fragile X syndrome males: A brain potential study
van der Molen, M. J. W., van der Molen, M. W., Ridderinkhof, K. R., Hamel, B. C. J., Curfs, L., & Ramakers, G. J. A. (2011) · Clinical Neurophysiology · doi:10.1016/j.clinph.2011.11.039 · Cited by 90
Consistent Anterior–Posterior Segregation of the Insula During the First 2 Years of Life
Alcauter, S., Lin, W., Smith, J. K., Gilmore, J. H., & Gao, W. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht312 · Cited by 94
Identifying major depressive disorder using Hurst exponent of resting-state brain networks
Wei, M., Qin, J., Yan, R., Li, H., Yao, Z., & Lü, Q. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2013.09.008 · Cited by 90
Li, X., & Wang, J. (2021) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00299-2 · Cited by 89
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Trevis, K. J., McLachlan, N. M., & Wilson, S. J. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.01262 · Cited by 92
The neuroscience of goals and behavior change.
Berkman, E. T. (2018) · Consulting psychology journal · doi:10.1037/cpb0000094 · Cited by 102
Hohenschurz‐Schmidt, D., Calcagnini, G., Dipasquale, O., Jackson, J. B., Medina, S., O’Daly, O., O’Muircheartaigh, J., Rubio, A. D. L., Williams, S., McMahon, S. B., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00147 · Cited by 91
Peng, H., Wu, K., Li, J., Qi, H., Guo, S., Chi, M., Wu, X.-M., Guo, Y., Yang, Y., & Ning, Y. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.04.046 · Cited by 89
Wang, T., Zhang, X., Li, A., Zhu, M., Liu, S., Qin, W., Li, J., Yu, C., Jiang, T., & Liu, B. (2017) · NeuroImage: Clinical · doi:10.1016/j.nicl.2017.02.011 · Cited by 88
Brain networks and cognitive impairment in psychiatric disorders
Menon, V. (2020) · World Psychiatry · doi:10.1002/wps.20799 · Cited by 88
Self-citationConcentration: The Neural Underpinnings of How Cognitive Load Shields Against Distraction
Sörqvist, P., Dahlström, Ö., Karlsson, T., & Rönnberg, J. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00221 · Cited by 93
Heine, J., Prüß, H., Kopp, U. A., Wegner, F., Bergh, F. T., Münte, T. F., Wandinger, K., Paul, F., Bartsch, T., & Finke, C. (2018) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-317780 · Cited by 90
Vartanian, O. A. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316979839.010 · Cited by 92
Altered resting‐state network connectivity in congenital blind
Wang, D., Qin, W., Liu, Y., Zhang, Y., Jiang, T., & Yu, C. (2013) · Human Brain Mapping · doi:10.1002/hbm.22350 · Cited by 91
Common brain activations for painful and non-painful aversive stimuli
Hayes, D. J., & Northoff, G. (2012) · BMC Neuroscience · doi:10.1186/1471-2202-13-60 · Cited by 99
Disrupted insula-based neural circuit organization and conflict interference in trauma-exposed youth
Marusak, H. A., Etkin, A., & Thomason, M. E. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.04.007 · Cited by 95
Sullivan, E. V., Müller‐Oehring, E. M., Pitel, A., Chanraud, S., Shankaranarayanan, A., Alsop, D. C., Torsten Rohlfing, B., & Pfefferbaum, A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.026 · Cited by 88
Fan, J., Zhong, M., Gan, J., Liu, W., Niu, C., Liao, H., Zhang, H., Yi, J., Chan, R. C. K., Tan, C., et al. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.07.041 · Cited by 88
The neural architecture of executive functions is established by middle childhood
Engelhardt, L. E., Harden, K. P., Tucker-Drob, E. M., & Church, J. A. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2018.10.024 · Cited by 87
Hyett, M. P., Breakspear, M. J., Friston, K. J., Guo, C. C., & Parker, G. B. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2490 · Cited by 88
Fanning, J. R., Keedy, S., Berman, M. E., Lee, R., & Coccaro, E. F. (2017) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-017-0115-8 · Cited by 92
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Yao, S., Becker, B., Zhao, W., Zhao, Z., Kou, J., Ma, X., Geng, Y., Ren, P., & Kendrick, K. M. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.189 · Cited by 88
Leptourgos, P., Fortier, M., Carhart-Harris, R. L., Corlett, P. R., Dupuis, D., Halberstadt, A. L., Kometer, M., Kozáková, E., Larøi, F., Noorani, T. N., et al. (2020) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaa117 · Cited by 90
Bittar, T. P., & Labonté, B. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.699592 · Cited by 87
Reorganization of brain connectivity in obesity
Geha, P., Cecchi, G., Constable, R. T., Abdallah, C. G., & Small, D. M. (2016) · Human Brain Mapping · doi:10.1002/hbm.23462 · Cited by 85
Anomalous network architecture of the resting brain in children who stutter
Chang, S., Angstadt, M., Chow, H. M., Etchell, A. C., Garnett, E. O., Choo, A. L., Kessler, D. A., Welsh, R. C., & Sripada, C. (2017) · Journal of Fluency Disorders · doi:10.1016/j.jfludis.2017.01.002 · Cited by 135
Buzzell, G. A., Richards, J. E., White, L. K., Barker, T. V., Pine, D. S., & Fox, N. A. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.05.045 · Cited by 86
Heuschkel, K., & Kuypers, K. P. C. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00224 · Cited by 86
“The DMN works in close accordance with the central executive network (CEN), a group of brain regions involved in WM and goal-directed behavior (24, 25), and the salience network (SN), which mediates the activity of the DMN and CEN according to the saliency of external or internal stimuli (26).”
Mooneyham, B. W., Mrazek, M. D., Mrazek, A. J., Mrazek, K. L., Phillips, D. T., & Schooler, J. W. (2017) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01066 · Cited by 86
Cognitive Vulnerability to Major Depression
Wang, X., Öngür, D., Auerbach, R. P., & Yao, S. (2016) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000081 · Cited by 96
Mallikarjun, P. K., Lalousis, P. A., Dunne, T. F., Heinze, K., Reniers, R. L. E. P., Broome, M. R., Farmah, B., Oyebode, F., Wood, S. J., & Upthegrove, R. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0118-6 · Cited by 91
The Brain-Gut-Microbiome System: Pathways and Implications for Autism Spectrum Disorder
Chernikova, M. A., Flores, G. D., Kilroy, E., Labus, J. S., Mayer, E. A., & Aziz‐Zadeh, L. (2021) · Nutrients · doi:10.3390/nu13124497 · Cited by 93
Tinnitus and the Triple Network Model: A Perspective
Ridder, D. D., Vanneste, S., Song, J., & Adhia, D. B. (2022) · Clinical and Experimental Otorhinolaryngology · doi:10.21053/ceo.2022.00815 · Cited by 91
Reduced insular volume in attention deficit hyperactivity disorder
Lopez-Larson, M. P., King, J. B., Terry, J., McGlade, E., & Yurgelun-Todd, D. A. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2012.09.009 · Cited by 92
Modality-Specific Neural Effects of Selective Attention to Taste and Odor
Veldhuizen, M. G., & Small, D. M. (2011) · Chemical Senses · doi:10.1093/chemse/bjr043 · Cited by 86
Fandakova, Y., Selmeczy, D., Leckey, S., Grimm, K. J., Wendelken, C., Bunge, S. A., & Ghetti, S. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1703079114 · Cited by 89
Affective neuroscience of self‐generated thought
Fox, K. C. R., Andrews‐Hanna, J. R., Mills, C., Dixon, M. L., Markovic, J., Thompson, E. T., & Kalina Christoff, A. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13740 · Cited by 101
The social mind: disentangling affective and cognitive routes to understanding others
Kanske, P. (2018) · Interdisciplinary Science Reviews · doi:10.1080/03080188.2018.1453243 · Cited by 99
Metadata
- Authors
- Menon, V., & Uddin, L. Q.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Menon, Vinod
- Uddin, Lucina Q.
- Venue
- Brain Structure and Function
- Published
- 2010-05-29
- Volume
- 214
- Issue
- 5-6
- Pages
- 655-667
- ISSN
- 1863-2653 (ISSN-L)
- 1863-2661
- PMC
- PMC2899886
- OpenAlex
- W2129624700
- Semantic Scholar
- 7fd8bee2d3a38b29ae2228466d3431a34c7ae240
- Cited by
- 5,592
- References
- 93
- Citations by year
- 2026: 429 · 2025: 445 · 2024: 429 · 2023: 398 · 2022: 428 · 2021: 568 · 2020: 437 · 2019: 397 · 2018: 389 · 2017: 368 · 2016: 356 · 2015: 334 · 2014: 225 · 2013: 200 · 2012: 118
- FWCI
- 8.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Brain Structure and Function (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (K01MH092288)
- National Institute of Neurological Disorders and Stroke (NS058899, R21NS058899)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD057610, HD047520, HD057610, R01HD047520, R01HD059205)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- anterior insula, salience network, cognitive control, attention, network switching, anterior cingulate cortex, saliency detection, bottom-up processing, interoception, autonomic reactivity, working memory, large-scale brain networks
- MeSH terms
- Animals, Cerebral Cortex, Humans, Nerve Net, Neural Networks, Computer, Executive Function
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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