Cited by 91Neural and Behavioral Psychology StudiesNeurobiology of Language and BilingualismNeurotransmitter Receptor Influence on Behavior

An anterior-posterior gradient of cognitive control within the dorsomedial striatum

Mestres-Missé, Anna, Turner, Robert, Friederici, Angela D.·2012·NeuroImage

Abstract

Lateral prefrontal cortex and basal ganglia work together to mediate working memory and top-down regulation of cognition. This circuit regulates the balance and interactions between automatic and high-order control responses. Using ultra-high-field high-resolution functional magnetic resonance imaging (7T-fMRI), the present study examined the role of subcortical structures in cognitive control during language processing. Participants were asked to judge the grammaticality of unambiguous, ungrammatical and ambiguous sentences. Grammatical unambiguous sentences should elicit an automatic response, while ambiguous and ungrammatical sentences should conflict with the automatic response and, hence, require a high-order control response. Within the control response domain, ambiguity and ungrammaticality represent two different dimensions of conflict resolution, while for a temporarily ambiguous sentence a correct interpretation is available, that is not the case for ungrammatical sentences. Our results reveal an anterior-posterior axis in the dorsomedial striatum with more rostral regions supporting higher levels of cognitive processing. This functional architecture mirrors the rostrocaudal hierarchical organization evidenced within the lateral prefrontal cortex.

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Crossref · 10.1016/j.neuroimage.2012.05.021

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Authors
Mestres-Missé, A., Turner, R., & Friederici, A. D.
Affiliations
Max Planck Society (DE)
Corresponding author
Mestres-Missé, Anna
Venue
NeuroImage
Publisher
Elsevier BV
Published
2012-08
Volume
62
Issue
1
Pages
41-47
ISSN
1053-8119 (ISSN-L)
OpenAlex
W2055439922
Cited by
91
References
66
Citations by year
2026: 4 · 2025: 6 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 7 · 2019: 7 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 8 · 2014: 16 · 2013: 7 · 2012: 3
FWCI
5.57
Type
journal article
Language
en
Open access
closed
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
Spanish Government
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
cognitive control, dorsomedial striatum, anterior-posterior gradient, language processing, grammaticality judgment, conflict resolution, top-down control, basal ganglia, lateral prefrontal cortex, 7T fMRI
MeSH terms
Adult, Brain Mapping, Cognition, Corpus Striatum, Female, Humans, Language, Magnetic Resonance Imaging, Male, Nerve Net, Speech Perception, Feedback, Physiological, Young Adult

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