An anterior-posterior gradient of cognitive control within the dorsomedial striatum
Abstract
Lateral prefrontal cortex and basal ganglia work together to mediate working memory and top-down regulation of cognition. This circuit regulates the balance and interactions between automatic and high-order control responses. Using ultra-high-field high-resolution functional magnetic resonance imaging (7T-fMRI), the present study examined the role of subcortical structures in cognitive control during language processing. Participants were asked to judge the grammaticality of unambiguous, ungrammatical and ambiguous sentences. Grammatical unambiguous sentences should elicit an automatic response, while ambiguous and ungrammatical sentences should conflict with the automatic response and, hence, require a high-order control response. Within the control response domain, ambiguity and ungrammaticality represent two different dimensions of conflict resolution, while for a temporarily ambiguous sentence a correct interpretation is available, that is not the case for ungrammatical sentences. Our results reveal an anterior-posterior axis in the dorsomedial striatum with more rostral regions supporting higher levels of cognitive processing. This functional architecture mirrors the rostrocaudal hierarchical organization evidenced within the lateral prefrontal cortex.
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Numerous studies have found selective involvement of the DMS in tasks requiring cognitive control and working memory.
“numerous studies have found selective involvement of the DMS in various tasks that require cognitive control and working memory [6,35,38]”
From Contributions of the striatum to learning, motivation, and performance: an associative account (2012) · cites this paper as [6]
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- Authors
- Mestres-Missé, A., Turner, R., & Friederici, A. D.
- Affiliations
- Max Planck Society (DE)
- Corresponding author
- Mestres-Missé, Anna
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 62
- Issue
- 1
- Pages
- 41-47
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2055439922
- Cited by
- 91
- References
- 66
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 7 · 2019: 7 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 8 · 2014: 16 · 2013: 7 · 2012: 3
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Spanish Government
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- cognitive control, dorsomedial striatum, anterior-posterior gradient, language processing, grammaticality judgment, conflict resolution, top-down control, basal ganglia, lateral prefrontal cortex, 7T fMRI
- MeSH terms
- Adult, Brain Mapping, Cognition, Corpus Striatum, Female, Humans, Language, Magnetic Resonance Imaging, Male, Nerve Net, Speech Perception, Feedback, Physiological, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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