Working memory training impacts the mean diffusivity in the dopaminergic system
Open accessAbstract
Dopaminergic transmission plays a critical role in working memory (WM). Mean diffusivity (MD) is a sensitive and unique neuroimaging tool for detecting microstructural differences particularly in the areas of the dopaminergic system. Despite previous investigation of the effects of WM training (WMT) on dopamine receptor binding potentials, the effects of WMT on MD remain unknown. In this study, we investigated these effects in young adult subjects who either underwent WMT or received no intervention for 4 weeks. Before and after the intervention or no-intervention periods, subjects underwent scanning sessions in diffusion-weighted imaging to measure MD. Compared with no intervention, WMT resulted in an increase in MD in the bilateral caudate, right putamen, left dorsolateral prefrontal cortex (DLPFC), right anterior cingulate cortex (ACC), right substantia nigra, and ventral tegmental area. Furthermore, the increase in performance on WMT tasks was significantly positively correlated with the mean increase in MD in the clusters of the left DLPFC and of the right ACC. These results suggest that WMT caused microstructural changes in the regions of the dopaminergic system in a way that is usually interpreted as a reduction in neural components.
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Only a few studies have investigated changes in structural connectivity following WM training.
“Similarly, only a few studies have investigated changes in structural connectivity, that is, neural tracts, following WM training [30–33].”
From Adaptive working memory training does not produce transfer effects in cognition and neuroimaging (2022) · cites this paper as [32]
The Results section (‘The effect of WMT on MD’; page not available) reports changes in mean diffusivity after working-memory training, so the paper is an example of research on training-related neural microstructure. It does not report changes in structural connectivity or neural tracts, and it does not establish that only a few studies have investigated them. (LLM, conf=0.83)
Experimental — accuracy not yet measuredTakeuchi et al. reported that WM training increased the mean diffusivity in regions of the dopaminergic system.
“Takeuchi et al. [32] reported that WM training increased the mean diffusivity in regions of the dopaminergic system.”
From Adaptive working memory training does not produce transfer effects in cognition and neuroimaging (2022) · cites this paper as [32]
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Research works printed but not linked: 2
- Osaka M Nishizaki Y Brain and working memory (in Japanese) 2000 Kyoto Kyoto University Press
- Takeuchi H, Kawashima R (2013) Neural bases of individual differences of creativity measured by the divergent thinking test (symposium). In: Association for psychological science 25th annual convention. Washington DC, USA
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Self-citationAdaptive working memory training does not produce transfer effects in cognition and neuroimaging
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“[32] reported that WM training increased the mean diffusivity in regions of the dopaminergic system.”
BackgroundHuman habit neural circuitry may be perturbed in eating disorders
Wang, A. R., Kuijper, F. M., Barbosa, D. A. N., Hagan, K. E., Lee, E., Tong, E., Choi, E. Y., McNab, J. A., Bohon, C., & Halpern, C. H. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.abo4919 · Cited by 27 · see citing works
- Authors
- Takeuchi, H., Taki, Y., Nouchi, R., Hashizume, H., Sekiguchi, A., Kotozaki, Y., Nakagawa, S., Miyauchi, C. M., Sassa, Y., & Kawashima, R.
- Affiliations
- Tohoku University (JP)
- Corresponding author
- Takeuchi, Hikaru
- ORCID
- Venue
- Brain Structure and Function
- Published
- 2014-07-15
- Volume
- 220
- Issue
- 6
- Pages
- 3101-3111
- ISSN
- 1863-2653 (ISSN-L)
- 1863-2661
- PMC
- PMC4575686
- OpenAlex
- W2167488754
- Cited by
- 35
- References
- 63
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 1
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Brain Structure and Function (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (23700306, 25700012, CREST)
- Core Research for Evolutional Science and Technology (KAKENHI 23700306, 25700012, 23700306)
- Research Institute of Science and Technology for Society (KAKENHI 23700306, 25700012)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- working memory training, mean diffusivity, dopaminergic system, white matter microstructure, diffusion-weighted imaging, caudate nucleus, putamen, dorsolateral prefrontal cortex, anterior cingulate cortex, substantia nigra, ventral tegmental area
- MeSH terms
- Brain Mapping, Dopamine, Female, Gyrus Cinguli, Humans, Learning, Male, Memory, Short-Term, Neuronal Plasticity, Neuropsychological Tests, Prefrontal Cortex, Diffusion Magnetic Resonance Imaging, Young Adult, Dopaminergic Neurons, Neuroimaging
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