Neural plasticity in amplitude of low frequency fluctuation, cortical hub construction, regional homogeneity resulting from working memory training
Open accessAbstract
Working memory training (WMT) induces changes in cognitive function and various neurological systems. Here, we investigated changes in recently developed resting state functional magnetic resonance imaging measures of global information processing [degree of the cortical hub, which may have a central role in information integration in the brain, degree centrality (DC)], the magnitude of intrinsic brain activity [fractional amplitude of low frequency fluctuation (fALFF)], and local connectivity (regional homogeneity) in young adults, who either underwent WMT or received no intervention for 4 weeks. Compared with no intervention, WMT increased DC in the anatomical cluster, including anterior cingulate cortex (ACC), to the medial prefrontal cortex (mPFC). Furthermore, WMT increased fALFF in the anatomical cluster including the right dorsolateral prefrontal cortex (DLPFC), frontopolar area and mPFC. WMT increased regional homogeneity in the anatomical cluster that spread from the precuneus to posterior cingulate cortex and posterior parietal cortex. These results suggest WMT-induced plasticity in spontaneous brain activity and global and local information processing in areas of the major networks of the brain during rest.
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The authors of that study found increased activity in the right dorsolateral prefrontal cortex, frontopolar area, and medial prefrontal cortex.
“The authors found increased activity in the right dorsolateral prefrontal cortex, frontopolar area, and medial prefrontal cortex.”
From Adaptive working memory training does not produce transfer effects in cognition and neuroimaging (2022) · cites this paper as [27]
Only one study has investigated effects of WM training on the magnitude of intrinsic neural activity at rest.
“Moreover, to the best of our knowledge, only one study has investigated effects of WM training on the magnitude of intrinsic neural activity at rest [27].”
From Adaptive working memory training does not produce transfer effects in cognition and neuroimaging (2022) · cites this paper as [27]
We did not detect any changes in ALFF or glucose metabolism after WM training.
“Different from the present study, in which we did not detect any changes in ALFF or glucose metabolism after WM training, Takeuchi et al. reported increased brain activity in the dorsal prefrontal cortex following WM training [27].”
From Adaptive working memory training does not produce transfer effects in cognition and neuroimaging (2022) · cites this paper as [27]
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Adaptive working memory training does not produce transfer effects in cognition and neuroimaging
Ripp, I., Emch, M., Wu, Q., Lizarraga, A., Udale, R., von Bastian, C. C., Koch, K., & Yakushev, I. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02272-7 · Cited by 31 · see citing works
“Moreover, to the best of our knowledge, only one study has investigated effects of WM training on the magnitude of intrinsic neural activity at rest [27].”
BackgroundFang, P., Gao, Y., Li, Y., Li, C., Zhang, T., Wu, L., Zhu, Y., & Xie, Y. (2024) · NeuroImage · doi:10.1016/j.neuroimage.2024.120785 · Cited by 18 · see citing works
“…activity changes associated with cognitive training (Li et al., 2019). for example, in a study of young adults who received four weeks of WMT (Takeuchi et al., 2017), fractional ALFF (fALFF) increased in the right dorsolateral prefrontal cortex, frontopolar region, and medial prefrontal…”
Background
- Authors
- Takeuchi, H., Taki, Y., Nouchi, R., Sekiguchi, A., Kotozaki, Y., Nakagawa, S., Makoto Miyauchi, C., Sassa, Y., & Kawashima, R.
- Affiliations
- Tohoku University (JP)
- Corresponding author
- Takeuchi, Hikaru
- ORCID
- Venue
- Scientific Reports
- Published
- 2017-05-03
- Volume
- 7
- Issue
- 1
- Pages
- 1470-1470
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5431219
- OpenAlex
- W2609765126
- Cited by
- 36
- References
- 63
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 7 · 2018: 1
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Society for the Promotion of Science (23700306, 25700012, CREST)
- Core Research for Evolutional Science and Technology (KAKENHI 23700306, 25700012, 23700306)
- Research Institute of Science and Technology for Society (KAKENHI 23700306, 25700012)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- working memory training, neuroplasticity, resting-state brain activity, fractional amplitude of low-frequency fluctuations, cortical hubs, degree centrality, regional homogeneity, anterior cingulate cortex, medial prefrontal cortex, dorsolateral prefrontal cortex, posterior cingulate cortex, precuneus, posterior parietal cortex, brain networks
- MeSH terms
- Brain Mapping, Female, Gyrus Cinguli, Humans, Learning, Magnetic Resonance Imaging, Male, Memory, Short-Term, Neural Pathways, Neuronal Plasticity, Parietal Lobe, Rest, Prefrontal Cortex, Young Adult, Healthy Volunteers
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