Effects of working-memory training on striatal dopamine release
Abstract
Updating of working memory has been associated with striato-frontal brain regions and phasic dopaminergic neurotransmission. We assessed raclopride binding to striatal dopamine (DA) D2 receptors during a letter-updating task and a control condition before and after 5 weeks of updating training. Results showed that updating affected DA activity before training and that training further increased striatal DA release during updating. These findings highlight the pivotal role of transient neural processes associated with D2 receptor activity in working memory.
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Using the running memory paradigm as a training task, studies demonstrated nearest transfer effects on other WMU tasks such as the n-back task, and far transfer to episodic memory tasks.
“using the running memory paradigm as a training task, different authors demonstrated nearest transfer effects on other WMU tasks, such as the n-back task [25–28], and far transfer to episodic memory tasks [27].”
From Nearest transfer effects of working memory training: A comparison of two programs focused on working memory updating (2019) · cites this paper as [25]
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- Authors
- Bäckman, L., Nyberg, L., Soveri, A., Johansson, J., Andersson, M., Dahlin, E., Neely, A. S., Virta, J., Laine, M., & Rinne, J. O.
- Affiliations
- Karolinska Institutet (SE)
- Umeå University (SE)
- Åbo Akademi University (FI)
- University of Turku (FI)
- Corresponding author
- Bäckman, Lars
- ORCID
- Venue
- Science
- Published
- 2011-08-05
- Volume
- 333
- Issue
- 6043
- Pages
- 718-718
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2083925654
- Cited by
- 232
- References
- 16
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 9 · 2023: 8 · 2022: 11 · 2021: 19 · 2020: 11 · 2019: 20 · 2018: 22 · 2017: 15 · 2016: 21 · 2015: 21 · 2014: 26 · 2013: 18 · 2012: 13
- FWCI
- 7.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- working memory, dopamine release, striatum, dopamine D2 receptor, memory updating, training effects, phasic dopamine release
- MeSH terms
- Adult, Corpus Striatum, Dopamine, Humans, Learning, Male, Memory, Short-Term, Receptors, Dopamine D2, Raclopride, Positron-Emission Tomography, Young Adult
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