CoChat
Sign Up
Cited by 7Neuroscience and Neural EngineeringVagus Nerve Stimulation ResearchPain Management and Treatment

Laparoscopic implantation of neural electrodes on pelvic nerves: an experimental study on the obturator nerve in a chronic minipig model

Rabischong, Benoit, Larraín, Demetrio, Rabischong, Pierre, Botchorishvili, Revaz, Fraisse, Georges, Gallego, Stephane, Gaydier, Philippe, Chardigny, Jean Michel +1 more·2011·Surgical Endoscopy
DOI 10.1007/s00464-011-1750-x
Open this paper in CoChat — free account

Abstract

Background Laparoscopic exposure of pelvic nerves has opened a new area in the field of neuromodulation. However, electrode design and material deterioration remain issues that limit clinical application. The objective of this study was to evaluate experimentally the laparoscopic implantation of different types of neural electrodes in order to achieve functional and selective electrical stimulation of pelvic nerves.Methods This was a prospective comparative study of the laparoscopic implantation and tolerance and efficacy of three monopolar cuff electrodes implanted on the obturator nerve in ten Göttingen minipigs (18-20 months old; 14.5-24 kg body weight). Animals were allocated to two groups. A 3-mm-diameter laparoscopic instrument was used during dissection of paravesical fossa and obturator nerve on both sides in order to minimize nerve damage. In all animals, a "split-cylinder" cuff electrode was implanted around the left obturator nerve. On the right side, a "lasso" cuff electrode was implanted in the first group and a "closed-cylinder" cuff was implanted in the second group. Electrical stimulation (0-5 V, 20 Hz) was performed for implanted electrodes on days 0, 7, 15, 30, 45, 60, and 90. Current intensity thresholds were identified by palpation of muscle contraction. Strength developed according to stimulation level and was measured using weight transducers.Results All procedures were performed by laparoscopy. Mean operative times differed significantly among groups, the shortest being for split-cylinder electrodes (P = 0.0002). No electrical spread phenomena were observed. Initial thresholds were below 1.5 V (range = 0.5-1.3); however, a significant rise was observed, with time to a maximum of 2.7 V (P < 0.0001). Only split-cylinder electrodes remained functional after 3 months. The mean value of maximum strength remained stable during the study period (P = 0.21, NS).Conclusions The laparoscopic approach to implanting neuroprostheses seems to be very attractive. Furthermore, this approach could allow highly selective nerve stimulation to be achieved using simpler devices such as split-cylinder monopolar electrodes.

Integrity signals

Registry

Crossref · 10.1007/s00464-011-1750-x

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Laparoscopic implantation of split cylinder cuff electrodes on pelvic nerves in pigs for 3 months resulted in functional electrodes at the end of the study, and the design was easy-to-use for laparoscopic placement.

    “An interesting study conducted with pigs observed the outcomes of laparoscopic implantation of split cylinder cuff electrodes on pelvic nerves for 3 months [67], where the electrodes were functional at the end of the study. Moreover, the design was found to be easy-to-use for laparoscopic placement because it was not necessary to close the electrode once it was installed over the nerve.”

    From Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review (2020) · cites this paper as [67]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Rabischong, B., Larraín, D., Rabischong, P., Botchorishvili, R., Fraisse, G., Gallego, S., Gaydier, P., Chardigny, J. M., & Avan, P.
Affiliations
  • Unité de Nutrition Humaine (FR)
  • Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
  • Université Clermont Auvergne (FR)
Corresponding author
Rabischong, Benoit
ORCID
Venue
Surgical Endoscopy
Publisher
Springer Science and Business Media LLC
Published
2011-06-03
Volume
25
Issue
11
Pages
3706-3712
ISSN
  • 0930-2794 (ISSN-L)
  • 1432-2218
DOI
10.1007/s00464-011-1750-x
OpenAlex
W2010731532
Cited by
7
References
32
Citations by year
2026: 1 · 2020: 1 · 2018: 2 · 2016: 1 · 2014: 1 · 2012: 1
FWCI
0.26
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Surgical Endoscopy (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords
obturator nerve, pelvic nerve, neuromodulation, electrical stimulation threshold, minipig model, neural prostheses
MeSH terms
Animals, Electrodes, Implanted, Electric Stimulation Therapy, Female, Obturator Nerve, Pelvis, Laparoscopy, Swine, Swine, Miniature

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review