Selective control of muscle activation with a multipolar nerve cuff electrode

Veraart, C.; Grill, W.M.; Mortimer, J.T.

doi:10.1109/10.237694

Cited by 320Neuroscience and Neural EngineeringMuscle activation and electromyography studiesVagus Nerve Stimulation Research

Selective control of muscle activation with a multipolar nerve cuff electrode

Veraart, C., Grill, W.M., Mortimer, J.T.·1993·IEEE Transactions on Biomedical Engineering

DOI 10.1109/10.237694

Open this paper in CoChat — free account

Abstract

Acute experiments were performed on adult cats to study selective activation of medial gastrocnemius, soleus, tibialis anterior, and extensor digitorum longus with a cuff electrode. A spiral nerve cuff containing twelve "dot" electrodes was implanted around the sciatic nerve and evoked muscle twitch forces were recorded in six experiments. Spatially isolated "dot" electrodes in four geometries: monopolar, longitudinal tripolar, tripolar with four common anodes, and two parallel tripoles, were combined with transverse field steering current(s) from an anode(s) located 180 degrees around from the cathode(s) to activate different regions of the nerve trunk. To quantify the degree of selectivity, a selectivity index was defined as the ratio of the force in one muscle to the force in all four muscles in response to a particular stimulus. The selectivity index was used to construct recruitment curves for a muscle with the optimal degree of selectivity. Physiological responses were correlated with the anatomical structure of the sciatic nerve by identifying the nerve fascicles innervating the four muscles, and by determining the relative positions of the electrodes and the nerve fascicles. The results indicated that the use of transverse field steering current improved selectivity. We also found that tripoles with individual dot anodes were more selective than tripoles with four common dot anodes. Stimulation with two parallel tripoles was effective in activating selectively fascicl…

Integrity signals

Registry

Crossref · 10.1109/10.237694

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Multichannel cuff electrodes enable selective stimulation of separate axonal fascicles within a nerve, each supplying innervation to a different muscle.
“Multichannel cuff electrodes enable selective stimulation of separate axonal fascicles within the nerve, each one supplying innervation to a different muscle (Rozman et al., 1993; Veraart et al., 1993; Grill and Mortimer, 1996a; Walter et al., 1997; Navarro et al., 2001) .”
From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Veraart et al., 1993
Cuff electrodes with multiple contacts can produce selective activation of different muscles innervated by a peripheral nerve at the interfascicular level.
“Cuff electrodes with multiple contacts can produce selective activation of different muscles innervated by a peripheral nerve (Veraart et al 1993, Grill and Mortimer 1996b, Navarro et al 2001, Tarler and Mortimer 2004, Polasek et al 2007, Schiefer et al 2010) at the interfascicular level”
From Comparative analysis of transverse intrafascicular multichannel, longitudinal intrafascicular and multipolar cuff electrodes for the selective stimulation of nerve fascicles (2011) · cites this paper as Veraart et al 1993
Extraneural cuff electrodes predominantly excite nerve fascicles that lie superficially in the nerve.
“extraneural electrodes (cuffs) predominantly excite nerve fascicles located superficially”
From Comparative analysis of transverse intrafascicular multichannel, longitudinal intrafascicular and multipolar cuff electrodes for the selective stimulation of nerve fascicles (2011) · cites this paper as Veraart et al 1993
Several indices of selectivity have been proposed as a measure of the potential functionality that nerve interfaces can offer.
“Several indices of selectivity have been proposed as a measure of the potential functionality that nerve interfaces can offer (Veraart et al 1993, Branner et al 2001, Schiefer et al 2008, Dowden et al 2009).”
From Comparative analysis of transverse intrafascicular multichannel, longitudinal intrafascicular and multipolar cuff electrodes for the selective stimulation of nerve fascicles (2011) · cites this paper as Veraart et al 1993

A spiral nerve cuff electrode for peripheral nerve stimulation
Naples, G. G., Mortimer, J. T., Scheiner, A., & Sweeney, J. D. (1988) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.8670 · Cited by 415 · see citing works
Self-citation

Flagged first, then by citations

Sorted by citations

A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems
Navarro, X., Krueger, T. B., Lago, N., Micera, S., Stieglitz, T., & Dario, P. (2005) · Journal of the Peripheral Nervous System · doi:10.1111/j.1085-9489.2005.10303.x · Cited by 845 · see citing works
Implanted Neural Interfaces: Biochallenges and Engineered Solutions
Grill, W. M., Norman, S. E., & Bellamkonda, R. V. (2009) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-061008-124927 · Cited by 488 · see citing works
Self-citation
A transverse intrafascicular multichannel electrode (TIME) to interface with the peripheral nerve
Boretius, T., Badia, J., Pascual-Font, A., Schuettler, M., Navarro, X., Yoshida, K., & Stieglitz, T. (2010) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2010.05.010 · Cited by 470 · see citing works
Selective Stimulation of Cat Sciatic Nerve Using an Array of Varying-Length Microelectrodes
Branner, A., Stein, R. B., & Normann, R. A. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.4.1585 · Cited by 358 · see citing works
Residual function in peripheral nerve stumps of amputees: implications for neural control of artificial limbs
Dhillon, G. S., Lawrence, S. M., Hutchinson, D. T., & Horch, K. W. (2004) · The Journal of Hand Surgery · doi:10.1016/j.jhsa.2004.02.006 · Cited by 354 · see citing works
Pattern recognition with the optic nerve visual prosthesis
Veraart, C., Wanet‐Defalque, M., Gérard, B., Vanlierde, A., & Delbeke, J. (2003) · Artificial Organs · doi:10.1046/j.1525-1594.2003.07305.x · Cited by 259 · see citing works
A multielectrode array for intrafascicular recording and stimulation in sciatic nerve of cats
Branner, A., & Normann, R. A. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00231-2 · Cited by 234 · see citing works
Comparative analysis of transverse intrafascicular multichannel, longitudinal intrafascicular and multipolar cuff electrodes for the selective stimulation of nerve fascicles
Badia, J., Boretius, T., Andreu, D., Azevedo-Coste, C., Stieglitz, T., & Navarro, X. (2011) · Journal of Neural Engineering · doi:10.1088/1741-2560/8/3/036023 · Cited by 227 · see citing works
The effect of stimulus pulse duration on selectivity of neural stimulation
Grill, W. M., & Mortimer, J. T. (1996) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.481985 · Cited by 215 · see citing works
Self-citation
Cuff electrodes for chronic stimulation and recording of peripheral nerve activity
Loeb, G. E., & Peck, R. A. (1996) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(95)00123-9 · Cited by 215 · see citing works
Long-term usability and bio-integration of polyimide-based intra-neural stimulating electrodes
Wurth, S., Capogrosso, M., Raspopovic, S., Gandar, J., Federici, G., Kinany, N., Cutrone, A., Piersigilli, A., Pavlova, N., Guiet, R., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.01.014 · Cited by 176 · see citing works
Stimulation Stability and Selectivity of Chronically Implanted Multicontact Nerve Cuff Electrodes in the Human Upper Extremity
Polasek, K. H., Hoyen, H. A., Keith, M. W., Kirsch, R. F., & Tyler, D. J. (2009) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2009.2032603 · Cited by 142 · see citing works
A review for the peripheral nerve interface designer
Larson, C. E., & Meng, E. (2020) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2019.108523 · Cited by 133 · see citing works
Quantification of recruitment properties of multiple contact cuff electrodes
Grill, W. M., & Mortimer, J. T. (1996) · IEEE Transactions on Rehabilitation Engineering · doi:10.1109/86.506402 · Cited by 136 · see citing works
Self-citation
Selective stimulation of the human femoral nerve with a flat interface nerve electrode
Schiefer, M. A., Polasek, K. H., Triolo, R. J., Pinault, G. C. J., & Tyler, D. J. (2010) · Journal of Neural Engineering · doi:10.1088/1741-2560/7/2/026006 · Cited by 130 · see citing works
On the Use of Longitudinal Intrafascicular Peripheral Interfaces for the Control of Cybernetic Hand Prostheses in Amputees
Micera, S., Navarro, X., Carpaneto, J., Citi, L., Tonet, O., Rossini, P. M., Carrozza, M. C., Hoffmann, K. P., Vivo, M., Yoshida, K., et al. (2008) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2008.2006207 · Cited by 120 · see citing works
Progress of flexible electronics in neural interfacing—A self-adaptive non-invasive neural ribbon electrode for small nerves recording
Xiang, Z., Yen, S., Sheshadri, S., Wang, J., Lee, S., Liu, Y., Liao, L., Thakor, N. V., & Lee, C. (2016) · Advanced Materials · doi:10.1002/adma.201503423 · Cited by 116 · see citing works
Human nerve stimulation thresholds and selectivity using a multi-contact nerve cuff electrode
Polasek, K. H., Hoyen, H. A., Keith, M. W., & Tyler, D. J. (2007) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2007.891383 · Cited by 111 · see citing works
Selective and independent activation of four motor fascicles using a four contact nerve-cuff electrode
Tarler, M. D., & Mortimer, J. T. (2004) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2004.828415 · Cited by 110 · see citing works
Self-citation
Inversion of the current-distance relationship by transient depolarization
Grill, W. M., & Mortimer, J. T. (1997) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.553708 · Cited by 109 · see citing works
Self-citation
A slowly penetrating interfascicular nerve electrode for selective activation of peripheral nerves
Tyler, D. J., & Durand, D. M. (1997) · IEEE Transactions on Rehabilitation Engineering · doi:10.1109/86.559349 · Cited by 108 · see citing works
Interfaces with the Peripheral Nerve for the Control of Neuroprostheses
del Valle, J., & Navarro, X. (2013) · International Review of Neurobiology · doi:10.1016/b978-0-12-420045-6.00002-x · Cited by 105 · see citing works
Stability of the input-output properties of chronically implanted multiple contact nerve cuff stimulating electrodes
Grill, W. M., & Mortimer, J. T. (1998) · IEEE Transactions on Rehabilitation Engineering · doi:10.1109/86.736150 · Cited by 103 · see citing works
Self-citation
Topographical distribution of motor fascicles in the sciatic‐tibial nerve of the rat
Badia, J., Pascual‐Font, A., Vivó, M., Udina, E., & Navarro, X. (2010) · Muscle & Nerve · doi:10.1002/mus.21652 · Cited by 98 · see citing works
Degeneration and regeneration in rabbit peripheral nerve with long-term nerve cuff electrode implant: A stereological study of myelinated and unmyelinated axons
Larsen, J. O., Thomsen, M., Haugland, M., & Sinkjær, T. (1998) · Acta Neuropathologica · doi:10.1007/s004010050907 · Cited by 96 · see citing works
Fabrication and characteristics of an implantable, polymer-based, intrafascicular electrode
Lawrence, S. M., Dhillon, G. S., & Horch, K. W. (2003) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(03)00231-0 · Cited by 93 · see citing works
Chronic stability and selectivity of four-contact spiral nerve-cuff electrodes in stimulating the human femoral nerve
Fisher, L. E., Tyler, D. J., Anderson, J. S., & Triolo, R. J. (2009) · Journal of Neural Engineering · doi:10.1088/1741-2560/6/4/046010 · Cited by 89 · see citing works
A three-dimensional self-opening intraneural peripheral interface (SELINE)
Cutrone, A., Valle, J. D., Santos, D., Badia, J., Filippeschi, C., Micera, S., Navarro, X., & Bossi, S. (2015) · Journal of Neural Engineering · doi:10.1088/1741-2560/12/1/016016 · Cited by 82 · see citing works
Stimulation selectivity of the “thin-film longitudinal intrafascicular electrode”(tfLIFE) and the “transverse intrafascicular multi-channel electrode”(TIME) in the large nerve animal model
Kundu, A., Harreby, K. R., Yoshida, K., Boretius, T., Stieglitz, T., & Jensen, W. (2014) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2013.2267936 · Cited by 83 · see citing works
Peripheral nerve stimulation for restoration of motor function
Bhadra, N., & Peckham, P. H. (1997) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199709000-00004 · Cited by 80 · see citing works
A regenerative microchannel neural interface for recording from and stimulating peripheral axons<i>in vivo</i>
FitzGerald, J. J., Lago, N., Benmerah, S., Serra, J., Watling, C. P., Cameron, R. E., Tarte, E., Lacour, S. P., McMahon, S. B., & Fawcett, J. W. (2012) · Journal of Neural Engineering · doi:10.1088/1741-2560/9/1/016010 · Cited by 73 · see citing works
Chapter 2 Bidirectional Interfaces with the Peripheral Nervous System
Micera, S., & Navarro, X. (2009) · International Review of Neurobiology · doi:10.1016/s0074-7742(09)86002-9 · Cited by 69 · see citing works
Concurrent recordings of bladder afferents from multiple nerves using a microfabricated PDMS microchannel electrode array
Delivopoulos, E., Chew, D. J., Minev, I. R., Fawcett, J. W., & Lacour, S. P. (2012) · Lab on a Chip · doi:10.1039/c2lc21277c · Cited by 68 · see citing works
Quantification of human upper extremity nerves and fascicular anatomy
Brill, N. A., & Tyler, D. J. (2017) · Muscle & Nerve · doi:10.1002/mus.25534 · Cited by 64 · see citing works
Spatial and functional selectivity of peripheral nerve signal recording with the transversal intrafascicular multichannel electrode (TIME)
Badia, J., Raspopovic, S., Carpaneto, J., Micera, S., & Navarro, X. (2016) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2015.2440768 · Cited by 65 · see citing works
Experimental Validation of a Hybrid Computational Model for Selective Stimulation Using Transverse Intrafascicular Multichannel Electrodes
Raspopovic, S., Capogrosso, M., Badia, J., Navarro, X., & Micera, S. (2012) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2012.2189021 · Cited by 63 · see citing works
Compliant peripheral nerve interfaces.
Paggi, V., Akouissi, O., Micera, S., & Lacour, S. P. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/abcdbe · Cited by 60 · see citing works
“For instance, tripolar electrodes that present evenly spaced rows of three contacts, can generate modulated transversal and/or longitudinal currents, targetingmore superficial fascicles [63, 64].”
Background
Design, fabrication and evaluation of a conforming circumpolar peripheral nerve cuff electrode for acute experimental use
Foldes, E. L., Ackermann, D. M., Bhadra, N., Kilgore, K. L., & Bhadra, N. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.12.020 · Cited by 61 · see citing works
A Parylene Self-Locking Cuff Electrode for Peripheral Nerve Stimulation and Recording
Yu, H., Xiong, W., Zhang, H., Wang, W., & Li, Z. (2014) · Journal of Microelectromechanical Systems · doi:10.1109/jmems.2014.2333733 · Cited by 56 · see citing works
Selective activation of the human tibial and common peroneal nerves with a flat interface nerve electrode
Schiefer, M. A., Freeberg, M., Pinault, G. J. C., Anderson, J., Hoyen, H., Tyler, D. J., & Triolo, R. J. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/5/056006 · Cited by 57 · see citing works
Recruitment characteristics of nerve fascicles stimulated by a multigroove electrode
Koole, P., Holsheimer, J., Struijk, J. J., & Verloop, A. J. (1997) · IEEE Transactions on Rehabilitation Engineering · doi:10.1109/86.559348 · Cited by 56 · see citing works
Probabilistic modeling of selective stimulation of the human sciatic nerve with a flat interface nerve electrode
Schiefer, M. A., Tyler, D. J., & Triolo, R. J. (2012) · Journal of Computational Neuroscience · doi:10.1007/s10827-011-0381-5 · Cited by 53 · see citing works
Neuromuscular stimulation selectivity of multiple-contact nerve cuff electrode arrays
Sweeney, J. D., Crawford, N. R., & Brandon, T. A. (1995) · Medical & Biological Engineering & Computing · doi:10.1007/bf02510525 · Cited by 51 · see citing works
Neural morphological effects of long-term implantation of the self-sizing spiral cuff nerve electrode
Romero, E., Denef, J. F., Delbeke, J., Robert, A., & Veraart, C. (2001) · Medical & Biological Engineering & Computing · doi:10.1007/bf02345271 · Cited by 49 · see citing works
Self-citation
Regenerated sciatic nerve axons stimulated through a chronically implanted macro-sieve electrode
MacEwan, M. R., Zellmer, E. R., Wheeler, J. J., Burton, H., & Moran, D. W. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00557 · Cited by 48 · see citing works
Chronic histological effects of the flat interface nerve electrode
Leventhal, D. K., Cohen, M., & Durand, D. M. (2006) · Journal of Neural Engineering · doi:10.1088/1741-2560/3/2/004 · Cited by 43 · see citing works
Cuff electrode implantation around the sciatic nerve is associated with an upregulation of TNF-α and TGF-β1
Vince, V., Thil, M.-A., Gérard, A.-C., Veraart, C., Delbeke, J., & Colin, I. M. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.10.010 · Cited by 35 · see citing works
Self-citation
Neurobiological evaluation of thin-film longitudinal intrafascicular electrodes as a peripheral nerve interface,
Navarro, X., Lago, N., Vivo, M., Yoshida, K., Koch, K. P., Poppendieck, W., & Micera, S. (2007) · 2007 IEEE 10th International Conference on Rehabilitation Robotics · doi:10.1109/icorr.2007.4428492 · Cited by 36 · see citing works
Fascicular nerve stimulation and recording using a novel double-aisle regenerative electrode
Delgado-Martínez, I., Righi, M., Santos, D., Cutrone, A., Bossi, S., D’Amico, S., Del Valle, J., Micera, S., & Navarro, X. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/aa6bac · Cited by 35 · see citing works
Long-term functionality of transversal intraneural electrodes is improved by dexamethasone treatment
de la Oliva, N., del Valle, J., Delgado-Martinez, I., Mueller, M., Stieglitz, T., & Navarro, X. (2019) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2019.2897256 · Cited by 26 · see citing works
ICFEM 2000. Third IEEE International Conference on Formal Engineering Methods
(2000) · IEEE Transactions on Rehabilitation Engineering · doi:10.1109/86.867869 · Cited by 20 · see citing works
A translational framework for peripheral nerve stimulating electrodes: Reviewing the journey from concept to clinic
Charkhkar, H., Christie, B. P., Pinault, G. J., Tyler, D. J., & Triolo, R. J. (2019) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2019.108414 · Cited by 19 · see citing works
Diameter-dependent excitation of peripheral nerve fibers by multipolar electrodes during electrical stimulation
Stieglitz, T. (2005) · Expert Review of Medical Devices · doi:10.1586/17434440.2.2.149 · Cited by 16 · see citing works
Laparoscopic implantation of neural electrodes on pelvic nerves: an experimental study on the obturator nerve in a chronic minipig model
Rabischong, B., Larraín, D., Rabischong, P., Botchorishvili, R., Fraisse, G., Gallego, S., Gaydier, P., Chardigny, J. M., & Avan, P. (2011) · Surgical Endoscopy · doi:10.1007/s00464-011-1750-x · Cited by 7 · see citing works
Peripheral Nerve Electrodes
Wu, Y., & Guo, L. (2020) · Neural Interface Engineering · doi:10.1007/978-3-030-41854-0_5 · Cited by 3 · see citing works

Authors: Veraart, C., Grill, W. M., & Mortimer, J. T.
Affiliations: Case Western Reserve University (US)
ORCID: Grill, W.M.
Mortimer, J.T.
Venue: IEEE Transactions on Biomedical Engineering
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Published: 1993-07
Volume: 40
Issue: 7
Pages: 640-653
ISSN: 0018-9294 (ISSN-L)
DOI: 10.1109/10.237694
OpenAlex: W2075966411
Cited by: 320
References: 1
Citations by year: 2026: 2 · 2025: 3 · 2024: 8 · 2023: 4 · 2022: 6 · 2021: 12 · 2020: 8 · 2019: 7 · 2018: 11 · 2017: 8 · 2016: 7 · 2015: 13 · 2014: 7 · 2013: 11 · 2012: 10
FWCI: 1.80
Type: journal article
Language: en
Open access: closed
Licence: ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html (vor)
Locations: IEEE Transactions on Biomedical Engineering (publishedVersion)
PubMed (publishedVersion)
DIAL (Catholic University of Leuven) (submittedVersion)
Funders: National Institutes of Health (5r01ns026476-03)
National Institute of General Medical Sciences (GM 07535, T32GM007535)
National Institute of Neurological Disorders and Stroke (NS-26476)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords: cuff electrodes, sciatic nerve, tripole, recruitment curves, nerve fascicles, peripheral nerve stimulation
MeSH terms: Animals, Cats, Electric Stimulation, Electrodes, Equipment Design, Isometric Contraction, Muscles, Sciatic Nerve, Sensitivity and Specificity, Time Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Selective control of muscle activation with a multipolar nerve cuff electrode

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Record

About these checks