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Cited by 49Neuroscience and Neural EngineeringVagus Nerve Stimulation ResearchNerve injury and regeneration

Neural morphological effects of long-term implantation of the self-sizing spiral cuff nerve electrode

Romero, E., Denef, J. F., Delbeke, J., Robert, A., Veraart, C.·2001·Medical & Biological Engineering & Computing
DOI 10.1007/bf02345271
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Abstract

The paper reports on the histological effects of chronic implantation of self-sizing spiral cuff nerve electrodes on the cat sciatic nerve. The implantation period is about 4.4 months. Four different experimental conditions are evaluated: control, sham, bare cuff (cuffs without contacts and leads) and full cuff. The total number of axons in the nerves of the control group is compared with the three other groups. The surface occupied by collagen fibres in the nerve section, perineurium thickness, fibre diameter and myelin thickness are also measured. The average number of axons in the control nerves is found to be 16,416 (+/- 1,509) and does not differ significantly from the three other groups (p > 0.1). Collagen measurements show an extrafascicular epineurial fibrosis in the two implanted groups that is found to be significantly different (p < 0.05). No differences are encountered in the perineurium thickness analysis. Fibre diameter distributions show a regular bimodal pattern for all groups. Centrality (mean and Pm) and dispersion statistics (P25 and P75) extracted from fibre diameter distributions do not reveal significant differences. Myelin thickness distributions are also similar for all groups, as well as centrality and dispersion statistics. The present morphometrical results suggest that the effects produced by a chronic spiral cuff implant on this animal model are negligible.

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Crossref · 10.1007/bf02345271

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48 of 48 references verified0 citation errors · 0 not checkable

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  • Gaps between the nerve epineurium and implant are prone to filling with fibrotic tissue.

    “Gaps between the nerve epineurium and implant are prone to filling with fibrotic tissue (Romero et al., 2001), and can increase trauma to the nerve due to mechanical shear damage during movement.”

    From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Romero et al., 2001

  • Nerve compression can exacerbate FBR to the implant.

    “Nerve compression is associated with axonal death and inflammation (Krarup et al., 1989; Grill and Mortimer, 2000; Vince et al., 2005), which can in turn exacerbate FBR to the implant (Romero et al., 2001).”

    From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Romero et al., 2001

  • Gaps between the nerve epineurium and implant can increase trauma to the nerve due to mechanical shear damage during movement.

    “Gaps between the nerve epineurium and implant are prone to filling with fibrotic tissue (Romero et al., 2001), and can increase trauma to the nerve due to mechanical shear damage during movement.”

    From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Romero et al., 2001

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Related

Authors
Romero, E., Denef, J. F., Delbeke, J., Robert, A., & Veraart, C.
Affiliations
UCLouvain (BE)
Corresponding author
Veraart, C.
ORCID
Venue
Medical & Biological Engineering & Computing
Publisher
Springer Science and Business Media LLC
Published
2001-01
Volume
39
Issue
1
Pages
90-100
ISSN
  • 0140-0118 (ISSN-L)
  • 1741-0444
DOI
10.1007/bf02345271
OpenAlex
W2005371728
Cited by
49
References
49
Citations by year
2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 1 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 4 · 2012: 2
FWCI
0.74
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Medical & Biological Engineering & Computing (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Access to Libraries (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
sciatic nerve, axon number, collagen fibrosis, fiber diameter distribution, myelin thickness, nerve histology, cats
MeSH terms
Animals, Axons, Cats, Electric Stimulation, Electrodes, Implanted, Myelin Sheath, Sciatic Nerve, Time Factors

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