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Cited by 69Cancer survivorship and careCardiovascular and exercise physiologyPhysical Activity and Health

Interval versus continuous aerobic exercise training in breast cancer survivors—a pilot RCT

Dolan, Lianne B., Campbell, Kristin, Gelmon, Karen, Neil-Sztramko, Sarah, Holmes, Daniel, McKenzie, Donald C.·2016·Supportive Care in Cancer
DOI 10.1007/s00520-015-2749-y
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Abstract

Background Exercise therapy is being explored in a variety of cancer populations to counteract treatment-related deconditioning. Higher intensity interval protocols are being prescribed to improve physical function and attenuate surrogates of comorbidity in non-cancer populations. The purpose of this study is to explore the safety of higher intensity exercise stimuli on cardiorespiratory fitness (VO2peak) in breast cancer survivors.Methods Postmenopausal breast cancer survivors were randomized into three groups: supervised aerobic interval training (AIT), supervised continuous moderate exercise training (CMT), and an unsupervised control group (CON). For 6 weeks, AIT exercised between 70 and 100% VO2peak, while CMT exercised between 60 and 70% VO2peak. Both groups followed a matched-work design.Results Thirty-three participants completed the study (age, 57.2 (9) years; weight, 67.6 (12) kg) with no adverse advents. Between-group baseline values were non-significant. VO2peak at baseline (25.3 (5.4) mL·kg(-1)·min(-1)) was below population norms. Compared to CON, cardiorespiratory fitness improved in AIT and CMT by 12% (P < 0.001) with no significant difference between exercise groups. AIT had a greater influence on lower extremity strength (P = 0.026) and body weight (P = 0.031).Conclusion This pilot study provides evidence that similar to CMT, AIT can safely increase VO2peak in a small group of breast cancer survivors. Further exploration of the benefits of implementing higher intensity training protocols is warranted.

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  • There is insufficient evidence for a definitive prescription around safety and efficacy for other exercise types such as dragon boating, recreational sports, wall/rock climbing, triathlon, or high intensity interval training.

    “there is also insufficient evidence at this time for a definitive prescription around safety and efficacy for other types of exercise for cancer survivors, such as dragon boating(79, 80), recreational sports(81), wall/rock climbing(82), triathalon(83), or high intensity interval training(84)”

    From Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable (2019) · cites this paper as [80]

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Authors
Dolan, L. B., Campbell, K., Gelmon, K., Neil-Sztramko, S., Holmes, D., & McKenzie, D. C.
Affiliations
  • University of British Columbia (CA)
  • BC Cancer Agency (CA)
  • St. Paul's Hospital (CA)
Corresponding author
Dolan, Lianne B.
ORCID
Venue
Supportive Care in Cancer
Publisher
Springer Science and Business Media LLC
Published
2015-05-09
Volume
24
Issue
1
Pages
119-127
ISSN
  • 0941-4355 (ISSN-L)
  • 1433-7339
DOI
10.1007/s00520-015-2749-y
OpenAlex
W2153145618
Cited by
69
References
44
Citations by year
2026: 3 · 2025: 8 · 2024: 5 · 2023: 7 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 8 · 2018: 9 · 2017: 7 · 2016: 2
FWCI
2.62
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Supportive Care in Cancer (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
Keywords
breast cancer survivors, interval training, aerobic exercise, cardiorespiratory fitness, peak oxygen uptake, exercise safety, postmenopausal women, lower limb strength, body weight, exercise prescription
MeSH terms
Breast Neoplasms, Exercise Therapy, Female, Humans, Middle Aged, Pilot Projects, Exercise, Survivors

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