Endotoxemia, nutrition, and cardiometabolic disorders
Abstract
Aims Circulating lipopolysaccharides (LPSs), associated with both infection and inflammation, may arise from the gastrointestinal tract microbiota, and the levels may be affected by daily nutrition. We investigated whether nutrient intake affects the association of serum LPS activity with prevalent obesity, metabolic syndrome (MetS), diabetes, and coronary heart disease (CHD) and with the risk of incident CHD events.Methods The nutrition cohort (n = 2,452, mean age ± SD, 52.2 ± 10.1 years) of the FINRISK 1997 Study was followed up for 10 years. Information on macronutrient intake at baseline was collected from 24-h dietary recall. Serum endotoxin activities were determined by the Limulus amebocyte lysate assay.Results LPS activity was associated directly with the total energy intake and indirectly with carbohydrate intake in lean, healthy subjects. High LPS was significantly associated with prevalent obesity, MetS, diabetes, and CHD events, independently of established risk factors, CRP, and total energy or nutrient intake. The ORs (95 % CI) were 1.49 (1.21-1.85, p < 0.001, Q2-4 vs. Q1) for obesity, 2.56 (1.97-3.32, p < 0.001, Q2-4 vs. Q1) for MetS, 1.94 (1.06-3.52, p = 0.031, Q2-4 vs. Q1) for CHD, and 1.01 (1.00-1.01, p = 0.032, LPS unit) for diabetes. In the follow-up, high LPS was significantly associated with the risk of CHD events with a hazard ratio of 1.88 (1.13-3.12, p = 0.013, Q2-4 vs. Q1). This association was independent of baseline established risk factors, diet, obesity, MetS, and diabetes.Conclusion A high serum LPS activity is strongly associated with cardiometabolic disorders, which supports the role of bacterial infections and immune response in their etiology.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cites
Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J.-C., James, W. P. T., Loria, C. M., & Smith, S. C. (2009) · Circulation · doi:10.1161/circulationaha.109.192644 · Cited by 14,860 · see citing works
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277 · see citing works
Commensal Host-Bacterial Relationships in the Gut
Hooper, L. V., & Gordon, J. I. (2001) · Science · doi:10.1126/science.1058709 · Cited by 2,362 · see citing works
WHO MONICA Project Principal Invest (1988) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(88)90084-4 · Cited by 1,798 · see citing works
Human blood pressure determination by sphygmomanometry.
Perloff, D., Grim, C. M., Flack, J. M., Frohlich, E. D., Hill, M. D., McDonald, M., & Morgenstern, B. Z. (1993) · Circulation · doi:10.1161/01.cir.88.5.2460 · Cited by 1,592 · see citing works
Kornitzer, M., Berghmans, L., Wilmet, M. D., Darquennes, H., Lagasse, R., & Payen, R. (1988) · Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) · Cited by 1,270 · see citing works
Dental disease and risk of coronary heart disease and mortality.
Destefano, F. R., Anda, R. F., Kahn, H. S., Williamson, D. F., & Russell, C. M. (1993) · BMJ · doi:10.1136/bmj.306.6879.688 · Cited by 1,113 · see citing works
Erridge, C., Attina, T., Spickett, C. M., & Webb, D. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1286 · Cited by 776 · see citing works
Chylomicrons promote intestinal absorption of lipopolysaccharides
Ghoshal, S., Witta, J., Zhong, J., de Villiers, W., & Eckhardt, E. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800156-jlr200 · Cited by 662 · see citing works
Interactions Between Gut Microbiota and Host Metabolism Predisposing to Obesity and Diabetes
Musso, G., Gambino, R., & Cassader, M. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-012510-175505 · Cited by 598 · see citing works
Energy intake is associated with endotoxemia in apparently healthy men
Amar, J., Burcelin, R., Ruidavets, J. B., Cani, P. D., Fauvel, J., Alessi, M., Chamontin, B., & Ferrières, J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1219 · Cited by 594 · see citing works
A high-fat diet is associated with endotoxemia that originates from the gut
Pendyala, S., Walker, J. M., & Holt, P. R. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.01.034 · Cited by 546 · see citing works
REPRODUCIBILITY AND VALIDITY OF DIETARY ASSESSMENT INSTRUMENTS
Pietinen, P., Hartman, A. M., Haapa, E., Räsänen, L., Haapakoski, J., Palmgren, J., Albanes, D., Virtamo, J. R. K., & Huttunen, J. K. (1988) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115013 · Cited by 515 · see citing works
Association of endotoxemia with carotid atherosclerosis and cardiovascular disease
Wiedermann, C. J., Kiechl, S., Dunzendorfer, S., Schratzberger, P., Egger, G., Oberhollenzer, F., & Willeit, J. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00448-9 · Cited by 505 · see citing works
Thirty-five-year trends in cardiovascular risk factors in Finland
Vartiainen, E. A., Laatikainen, T. K., Peltonen, M., Juolevi, A., Männistö, S., Sundvall, J., Jousilahti, P., Salomaa, V. V., Valsta, L. M., & Puska, P. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp330 · Cited by 500 · see citing works
Self-citationGhanim, H., Abuaysheh, S., Sia, C. L., Korzeniewski, K., Chaudhuri, A., Fernandez-Real, J. M., & Dandona, P. (2009) · Diabetes Care · doi:10.2337/dc09-0979 · Cited by 494 · see citing works
Endotoxemia Is Associated With an Increased Risk of Incident Diabetes
Pussinen, P. J., Havulinna, A. S., Lehto, M. J., Sundvall, J., & Salomaa, V. V. (2011) · Diabetes Care · doi:10.2337/dc10-1676 · Cited by 407 · see citing works
Self-citationLassenius, M., Pietiläinen, K., Kaartinen, K., Pussinen, P., Syrjänen, J., Forsblom, C., Pörsti, I., Rissanen, A., Kaprio, J., Mustonen, J., et al. (2011) · Diabetes Care · doi:10.2337/dc10-2197 · Cited by 404 · see citing works
Self-citationPeriodontal Disease and Incident Type 2 Diabetes
Demmer, R. T., Jacobs, D. R., & Desvarieux, M. (2008) · Diabetes Care · doi:10.2337/dc08-0026 · Cited by 336 · see citing works
Pajunen, P., Koukkunen, H., Ketonen, M., Jerkkola, T., Immonen‐Räihä, P., K??rj??-Koskenkari, P., nen, M. M. H., Niemel, M., Kuulasmaa, K., ki, P. P. A., et al. (2005) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/00149831-200504000-00007 · Cited by 334 · see citing works
Self-citationGhanim, H., Sia, C. L., Upadhyay, M., Korzeniewski, K., Viswanathan, P., Abuaysheh, S., Mohanty, P., & Dandona, P. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28584 · Cited by 299 · see citing works
Bacteraemia following periodontal procedures
Kinane, D. F., Riggio, M. P., Walker, K. F., MacKenzie, D., & Shearer, B. (2005) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2005.00741.x · Cited by 286 · see citing works
Meat and dairy food consumption and breast cancer: a pooled analysis of cohort studies
Missmer, S. A. (2002) · International Journal of Epidemiology · doi:10.1093/ije/31.1.78 · Cited by 267 · see citing works
Pussinen, P. J., Tuomisto, K., Jousilahti, P., Havulinna, A. S., Sundvall, J., & Salomaa, V. V. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.106.138743 · Cited by 265 · see citing works
Self-citationDeopurkar, R., Ghanim, H., Friedman, J., Abuaysheh, S., Sia, C. L., Mohanty, P., Viswanathan, P., Chaudhuri, A., & Dandona, P. (2010) · Diabetes Care · doi:10.2337/dc09-1630 · Cited by 246 · see citing works
Harte, A. L., Varma, M. C., Tripathi, G., McGee, K. C., Al‐Daghri, N. M., Al-Attas, O. S., Sabico, S., O’Hare, J. P., Ceriello, A., Saravanan, P., et al. (2011) · Diabetes Care · doi:10.2337/dc11-1593 · Cited by 236 · see citing works
Metabolic endotoxemia: a molecular link between obesity and cardiovascular risk
Neves, A. L., Coelho, J., Couto, L., Leite-Moreira, A., & Roncon-Albuquerque, R. (2013) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0079 · Cited by 211 · see citing works
Clemente‐Postigo, M., Queipo‐Ortuño, M. I., Murri, M., Boto‐Ordóñez, M., Pérez‐Martínez, P., Andrés‐Lacueva, C., Cardona, F., & Tinahones, F. J. (2012) · Journal of Lipid Research · doi:10.1194/jlr.p020909 · Cited by 139 · see citing works
The role of M cells in mucosal immunity
Hathaway, L. J., & Kraehenbuhl*, J.-P. (2000) · Cellular and Molecular Life Sciences CMLS · doi:10.1007/pl00000693 · Cited by 131 · see citing works
Dietary survey methodology of FINDIET 2007 with a risk assessment perspective
Reinivuo, H., Hirvonen, T., Ovaskainen, M., Korhonen, T., & Valsta, L. M. (2010) · Public Health Nutrition · doi:10.1017/s1368980010001096 · Cited by 125 · see citing works
Kelly, C. J., Colgan, S. P., & Frank, D. N. (2012) · Nutrition in Clinical Practice · doi:10.1177/0884533611434934 · Cited by 98 · see citing works
Endotoxin levels in sera of elderly individuals
Goto, T., Edén, S., Nordenstam, G., Sundh, V., Svanborg-Edén, C., & Mattsby‐Baltzer, I. (1994) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.1.6.684-688.1994 · Cited by 78 · see citing works
Pearson, F. C., Dubczak, J., Weary, M. E., Bruszer, G. V., & Donohue, G. (1985) · Journal of Clinical Microbiology · doi:10.1128/jcm.21.6.865-868.1985 · Cited by 76 · see citing works
Wachtel, R. E., & Tsuji, K. (1977) · Applied and Environmental Microbiology · doi:10.1128/aem.33.6.1265-1269.1977 · Cited by 62 · see citing works
Lappin, D. F., Sherrabeh, S., & Erridge, C. (2011) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2011.01702.x · Cited by 50 · see citing works
Pradhan‐Palikhe, P., Vikatmaa, P., Lajunen, T. K., Palikhe, A., Lepäntalo, M., Tervahartiala, T. I., Salo, T. A., Saikku, P., Leinonen, M., Pussinen, P. J., et al. (2010) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2010.02418.x · Cited by 49 · see citing works
Self-citationLassenius, M. I., Mäkinen, V., Fogarty, C. L., Peräneva, L., Jauhiainen, M., Pussinen, P. J., Taskinen, M., Kirveskari, J., Vaarala, O., Nieminen, J. K., et al. (2014) · Nutrition & Metabolism · doi:10.1186/1743-7075-11-28 · Cited by 22 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The gut microbiota at the intersection of diet and human health
Gentile, C. L., & Weir, T. L. (2018) · Science · doi:10.1126/science.aau5812 · Cited by 1,049 · see citing works
Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors
Fiuza-Luces, C., Santos-Lozano, A., Joyner, M., Carrera-Bastos, P., Picazo, O., Zugaza, J. L., Izquierdo, M., Ruilope, L. M., & Lucia, A. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0065-1 · Cited by 803 · see citing works
Intestinal Barrier Dysfunction, LPS Translocation, and Disease Development
Ghosh, S. S., Wang, J., Yannie, P. J., & Ghosh, S. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvz039 · Cited by 780 · see citing works
Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions
Mohammad, S., & Thiemermann, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.594150 · Cited by 585 · see citing works
Therapies from Fucoidan: An Update
Fitton, J., Stringer, D., & Karpiniec, S. (2015) · Marine Drugs · doi:10.3390/md13095920 · Cited by 418 · see citing works
Metabolic endotoxemia with obesity: Is it real and is it relevant?
Boutagy, N. E., McMillan, R. P., Frisard, M. I., & Hulver, M. W. (2016) · Biochimie · doi:10.1016/j.biochi.2015.06.020 · Cited by 413 · see citing works
Missing Teeth Predict Incident Cardiovascular Events, Diabetes, and Death
Liljestrand, J. M., Havulinna, A. S., Paju, S., Männistö, S., Salomaa, V. V., & Pussinen, P. J. (2015) · Journal of Dental Research · doi:10.1177/0022034515586352 · Cited by 234 · see citing works
Self-citationGut Microbiome and Obesity: A Plausible Explanation for Obesity
Sanmiguel, C. P., Gupta, A., & Mayer, E. A. (2015) · Current Obesity Reports · doi:10.1007/s13679-015-0152-0 · Cited by 203 · see citing works
Guerville, M., & Boudry, G. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00098.2016 · Cited by 189 · see citing works
The gut microbiota and its interactions with cardiovascular disease
Xu, H., Wang, X., Feng, W., Liu, Q., Zhou, S., Liu, Q., & Cai, L. (2020) · Microbial Biotechnology · doi:10.1111/1751-7915.13524 · Cited by 192 · see citing works
Stenman, L. K., Lehtinen, M. J., Meland, N., Christensen, J. E., Yeung, N., Saarinen, M. T., Courtney, M., Burcelin, R., Lähdeaho, M.-L., Linros, J., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.10.036 · Cited by 177 · see citing works
The oral microbiome in the pathophysiology of cardiovascular disease
Tonelli, A., Lumngwena, E. N., & Ntusi, N. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00825-3 · Cited by 171 · see citing works
Butyrate-producing bacteria and the gut-heart axis in atherosclerosis
Chen, W., Zhang, S., Wu, J., Ye, T., Wang, S., Wang, P., & Xing, D. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.04.037 · Cited by 144 · see citing works
Periodontitis and cardiometabolic disorders: The role of lipopolysaccharide and endotoxemia
Pussinen, P. J., Kopra, E., Pietiäinen, M., Lehto, M. J., Zarić, S., Paju, S., & Salminen, A. (2022) · Periodontology 2000 · doi:10.1111/prd.12433 · Cited by 138 · see citing works
Self-citationRole of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder
Luqman, A., Hassan, A., Ullah, M., Naseem, S., Ullah, M., Zhang, L., Din, A. U., Ullah, K., Ahmad, W., & Wang, G. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1321395 · Cited by 138 · see citing works
MINAMI, J., Iwabuchi, N., Tanaka, M., Yamauchi, K., Xiao, J., Abe, F., & Sakane, N. (2018) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.18-001 · Cited by 123 · see citing works
Martínez-Colón, G. J., Ratnasiri, K., Chen, R., Jiang, S., ZANLEY, E. J., Rustagi, A., Verma, R., Chen, H. M., Andrews, J. R., Mertz, K. D., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abm9151 · Cited by 136 · see citing works
Moludi, J., Maleki, V., Vayghan, H. J., Vaghef‐Mehrabany, E., & Alizadeh, M. (2020) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13250 · Cited by 113 · see citing works
Ghosh, S. S., He, H., Wang, J., Gehr, T. W. B., & Ghosh, S. (2018) · Tissue Barriers · doi:10.1080/21688370.2018.1425085 · Cited by 107 · see citing works
Mediators between oral dysbiosis and cardiovascular diseases
Pietiäinen, M., Liljestrand, J. M., Kopra, E., & Pussinen, P. J. (2018) · European Journal Of Oral Sciences · doi:10.1111/eos.12423 · Cited by 109 · see citing works
Self-citationNutritional modulation of gut microbiota — the impact on metabolic disease pathophysiology
Ojeda, P., Bobe, A. M., Dolan, K. T., Leone, V., & Martinez, K. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.08.013 · Cited by 104 · see citing works
Association of Endodontic Lesions with Coronary Artery Disease
Liljestrand, J. M., Mäntylä, P., Paju, S., Buhlin, K., Kopra, K. A. E., Persson, G. R., Hernández, M., Nieminen, M. S., Sinisalo, J. P., Tjäderhane, L., et al. (2016) · Journal of Dental Research · doi:10.1177/0022034516660509 · Cited by 99 · see citing works
Self-citationKarhu, E., Forsgård, R. A., Alanko, L., Alfthan, H. V., Pussinen, P. J., Hämäläinen, E. K., & Korpela, R. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3739-1 · Cited by 96 · see citing works
Self-citationAndré, P., Laugerette, F., & Féart, C. (2019) · Nutrients · doi:10.3390/nu11081887 · Cited by 87 · see citing works
Mokkala, K., Pellonperä, O., Röytiö, H., Pussinen, P. J., Rönnemaa, T., & Laitinen, K. (2017) · Metabolism · doi:10.1016/j.metabol.2016.12.015 · Cited by 86 · see citing works
Self-citationDietary patterns reflecting healthy food choices are associated with lower serum LPS activity
Ahola, A. J., Lassenius, M. I., Forsblom, C. M., Harjutsalo, V., Lehto, M. J., & Groop, P. (2017) · Scientific Reports · doi:10.1038/s41598-017-06885-7 · Cited by 86 · see citing works
Self-citationAlbany, C. J., Trevelin, S. C., Giganti, G., Lombardi, G., & Scottà, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02795 · Cited by 85 · see citing works
The heart-gut axis: new target for atherosclerosis and congestive heart failure therapy
Forkosh, E., & Ilan, Y. (2019) · Open Heart · doi:10.1136/openhrt-2018-000993 · Cited by 82 · see citing works
Roles of Oral Infections in the Pathomechanism of Atherosclerosis
Aarabi, G., Heydecke, G., & Seedorf, U. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071978 · Cited by 80 · see citing works
Hu, N., & Zhang, Y. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.01.010 · Cited by 76 · see citing works
Hodges, J. K., Sasaki, G. Y., & Bruno, R. S. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108478 · Cited by 76 · see citing works
Guerville, M., Leroy, A., Sinquin, A., Laugerette, F., Michalski, M., & Boudry, G. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00372.2016 · Cited by 75 · see citing works
Tremellen, K. P. (2016) · Basic and Clinical Andrology · doi:10.1186/s12610-016-0034-7 · Cited by 73 · see citing works
Lipopolysaccharide, a possible molecular mediator between periodontitis and coronary artery disease
Liljestrand, J. M., Paju, S., Buhlin, K., Persson, G. R., Sarna, S. J., Nieminen, M. S., Sinisalo, J. P., Mäntylä, P., & Pussinen, P. J. (2017) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12751 · Cited by 71 · see citing works
Self-citationPei, R., DiMarco, D. M., Putt, K. K., Martin, D., Gu, Q., Chitchumroonchokchai, C., White, H. M., Scarlett, C. O., Bruno, R. S., & Bolling, B. W. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114517003038 · Cited by 71 · see citing works
Alfakry, H., Malle, E., Koyani, C. N., Pussinen, P. J., & Sorsa, T. A. (2015) · Innate Immunity · doi:10.1177/1753425915617521 · Cited by 68 · see citing works
Self-citationGut Microbiota Parameters Potentially Useful in Clinical Perspective
Pierro, F. D. (2021) · Microorganisms · doi:10.3390/microorganisms9112402 · Cited by 66 · see citing works
Vliex, L. M. M., Penders, J., Nauta, A., Zoetendal, E. G., & Blaak, E. E. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-00966-0 · Cited by 63 · see citing works
Altered Gut Microbiota: A Link Between Diet and the Metabolic Syndrome
Velasquez, M. T. (2018) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2017.0163 · Cited by 63 · see citing works
Gut Microbiota Modulation as a Novel Therapeutic Strategy in Cardiometabolic Diseases
Mutalub, Y. B., Abdulwahab, M., Mohammed, A., Yahkub, A. M., Al-Mhanna, S. B., Yusof, W., Tang, S. P., Rasool, A. H. G., & Mokhtar, S. S. (2022) · Foods · doi:10.3390/foods11172575 · Cited by 60 · see citing works
Poljšak, B., Kovač, V., Špalj, S., & Milisav, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032959 · Cited by 58 · see citing works
Fedirko, V., Tran, H. Q., Gewirtz, A. T., Stepien, M., Trichopoulou, A., Aleksandrova, K., Olsen, A., Tjønneland, A., Overvad, K., Carbonnel, F., et al. (2017) · BMC Medicine · doi:10.1186/s12916-017-0830-8 · Cited by 50 · see citing works
Berries as a Treatment for Obesity-Induced Inflammation: Evidence from Preclinical Models
Lail, H. L., Feresin, R. G., Hicks, D., Stone, B., Price, E., & Wanders, D. (2021) · Nutrients · doi:10.3390/nu13020334 · Cited by 42 · see citing works
Gastrointestinal Dysfunction and HIV Comorbidities
Sim, J. H., Mukerji, S. S., Russo, S. C., & Lo, J. (2021) · Current HIV/AIDS Reports · doi:10.1007/s11904-020-00537-8 · Cited by 42 · see citing works
Chronic oral infection: An emerging risk factor of cerebral small vessel disease
Aarabi, G., Thomalla, G., Heydecke, G., & Seedorf, U. (2018) · Oral Diseases · doi:10.1111/odi.12912 · Cited by 41 · see citing works
Bianchi, M. G., Allegri, M., Chiu, M., Costa, A. L., Blosi, M., Ortelli, S., Bussolati, O., & Bergamaschi, E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00866 · Cited by 39 · see citing works
Current Uncertainties and Future Challenges Regarding NAD+ Boosting Strategies
Poljšak, B., Kovač, V., & Milisav, I. (2022) · Antioxidants · doi:10.3390/antiox11091637 · Cited by 39 · see citing works
Microbiota’s Role in Diet-Driven Alterations in Food Intake: Satiety, Energy Balance, and Reward
Rautmann, A. W., & Serre, C. B. D. L. (2021) · Nutrients · doi:10.3390/nu13093067 · Cited by 37 · see citing works
Gaber, M. K., Wilson, A. S., Millen, A. E., Hovey, K. M., LaMonte, M. J., Wactawski‐Wende, J., Ochs‐Balcom, H. M., & Cook, K. L. (2024) · Microbiome · doi:10.1186/s40168-024-01901-1 · Cited by 39 · see citing works
The Effect of Enteric-Derived Lipopolysaccharides on Obesity
Wang, K., Lai, W., Min, T., Wei, J., Bai, Y., Cao, H., Guo, J., & Su, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084305 · Cited by 35 · see citing works
The Role of Diet, Additives, and Antibiotics in Metabolic Endotoxemia and Chronic Diseases
Park, J., Park, H., Kim, Y., & Park, M. (2024) · Metabolites · doi:10.3390/metabo14120704 · Cited by 39 · see citing works
Leite, F. R. M., Peres, K. G., Do, L., Demarco, F. F., & Peres, M. A. (2017) · Journal of Periodontology · doi:10.1902/jop.2017.160607 · Cited by 34 · see citing works
Serum LPS and CD163 Biomarkers Confirming the Role of Gut Dysbiosis in Overweight Patients with NASH
Hegazy, M., Mogawer, S., Alnaggar, A. R., Ghoniem, O. A., & Samie, R. M. A. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s249949 · Cited by 34 · see citing works
Role of Periodontal Infection, Inflammation and Immunity in Atherosclerosis
Choi, H., Dey, A. K., Priyamvara, A., Aksentijevich, M., Bandyopadhyay, D., Dey, D. K., Dani, S. S., Guha, A., Nambiar, P. H., Nasir, K., et al. (2020) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2020.100638 · Cited by 33 · see citing works
Antunes, B. M., Neto, J. C. R., Batatinha, H., Franchini, É., Teixeira, A. M., & Lira, F. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-70731-6 · Cited by 33 · see citing works
Metabolic Endotoxemia: From the Gut to Neurodegeneration
Chmielarz, M., Sobieszczańska, B., & Środa-Pomianek, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137006 · Cited by 34 · see citing works
Daulatzai, M. A. (2016) · Europe PMC (PubMed Central) · Cited by 31 · see citing works
Nozu, T., & Okumura, T. (2022) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm21002 · Cited by 31 · see citing works
Dopaminergic Pathways in Obesity-Associated Inflammation
Leite, F., & Ribeiro, L. V. P. T. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09863-0 · Cited by 31 · see citing works
Daulatzai, M. A. (2016) · Europe PMC (PubMed Central) · Cited by 60 · see citing works
RetractedAli, S., Malloci, M., Safiedeen, Z., Soleti, R., Vergori, L., Vidal‐Gómez, X., Besnard, C., Dubois, S. G., Lay, S. L., Boursier, J., et al. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154727 · Cited by 27 · see citing works
Mokkala, K., Pussinen, P. J., Houttu, N., Koivuniemi, E., Vahlberg, T. J., & Laitinen, K. (2018) · Beneficial Microbes · doi:10.3920/bm2017.0072 · Cited by 27 · see citing works
Self-citationOh, T. J., Ahn, C. H., & Cho, Y. M. (2016) · Journal of Diabetes Investigation · doi:10.1111/jdi.12444 · Cited by 25 · see citing works
Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke
Leskelä, J., Toppila, I., Härma, M., Palviainen, T., Salminen, A., Sandholm, N., Pietiäinen, M., Kopra, E., de Barros, J.-P. P., FinnGen, et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.022482 · Cited by 25 · see citing works
Self-citationExercise and nutrition in type 1 diabetes: Insights from the FinnDiane cohort
Barlovič, D. P., Harjutsalo, V., & Groop, P. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1064185 · Cited by 26 · see citing works
HIV and comorbidities – the importance of gut inflammation and the kynurenine pathway
MacCann, R., LANDAY, A. L., & Mallon, P. W. G. (2022) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000782 · Cited by 25 · see citing works
Wang, X., Liu, Y., Zhang, S., Ouyang, X., Wang, Y., Jiang, Y., & An, N. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15430 · Cited by 22 · see citing works
Sala, P., Torrinhas, R. S., Fonseca, D. C., Machado, N. M., Singer, J., Singer, P., Ravacci, G. R., Belarmino, G., Ferreira, B. D. A. M., Marques, M. Q., et al. (2020) · Nutrition · doi:10.1016/j.nut.2020.110885 · Cited by 21 · see citing works
Simonsen, J. R., Järvinen, A., Harjutsalo, V., Forsblom, C. M., Groop, P., & Lehto, M. J. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13138 · Cited by 18 · see citing works
Self-citationHuman Gut Microbiota in Cardiovascular Disease
Ronen, D., Rokach, Y., Abedat, S., Qadan, A., Daana, S., Amir, O., & Asleh, R. (2024) · Comprehensive physiology · doi:10.1002/cphy.c230012 · Cited by 28 · see citing works
Cui, Y., Zhang, F., Xu, W., Li, Z., Zou, J., Gao, P., & Hu, J. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04013-9 · Cited by 17 · see citing works
Mikołajczyk, A., & Złotkowska, D. (2019) · Toxins · doi:10.3390/toxins11020091 · Cited by 17 · see citing works
Simonsen, J. R., Järvinen, A., Hietala, K., Harjutsalo, V., Forsblom, C. M., Groop, P., & Lehto, M. J. (2020) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2020-316202 · Cited by 17 · see citing works
Self-citationBishehsari, F., Drees, M., Adnan, D., Sharma, D., Green, S. J., Koshy, J., Giron, L. B., Goldman, A. R., Abdel‐Mohsen, M., Rasmussen, H. E., et al. (2023) · PROTEOMICS · doi:10.1002/pmic.202300023 · Cited by 14 · see citing works
Serum lipopolysaccharide neutralizing capacity in ischemic stroke
Leskelä, J., Pietiäinen, M., Safer, A., Lehto, M. J., Metso, J., Malle, E., Buggle, F., Becher, H., Sundvall, J., Grau, A., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0228806 · Cited by 13 · see citing works
Self-citationOh, T. J., Lee, H., & Cho, Y. M. (2015) · Obesity Surgery · doi:10.1007/s11695-015-1879-0 · Cited by 13 · see citing works
Sex-Specific Metabolite Biomarkers of NAFLD in Youth: A Prospective Study in the EPOCH Cohort
Perng, W., Francis, E. C., Smith, H., Carey, J., Wang, D., Kechris, K. J., & Dabelea, D. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa467 · Cited by 13 · see citing works
Ogilvie, A. R., Onishi, J. C., Schlussel, Y., Kumar, A., V, Häggblom, M. M., Kerkhof, L. J., & Shapses, S. A. (2025) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.06.001 · Cited by 12 · see citing works
Rodríguez-Vera, D., Vergara‐Castañeda, A., Lazcano-Orozco, D. K., Ramírez-Vélez, G., Vivar-Sierra, A., Araiza-Macías, M. J., Contreras, J. P. H., Naranjo-Navarro, C. R., Salazar, J. R., Loza-Mejía, M. A., et al. (2021) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2021.0022 · Cited by 14 · see citing works
Oral health: A modifiable risk factor for cardiovascular diseases or a confounded association?
Pussinen, P. J., & Könönen, E. (2016) · European Journal of Preventive Cardiology · doi:10.1177/2047487316636506 · Cited by 11 · see citing works
Self-citationMehmood, K., Moin, A., Hussain, T., Rizvi, S. M. D., Gowda, D., Shakil, S., & Kamal, M. (2021) · Folia Microbiologica · doi:10.1007/s12223-021-00926-5 · Cited by 11 · see citing works
Rehues, P., Rodríguez, M. M., Alvarez-Borillo, J., Jiménez, M. P. C., Melià, A., Sempere, M., Balsells, C., Castillejo, G., Guardiola, M., Castro, A., et al. (2021) · Biomolecules · doi:10.3390/biom12010047 · Cited by 10 · see citing works
Perng, W., Friedman, J. E., Janssen, R. C., Glueck, D. H., & Dabelea, D. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac149 · Cited by 10 · see citing works
Infection and food combine to cause atherosclerotic coronary heart disease – Review and hypothesis
Lawson, J. S., & Glenn, W. K. (2021) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2021.100807 · Cited by 10 · see citing works
Gender Differences in the Gut Microbiome and How These Affect Cardiovascular Diseases
Rosel, A. C., Wassenaar, T. M., & Ussery, D. W. (2018) · Springer eBooks · doi:10.1007/978-3-319-71135-5_7 · Cited by 10 · see citing works
Gut microbiome metabolites as key actors in atherosclerosis co-depression disease
Liao, X.-X., Wu, X., Zhou, Y.-L., Li, J., Wen, Y.-L., & Zhou, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.988643 · Cited by 9 · see citing works
Viewpoint: Is lipopolysaccharide a hormone or a vitamin?
Jiang, W., & Banks, W. A. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.07.018 · Cited by 9 · see citing works
Influence of Energy Balance and Glycemic Index on Metabolic Endotoxemia in Healthy Men
Breusing, N., Lagerpusch, M., Engstler, A. J., Bergheim, I., Mueller, M. J., & Bosy‐Westphal, A. (2017) · Journal of the American College of Nutrition · doi:10.1080/07315724.2016.1156036 · Cited by 9 · see citing works
Δάσκου, Μ., Sharma, M. B., Mu, W., Heymans, R., Ritou, E., Rezek, V. K., Hamid, P., Kossyvakis, A., Roy, S. S., Grijalva, V. R., et al. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154888 · Cited by 9 · see citing works
Cardiovascular Involvement in Sepsis
Turillazzi, E., Fineschi, V., Palmière, C., & Sergi, C. M. (2016) · Mediators of Inflammation · doi:10.1155/2016/8584793 · Cited by 9 · see citing works
Kwon, H.-S., Kim, S.-J., Shin, K. J., Kim, S. H., Yun, J., Bae, J., Tak, H.-J., Lee, N., & Kim, H.-J. (2024) · Nutrients · doi:10.3390/nu16131993 · Cited by 8 · see citing works
Metabolic endotoxemia: possible causes and consequences
Beloglazov, V. A., Yatskov, I. A., Кумельский, Е. Д., & Polovinkina, V. V. (2021) · Obesity and metabolism · doi:10.14341/omet12750 · Cited by 8 · see citing works
Association between severity of dental caries and the risk of stroke
Ono, Y., Chou, Y., Chien, W., & Sun, C. (2023) · Oral Diseases · doi:10.1111/odi.14756 · Cited by 8 · see citing works
Gut-Heart Axis: Microbiome Involvement in Restrictive Cardiomyopathies
Alvarado, S. J., López-Tenorio, I. I., Santos, J. B.-D. L., Bello-Vega, D. C., Roldán, F., Amedei, A., Berrios-Bárcenas, E. A., & Aguirre‐García, M. M. (2025) · Biomedicines · doi:10.3390/biomedicines13010144 · Cited by 9 · see citing works
Cornò, M. D., Aureli, A., Varano, B., & Conti, L. (2026) · Biomolecules · doi:10.3390/biom16020226 · Cited by 7 · see citing works
Human Gut Microbiota in Cardiovascular Disease
Ronen, D., Rokach, Y., Abedat, S., Qadan, A., Daana, S., Amir, O., & Asleh, R. (2024) · Comprehensive physiology · doi:10.1002/j.2040-4603.2024.tb00298.x · Cited by 7 · see citing works
Climate Change, Urbanisation, and Their Impact on Increased Occurrence of Cardiometabolic Syndrome
Choudhury, S. P., Arora, A., Jain, N., & Dey, S. K. (2022) · doi:10.1002/9781119807216.ch2 · Cited by 7 · see citing works
Trandafir, L. M., Cojocaru, E., Moscalu, M., Leon, M. M., Miron, I. C., Maștaleru, A., Teslariu, O., Datcu, M., Fotea, S., & Frăsinariu, O. E. (2021) · Diagnostics · doi:10.3390/diagnostics11040735 · Cited by 6 · see citing works
Impact of Early Nutrition on Intestinal Microbiome: Effects on Immunity and Long-Term Health
Laitinen, K., Mokkala, K., & Kalliomäki, M. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-08-100168-4.00008-2 · Cited by 5 · see citing works
Federici, M. (2019) · Acta Diabetologica · doi:10.1007/s00592-019-01315-8 · Cited by 6 · see citing works
- Authors
- Kallio, K. A. E., Hätönen, K. A., Lehto, M., Salomaa, V., Männistö, S., & Pussinen, P. J.
- Affiliations
- University of Helsinki (FI)
- Finnish Institute for Health and Welfare (FI)
- Helsinki University Hospital (FI)
- Corresponding author
- Kallio, K. A. Elisa
- Venue
- Acta Diabetologica
- Published
- 2014-10-19
- Volume
- 52
- Issue
- 2
- Pages
- 395-404
- ISSN
- 0940-5429 (ISSN-L)
- 1432-5233
- OpenAlex
- W2016971083
- Cited by
- 125
- References
- 38
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 11 · 2023: 7 · 2022: 13 · 2021: 17 · 2020: 18 · 2019: 7 · 2018: 12 · 2017: 12 · 2016: 13 · 2015: 10
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Diabetologica (publishedVersion)
- PubMed (publishedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Funders
- Aarne Koskelon Säätiö
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- endotoxemia, lipopolysaccharide, macronutrient intake, carbohydrate intake, energy intake, obesity, metabolic syndrome, diabetes mellitus, coronary artery disease, cardiometabolic disease, gut microbiota, bacterial infection, inflammation
- MeSH terms
- Adult, Aged, Energy Intake, Coronary Disease, Endotoxins, Female, Follow-Up Studies, Humans, Lipopolysaccharides, Male, Middle Aged, Cohort Studies, Nutrition Assessment, Endotoxemia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review