Centella asiatica attenuates the neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion rats
Abstract
Centella asiatica has been used as psychoactive and antioxidant herbal medicine since ancient time. The present study was design to evaluate the preventive role of ethanolic extract of C. asiatica in middle cerebral artery occlusion (MCAO) in rats. Male Wistar rats were gavaged orally with C. asiatica extract (100, 200 and 300 mg/kg body weight once daily) for 21 days and thereafter subjected to right MCAO for 2 h followed by 22-h reperfusion. Brain injury was evaluated by 2,3,5-triphenyltetrazolium chloride and hematoxylin and eosin staining. Behavioural outcomes as neurological deficit, rota rod test, and grip strength were assessed. In addition, lipid peroxidation, enzymatic and non enzymatic antioxidants were analyzed to assess the oxidative stress. Our results revealed that C. asiatica administration greatly improved neurobehavioral activity and diminished infarction volume along with the restored histological morphology of brain in MCAO rats. Furthermore, supplementation with this extract to MCAO group has reduced the level of thiobarbituric acid reactive species, restored glutathione content and augmented the activities of antioxidant enzymes-catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase and superoxide dismutase in a dose-dependent manner in ischemic rats. The remarkable antioxidant activity of C. asiatica may be attributed to its bioactive triterpenes, asiatic acid, asiaticoside, madecassic acid and madecosside and may be translated to clinical level for prevention of ischemic stroke.
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Asiaticoside can alleviate neuronal damage.
“Asiaticoside can alleviate neuronal damage, 28”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [28]
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Centella asiatica: Phytochemistry and mechanisms of neuroprotection and cognitive enhancement
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NRF2 as a Therapeutic Target in Neurodegenerative Diseases
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Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review
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Caffeoylquinic Acids in Centella asiatica Protect against Amyloid-β Toxicity
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- Authors
- Tabassum, R., Vaibhav, K., Shrivastava, P., Khan, A., Ahmed, M. E., Javed, H., Islam, F., Ahmad, S., Siddiqui, M. S., Safhi, M. M., & Islam, F.
- Affiliations
- Hamdard University (PK)
- Jazan University (SA)
- Corresponding author
- Farah Islam
- Fakhrul Islam
- ORCID
- Venue
- Neurological Sciences
- Published
- 2012-08-04
- Volume
- 34
- Issue
- 6
- Pages
- 925-933
- ISSN
- 1590-1874 (ISSN-L)
- 1590-3478
- OpenAlex
- W1986386240
- Cited by
- 82
- References
- 2
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 9 · 2020: 4 · 2019: 2 · 2018: 8 · 2017: 6 · 2016: 4 · 2015: 8 · 2014: 9 · 2013: 4
- FWCI
- 16.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Centella asiatica, middle cerebral artery occlusion, ischemic stroke, neuroprotection, antioxidant activity, oxidative stress, lipid peroxidation, neurobehavioral deficits, infarct size, triterpenoids, asiatic acid, asiaticoside, madecassic acid, glutathione, antioxidant enzymes, herbal medicine
- MeSH terms
- Animals, Brain Chemistry, Catalase, Cerebral Infarction, Disease Models, Animal, Dose-Response Relationship, Drug, Glutathione, Glutathione Peroxidase, Glutathione Transferase, Male, Nervous System Diseases, Plant Extracts, Superoxide Dismutase, Time Factors, Triterpenes, Lipid Peroxidation, Rats, Wistar, Muscle, Skeletal, Neuroprotective Agents, Hand Strength, Infarction, Middle Cerebral Artery, Centella, Rats
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