Insights into antioxidant activities and anti-skin-aging potential of callus extract from Centella asiatica (L.)

Buranasudja, Visarut; Rani, Dolly; Malla, Ashwini; Kobtrakul, Khwanlada; Vimolmangkang, Sornkanok

doi:10.1038/s41598-021-92958-7

Cited by 112Skin Protection and AgingPlant tissue culture and regenerationMedicinal Plant Research

Insights into antioxidant activities and anti-skin-aging potential of callus extract from Centella asiatica (L.)

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Buranasudja, Visarut, Rani, Dolly, Malla, Ashwini, Kobtrakul, Khwanlada, Vimolmangkang, Sornkanok·2021·Scientific Reports

DOI 10.1038/s41598-021-92958-7PMC PMC8241881

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Abstract

Formation of oxidative stress in dermal fibroblasts plays crucial roles in aging processes of skin. The use of phytochemicals that can promote capacity of fibroblasts to combat oxidative stress is an attractive strategy to prevent skin aging and promote skin beauty. Centella asiatica has been used to treat multitude of diseases for centuries. Previous investigations demonstrated that extracts from C. asiatica have a broad range of beneficial activities through their antioxidant activity. Hence, the extract from this medicinal plant could be a great candidate for anti-skin-aging agent. Callus culture offers a powerful platform for sustainable, rapid and large-scale production of phytochemicals to serve extensive demands of pharmaceutical and cosmeceutical industries. Here, we demonstrated the application of callus culture of Centella asiatica to produce bioactive metabolites. The 50% ethanolic extract of callus culture has distinctive features of chemical compositions and biological profiles. Information from HPTLC-DPPH and HPLC analysis suggested that the callus extract comprises distinctive antioxidant compounds, compared with those isolated from authentic plant. Moreover, results from cell culture experiment demonstrated that callus extract possesses promising antioxidant and anti-skin-aging activities. Pre-treatment with callus extract attenuated H 2 O 2-induced-cytotoxicity on human dermal fibroblasts. The results from RT-qPCR clearly suggested that the upregulation of cellular antioxidant enzymes appeared to be major contributor for the protective effects of callus extract against oxidative stress. Moreover, supplementation with callus extract inhibited induction of matrix metalloprotease-9 following H 2 O 2 exposure, suggesting its potential anti-skin-aging activity. Our results demonstrate the potential utility of C. asiatica callus extract as anti-skin-aging agent in cosmeceutical preparations.

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C. asiatica callus extract exhibited strong antioxidant activities and anti-skin-aging potential.
“The results showed that the callus extract exhibited strong antioxidant activities and anti‐skin‐aging potential”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [37]
These findings are consistent with earlier reports on the antioxidant properties of C. asiatica.
“These findings are consistent with earlier reports on the antioxidant properties of C. asiatica [35].”
From Oral Centella asiatica Extract Attenuates UVB-Induced Skin Photoaging via Antioxidant, Anti-Inflammatory, and Extracellular Matrix-Preserving Effects in Hairless Mice (2025) · cites this paper as [35]
The Buranasudja et al. 37 study level of evidence is categorized as Level IV according to the Oxford Centre for Evidence-Based Medicine.
“The level of evidence for this study can be categorized as Level IV according to the Oxford Centre for Evidence‐Based Medicine's hierarchical system.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [37]
The Material and methods section describes cell-culture experiments, and the Statistical analysis section describes how their results were analyzed. Our copy does not assign the study an Oxford Centre for Evidence-Based Medicine level; a search for “Level IV” and the Oxford hierarchy found no relevant passage. The Level IV designation appears to be the citing authors’ assessment, not a classification stated by Buranasudja et al. (LLM, conf=0.76)
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Protective potential of frankincense essential oil and its loaded solid lipid nanoparticles against UVB-induced photodamage in rats via MAPK and PI3K/AKT signaling pathways; A promising anti-aging therapy
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Characterization of Rosa damascena Callus-Derived Exosome-like Vesicles and Their Multifunctional Activities in Skin-Related Cellular Models
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Can Asiatic Acid from Centella asiatica Be a Potential Remedy in Cancer Therapy?—A Review
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CORM‐3 Attenuates Oxidative Stress‐Induced Bone Loss via the Nrf2/HO‐1 Pathway
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The Potential Application of Nanocarriers in Delivering Topical Antioxidants
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The Skin-Whitening and Antioxidant Effects of Protocatechuic Acid (PCA) Derivatives in Melanoma and Fibroblast Cell Lines
Cho, J. H., Jung, H., Kang, D. Y., Sp, N., Shin, W.-S., Lee, J., Park, B. G., Kang, Y. A., Jang, K., & Bae, S. W. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45030138 · Cited by 23 · see citing works
The Standardized Extract of Centella asiatica and Its Fractions Exert Antioxidative and Anti-Neuroinflammatory Effects on Microglial Cells and Regulate the Nrf2/HO-1 Signaling Pathway
Hambali, A., Jusril, N. A., Hashim, N. F. M., Manan, N. A., Adam, S. K., Mehat, M. Z., Adenan, M. I., Stanslas, J., & Hamid, H. A. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-230875 · Cited by 23 · see citing works
Cosmeceuticals in photoaging: A review.
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A Practical Approach for the In Vitro Safety and Efficacy Assessment of an Anti-Ageing Cosmetic Cream Enriched with Functional Compounds
Zerbinati, N., Sommatis, S., Maccario, C., Di Francesco, S., Capillo, M. C., Grimaldi, G., Rauso, R., Herrera, M., Bencini, P. L., & Mocchi, R. (2021) · Molecules · doi:10.3390/molecules26247592 · Cited by 16 · see citing works
RETRACTED: Chemical profiles and pharmacological attributes of Apis cerana indica beehives using combined experimental and computer-aided studies
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Selected Plants as Sources of Natural and Active Ingredients for Cosmetics of the Future
Kowalczyk, S. J., Grymel, M., Bilik, J., Kula, W., Wawoczny, A., Grymel, P., & Gillner, D. (2024) · Applied Sciences · doi:10.3390/app14083487 · Cited by 18 · see citing works
Centella asiatica-Derived Endothelial Paracrine Restores Epithelial Barrier Dysfunction in Radiation-Induced Enteritis
Kwak, S. Y., Jang, W. I., Lee, S. B., Kim, M., Park, S., Cho, S. S., Kim, H., Lee, S., Shim, S., & Jang, H. (2022) · Cells · doi:10.3390/cells11162544 · Cited by 13 · see citing works
Three decades of research on Centella asiatica: Insights and future trends from bibliometric analysis
Oyenihi, A. B., George, T., Oyenihi, O., Obilana, A. O., & Opperman, M. (2023) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2023.100662 · Cited by 13 · see citing works
Curcumin Nanoemulgel: Characterization, Optimization, and Evaluation of Photoprotective Efficacy, Anti-Inflammatory Properties, and Antibacterial Activity
Bagheri, A. M., Ranjbar, M., Karami‐Mohajeri, S., Moshafi, M. H., Noudeh, Y. D., Ohadi, M., & Dehghannoudeh, G. (2024) · Journal of Cluster Science · doi:10.1007/s10876-024-02651-8 · Cited by 13 · see citing works
Preparation, identification, and anti-photoaging effect of royal jelly protein peptides on UVB-irradiated HaCaT cells
Li, Z., Liang, J., Feng, J., Xing, H., Wang, R., Li, P., Su, J., & Yang, X. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116548 · Cited by 13 · see citing works
Liposomal stem cell extract formulation from Coffea canephora shows outstanding anti-inflammatory activity, increased tissue repair, neocollagenesis and neoangiogenesis
Guidoni, M., Júnior, A. D. D. S., Aragão, V. P. M., Pereira, T. D. M. C., dos Santos, W. C., Monteiro, F. C., Guimarães, M. C. C., & Fronza, M. (2022) · Archives of Dermatological Research · doi:10.1007/s00403-022-02388-2 · Cited by 13 · see citing works
Analysis of Active Components and Transcriptome of Freesia refracta Callus Extract and Its Effects against Oxidative Stress and Wrinkles in Skin
Kim, E., Tollenaere, M. D., Sennelier, B., Lambert, C., Durduret, A., Kim, S., Seo, H.-H., Lee, J.-H., Scandolera, A., Reynaud, R., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158150 · Cited by 12 · see citing works
Wound healing efficacy of a polymeric spray film solution containing Centella asiatica leaf extract on acute wounds
Changsan, N., Srichana, T., Atipairin, A., & Sawatdee, S. (2023) · Journal of Wound Care · doi:10.12968/jowc.2023.32.sup12.s22 · Cited by 13 · see citing works
Essential Oil Compounds of Andaliman (Zanthoxylum acanthopodium DC.) Fruit Varieties and Their Utilization as Skin Anti-Aging Using Molecular Docking
Kintamani, E., Batubara, I., Kusmana, C., Tiryana, T., Mirmanto, E., & Asoka, S. F. (2023) · Life · doi:10.3390/life13030754 · Cited by 11 · see citing works
Some Antioxidant Properties of Components from the Flower of Ochna integerrima and Their Beneficial Effects on HaCaT Keratinocytes and in Silico Analysis on Tyrosinase
Buranasudja, V., Kobtrakul, K., Vimolmangkang, S., Binalee, A., Sanookpan, K., Vu, T., Vu‐Huynh, K. L., Le, B., Nguyen, H. T., Minh, K., et al. (2022) · Chemistry & Biodiversity · doi:10.1002/cbdv.202100882 · Cited by 10 · see citing works
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Centella asiatica and its bioactive compounds: a comprehensive approach to managing hyperglycemia and associated disorders
Singh, L. S., & Singh, W. S. (2024) · Discover Plants. · doi:10.1007/s44372-024-00070-7 · Cited by 9 · see citing works
Skin recovery by Lavandula angustifolia leaf callus extract: Redox control of Nrf2 signaling
Kim, E., Kim, S., Song, J., Jang, J., Seo, H. H., Lee, J. H., & Moh, S. H. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.04.048 · Cited by 9 · see citing works
Biotechnological and endophytic-mediated production of centellosides in Centella asiatica
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Antioxidant, Anti‐Skin‐Aging, Anti‐Inflammatory, and Anti‐Acetylcholinesterase Activities of Rourea oligophlebia Extracts
Buranasudja, V., Vimolmangkang, S., Sanookpan, K., Binalee, A., Nguyen, A. B., Thach, U. D., Do, B. H., Đặng, V. S., Minh, K., & Nguyen, H. M. (2023) · Chemistry & Biodiversity · doi:10.1002/cbdv.202201096 · Cited by 9 · see citing works
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Potential of Plant Stem Cells as Helpful Agents for Skin Disorders—A Narrative Review
Hermosaningtyas, A. A., Chanaj-Kaczmarek, J., Kikowska, M. A., Gornowicz‐Porowska, J., Budzianowska, A., & Pawlaczyk, M. (2024) · Applied Sciences · doi:10.3390/app14167402 · Cited by 11 · see citing works
Citric Acid and Magnolol Ameliorate Clostridium perfringens Challenge in Broiler Chickens
Ding, X., Zhong, X., Yang, Y., Zhang, G., & Si, H. (2023) · Animals · doi:10.3390/ani13040577 · Cited by 9 · see citing works
Ameliorative effect of gel combination of Centella asiatica extract transfersomes and rosemary essential oil nanoemulsion against UVB-induced skin aging in Balb/c mice
Khotimah, H., Ismail, D. D. L., Widasmara, D., Riawan, W., Retnaningtyas, E., Nugraheni, R. W., Puspita, O. E., Adianingsih, O. R., Mardiyah, M., & Setiawan, A. (2022) · F1000Research · doi:10.12688/f1000research.109318.1 · Cited by 9 · see citing works
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Classification and application of metal-based nanoantioxidants in medicine and healthcare
Nam, N. N., Tran, N. K. S., Nguyen, T. T., Trai, N. N., Thúy, N. P., Do, H. D. K., Tran, N. H. T., & Trinh, K. T. L. (2024) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.15.36 · Cited by 8 · see citing works
Simultaneous determination of four active compounds in Centella asiatica by supramolecular solvent-based extraction coupled with high performance liquid chromatography-tandem mass spectrometry
Yuan, Y., Qiao, Y., Zheng, X. X., Yu, X., Dong, Y., Wang, H., & Sun, L. (2023) · Journal of Chromatography A · doi:10.1016/j.chroma.2023.464298 · Cited by 8 · see citing works
Research on the mechanisms of plant bioactive metabolites in anti-skin aging and future development prospects
Wang, H., Zheng, J., Cao, S., & Lv, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1673075 · Cited by 8 · see citing works
Exploring the Role of Herbal Compounds in Skin Aging: A Systematic Review of Topical Approaches
Goh, A. P., Goh, S., Tow, W., Men, T. K., Palanisamy, U. D., & Sundralingam, U. (2024) · Phytotherapy Research · doi:10.1002/ptr.8375 · Cited by 8 · see citing works
Exploring the composition and properties of Centella asiatica metabolites and investigating their impact on BSA glycation, LDL oxidation and α-amylase inhibition
Borges, A. L. S., Bittar, V. P., Justino, A. B., Carrillo, M. S. P., Duarte, R. F. M., Silva, N. B. S., Gonçalves, D. S., Prado, D. G., Araújo, I. A. C., Martins, M. M., et al. (2024) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2024.116143 · Cited by 6 · see citing works
Toxicity Studies of Centella asiatica for Drug Development: Mini Review
(2021) · Biointerface Research in Applied Chemistry · doi:10.33263/briac126.80818093 · Cited by 6 · see citing works
Plant stem cell extract from Coffea canephora shows antioxidant, anti-inflammatory, and skin regenerative properties mediated by suppression of nuclear factor-κB.
Guidoni, M., Júnior, A. D. D. S., Aragão, V. P. M., Silva, M. V. T. E., Barth, T., Clarindo, W. R., Endringer, D. C., Scherer, R., & Fronza, M. (2023) · PubMed Central · doi:10.1590/1414-431x2023e12849 · Cited by 6 · see citing works
The effects of glycoside-rich green extract from Centella asiatica (L.) Urban on wound healing and anti-aging activity
Thong-on, W., Sakchaisri, K., & Prathanturarug, S. (2024) · Phytomedicine Plus · doi:10.1016/j.phyplu.2024.100628 · Cited by 6 · see citing works
Enhancing Antioxidant Activities and Anti-Aging Effect of Rice Stem Cell Extracts by Plasma Treatment
Ji, S. H., Akter, M., Ko, E. Y., Choi, E. H., Keum, Y. S., & Han, I. (2022) · Applied Sciences · doi:10.3390/app12062903 · Cited by 6 · see citing works
Advanced applications of synthetic biology technology in biosynthesis of bioactive compounds from medicinal plants
Liu, Y., Ji, A., Jia, H., & Sun, H. (2025) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2025.11.006 · Cited by 5 · see citing works
Callus Culture System from Lonicera japonica Thunb Anthers: Light Quality Effects on Callus Quality Evaluation
Cheng, J., Guo, F., Zhou, C., Chen, Y., Li, Z., Liang, W., Wang, H., Chen, Y., & Dong, P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052351 · Cited by 5 · see citing works
Topical hydrogel formulation based on nano-aspasomes encapsulating Caffeic acid and Retinoic acid for antiaging effects
Shahid, M., Usman, F., & Abbas, S. R. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107360 · Cited by 5 · see citing works
Does Centella Asiatica Have Antiaging Activity in Skincare Products?
Krisnamurti, G. C., & Sari, D. R. T. (2022) · Advances in Social Science, Education and Humanities Research/Advances in social science, education and humanities research · doi:10.2991/assehr.k.220103.035 · Cited by 5 · see citing works
Investigating the Effects of Chelidonic Acid on Oxidative Stress-Induced Premature Cellular Senescence in Human Skin Fibroblast Cells
Türkoğlu, B., & Mansuroğlu, B. (2024) · Life · doi:10.3390/life14091070 · Cited by 7 · see citing works
Enhanced Skin-Protective Effects of a Novel Centella asiatica Variety (BT-Care) Cultivated for 75 Days via Modulation of Antioxidant Defense, Collagen Synthesis, and Skin Barrier Function
Ko, K., Cheon, G. Y., Ha, Y. J., Ko, Y. R., Kim, J. H., Seo, D., Park, S. Y., Lee, B., & Hong, K.-B. (2025) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2504.04036 · Cited by 4 · see citing works
The potential of plant-derived exosome-like nanovesicles from Centella asiatica leaves (CA-PDENs) for anti-inflammation and prevention of UVB-induced photoaging
Barlian, A., Cho, Y., Rahmah, Y., Zahra, A. N. A., Maulidisya, H. A., Vanawati, N., & Nursatya, S. M. (2026) · Future Science OA · doi:10.1080/20565623.2026.2654777 · Cited by 4 · see citing works
The Incorporation of Clove Essential Oil into Nanostructured Lipid Carrier for Improvement of the Delivery and Antioxidant Effects on the Fibroblast Cells
Satrialdi, S., Husna, N. N., Rihad, R. Q., & Utami, R. A. (2024) · Pharmaceutical Nanotechnology · doi:10.2174/0122117385304491240320040711 · Cited by 4 · see citing works
Pretreatment with aqueous Moringa oleifera Lam. leaf extract prevents cadmium-induced hepatotoxicity by improving cellular antioxidant machinery and reducing cadmium accumulation
Buranasudja, V., Sanookpan, K., Vimolmangkang, S., Binalee, A., Mika, K., Krobthong, S., Kerdsomboon, K., Kumkate, S., Poolpak, T., Kidhakarn, S., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e37424 · Cited by 4 · see citing works
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Extraction of Asiaticoside from Centella asiatica Using Natural Deep Eutectic Solvent: Kinetic Studies and Recovery of Asiaticoside by Macroporous Adsorption Resin
Fuad, F. M., Uyama, H., Yang, J., & Nadzir, M. M. (2025) · Arabian Journal for Science and Engineering · doi:10.1007/s13369-024-09892-9 · Cited by 4 · see citing works
In vivo and ex vivo studies support the immunostimulant and immunoprotective effect of Damiana (Turnera diffusa Willd) in Almaco Jack (Seriola rivoliana)
Reyes‐Becerril, M., Maldonado-Garcı́a, M., Vimolmangkang, S., & Angulo, C. (2024) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2024.109369 · Cited by 4 · see citing works
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Centella triterpenes cream as a potential drug for the treatment of hypertrophic scar through inhibiting the phosphorylation of STAT3 : A network pharmacology analysis and in vitro experiments
Tan, M., Wu, D., Zhou, Y., & Duan, B. (2023) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.15883 · Cited by 4 · see citing works
Oral Centella asiatica Extract Attenuates UVB-Induced Skin Photoaging via Antioxidant, Anti-Inflammatory, and Extracellular Matrix-Preserving Effects in Hairless Mice
Choi, Y. J., Cho, E.-C., Lim, S., Lee, J., Bae, J., Oh, T. K., Lee, J. K., & Kim, E. J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010204 · Cited by 3 · see citing works
Anti-Inflammatory and Antioxidant Effects of Topical Formulations Containing Plant Extracts, Methylsulfonylmethane, and Peptiskin® in In Vitro Models of Arthritis
Hoang, T. X., Dang, N. M., Bae, K. G., & Kim, J. Y. (2025) · Pharmaceuticals · doi:10.3390/ph18091270 · Cited by 3 · see citing works
Hesperidin Reverses Oxidative Stress-Induced Damage in Kidney Cells by Modulating Antioxidant, Longevity, and Senescence-Related Genes
Buakaew, S., Sakonsinsiri, C., Lert-itthiporn, W., Cha’on, U., Rudtanatip, T., Kraiklang, R., Kaewlert, W., Rattanaseth, P., Pakdeechote, P., & Thanan, R. (2025) · Biomedicines · doi:10.3390/biomedicines13123016 · Cited by 3 · see citing works
The battle against skin aging: Advances in natural anti-aging compounds and innovative delivery systems
Zhang, S., Guo, X., Hao, L., Jiang, Y., Chen, Z., Wang, J., 冉柳毅, Yang, Y., Wang, Y., Wang, Y., et al. (2026) · Chinese Chemical Letters · doi:10.1016/j.cclet.2026.112503 · Cited by 3 · see citing works
Therapeutic potential of Asiaticoside in wound healing after endoscopic submucosal dissection (ESD)
Li, Q., Chen, W., Xie, Y., & Zhu, H. (2026) · Pharmaceutical Biology · doi:10.1080/13880209.2026.2638602 · Cited by 3 · see citing works
Isolation, genomic analysis and functional characterization of Enterococcus rotai CMTB-CA6, a putative probiotic strain isolated from a medicinal plant Centella asiatica
Kim, Y., Lee, J. H., Ha, J., & Cho, E. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1452127 · Cited by 3 · see citing works
Natural Antioxidant Compounds for Skincare
Ogidi, O. I., Ajoko, I. T., & Chukwudi, P. (2024) · Advances in chemical and materials engineering book series · doi:10.4018/979-8-3693-5473-5.ch008 · Cited by 3 · see citing works
Arctiin Inhibits Hyperglycemia‐Induced Oxidative Stress by Activating the Nrf2/HO‐1 Signaling Pathway to Treat Type 2 Diabetic Osteoporosis
Sun, W., Li, M., Lin, Q., Jin, X., Zhao, B., Jiang, Z., Zhang, R., & Li, X. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70053 · Cited by 3 · see citing works
Immunoregulatory protein-hybrid extracellular vesicles via self-loadable backbone cyclization for oral inflammatory bowel disease therapy
Lee, Y., Yoo, C., Kim, K.-M., Kim, S., Oh, Y. K., Cho, S., Kim, G.-R., Choi, J.-M., Yang, J. Y., Jung, H.-I., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.11.036 · Cited by 3 · see citing works
Charting the Phytopharmacological Frontier of Centella asiatica: A Quarter-Century Bibliometric Atlas Unlocking Translational Potential
Yang, J., Zhu, H., Zhang, Q., Dai, Y., Yao, Q., & Nie, X. (2026) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-026-00747-y · Cited by 2 · see citing works
Traditional Chinese medicinal strategies for enhanced wound healing: Mechanistic insights and translational advancements
Priyadharshini, D., & Sabarees, G. (2026) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2026.100814 · Cited by 2 · see citing works
Intradermal delivery of N1-methylpseudouridine-modified BCL-2 mRNA as a programmable gene therapy to reverse UVB-induced skin photoaging
Huang, J., Cheng, R., Zhou, X. Y., Lin, J. I. N. Y. I., Wu, W., Wang, X., & Liu, K. (2026) · Biomedical Technology · doi:10.1016/j.bmt.2026.100154 · Cited by 2 · see citing works
Graph Attention Network based mapping of knowledge relations between chemical spaces of Nuclear factor kappa B and Centella asiatica
Vivek, P. V., Mohanan, M., Shajil, U. K., PA, S. E., & A, J. U. C. (2023) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2023.107955 · Cited by 3 · see citing works
Potential anti-aging applications of microbial-derived surfactantsin cosmetic formulations
Bagheri, A. M., Mirzahashemi, M., Salarpour, S., Dehghnnoudeh, Y., Banat, I. M., Ohadi, M., & Dehghannoudeh, G. (2024) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2024.2393420 · Cited by 3 · see citing works
Comparative Antioxidant and Phytochemical Evaluation of Selected Varieties of Colocasia esculenta (L.) Schott Leaves
Varghese, J., V, Nair, A. R. K., & Joseph, E. (2024) · International Journal of Pharmaceutical Sciences and Drug Research · doi:10.25004/ijpsdr.2024.160308 · Cited by 2 · see citing works
Development of gotu kola (Centella asiatica (L.) Urban) gummy candy and its evaluation on antioxidant activity
Syaifabila, I. A., Yuniarti, N., Darsih, C., & Laksitorini, M. D. (2024) · Journal of Research in Pharmacy · doi:10.29228/jrp.787 · Cited by 2 · see citing works
Comparing the effect of Centella asiatica L. and Acalypha indica L. treatment to carbonyl and glutathione level in the brains of old rats
Mudjihartini, N., Paramita, R., Siregar, A. M. K., Filzadiyanti, E., Sarsanti, P. A. N., & Purwaningsih, E. H. (2022) · Acta Biochimica Indonesiana · doi:10.32889/actabioina.79 · Cited by 2 · see citing works
Asiaticoside reverses the inhibition effect of miR-184 on proliferation, migration and AKT phosphorylation of HTR-8/Svneo cells
Jia, Z., Long, Y., Li, X., Hu, Z., Wang, M., Xuemei, H., & Yu, X. (2024) · Turkish Journal of Biochemistry · doi:10.1515/tjb-2024-0014 · Cited by 1 · see citing works
In vivo immunostimulatory activity of Centella asiatica extract on the intestinal immune system in native C3H / HeN mice
Shin, H. Y., Jeon, J. H., Kim, J., Shin, K., & Yu, K. (2025) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.70102 · Cited by 1 · see citing works
Cosmetic and Application Qualities of the Cream Physiorelax Compared to Another Topical Cream for Musculoskeletal Health Care: An Organoleptic Expert Panel Approach
Novella, J. B., Gonzalez, N. G., Coll, P. G., Torres, D. A., Larrarte, S. P., & Giménez, M. (2025) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.70368 · Cited by 1 · see citing works
Sustainable biovalorization of Centella asiatica L. urban using butylene glycol: a green extraction for anti-acne and wound healing potential
Myo, H., Khat‐udomkiri, N., Kittakoop, P., & Phanumartwiwath, A. (2025) · Green Chemistry Letters and Reviews · doi:10.1080/17518253.2025.2607225 · Cited by 1 · see citing works
Centella asiatica: An ethnobotanical treasure with promising anticancer properties
Sen, S., Siuli, S., & Karati, D. (2026) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2026.100490 · Cited by 3 · see citing works
Advances in the pharmacology and mechanism of anti-skin aging in Tonifying Traditional Chinese Medicines
Chen, T., Chen, X., Chen, X., Zhang, W., Li, B., Chu, C., Lv, G., & Chen, S. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121233 · Cited by 1 · see citing works
Natural Product Modulation of Oxidative Stress in the Treatment of Extrinsic Skin Aging: Mechanisms of Action and Future Perspectives
Zhang, X., Wang, J., Kang, J., Li, J., Li, J., Guo, C., Hao, Z., & Liu, D. (2026) · Chemical Research in Chinese Universities · doi:10.1007/s40242-026-6027-y · Cited by 1 · see citing works
Effect of microwave pretreatment on the extraction of bioactives from Centella asiatica and its utilization in developing smoothies
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Authors: Buranasudja, V., Rani, D., Malla, A., Kobtrakul, K., & Vimolmangkang, S.
Affiliations: Chulalongkorn University (TH)
Corresponding author: Vimolmangkang, Sornkanok
ORCID: Buranasudja, Visarut
Malla, Ashwini
Vimolmangkang, Sornkanok
Venue: Scientific Reports
Publisher: Springer Science and Business Media LLC
Published: 2021-06-29
Volume: 11
Issue: 1
Pages: 13459-13459
ISSN: 2045-2322 (ISSN-L)
DOI: 10.1038/s41598-021-92958-7
PMC: PMC8241881
OpenAlex: W3135110362
Cited by: 112
References: 60
Citations by year: 2026: 24 · 2025: 24 · 2024: 27 · 2023: 22 · 2022: 13 · 2021: 2
FWCI: 14.21
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Scientific Reports (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Rachadapisek Sompote Fund for Postdoctoral Fellowships, Graduate School of Chulalongkorn University
Postdoctoral fellowship, the Second Century Fund (C2F), Chulalongkorn University
PMU-C of the Office of the National Higher Education Science Research and Innovation Policy Council, Thailand
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant tissue culture and regeneration
Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords: Centella asiatica, callus culture, antioxidant activity, oxidative stress, dermal fibroblasts, hydrogen peroxide cytotoxicity, antioxidant enzymes, MMP-9, cosmeceuticals, phytochemicals, ethanol extract
MeSH terms: Antioxidants, Cells, Cultured, Fibroblasts, Humans, Plant Extracts, Triterpenes, Skin Aging, Centella

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Insights into antioxidant activities and anti-skin-aging potential of callus extract from Centella asiatica (L.)

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