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Cited by 115Cardiovascular Syncope and Autonomic DisordersHeart Rate Variability and Autonomic ControlVestibular and auditory disorders

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Influence of age and gender on the occurrence and presentation of reflex syncope

Romme, Jacobus J. C. M., van Dijk, Nynke, Boer, Kimberly R., Dekker, Lukas R. C., Stam, Jan, Reitsma, Johannes B., Wieling, Wouter·2008·Clinical Autonomic Research
DOI 10.1007/s10286-008-0465-0
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Abstract

Background The clinical history is the cornerstone of diagnosing patients with transient loss of consciousness (TLOC). Reflex syncope is the most common cause of TLOC in patients across all ages. Knowledge of the variation in incidence and clinical features of reflex syncope by age and gender provides important background information to acquire an accurate diagnosis.Methods In a cohort of 503 patients presenting with TLOC we established a final diagnosis after systematic evaluation and two years of follow-up. The occurrence of prodromal signs, symptoms, and triggers in patients with reflex syncope was analyzed by both age (< 40 yrs, 40-59 yrs and > or = 60 years) and gender.Results Reflex syncope was the most frequently obtained diagnosis (60.2%) in patients of all ages presenting with TLOC. Its occurrence was higher in patients under 40 years (73.4%), than above 60 years of age (45.3%). Pallor (79.9%), dizziness (73.4%), and diaphoresis (63.0%) were the most frequently reported prodromal signs and symptoms. Most triggers and prodromal signs and symptoms were more common in patients under 40 years of age and in women.Conclusions Reflex syncope is nearly twice as common in patients under 40 years of age than in patients aged 60 years or above. Typical signs and symptoms of reflex syncope are more common in younger patients and in women. Therefore, age and gender provide important diagnostic information and can help to decide whether additional testing is necessary.

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Crossref · 10.1007/s10286-008-0465-0

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Metadata

Authors
Romme, J. J. C. M., van Dijk, N., Boer, K. R., Dekker, L. R. C., Stam, J., Reitsma, J. B., & Wieling, W.
Affiliations
Amsterdam UMC Location University of Amsterdam (NL)
Corresponding author
Romme, Jacobus J. C. M.
ORCID
Venue
Clinical Autonomic Research
Publisher
Springer Science and Business Media LLC
Published
2008-04-30
Volume
18
Issue
3
Pages
127-133
ISSN
  • 0959-9851 (ISSN-L)
  • 1619-1560
DOI
10.1007/s10286-008-0465-0
OpenAlex
W2155882327
Cited by
115
References
39
Citations by year
2026: 2 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 15 · 2021: 9 · 2020: 5 · 2019: 4 · 2018: 8 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 10 · 2013: 6 · 2012: 5
FWCI
9.84
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Clinical Autonomic Research (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • TU/e Research Portal (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
Keywords
reflex syncope, transient loss of consciousness, age differences, gender differences, prodromal symptoms, syncope triggers, pallor, dizziness, diaphoresis, syncope diagnosis
MeSH terms
Adult, Age Factors, Aged, Diagnosis, Differential, Epilepsy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Sex Factors, Syncope, Cohort Studies, Incidence, Multivariate Analysis

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