Efficacy of Behavioral Intervention, Text Messaging, and Extended Intervention to Address Alcohol Misuse in Sexual Minority Men with HIV: A Factorial Randomized Clinical Trial
Open accessAbstract
This clinical trial examined the individual and combined effects of three different approaches to reducing alcohol misuse among a sample of sexual minority men (SMM) with HIV. Specifically, we used a 2 × 2 × 2 randomized factorial design to compare: (a) behavioral intervention based in motivational interviewing (MI) vs. brief intervention (BI), (b) interactive text messaging (ITM) for alcohol use vs. no ITM, and (c) extended intervention (EI) length of nine months vs. a one-month intervention duration. Participants (N = 188) were SMM with HIV and alcohol misuse recruited in Miami, FL, and Boston, MA. Participants were randomized to one of eight intervention combinations and assessed at 6- and 12-month follow-ups. Large reductions of over 50% in drinks per week and heavy drinking days were observed in all conditions at follow-up. Those who received ITM, compared to those who did not, reported significantly lower drinks consumed per week at 6 and 12 months (incidence rate ratios = 0.73 [95% CI = 0.57, 0.90] and 0.72 [95% CI = 0.56, 0.87], respectively), and increased odds of cessation of alcohol misuse at 12 months, odds ratio = 1.46, 95% CI = 1.03, 2.08. Results provided no evidence of better alcohol use outcomes for either MI or EI relative to their comparison conditions, and no specific combination of intervention components demonstrated a notable benefit. This study suggests a two-session BI can effectuate substantial reductions in alcohol use in SMM with HIV and that adding one month of ITM can yield further improvements. Clinical Trials Number: NCT02709759.
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Of trials conducted in the U.S. with adult samples of people with HIV, only three trials have produced significant effects on alcohol-related outcomes different from the control group at 12-month follow-up.
“Of the trials conducted in the U.S. with adult samples of PWH, only three trials [16–18] have produced significant effects on alcohol-related outcomes that were different from the control group at 12-month follow-up.”
From A Randomized Feasibility/Acceptability Trial of Acceptance and Commitment Therapy for People with HIV Who Drink at Unhealthy Levels. (2026) · cites this paper as [18]
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Hahn, J. A., Kane, J. C., Fatch, R., da Silva, C. E., Emenyonu, N. I., Scheffler, A., Chirayil, P., So‐Armah, K., Kahler, C. W., Conroy, A. A., et al. (2025) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2025.112879 · Cited by 4 · see citing works
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Self-citationMeta-Analysis on the Effectiveness of mHealth Interventions for Mental Health: A 10-Year Update
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- Authors
- Kahler, C. W., Surace, A., Liu, T., Pantalone, D. W., Mastroleo, N. R., Yan, Y., Wray, T. B., Mayer, K. H., & Monti, P. M.
- Affiliations
- Brown University (US)
- Public Health Institute (US)
- University of Massachusetts Boston (US)
- Binghamton University (US)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Kahler, Christopher W.
- ORCID
- Venue
- AIDS and Behavior
- Published
- 2024-09-13
- Volume
- 28
- Issue
- 12
- Pages
- 3970-3983
- ISSN
- 1090-7165 (ISSN-L)
- 1573-3254
- PMC
- PMC11932048
- OpenAlex
- W4402531479
- Cited by
- 4
- References
- 49
- Citations by year
- 2025: 3 · 2024: 1
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- green
- pmc.ncbi.nlm.nih.gov
- Licence
- Locations
- AIDS and Behavior (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (P01AA19072, U24AA022003, T32AA007240)
- National Institute of Allergy and Infectious Diseases (P30AI042853)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Keywords
- alcohol abuse, sexual minority men, HIV, motivational interviewing, brief intervention, heavy drinking, alcohol consumption reduction, intervention efficacy
- MeSH terms
- Sexual and Gender Minorities, Adult, Alcohol Drinking, Alcoholism, Behavior Therapy, Boston, Florida, Follow-Up Studies, Humans, Male, Middle Aged, HIV Infections, Treatment Outcome, Homosexuality, Male, Text Messaging, Motivational Interviewing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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