Cited by 216MicroRNA in disease regulationCancer-related molecular mechanisms researchCancer-related Molecular Pathways

miR-155 in cancer drug resistance and as target for miRNA-based therapeutics

Bayraktar, Recep, Van Roosbroeck, Katrien·2018·Cancer and Metastasis Reviews

Abstract

Small non-coding microRNAs (miRNAs) are instrumental in physiological processes, such as proliferation, cell cycle, apoptosis, and differentiation, processes which are often disrupted in diseases like cancer. miR-155 is one of the best conserved and multifunctional miRNAs, which is mainly characterized by overexpression in multiple diseases including malignant tumors. Altered expression of miR-155 is found to be associated with various physiological and pathological processes, including hematopoietic lineage differentiation, immune response, inflammation, and tumorigenesis. Furthermore, miR-155 drives therapy resistance mechanisms in various tumor types. Therefore, miR-155-mediated signaling pathways became a potential target for the molecular treatment of cancer. In this review, we summarize the current findings of miR-155 in hematopoietic lineage differentiation, the immune response, inflammation, and cancer therapy resistance. Furthermore, we discuss the potential of miR-155-based therapeutic approaches for the treatment of cancer.

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Crossref · 10.1007/s10555-017-9724-7

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123 of 123 references verified0 citation errors · 0 not checkable

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Authors
Bayraktar, R., & Van Roosbroeck, K.
Affiliations
The University of Texas MD Anderson Cancer Center (US)
Venue
Cancer and Metastasis Reviews
Published
2017-12-27
Volume
37
Issue
1
Pages
33-44
ISSN
  • 0167-7659 (ISSN-L)
  • 1573-7233
OpenAlex
W2779116051
Cited by
216
References
125
Citations by year
2026: 9 · 2025: 24 · 2024: 30 · 2023: 32 · 2022: 36 · 2021: 32 · 2020: 27 · 2019: 17 · 2018: 9
FWCI
1.48
Type
journal article
Language
en
Open access
closed
Locations
  • Cancer and Metastasis Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
Lauri Strauss Leukemia Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords
miR-155, microRNA, chemoresistance, miRNA-based therapy, hematopoietic differentiation, immune response, inflammation, carcinogenesis, cancer therapy resistance
MeSH terms
Animals, Humans, Neoplasms, Oncogenes, Radiation Tolerance, Biomarkers, Tumor, Genetic Therapy, Gene Expression Regulation, Neoplastic, Drug Resistance, Neoplasm, MicroRNAs, Molecular Targeted Therapy, ErbB Receptors

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