Cited by 348Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

The telomerase activator TA‐65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence

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de Jesus, Bruno Bernardes, Schneeberger, Kerstin, Vera, Elsa, Tejera, Agueda, Harley, Calvin B., Blasco, Maria A.·2011·Aging Cell

Abstract

Summary: Here, we show that a small‐molecule activator of telomerase (TA‐65) purified from the root of Astragalus membranaceus is capable of increasing average telomere length and decreasing the percentage of critically short telomeres and of DNA damage in haploinsufficient mouse embryonic fibroblasts (MEFs) that harbor critically short telomeres and a single copy of the telomerase RNA Terc gene (G3 Terc+/− MEFs). Importantly, TA‐65 does not cause telomere elongation or rescue DNA damage in similarly treated telomerase‐deficient G3 Terc−/− littermate MEFs. These results indicate that TA‐65 treatment results in telomerase‐dependent elongation of short telomeres and rescue of associated DNA damage, thus demonstrating that TA‐65 mechanism of action is through the telomerase pathway. In addition, we demonstrate that TA‐65 is capable of increasing mouse telomerase reverse transcriptase levels in some mouse tissues and elongating critically short telomeres when supplemented as part of a standard diet in mice. Finally, TA‐65 dietary supplementation in female mice leads to an improvement of certain health‐span indicators including glucose tolerance, osteoporosis and skin fitness, without significantly increasing global cancer incidence.

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Crossref · 10.1111/j.1474-9726.2011.00700.x

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  • TA-65 has been reported to boost telomerase activity and lengthen telomeres in mice.

    “A natural plant compound named TA-65 has been reported to boost telomerase activity and lengthen telomeres in mice189.”

    From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [189]

    The Results section on mouse embryonic fibroblasts reports increased telomerase activity after TA-65 treatment. The Results section on dietary supplementation in mice reports fewer very short telomeres, but not a significant increase in average telomere length; it reports increased telomerase expression in liver rather than a direct measurement of activity in treated mice. The claim therefore omits important limits on both findings. (LLM, conf=0.88)

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Authors
de Jesus, B. B., Schneeberger, K., Vera, E., Tejera, A., Harley, C. B., & Blasco, M. A.
Affiliations
Spanish National Cancer Research Centre (ES)
Venue
Aging Cell
Publisher
Wiley
Published
2011-04-14
Volume
10
Issue
4
Pages
604-621
ISSN
  • 1474-9718 (ISSN-L)
  • 1474-9726
OpenAlex
W2102172732
Cited by
348
References
85
Citations by year
2026: 15 · 2025: 22 · 2024: 23 · 2023: 30 · 2022: 31 · 2021: 34 · 2020: 31 · 2019: 18 · 2018: 21 · 2017: 25 · 2016: 18 · 2015: 21 · 2014: 15 · 2013: 21 · 2012: 21
FWCI
12.65
Type
journal article
Language
en
Open access
Locations
  • Aging Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Eli Lilly and Company
  • European Commission
  • Ministerio de Ciencia e Innovación
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Keywords
telomerase activators, telomere length, telomerase reverse transcriptase, Astragalus membranaceus, DNA damage, healthspan, dietary supplementation, cancer incidence, glucose tolerance, osteoporosis, skin aging
MeSH terms
Animals, Diet, DNA Damage, Embryo, Mammalian, Female, Fibroblasts, Mice, Inbred C57BL, Neoplasms, RNA, Anticarcinogenic Agents, Telomere, Telomerase, Astragalus propinquus, Mice

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