The telomerase activator TA‐65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence
Open accessAbstract
Summary: Here, we show that a small‐molecule activator of telomerase (TA‐65) purified from the root of Astragalus membranaceus is capable of increasing average telomere length and decreasing the percentage of critically short telomeres and of DNA damage in haploinsufficient mouse embryonic fibroblasts (MEFs) that harbor critically short telomeres and a single copy of the telomerase RNA Terc gene (G3 Terc+/− MEFs). Importantly, TA‐65 does not cause telomere elongation or rescue DNA damage in similarly treated telomerase‐deficient G3 Terc−/− littermate MEFs. These results indicate that TA‐65 treatment results in telomerase‐dependent elongation of short telomeres and rescue of associated DNA damage, thus demonstrating that TA‐65 mechanism of action is through the telomerase pathway. In addition, we demonstrate that TA‐65 is capable of increasing mouse telomerase reverse transcriptase levels in some mouse tissues and elongating critically short telomeres when supplemented as part of a standard diet in mice. Finally, TA‐65 dietary supplementation in female mice leads to an improvement of certain health‐span indicators including glucose tolerance, osteoporosis and skin fitness, without significantly increasing global cancer incidence.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
TA-65 has been reported to boost telomerase activity and lengthen telomeres in mice.
“A natural plant compound named TA-65 has been reported to boost telomerase activity and lengthen telomeres in mice189.”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [189]
The Results section on mouse embryonic fibroblasts reports increased telomerase activity after TA-65 treatment. The Results section on dietary supplementation in mice reports fewer very short telomeres, but not a significant increase in average telomere length; it reports increased telomerase expression in liver rather than a direct measurement of activity in treated mice. The claim therefore omits important limits on both findings. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750 · see citing works
Self-citationMammalian MAP kinase signalling cascades
Chang, L., & Karin, M. (2001) · Nature · doi:10.1038/35065000 · Cited by 5,118 · see citing works
Identification of a specific telomere terminal transferase activity in tetrahymena extracts
Greider, C. W., & Blackburn, E. H. (1985) · Cell · doi:10.1016/0092-8674(85)90170-9 · Cited by 3,400 · see citing works
Kyriakis, J. M., & Avruch, J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.807 · Cited by 3,369 · see citing works
Shelterin: the protein complex that shapes and safeguards human telomeres
de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056 · see citing works
Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739 · see citing works
Statistical analysis of real-time PCR data
Yuan, J. S., Reed, A., Chen, F., & Stewart, C. N. (2006) · BMC Bioinformatics · doi:10.1186/1471-2105-7-85 · Cited by 2,192 · see citing works
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
Blasco, M. A., Lee, H.-W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., & Greider, C. W. (1997) · Cell · doi:10.1016/s0092-8674(01)80006-4 · Cited by 2,108 · see citing works
Self-citationSwitching and Signaling at the Telomere
Blackburn, E. H. (2001) · Cell · doi:10.1016/s0092-8674(01)00492-5 · Cited by 2,097 · see citing works
Kirkwood, T. B. L., & Austad, S. N. (2000) · Nature · doi:10.1038/35041682 · Cited by 1,774 · see citing works
Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis
Armanios, M. Y., Chen, J. J.-L., Cogan, J. D., Alder, J. K., Ingersoll, R. G., Markin, C., Lawson, W. E., Xie, M., Vulto, I., Phillips, J. A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066157 · Cited by 1,357 · see citing works
Genetic pathways that regulate ageing in model organisms
Guarente, L., & Kenyon, C. J. (2000) · Nature · doi:10.1038/35041700 · Cited by 1,337 · see citing works
Hemann, M. T., Strong, M. A., Hao, L.-Y., & Greider, C. W. (2001) · Cell · doi:10.1016/s0092-8674(01)00504-9 · Cited by 1,219 · see citing works
A telomerase component is defective in the human disease dyskeratosis congenita
Mitchell, J. R., Wood, E., & Collins, K. (1999) · Nature · doi:10.1038/990141 · Cited by 1,168 · see citing works
Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
Feldstein, A. E., Canbay, A., Angulo, P., Taniai, M., Burgart, L. J., Lindor, K. D., & Gores, G. J. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00907-7 · Cited by 1,085 · see citing works
The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita
Vulliamy, T., Marrone, A., Goldman, F., Dearlove, A., Bessler, M., Mason, P. J., & Dokal, I. (2001) · Nature · doi:10.1038/35096585 · Cited by 960 · see citing works
Sirt1 protects against high-fat diet-induced metabolic damage
Pfluger, P. T., Herranz, D., Velasco-Miguel, S., Serrano, M., & Tschöp, M. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802917105 · Cited by 932 · see citing works
Adult-onset pulmonary fibrosis caused by mutations in telomerase
Tsakiri, K. D., Cronkhite, J. T., Kuan, P. J., Xing, C., Raghu, G., Weissler, J. C., Rosenblatt, R. L., Shay, J. W., & Garcia, C. K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701009104 · Cited by 894 · cited 2× · see citing works
“Further supporting the notion that telomerase levels may be rate-limiting for organismal aging, some diseases characterized by premature loss of tissue renewal and premature death, such as dyskeratosis congenita, aplastic anemia and idiopathic pulmonary fibrosis, are linked to germline mutations in Tert and Terc genes…”
BackgroundTelomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
Jaskelioff, M., Muller, F. L., Paik, J.-H., Thomas, E., Jiang, S., Adams, A. C., Sahin, E., Kost-Alimova, M., Protopopov, A., Cadiñanos, J., et al. (2011) · Nature · doi:10.1038/nature09603 · Cited by 857 · see citing works
Calado, R. T., & Young, N. S. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0903373 · Cited by 783 · see citing works
Mutations in <i>TERT,</i> the Gene for Telomerase Reverse Transcriptase, in Aplastic Anemia
Yamaguchi, H., Calado, R. T., Ly, H., Kajigaya, S., Baerlocher, G. M., Chanock, S. J., Lansdorp, P. M., & Young, N. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042980 · Cited by 723 · see citing works
Telomerase modulates Wnt signalling by association with target gene chromatin
Park, J.-I., Venteicher, A. S., Hong, J. Y., Choi, J., Jun, S., Shkreli, M., Chang, W., Meng, Z., Cheung, P., Ji, H., et al. (2009) · Nature · doi:10.1038/nature08137 · Cited by 707 · see citing works
Myc activates telomerasePreprint
Wang, J., Xie, L. Y., Allan, S., Beach, D., & Hannon, G. J. (1998) · Genes & Development · doi:10.1101/gad.12.12.1769 · Cited by 653 · see citing works
Moynihan, K. A., Grimm, A. A., Plueger, M. M., Bernal‐Mizrachi, E., Ford, E. L., CRAS-MÉNEUR, C. M. H., Permutt, M. A., & Imai, S. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.07.001 · Cited by 630 · see citing works
Sequence variants at the TERT-CLPTM1L locus associate with many cancer types
Rafnar, Þ., Sulem, P., Stacey, S., Geller, F., Guðmundsson, J., Sigurðsson, Á., Jakobsdottir, M., Helgadottir, H. T., Thorlacius, S., Aben, K. K. H., et al. (2009) · Nature Genetics · doi:10.1038/ng.296 · Cited by 608 · see citing works
Lung cancer susceptibility locus at 5p15.33
Study, E., McKay, J., Hung, R. J., Gaborieau, V., Boffetta, P., Chabrier, A., Byrnes, G. B., Zaridze, D. G., Mukeria, A., Szeszenia‐Dabrowska, N., et al. (2008) · Nature Genetics · doi:10.1038/ng.254 · Cited by 563 · see citing works
Teixeira, M. T., Arneric, M., Sperisen, P., & Lingner, J. (2004) · Cell · doi:10.1016/s0092-8674(04)00334-4 · Cited by 526 · see citing works
Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice
Tomás-Loba, A., Flores, I., Fernández-Marcos, P. J., Cayuela, M. L., Maraver, A., Tejera, A., Borrás, C., Matheu, A., Klatt, P., Flores, J. M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.09.034 · Cited by 484 · cited 15× · see citing works
“These enhancements could be related to the TA-65-dependent extracellular signal-regulated kinase (ERK) pathway activation in the liver and subsequent telomerase expression, which have been shown to mediate the glucose tolerance and insulin response (Tomas-Loba et al., 2008).”
BackgroundMethodResultInfluentialSelf-citationKang, S. S., Kwon, T., Kwon, D. Y., & Do, S.-I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13085 · Cited by 480 · see citing works
Disease states associated with telomerase deficiency appear earlier in mice with short telomeres
Herrera, E., Samper, E., Martín‐Caballero, J., Flores, J. M., Lee, H., & Blasco, M. A. (1999) · The EMBO Journal · doi:10.1093/emboj/18.11.2950 · Cited by 471 · cited 4× · see citing works
“…fourth (G4) generation when in a pure C57BL6 background by which stage they present critically short telomeres, defective stem cell proliferative capacity, infertility because of germ cell apoptosis and increased genomic instability (Blasco et al., 1997; Herrera et al., 1999; Flores et al., 2005).”
BackgroundMethodInfluentialSelf-citationSirtuins as potential targets for metabolic syndrome
Guarente, L. (2006) · Nature · doi:10.1038/nature05486 · Cited by 468 · see citing works
Delayed ageing through damage protection by the Arf/p53 pathway
Matheu, A., Maraver, A., Klatt, P., Flores, I., Garcia-Cao, I., Borras, C., Flores, J. M., Viña, J., Blasco, M. A., & Serrano, M. (2007) · Nature · doi:10.1038/nature05949 · Cited by 466 · see citing works
Self-citationEffects of Telomerase and Telomere Length on Epidermal Stem Cell Behavior
Flores, I., Cayuela, M. L., & Blasco, M. A. (2005) · Science · doi:10.1126/science.1115025 · Cited by 448 · see citing works
Self-citationGreenberg, R. A., O’Hagan, R. C., Deng, H., Xiao, Q., Hann, S. R., Adams, R. R., Lichtsteiner, S., Chin, L., Morin, G. B., & DePinho, R. A. (1999) · Oncogene · doi:10.1038/sj.onc.1202669 · Cited by 411 · see citing works
Telomerase activity, cell proliferation, and cancer
Greider, C. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.90 · Cited by 401 · see citing works
Bone development and age-related bone loss in male C57BL/6J mice
Ferguson, V. L., Ayers, R. A., Bateman, T. A., & Simske, S. J. (2003) · Bone · doi:10.1016/s8756-3282(03)00199-6 · Cited by 379 · see citing works
González‐Suárez, E., Samper, E., Ramírez, A., Flores, J. M., Martín‐Caballero, J., Jorcano, J. L., & Blasco, M. A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.11.2619 · Cited by 372 · see citing works
Self-citationHayflick, L. (2000) · Nature · doi:10.1038/35041709 · Cited by 360 · see citing works
The longest telomeres: a general signature of adult stem cell compartments
Flores, I., Canela, A., Vera, E., Tejera, A., Cotsarelis, G., & Blasco, M. A. (2008) · Genes & Development · doi:10.1101/gad.451008 · Cited by 352 · see citing works
Self-citationCanela, A., Vera, E., Klatt, P., & Blasco, M. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609367104 · Cited by 336 · see citing works
Self-citationStudies in the Distribution of Body Fat: I. Effects of Age, Sex, and Obesity
Shimokata, H., Tobin, J. D., Muller, D. C., Elahi, D., Coon, P. J., & Andres, R. (1989) · Journal of Gerontology · doi:10.1093/geronj/44.2.m66 · Cited by 319 · see citing works
Samper, E., Goytisolo, F. A., Slijepčević, P., van Buul, P. P. W., & Blasco, M. A. (2000) · EMBO Reports · doi:10.1093/embo-reports/kvd051 · Cited by 317 · see citing works
Self-citationConstitutive telomerase expression promotes mammary carcinomas in aging mice
Artandi, S. E., Alson, S., Tietze, M. K., Sharpless, N. E., Ye, S., Greenberg, R. A., Castrillon, D. H., Horner, J. W., Weiler, S. R., Carrasco, R. D., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.112515399 · Cited by 317 · see citing works
Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity
Hao, L.-Y., Armanios, M., Strong, M. A., Karim, B., Feldser, D. M., Huso, D., & Greider, C. W. (2005) · Cell · doi:10.1016/j.cell.2005.11.020 · Cited by 302 · see citing works
Role of the GH/IGF-1 axis in lifespan and healthspan: Lessons from animal models
Berryman, D. E., Christiansen, J. S., Johannsson, G., Thorner, M. O., & Kopchick, J. J. (2008) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2008.05.005 · Cited by 288 · see citing works
Samper, E., Flores, J. M., & Blasco, M. A. (2001) · The EMBO Reports · doi:10.1093/embo-reports/kve174 · Cited by 263 · cited 3× · see citing works
“mosomal instability and cell and tissue defects associated with late-generation telomerase deficiency, including rescue of stem cell dysfunction and of organismal lifespan (Hemann et al., 2001a; Samper et al., 2001; Siegl-Cachedenier et al., 2007).”
BackgroundSelf-citationMartínez, P., Thanasoula, M., Carlos, A. R., Goméz-López, G., Tejera, Á. M., Schoeftner, S., Domı́nguez, O., Pisano, D. G., Tarsounas, M., & Blasco, M. A. (2010) · Nature Cell Biology · doi:10.1038/ncb2081 · Cited by 257 · see citing works
Self-citationThe telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo
Liu, Y., Snow, B. E., Hande, M. P., Yeung, D., Erdmann, N. J., Wakeham, A., Itie, A., Siderovski, D. P., Lansdorp, P. M., Robinson, M. O., et al. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00805-8 · Cited by 244 · see citing works
LeFloch, R., Pouysségur, J., & Lenormand, P. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00800-07 · Cited by 204 · see citing works
A Natural Product Telomerase Activator As Part of a Health Maintenance Program
Harley, C. B., Liu, W., Blasco, M. A., Vera, E., Andrews, W. H., Briggs, L., & Raffaele, J. M. (2010) · Rejuvenation Research · doi:10.1089/rej.2010.1085 · Cited by 196 · see citing works
Self-citationTelomerase and Tel1p Preferentially Associate with Short Telomeres in S. cerevisiae
Sabourin, M., Tuzon, C. T., & Zakian, V. A. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.016 · Cited by 195 · see citing works
Increased hematopoietic stem cell mobilization in aged mice
Xing, Z., Ryan, M. A., Daria, D., Nattamai, K., Zant, G. E. V., Wang, L., Zheng, Y., & Geiger, H. (2006) · Blood · doi:10.1182/blood-2005-12-010272 · Cited by 178 · see citing works
Shen, P., Liu, M., Ng, T., Chan, Y., & Yong, E. (2006) · Journal of Nutrition · doi:10.1093/jn/136.4.899 · Cited by 171 · see citing works
Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes
Fauce, S. R., Jamieson, B. D., Chin, A. C., Mitsuyasu, R. T., Parish, S. T., Ng, H. L., Ramirez, C. M., Yang, O. O., Harley, C. B., & Effros, R. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.7400 · Cited by 170 · see citing works
Self-citationJiang, H., Schiffer, E., Song, Z., Wang, J., Zürbig, P., Thedieck, K., Moes, S., Bantel, H., Saal, N., Jantos, J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801457105 · Cited by 169 · see citing works
Telomere Dysfunction Triggers Developmentally Regulated Germ Cell Apoptosis
Hemann, M. T., Rudolph, K. L., Strong, M. A., DePinho, R. A., Chin, L., & Greider, C. W. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.7.2023 · Cited by 162 · see citing works
Gupta, S., Seth, A., & Davis, R. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3216 · Cited by 152 · see citing works
Telomere length abnormalities in mammalian radiosensitive cells.
McIlrath, J. M., Bouffler, S. D., Samper, E., Cuthbert, A. P., Wójcik, A., Szumiel, I., Bryant, P. E., Riches, A., Thompson, A., Blasco, M. A., et al. (2001) · PubMed · Cited by 142 · see citing works
Self-citationMechanisms of Liver Injury: An Overview
Higuchi, H., & Gores, G. J. (2003) · Current Molecular Medicine · doi:10.2174/1566524033479528 · Cited by 134 · see citing works
Li, G., Barrett, E. J., Barrett, M. O., Cao, W., & Liu, Z. (2007) · Endocrinology · doi:10.1210/en.2006-1441 · Cited by 132 · see citing works
Increased association of telomerase with short telomeres in yeastPreprint
Bianchi, A., & Shore, D. (2007) · Genes & Development · doi:10.1101/gad.438907 · Cited by 130 · see citing works
Evaluation of Glucose Homeostasis
Heikkinen, S., Argmann, C., Champy, M., & Auwerx, J. H. (2007) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb29b03s77 · Cited by 125 · see citing works
Regulation of Microsomal Triglyceride Transfer Protein Gene by Insulin in HepG2 Cells
Au, W.-S., Kung, H.-F., & Lin, M. C.-M. (2003) · Diabetes · doi:10.2337/diabetes.52.5.1073 · Cited by 108 · see citing works
Takakura, M., Kyo, S., Inoue, M., Wright, W. E., & Shay, J. W. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8037-8043.2005 · Cited by 107 · see citing works
Mao, X., Yu, F., Wang, N., Wu, Y., Zou, F., Wu, K., Liu, M., & Ouyang, J. (2009) · Phytomedicine · doi:10.1016/j.phymed.2008.12.011 · Cited by 106 · see citing works
Blüher, M., Bashan, N., Shai, I., Harman‐Boehm, I., Tarnovscki, T., Avinaoch, E., Stümvoll, M., Dietrich, A., Klöting, N., & Rudich, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0002 · Cited by 99 · see citing works
Canela, A., Martín-Caballero, J., Flores, J. M., & Blasco, M. A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.10.4275-4293.2004 · Cited by 90 · see citing works
Self-citationSamper, E., Goytisolo, F. A., Murcia, J. M., González‐Suárez, E., Cigudosa, J. C., de MURCIA, G., & Blasco, M. A. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200103049 · Cited by 86 · see citing works
Self-citationCayuela, M. L., Flores, J. M., & Blasco, M. A. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400359 · Cited by 76 · see citing works
Self-citationSiegl-Cachedenier, I., Flores, I., Klatt, P., & Blasco, M. A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704141 · Cited by 64 · see citing works
Self-citationTelomerase Therapeutics for Degenerative Diseases
Harley, C. B. (2005) · Current Molecular Medicine · doi:10.2174/1566524053586671 · Cited by 51 · see citing works
Self-citationImmune Modulation of Macrophage Pro-Inflammatory Response by Goldenseal and Astragalus Extracts
Clement-Kruzel, S., Hwang, S., Kruzel, M. C., Dasgupta, A., & Actor, J. K. (2008) · Journal of Medicinal Food · doi:10.1089/jmf.2008.0044 · Cited by 50 · see citing works
Cerezo, A., Stark, H., Moshir, S., & Boukamp, P. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12304.x · Cited by 38 · see citing works
Hematologic and serum electrolyte values of the C57BL-6J male mouse in maturity and senescence.
Ce, F., & Foster (1973) · PubMed · Cited by 36 · see citing works
Impact of Sirt1 on mammalian aging
Herranz, D., & Serrano, M. (2010) · Aging · doi:10.18632/aging.100156 · Cited by 36 · see citing works
Hormonal control of glucose homeostasis during development and ageing in mice
Bailey, C. J., & Flatt, P. R. (1982) · Metabolism · doi:10.1016/0026-0495(82)90059-2 · Cited by 34 · see citing works
CIDE-A is expressed in liver of old mice and in type 2 diabetic mouse liver exhibiting steatosis
Kelder, B., Boyce, K., Kriete, A., Clark, R., Berryman, D. E., Nagatomi, S., List, E. O., Braughler, M., & Kopchick, J. J. (2007) · Comparative Hepatology · doi:10.1186/1476-5926-6-4 · Cited by 28 · see citing works
Pericuesta, E., Ramírez, M. Á., Villa, A., Relaño-Ginés, A., Torres, J. M., Nieto, M., Pintado, B., & Gutiérrez‐Adán, A. (2006) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-4-5 · Cited by 24 · see citing works
Age-related increase in erythrocyte oxidant sensitivity
Tyan, M. L. (1982) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(82)90071-9 · Cited by 20 · see citing works
Hematological Changes in Aging Male C57BL/6 Jax Mice
Ewing, K. L., & Tauber, O. E. (1964) · Journal of Gerontology · doi:10.1093/geronj/19.2.165 · Cited by 18 · see citing works
Telomerase activation and MAPK pathways in regenerating hepatocytes.
Inui, T., Shinomiya, N., Fukasawa, M., Kuranaga, N., Ohkura, S., & Seki, S. (2001) · PubMed · Cited by 13 · see citing works
Direct activation of telomerase by GH via phosphatidylinositol 3′-kinase
Gómez-García, L., Sánchez, F. M., Vallejo‐Cremades, M. T., de Segura, I. Á. G., & del Campo, E. D. M. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.05766 · Cited by 12 · see citing works
Effect of age on the intrinsic regulation of murine hemopoiesis
Tyan, M. L. (1982) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(82)90045-8 · Cited by 8 · see citing works
Tyan, M. L. (1980) · Experimental Biology and Medicine · doi:10.3181/00379727-165-40985 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
Self-citationAging and aging-related diseases: from molecular mechanisms to interventions and treatments
Guo, J., Huang, X., Dou, L., Yan, M., Shen, T., Tang, W., & Li, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01251-0 · Cited by 1,834 · see citing works
Telomere dysfunction in ageing and age-related diseases
Rossiello, F., Jurk, D., Passos, J. F., & d’Adda di Fagagna, F. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00842-x · Cited by 754 · see citing works
Bernardes de Jesus, B., Vera, E., Schneeberger, K., Tejera, A. M., Ayuso, E., Bosch, F., & Blasco, M. A. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200245 · Cited by 548 · see citing works
Self-citationAgeing and the telomere connection: An intimate relationship with inflammation
Zhang, J., Rane, G., Dai, X., Shanmugam, M. K., Arfuso, F., Samy, R. P., Lai, M. K. P., Kappei, D., Kumar, A. P., & Sethi, G. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.11.006 · Cited by 386 · see citing works
Axis of ageing: telomeres, p53 and mitochondria
Sahin, E., & DePinho, R. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3352 · Cited by 380 · see citing works
Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic
Liu, P., Zhao, H., & Luo, Y. (2017) · Aging and Disease · doi:10.14336/ad.2017.0816 · Cited by 348 · see citing works
Stress, cell senescence and organismal ageing
de Magalhães, J. P., & Passos, J. F. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.07.001 · Cited by 316 · see citing works
Comparison of telomere length measurement methods
Lai, T., Wright, W. E., & Shay, J. W. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0451 · Cited by 288 · see citing works
Telomeres—structure, function, and regulation
Lu, W., Zhang, Y., Liu, D., Songyang, Z., & Wan, M. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.09.005 · Cited by 265 · see citing works
Telomere-driven diseases and telomere-targeting therapies
Martínez, P., & Blasco, M. A. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201610111 · Cited by 257 · see citing works
“…activators of telomerase or telomerase-based gene therapy are currently being investigated in mouse models for their potential to improve health and extend life span, and as a treatment for short telomere syndromes (Bernardes de Jesus et al., 2011; Bär et al., 2014, 2015; Bär and Blasco, 2016).”
BackgroundSelf-citationZhu, Y., Liu, X., Ding, X., Wang, F., & Geng, X. (2019) · Biogerontology · doi:10.1007/s10522-018-9769-1 · Cited by 255 · see citing works
Telomerase at the intersection of cancer and aging
de Jesus, B. B., & Blasco, M. A. (2013) · Trends in Genetics · doi:10.1016/j.tig.2013.06.007 · Cited by 251 · see citing works
Self-citationAhmed, A. S. I., Sheng, M. H. ‐., Wasnik, S., Baylink, D. J., & Lau, K. ‐. W. (2017) · World Journal of Experimental Medicine · doi:10.5493/wjem.v7.i1.1 · Cited by 202 · see citing works
Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms
Chen, S., Gan, D., Lin, S., Zhong, Y., Chen, M., Zou, X., Shao, Z., & Xiao, G. (2022) · Theranostics · doi:10.7150/thno.71360 · Cited by 197 · see citing works
Assessing cell and organ senescence biomarkers
de Jesus, B. B., & Blasco, M. A. (2012) · Circulation Research · doi:10.1161/circresaha.111.247866 · Cited by 187 · see citing works
Self-citationMediterranean Diet, Telomere Maintenance and Health Status among Elderly
Boccardi, V., Esposito, A., Rizzo, M. R., Marfella, R., Barbieri, M., & Paolisso, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062781 · Cited by 189 · see citing works
Lifelong leukocyte telomere dynamics and survival in a free-living mammal
Fairlie, J., Holland, R., Pilkington, J. G., Pemberton, J. M., Harrington, L. A., & Nussey, D. H. (2015) · Aging Cell · doi:10.1111/acel.12417 · Cited by 174 · see citing works
Roles of telomere biology in cell senescence, replicative and chronological ageing
Liu, J., Wang, L., Wang, Z., & Liu, J.-P. (2019) · Cells · doi:10.3390/cells8010054 · Cited by 164 · see citing works
Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence
Gude, N. A., Broughton, K. M., Firouzi, F., & Sussman, M. A. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0061-5 · Cited by 166 · see citing works
Signaling networks determining life span
Riera, C. E., Merkwirth, C., De Magalhaes Filho, C. D., & Dillin, A. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014451 · Cited by 161 · see citing works
Cellular Senescence as the Causal Nexus of Aging
Bhatia‐Dey, N., Kanherkar, R. R., Stair, S. E., Makarev, E., & Csoka, A. B. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00013 · Cited by 147 · see citing works
The Link between Chronic Stress and Accelerated Aging
Yegorov, Y. E., Poznyak, A. V., Nikiforov, N. G., Sobenin, I. A., & Orekhov, A. N. (2020) · Biomedicines · doi:10.3390/biomedicines8070198 · Cited by 147 · see citing works
Anti-aging pharmacology: Promises and pitfalls
Vaiserman, A. M., Lushchak, O. V., & Koliada, A. K. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.004 · Cited by 144 · see citing works
Therapeutic Targeting of Telomerase
Jäger, K., & Walter, M. (2016) · Genes · doi:10.3390/genes7070039 · Cited by 142 · see citing works
Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives
Tsoukalas, D., Fragkiadaki, P., Docea, A. O., Alegakis, A. K., Sarandi, E., Thanasoula, M., Spandidos, D. A., Tsatsakis, A. M., Razgonova, M. P., & Călina, D. C. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10614 · Cited by 131 · see citing works
Salvador, L., Singaravelu, G., Harley, C. B., Flom, P. L., Suram, A., & Raffaele, J. M. (2016) · Rejuvenation Research · doi:10.1089/rej.2015.1793 · Cited by 126 · see citing works
Self-citationJayasena, T., Poljak, A., Smythe, G. A., Braidy, N., Münch, G. W., & Sachdev, P. S. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.06.003 · Cited by 120 · see citing works
Telomere Shortening and Alzheimer’s Disease
Cai, Z., Yan, L., & Ratka, A. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8207-9 · Cited by 120 · see citing works
Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells
Ramunas, J., Yakubov, E., Brady Jennifer, J., Corbel, S. Y., Holbrook, C., Brandt, M., Stein, J., Santiago, J. G., Cooke, J. P., & Blau, H. M. (2015) · The FASEB Journal · doi:10.1096/fj.14-259531 · Cited by 123 · see citing works
Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases
Bär, C., & Blasco, M. A. (2016) · F1000Research · doi:10.12688/f1000research.7020.1 · Cited by 115 · see citing works
Self-citationEnzyme Inhibitors and Activators
Şentürk, M. (2017) · InTech eBooks · doi:10.5772/63325 · Cited by 113 · see citing works
Current Perspective in the Discovery of Anti-aging Agents from Natural Products
Ding, A., Zheng, S., Huang, X., Xing, T.-K., Wu, G.-S., Sun, H., Qi, S., & Luo, H. (2017) · Natural Products and Bioprospecting · doi:10.1007/s13659-017-0135-9 · Cited by 111 · see citing works
Telomeres, Telomerase and Ageing
Saretzki, G. C. (2018) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-2835-0_9 · Cited by 114 · see citing works
Questioning causal involvement of telomeres in aging
Simons, M. J. P. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.08.002 · Cited by 108 · see citing works
Beyond average: potential for measurement of short telomeres
Vera, E., & Blasco, M. A. (2012) · Aging · doi:10.18632/aging.100462 · Cited by 106 · see citing works
Self-citationGeroprotectors: A Unified Concept and Screening Approaches
Moskalev, A., Chernyagina, E., Kudryavtseva, A. V., & Shaposhnikov, M. V. (2017) · Aging and Disease · doi:10.14336/ad.2016.1022 · Cited by 107 · see citing works
Antiaging agents: safe interventions to slow aging and healthy life span extension
Liu, J. (2022) · Natural Products and Bioprospecting · doi:10.1007/s13659-022-00339-y · Cited by 107 · see citing works
TERT activation targets DNA methylation and multiple aging hallmarks
Shim, H. S., Iaconelli, J., Shang, X., Li, J., Lan, Z. D., Jiang, S., Nutsch, K., Beyer, B. A., Lairson, L. L., Boutin, A. T., et al. (2024) · Cell · doi:10.1016/j.cell.2024.05.048 · Cited by 104 · see citing works
Harley, C. B., Liu, W., Flom, P. L., & Raffaele, J. M. (2013) · Rejuvenation Research · doi:10.1089/rej.2013.1430 · Cited by 100 · see citing works
Self-citationShort Telomere Syndromes in Clinical Practice: Bridging Bench and Bedside
Mangaonkar, A. A., & Patnaik, M. M. (2018) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2018.03.020 · Cited by 99 · see citing works
Are Anxiety Disorders Associated with Accelerated Aging? A Focus on Neuroprogression
Perna, G., Iannone, G., Alciati, A., & Caldirola, D. (2015) · Neural Plasticity · doi:10.1155/2016/8457612 · Cited by 96 · see citing works
Current nutritional and pharmacological anti-aging interventions
Ros, M., & Carrascosa, J. M. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165612 · Cited by 95 · see citing works
Telomere length: how the length makes a difference
Lulkiewicz, M., Bajsert, J., Kopczynski, P., Barczak, W., & Rubiś, B. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05551-y · Cited by 89 · see citing works
Non-canonical functions of Telomerase Reverse Transcriptase – Impact on redox homeostasis
Rosen, J., Jakobs, P., Ale‐Agha, N., Altschmied, J., & Haendeler, J. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101543 · Cited by 87 · see citing works
Casagrande, S., Stier, A., Monaghan, P., Loveland, J. L., Boner, W., Lupi, S., Trevisi, R., & Hau, M. (2020) · Journal of Experimental Biology · doi:10.1242/jeb.222513 · Cited by 85 · see citing works
Ip, F. C. F., Ng, Y. P., An, H. J., Ying, D., Pang, H. H., Hu, Y., Chin, A. C., Harley, C. B., Wong, Y. H., & Ip, N. Y. (2014) · Neurosignals · doi:10.1159/000365290 · Cited by 83 · see citing works
Self-citationTelomere Length Correlates with Life Span of Dog Breeds
Fick, L. J., Fick, G. H., Li, Z., Cao, E. Y., Bao, B., Heffelfinger, D., Parker, H. G., Ostrander, E. A., & Riabowol, K. T. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.11.021 · Cited by 85 · see citing works
Management of suspected monogenic lung fibrosis in a specialised centre
Borie, R., Kannengiesser, C., de Fontbrune, F. S., Gouya, L., Nathan, N., & Crestani, B. (2017) · European Respiratory Review · doi:10.1183/16000617.0122-2016 · Cited by 81 · see citing works
Beier, F., Foronda, M., Martinez, P., & Blasco, M. A. (2012) · Blood · doi:10.1182/blood-2012-03-418038 · Cited by 79 · see citing works
Self-citationAviv, A. (2020) · The FASEB Journal · doi:10.1096/fj.202001025 · Cited by 73 · see citing works
Antiaging effects of bioactive molecules isolated from plants and fungi
Martel, J., Ojcius, D. M., Ko, Y., Chang, C., & Young, J. D. (2019) · Medicinal Research Reviews · doi:10.1002/med.21559 · Cited by 79 · see citing works
Sudyka, J. (2019) · BioEssays · doi:10.1002/bies.201900095 · Cited by 78 · see citing works
A new pleiotropic effect of statins in elderly: modulation of telomerase activity
Boccardi, V., Barbieri, M., Rizzo, M. R., Marfella, R., Esposito, A., Marano, L., & Paolisso, G. (2013) · The FASEB Journal · doi:10.1096/fj.13-232066 · Cited by 77 · see citing works
Martínez, P., & Blasco, M. A. (2018) · Circulation Research · doi:10.1161/circresaha.118.312202 · Cited by 71 · see citing works
Self-citationTherapeutic Potential of Senolytics in Cardiovascular Disease
Dookun, E., Passos, J. F., Arthur, H. M., & Richardson, G. D. (2022) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07075-w · Cited by 69 · see citing works
Telomerase activation: A potential key modulator for human healthspan and longevity
Boccardi, V., & Paolisso, G. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2013.12.006 · Cited by 69 · see citing works
Current Insights to Regulation and Role of Telomerase in Human Diseases
Ozturk, M. B., Li, Y., & Tergaonkar, V. (2017) · Antioxidants · doi:10.3390/antiox6010017 · Cited by 66 · see citing works
Novel strategies for anti-aging drug discovery
Saraswat, K., & Rizvi, S. I. (2017) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2017.1349750 · Cited by 66 · see citing works
Chen, S., Chen, L., Qi, Y., Xu, J., Ge, Q., Fan, Y., Chen, D., Zhang, Y., Wang, L., Hou, T., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00129-0 · Cited by 66 · see citing works
Tang, J., Wang, X., Lin, X., & Wu, C. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01973-w · Cited by 69 · see citing works
Cycloastragenol: An exciting novel candidate for age‑associated diseases (Review)
Yu, Y., Zhou, L., Yang, Y., & Liu, Y. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6501 · Cited by 66 · see citing works
Evolutionary ecology of telomeres: a review
Olsson, M. M., Wapstra, E., & Friesen, C. R. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13443 · Cited by 63 · see citing works
Telomerase as a Therapeutic Target in Cardiovascular Disease
Hoffmann, J., Richardson, G. D., Haendeler, J., Altschmied, J., Andrés, V., & Spyridopoulos, I. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315695 · Cited by 65 · see citing works
Why are there associations between telomere length and behaviour?
Bateson, M., & Nettle, D. (2018) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2016.0438 · Cited by 61 · see citing works
Telomere length reflects individual quality in free-living adult king penguins
Vaillant, M. L., Viblanc, V. A., Saraux, C., Bohec, C. L., Maho, Y. L., Kato, A., Criscuolo, F., & Ropert‐Coudert, Y. (2015) · Polar Biology · doi:10.1007/s00300-015-1766-0 · Cited by 60 · see citing works
Anti-Aging Activity and Modes of Action of Compounds from Natural Food Sources
Song, L., & Zhang, S. (2023) · Biomolecules · doi:10.3390/biom13111600 · Cited by 58 · see citing works
Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise
Tenchov, R., Sasso, J. M., Wang, X., & Zhou, Q. A. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00532 · Cited by 59 · see citing works
Bennaceur, K., Atwill, M., Al Zhrany, N., Hoffmann, J., Keavney, B., Breault, D., Richardson, G., von Zglinicki, T., Saretzki, G., & Spyridopoulos, I. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.07.020 · Cited by 51 · see citing works
Wan, T., Weir, E. J., Johnson, M., Korolchuk, V. I., & Saretzki, G. C. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101953 · Cited by 52 · see citing works
Stabilization of telomere by the antioxidant property of polyphenols: Anti-aging potential
Maleki, M., Khelghati, N., Alemi, F., Bazdar, M., Asemi, Z., Majidinia, M., Sadeghpoor, A., Mahmoodpoor, A., Jadidi‐Niaragh, F., Targhazeh, N., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118341 · Cited by 52 · see citing works
NRF2 signaling pathway and telomere length in aging and age-related diseases
Medoro, A., Saso, L., Scapagnini, G., & Davinelli, S. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04878-x · Cited by 54 · see citing works
Role for Telomerase in Pulmonary Hypertension
Mouraret, N., Houssaïni, A., Abid, S., Quarck, R. A., Marcos, É., Parpaleix, A., Gary‐Bobo, G., Dubois‐Randé, J., Dérumeaux, G., Boczkowski, J., et al. (2014) · Circulation · doi:10.1161/circulationaha.114.013258 · Cited by 50 · see citing works
Self-citationTelomere length and telomerase activity in osteoporosis and osteoarthritis (Review)
Fragkiadaki, P., Nikitovic, D., Kalliantasi, K., Sarandi, E., Thanasoula, M., Stivaktakis, P. D., Nepka, C., Spandidos, D. A., Theodoros, T., & Tsatsakis, A. M. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.8370 · Cited by 50 · see citing works
Telomeres as Therapeutic Targets in Heart Disease
Yeh, J.-K., Lin, M.-H., & Wang, C.-Y. (2019) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2019.05.009 · Cited by 49 · see citing works
Reprogramming aging and progeria
Freije, J. M. P., & López-Otı́n, C. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.08.009 · Cited by 47 · see citing works
Functional Assessment of Pharmacological Telomerase Activators in Human T Cells
Molgora, B. M., Bateman, R., Sweeney, G. M., Finger, D., Dimler, T., Effros, R. B., & Valenzuela, H. (2013) · Cells · doi:10.3390/cells2010057 · Cited by 47 · see citing works
Dietary safety of cycloastragenol from Astragalus spp.: Subchronic toxicity and genotoxicity studies
Szabo, N. J. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.11.041 · Cited by 48 · see citing works
Criscuolo, F., Smith, S., Zahn, S., Heidinger, B. J., & Haussmann, M. F. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0440 · Cited by 47 · see citing works
The Importance of Telomere Shortening for Atherosclerosis and Mortality
Herrmann, W., & Herrmann, M. (2020) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd7030029 · Cited by 46 · see citing works
Wang, W., Chen, C., Wang, Q., Ma, J., Li, Y., Guan, Z., Wang, R., & Chen, X. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14373 · Cited by 45 · see citing works
Giraudeau, M., Angelier, F., & Sepp, T. (2019) · BioEssays · doi:10.1002/bies.201800162 · Cited by 45 · see citing works
Potential of telomerase activation in extending health span and longevity
de Jesus, B. B., & Blasco, M. A. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.09.004 · Cited by 45 · see citing works
Self-citationFernandes, S. G., Dsouza, R., & Khattar, E. (2021) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2021.103633 · Cited by 42 · see citing works
The relationship between telomere length and aging-related diseases
Huang, X., Huang, L., Lu, J., Cheng, L., Wu, D. A., Li, L., Zhang, S., Lai, X., & Xu, L. (2025) · Clinical and Experimental Medicine · doi:10.1007/s10238-025-01608-z · Cited by 52 · see citing works
Vecoli, C., Borghini, A., & Andreassi, M. G. (2020) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2020.108309 · Cited by 43 · see citing works
The Interaction of Diet and Mitochondrial Dysfunction in Aging and Cognition
Kaliszewska, A., Allison, J., Martini, M., & Arias, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073574 · Cited by 48 · see citing works
Telomere Length: A Cardiovascular Biomarker and a Novel Therapeutic Target
Sagris, Μ., Theofilis, P., Antonopoulos, A. S., Tsioufis, K. P., & Tousoulis, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232416010 · Cited by 42 · see citing works
Kim, Y. B., Thwe, A. A., Li, X., Tuan, P. A., Lee, S., Lee, J., Arasu, M. V., Al-Dhabi, N. A., & Park, S. U. (2014) · Molecules · doi:10.3390/molecules190810922 · Cited by 41 · see citing works
Genome-Protecting Compounds as Potential Geroprotectors
Proshkina, E., Shaposhnikov, M. V., & Moskalev, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124484 · Cited by 42 · see citing works
Derevyanko, A., Whittemore, K., Schneider, R. P., Jiménez, V., Bosch, F., & Blasco, M. A. (2017) · Aging Cell · doi:10.1111/acel.12677 · Cited by 40 · see citing works
Self-citationTao, L., Zhang, W. J., Zhang, Y., Zhang, M., Zhang, Y., Niu, X., Zhao, Q. C., Liu, Z., Li, Y., & Diao, A. (2021) · Food & Function · doi:10.1039/d0fo03246h · Cited by 39 · see citing works
Telomere dynamics in a lizard with morph‐specific reproductive investment and self‐maintenance
Rollings, N., Friesen, C. R., Sudyka, J., Whittington, C. M., Giraudeau, M., Wilson, M. R., & Olsson, M. M. (2017) · Ecology and Evolution · doi:10.1002/ece3.2712 · Cited by 39 · see citing works
Telomerase activity promotes osteoblast differentiation by modulating IGF-signaling pathway
Saeed, H., Qiu, W., Chen, L., Flyvbjerg, A., Abdallah, B. M., & Kassem, M. S. (2015) · Biogerontology · doi:10.1007/s10522-015-9596-6 · Cited by 38 · see citing works
Telomere biology: Cancer firewall or aging clock?
Mitteldorf, J. (2013) · Biochemistry (Moscow) · doi:10.1134/s0006297913090125 · Cited by 36 · see citing works
Telomerase in Brain: The New Kid on the Block and Its Role in Neurodegenerative Diseases
Saretzki, G. C., & Wan, T. (2021) · Biomedicines · doi:10.3390/biomedicines9050490 · Cited by 36 · see citing works
Malavolta, M., Costarelli, L., Giacconi, R., Piacenza, F., Basso, A., Pierpaoli, E., Marchegiani, F., Cardelli, M., Provinciali, M., & Mocchegiani, E. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.02.006 · Cited by 35 · see citing works
Giraudeau, M., Heidinger, B. J., Bonneaud, C., & Sepp, T. (2019) · Biology Letters · doi:10.1098/rsbl.2019.0190 · Cited by 35 · see citing works
Potential roles of telomeres and telomerase in neurodegenerative diseases
Wang, J., Liu, Y., Xia, Q., Xia, Q., Wang, B., Yang, C., Liang, J., & Liu, X. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.07.046 · Cited by 34 · see citing works
Clinical implications of telomere dysfunction in lung fibrosis
Molina‐Molina, M., & Borie, R. (2018) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000506 · Cited by 36 · see citing works
- Authors
- de Jesus, B. B., Schneeberger, K., Vera, E., Tejera, A., Harley, C. B., & Blasco, M. A.
- Affiliations
- Spanish National Cancer Research Centre (ES)
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2011-04-14
- Volume
- 10
- Issue
- 4
- Pages
- 604-621
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC3627294
- OpenAlex
- W2102172732
- Cited by
- 348
- References
- 85
- Citations by year
- 2026: 15 · 2025: 22 · 2024: 23 · 2023: 30 · 2022: 31 · 2021: 34 · 2020: 31 · 2019: 18 · 2018: 21 · 2017: 25 · 2016: 18 · 2015: 21 · 2014: 15 · 2013: 21 · 2012: 21
- FWCI
- 12.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Aging Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eli Lilly and Company
- European Commission
- Ministerio de Ciencia e Innovación
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- telomerase activators, telomere length, telomerase reverse transcriptase, Astragalus membranaceus, DNA damage, healthspan, dietary supplementation, cancer incidence, glucose tolerance, osteoporosis, skin aging
- MeSH terms
- Animals, Diet, DNA Damage, Embryo, Mammalian, Female, Fibroblasts, Mice, Inbred C57BL, Neoplasms, RNA, Anticarcinogenic Agents, Telomere, Telomerase, Astragalus propinquus, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review