A Possible Role of GLP-1 in the Pathophysiology of Early Dumping Syndrome
Abstract
Exaggerated plasma concentrations of GLP-1 precede reactive hypoglycemia after oral glucose in gastrectomy patients, resulting in late dumping syndrome. Recently, we showed that GLP-1 elicits the activation of sympathetic outflow. Because sympathetic activation is thought to be a cause of early dumping, we hypothesized that exaggerated GLP-1 may contribute to the pathophysiology of early dumping syndrome. In 11 patients after gastrectomy and 14 controls, blood pressure, heart rate, and plasma concentrations of norepinephrine, epinephrine, GLP-1, glucagon, insulin, and glucose were measured after oral glucose. In gastrectomy patients, GLP-1, norepinephrine, and heart rate peaked 15 to 30 min after oral glucose. Significant positive correlations were found among GLP-1, norepinephrine, and heart rate at 30 min, and these parameters at 30 min were significantly higher in patients with early dumping syndrome. These results suggest that GLP-1 is involved in the pathophysiology of early dumping syndrome.
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GLP-1 has been implicated to cause tachycardia in patients who have rapid gastric emptying after gastric resection (postgastrectomy dumping syndrome).
“GLP-1 has also been implicated to cause tachycardia in patients who have rapid gastric emptying after gastric resection (i.e., postgastrectomy dumping syndrome), because these patients have increased heart rate, plasma GLP-1, and plasma norepinephrine concentrations after an oral glucose challenge (54).”
From Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans (2008) · cites this paper as [54]
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- Authors
- Yamamoto, H., Mori, T., Tsuchihashi, H., Akabori, H., Naito, H., & Tani, T.
- Affiliations
- Shiga University of Medical Science (JP)
- Corresponding author
- Yamamoto, Hiroshi
- Venue
- Digestive Diseases and Sciences
- Published
- 2005-12
- Volume
- 50
- Issue
- 12
- Pages
- 2263-2267
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- OpenAlex
- W2025076466
- Cited by
- 43
- References
- 32
- Citations by year
- 2024: 3 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 5
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- glucagon-like peptide-1, early dumping syndrome, gastrectomy, reactive hypoglycemia, sympathetic activation, norepinephrine, heart rate, postprandial blood glucose, glucagon, insulin, postgastrectomy syndrome
- MeSH terms
- Adult, Analysis of Variance, Blood Glucose, Catecholamines, Dumping Syndrome, Female, Gastrectomy, Hemodynamics, Humans, Insulin, Male, Middle Aged, Prognosis, Reference Values, Sensitivity and Specificity, Severity of Illness Index, Stomach Neoplasms, Biomarkers, Linear Models, Case-Control Studies, Risk Assessment, Glucagon-Like Peptide 1
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