Enrichment of gilthead seabream (Sparus aurata L.) diet with microalgae: effects on the immune system
Abstract
The present study assessed the effects of three orally administered microalgae (Nannochloropsis gaditana, Tetraselmis chuii and Phaeodactylum tricornutum) on different immune parameters and immune-related gene expression of gilthead seabream (Sparus aurata L.). Fish were fed a control or one of six experimental diets and sampled at 2 and 4 weeks of treatment. At the end of the trial, growth performance and different systemic and local immune activities were measured (natural haemolytic complement activity, IgM levels, phagocytosis and respiratory burst). The expression levels of different immune-associated genes (EF-1α, IgM(H), TCR-β, MHCIα, MHCIIα, CSF-1R and β-defensin) were analysed in head-kidney and gut. Administration of N. gaditana and T. chuii resulted in a significant increase in haemolytic complement activity, phagocytic capacity, as well expression level of β-defensin, as well as MHCIIα and CSF-1R, respectively. The P. tricornutum-supplemented diet provoked immunostimulation, and very little effect on gene expression was observed. These results suggest that dietary microalgae enhance gilthead seabream defence activity, which could be very important in order to consider such microalgae as a possible additive in fish diets.
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Administration of Tetraselmis chuii, Nannochloropsis gaditana, and P. tricornutum orally enhanced the defence activity of gilthead seabream.
“In another study, administration of (Tetraselmis chuii, Nannochloropsis gaditana, and P. tricornutum) orally enhanced the defence activity of gilthead seabream (S. aurata) (Cerezuela et al., 2012).”
From Potential of microalgae as a sustainable feed ingredient for aquaculture (2021) · cites this paper as Cerezuela et al., 2012
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- Authors
- Cerezuela, R., Guardiola, F. A., Meseguer, J., & Esteban, M. Á.
- Affiliations
- Universidad de Murcia (ES)
- Corresponding author
- Esteban, M. Ángeles
- Venue
- Fish Physiology and Biochemistry
- Published
- 2012-12
- Volume
- 38
- Issue
- 6
- Pages
- 1729-1739
- ISSN
- 0920-1742 (ISSN-L)
- 1573-5168
- OpenAlex
- W2048560883
- Cited by
- 137
- References
- 41
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 11 · 2023: 10 · 2022: 21 · 2021: 22 · 2020: 17 · 2019: 11 · 2018: 4 · 2017: 9 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 2 · 2012: 1
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Fish Physiology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Aquaculture disease management and microbiota
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- Sparus aurata, Nannochloropsis gaditana, Tetraselmis chuii, Phaeodactylum tricornutum, fish immunity, immunostimulation, IgM, phagocytosis, respiratory burst, immune gene expression, beta-defensins, MHC class II, CSF1R, head kidney, intestine, fish feed additives
- MeSH terms
- Animals, Animal Feed, Animal Nutritional Physiological Phenomena, Diet, Immunoglobulin M, Leukocytes, Respiratory Burst, Sea Bream, Microalgae, Real-Time Polymerase Chain Reaction
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