Cerebrospinal fluid levels of oxytocin in Prader–Willi syndrome: a preliminary report
Open accessAbstract
Background Prader-Willi syndrome (PWS) is a genetic disorder characterized by mental retardation, appetite dysregulation, and a high risk for obsessive-compulsive disorder (OCD). Microscopic abnormalities of the hypothalamus have been described in PWS, and oxytocin has been implicated in both appetite regulation and OCD. Methods Oxytocin and arginine vasopressin (AVP) were measured in the cerebrospinal fluid of 5 subjects with PWS (2 male, 3 female) and in 6 normal control subjects (all female). Results CSF oxytocin was elevated in PWS (9.2 +/- 3.9 pmol/L) as compared to normal control subjects (5.1 +/- 0.9 pmol/L, p = 0.045), a finding that was more significant when excluding male subjects from analysis (p = 0.02). AVP was not significantly different between the groups as a whole. Conclusions These data provide further evidence for hypothalamic and oxytocinergic dysfunction in PWS. The associations between oxytocin, appetite regulation, and obsessive compulsive symptomatology in PWS warrant further investigation.
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Individuals with Prader-Willi syndrome have shown lower levels of OT in CSF and fewer OT producing cells in the PVN.
“Individuals with PWS have shown lower levels of OT in CSF (Martin et al., 1998) and fewer OT producing cells in the PVN (Swaab et al., 1995).”
From Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders (2014) · cites this paper as Martin et al., 1998
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- Authors
- Martin, A., State, M., Anderson, G. M., Kaye, W. M., Hanchett, J. M., McConaha, C. W., North, W. G., & Leckman, J. F.
- Affiliations
- Yale University (US)
- University of Pittsburgh Medical Center (US)
- Dartmouth College (US)
- Corresponding author
- Martin, Andrés
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1998-12
- Volume
- 44
- Issue
- 12
- Pages
- 1349-1352
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2069631667
- Cited by
- 89
- References
- 15
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 9 · 2021: 9 · 2020: 4 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 1 · 2015: 6 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Biological Psychiatry (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (T32MH18268-12, T32MH018268)
- National Center for Research Resources (RR 00084)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P02-HD-03008-31)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- Prader-Willi syndrome, oxytocin, cerebrospinal fluid, vasopressin, hypothalamic dysfunction, appetite regulation, obsessive-compulsive disorder, sex differences
- MeSH terms
- Adolescent, Adult, Arginine Vasopressin, Female, Humans, Male, Oxytocin, Prader-Willi Syndrome, Reference Values, Sex Characteristics
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