Greater corticolimbic activation to high-calorie food cues after eating in obese vs. normal-weight adults
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The goal of this research is to identify the neural response to rewarding food cues before and after eating in overweight/obese (OB) and normal-weight (NW) adults. Based on the previous literature, we expected greater differential activation to food cues vs. objects for OB compared to NW participants both prior to eating and after consumption of a typical lunch. Twenty-two overweight/obese (11 male) and 16 normal-weight (6 male) individuals participated in a functional magnetic resonance imaging task examining neural response to visual cues of high- and low-calorie foods before and after eating. The OB group demonstrated increased neural response to high- and low-calorie foods after eating in comparison to the NW participants in frontal, temporal, and limbic regions. In addition, greater activation in corticolimbic regions (lateral OFC, caudate, anterior cingulate) to high-calorie food cues was evident in OB vs. NW participants after eating. These findings suggest that for OB individuals, high-calorie food cues show sustained response in brain regions implicated in reward and addiction even after eating. Moreover, food cues did not elicit similar brain response after eating in the NW group suggesting that neural activity in response to food cues diminishes with reduced hunger for these individuals.
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The study focused on a specific dietary factor by controlling for calorie content, macronutrient composition, ingredient sources, and food form.
“Third, we focused on a spe-cific dietary factor by controlling for calorie content, macronutrient composition, ingredient sources, and food form, instead of comparing grossly different foods (eg, cheesecake compared with vegetables) (6,10,31,32).”
From Effects of dietary glycemic index on brain regions related to reward and craving in men (2013) · cites this paper as [31]
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Cites
Talairach, J., Tournoux, P., & Rayport, M. (1988) · Thieme eBooks · Cited by 5,058 · see citing works
Rolls, E. T. (1998) · doi:10.1093/oso/9780198524649.001.0001 · Cited by 1,314 · see citing works
Dopamine in drug abuse and addiction: results from imaging studies and treatment implications
Volkow, N. D., Fowler, J. S., Wang, G.-J., & Swanson, J. M. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001507 · Cited by 1,101 · see citing works
Goebel, R., Esposito, F., & Formisano, E. (2006) · Human Brain Mapping · doi:10.1002/hbm.20249 · Cited by 1,053 · see citing works
Widespread reward-system activation in obese women in response to pictures of high-calorie foods
Stoeckel, L. E., Weller, R. E., Cook, E. W., Twieg, D. B., Knowlton, R. C., & Cox, J. E. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.02.031 · Cited by 857 · see citing works
Kringelbach, M. L. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.10.1064 · Cited by 824 · see citing works
Corticostriatal-hypothalamic circuitry and food motivation: Integration of energy, action and reward
Kelley, A. E., Baldo, B. A., Pratt, W. E., & Will, M. J. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.066 · Cited by 752 · see citing works
Multiple neural systems controlling food intake and body weight
Berthoud, H.-R. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00014-3 · Cited by 725 · see citing works
Neural correlates of food addiction
Gearhardt, A. N. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.32 · Cited by 707 · see citing works
Rothemund, Y., Preuschhof, C., Bohner, G., Bauknecht, H.-C., Klingebiel, R., Flor, H., & Klapp, B. F. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.05.008 · Cited by 679 · cited 5× · see citing works
“The lateral OFC plays an important role in food-related neural circuitry and responds preferentially to high-calorie food cues (Goldstone et al., 2009; Rothemund et al., 2007; Stoeckel et al., 2008).”
BackgroundInfluentialThe Brain, Appetite, and Obesity
Berthoud, H., & Morrison, C. D. (2007) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093551 · Cited by 661 · see citing works
Leptin Regulates Striatal Regions and Human Eating Behavior
Farooqi, I. S., Bullmore, E., Keogh, J., Gillard, J., O'Rahilly, S., & Fletcher, P. C. (2007) · Science · doi:10.1126/science.1144599 · Cited by 622 · see citing works
Dopamine in Drug Abuse and Addiction: Results of Imaging Studies and Treatment Implications
Volkow, N. D., Fowler, J. S., Wang, G.-J., Swanson, J. M., & Telang, F. (2007) · Archives of Neurology · doi:10.1001/archneur.64.11.1575 · Cited by 605 · see citing works
Gr�sser, S. M., Wrase, J., Klein, S., Hermann, D., Smolka, M. N., Ruf, M., Weber-Fahr, W., Flor, H., Mann, K., Braus, D. F., et al. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1828-4 · Cited by 598 · see citing works
Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography
Tataranni, P. A., Gautier, J., Chen, K., Uecker, A., Bandy, D. J., Salbe, A. D., Pratley, R. E., Lawson, M. A., Reiman, E. M., & Ravussin, É. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4569 · Cited by 592 · see citing works
Cortical and limbic activation during viewing of high- versus low-calorie foods
Killgore, W. D. S., Young, A. D., Femia, L. A., Bogorodzki, P., Rogowska, J., & Yurgelun-Todd, D. A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00191-5 · Cited by 581 · see citing works
Menstrual cycle phase modulates reward-related neural function in women
Dreher, J.-C., Schmidt, P. J., Kohn, P., Furman, D., Rubinow, D., & Berman, K. F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605569104 · Cited by 567 · see citing works
Castellanos, E. H., Charboneau, E., Dietrich, M. S., Park, S., Bradley, B. P., Mogg, K., & Cowan, R. L. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.138 · Cited by 564 · see citing works
Wang, G.-J., Volkow, N. D., Thanos, P. K., & Fowler, J. S. (2004) · Journal of Addictive Diseases · doi:10.1300/j069v23n03_04 · Cited by 502 · see citing works
Critchley, H., & Rolls, E. T. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.4.1673 · Cited by 467 · see citing works
Hunger selectively modulates corticolimbic activation to food stimuli in humans
LaBar, K. S., Gitelman, D. R., Parrish, T. B., Kim, Y.-H., Nobre, A. C., & Mesulam, M. M. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.2.493 · Cited by 444 · see citing works
George, M. S., Anton, R. F., Bloomer, C., Tenebäck, C. C., Drobes, D. J., Lorberbaum, J. P., Nahas, Z. H., & Vincent, D. J. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.4.345 · Cited by 382 · see citing works
Representation in the Human Brain of Food Texture and Oral Fat
de Araujo, I. E., & Rolls, E. T. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0130-04.2004 · Cited by 365 · see citing works
Fasting biases brain reward systems towards high‐calorie foods
Goldstone, A. P., Prechtl de Hernandez, C. G., Beaver, J. D., Muhammed, K., Croese, C., Bell, G., Durighel, G., Hughes, E., Waldman, A. D., Frost, G., et al. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06949.x · Cited by 356 · see citing works
Processing of food pictures: Influence of hunger, gender and calorie content
Frank, S., Laharnar, N., Kullmann, S., Veit, R., Canova, C., Hegner, Y. L., Fritsche, A., & Preissl, H. T. (2010) · Brain Research · doi:10.1016/j.brainres.2010.04.030 · Cited by 298 · see citing works
Differential brain responses to satiation in obese and lean men.
Gautier, J., Chen, K., Salbe, A. D., Bandy, D. J., Pratley, R. E., Heiman, M. L., Ravussin, É., Reiman, E. M., & Tataranni, P. A. (2000) · Diabetes · doi:10.2337/diabetes.49.5.838 · Cited by 283 · see citing works
Bruce, A. S., Holsen, L. M., Chambers, R. J., Martin, L. E., Brooks, W. M., Zarcone, J. R., Butler, M. G., & Savage, C. R. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.84 · Cited by 282 · see citing works
Neural Mechanisms Associated With Food Motivation in Obese and Healthy Weight Adults
Martin, L. E., Holsen, L. M., Chambers, R. J., Bruce, A. S., Brooks, W. M., Zarcone, J. R., Butler, M. G., & Savage, C. R. (2009) · Obesity · doi:10.1038/oby.2009.220 · Cited by 278 · see citing works
Test–retest and between‐site reliability in a multicenter fMRI study
Friedman, L., Stern, H. S., Brown, G. G., Mathalon, D. H., Turner, J. A., Glover, G. H., Gollub, R. L., Lauriello, J., Lim, K. O., Cannon, T. D., et al. (2007) · Human Brain Mapping · doi:10.1002/hbm.20440 · Cited by 245 · see citing works
Food for thought: hedonic experience beyond homeostasis in the human brain
Kringelbach, M. L. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.04.035 · Cited by 236 · see citing works
Taste perception in patients with insular cortex lesions
Pritchard, T. C., Macaluso, D. A., & Eslinger, P. J. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.4.663 · Cited by 225 · see citing works
Afferent connections of the caudolateral orbitofrontal cortex taste area of the primate
Baylis, L. L., Rolls, E. T., & Baylis, G. C. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00449-f · Cited by 217 · see citing works
Effect of Satiation on Brain Activity in Obese and Lean Women
Gautier, J., Parigi, A. D., Chen, K., Salbe, A. D., Bandy, D. J., Pratley, R. E., Ravussin, É., Reiman, E. M., & Tataranni, P. A. (2001) · Obesity Research · doi:10.1038/oby.2001.92 · Cited by 207 · see citing works
Neural Mechanisms Underlying Hyperphagia in Prader‐Willi Syndrome
Holsen, L. M., Zarcone, J. R., Brooks, W. M., Butler, M. G., Thompson, T. I., Ahluwalia, J. S., Nollen, N. L., & Savage, C. R. (2006) · Obesity · doi:10.1038/oby.2006.118 · Cited by 189 · see citing works
Food‐Related Odor Probes of Brain Reward Circuits During Hunger: A Pilot fMRI Study
Bragulat, V., Dzemidzic, M., Bruno, C., Cox, C. A., Talavage, T., Considine, R. V., & Kareken, D. A. (2010) · Obesity · doi:10.1038/oby.2010.57 · Cited by 128 · see citing works
Responsivity to food stimuli in obese and lean binge eaters using functional MRI
Geliebter, A., Ladell, T., Logan, M. S., Schweider, T., Sharafi, M., & Joy Hirsch, C. (2005) · Appetite · doi:10.1016/j.appet.2005.09.002 · Cited by 121 · see citing works
Haase, L., Green, E., & Murphy, C. (2011) · Appetite · doi:10.1016/j.appet.2011.06.009 · Cited by 118 · see citing works
Leidy, H. J., & Racki, E. M. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.3 · Cited by 112 · see citing works
Regional cerebral blood flow during food exposure in obese and normal- weight women
Karhunen, L. J. (1997) · Brain · doi:10.1093/brain/120.9.1675 · Cited by 107 · see citing works
The time of day and the proportions of macronutrients eaten are related to total daily food intake
de Castro, J. M. (2007) · British Journal of Nutrition · doi:10.1017/s0007114507754296 · Cited by 97 · see citing works
Stability of fMRI striatal response to alcohol cues: A hierarchical linear modeling approach
Schacht, J. P., Anton, R. F., Randall, P. K., Li, X., Henderson, S., & Myrick, H. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.02.004 · Cited by 77 · see citing works
Food-related Neural Circuitry in Prader-Willi Syndrome: Response to High- Versus Low-calorie Foods
Dimitropoulos, A., & Schultz, R. T. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0546-x · Cited by 73 · see citing works
Self-citationMental phenomena induced by stimulation in the limbic system.
Halgren, E. (1982) · PubMed · Cited by 54 · see citing works
Confronting the Epidemic: The Need for Global Solutions
Rigby, N. J., Kumanyika, S., & James, W. P. T. (2004) · Journal of Public Health Policy · doi:10.1057/palgrave.jphp.3190040 · Cited by 49 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Depression and obesity: evidence of shared biological mechanisms
Milaneschi, Y., Simmons, W. K., van Rossum, E. F. C., & Penninx, B. W. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0017-5 · Cited by 1,073 · see citing works
The Prevalence of Food Addiction as Assessed by the Yale Food Addiction Scale: A Systematic Review
Pursey, K., Stanwell, P., Gearhardt, A. N., Collins, C. E., & Burrows, T. L. (2014) · Nutrients · doi:10.3390/nu6104552 · Cited by 548 · see citing works
Food‐related impulsivity in obesity and Binge Eating Disorder – a systematic review
Schag, K., Schönleber, J., Teufel, M., Zipfel, S., & Giel, K. E. (2013) · Obesity Reviews · doi:10.1111/obr.12017 · Cited by 404 · see citing works
“Liking” and “wanting” in eating and food reward: Brain mechanisms and clinical implications
Morales, I., & Berridge, K. C. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113152 · Cited by 346 · see citing works
The Prefrontal Cortex and Obesity: A Health Neuroscience Perspective
Lowe, C. J., Reichelt, A. C., & Hall, P. A. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.01.005 · Cited by 295 · see citing works
Brooks, S. J., Cedernaes, J., & Schiöth, H. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060393 · Cited by 269 · see citing works
Pursey, K. M., Stanwell, P., Callister, R. J., Brain, K., Collins, C. E., & Burrows, T. L. (2014) · Frontiers in Nutrition · doi:10.3389/fnut.2014.00007 · Cited by 239 · see citing works
Striatocortical pathway dysfunction in addiction and obesity: differences and similarities
Tomasi, D. G., & Volkow, N. D. (2012) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2012.735642 · Cited by 232 · see citing works
Reward processing in obesity, substance addiction and non‐substance addiction
García‐García, I., Horstmann, A., Jurado, M. Á., Garolera, M., Chaudhry, S. J., Margulies, D. S., Villringer, A., & Neumann, J. (2014) · Obesity Reviews · doi:10.1111/obr.12221 · Cited by 180 · see citing works
Neural vulnerability factors that increase risk for future weight gain
Stice, E., & Yokum, S. (2016) · Psychological Bulletin · doi:10.1037/bul0000044 · Cited by 179 · see citing works
Neural Responses to Visual Food Cues: Insights from Functional Magnetic Resonance Imaging
García‐García, I., Narberhaus, A., Marqués‐Iturria, I., Garolera, M., Rădoi, A., Segura, B., Pueyo, R., Ariza, M., & Jurado, M. Á. (2013) · European Eating Disorders Review · doi:10.1002/erv.2216 · Cited by 166 · see citing works
Busetto, L., Bettini, S., Makaronidis, J., Roberts, C. A., Halford, J. C. G., & Batterham, R. L. (2021) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2021.01.002 · Cited by 159 · see citing works
Neural vulnerability factors for obesity
Stice, E. M., & Burger, K. S. (2018) · Clinical Psychology Review · doi:10.1016/j.cpr.2018.12.002 · Cited by 155 · see citing works
Relation of obesity to neural activation in response to food commercials
Gearhardt, A. N., Yokum, S., Stice, E. M., Harris, J. L., & Brownell, K. D. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst059 · Cited by 153 · see citing works
Devoto, F., Zapparoli, L., Bonandrini, R., Berlingeri, M., Ferrulli, A., Luzi, L., Banfi, G., & Paulesu, E. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.07.017 · Cited by 140 · see citing works
A core eating network and its modulations underlie diverse eating phenomena
Chen, J., Papies, E. K., & Barsalou, L. W. (2016) · Brain and Cognition · doi:10.1016/j.bandc.2016.04.004 · Cited by 144 · see citing works
Effects of dietary glycemic index on brain regions related to reward and craving in men
Lennerz, B. S., Alsop, D. C., Holsen, L. M., Stern, E., Rojas, R., Ebbeling, C. B., Goldstein, J. M., & Ludwig, D. S. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.064113 · Cited by 140 · see citing works
Bhargava, A., Arnold, A. P., Bangasser, D. A., Denton, K. M., Gupta, A., Hilliard Krause, L. M., Mayer, E. A., McCarthy, M., Miller, W. L., Raznahan, A., et al. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnaa034 · Cited by 130 · see citing works
Where is the comfort in comfort foods? Mechanisms linking fat signaling, reward, and emotion
Weltens, N., Zhao, D., & Oudenhove, L. V. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12309 · Cited by 113 · see citing works
A functional neuroimaging review of obesity, appetitive hormones and ingestive behavior
Burger, K. S., & Berner, L. A. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.04.025 · Cited by 110 · see citing works
Lips, M. A., Wijngaarden, M. A., van der Grond, J., van Buchem, M. A., de Groot, G. H., Rombouts, S. A. R. B., Pijl, H., & Veer, I. M. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.080671 · Cited by 110 · see citing works
The Use of Functional MRI to Study Appetite Control in the CNS
Silva, A. D., Salem, V., Matthews, P. M., & Dhillo, W. S. (2012) · Experimental Diabetes Research · doi:10.1155/2012/764017 · Cited by 105 · see citing works
Interoceptive contributions to healthy eating and obesity
Simmons, W. K., & DeVille, D. C. (2017) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2017.07.001 · Cited by 96 · see citing works
Rapuano, K. M., Huckins, J. F., Sargent, J. D., Heatherton, T. F., & Kelley, W. M. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhv097 · Cited by 90 · see citing works
Food Cues and Obesity: Overpowering Hormones and Energy Balance Regulation
Belfort-DeAguiar, R., & Seo, D. (2018) · Current Obesity Reports · doi:10.1007/s13679-018-0303-1 · Cited by 84 · see citing works
The Trace Amine-Associated Receptor 1 Agonist RO5256390 Blocks Compulsive, Binge-like Eating in Rats
Ferragud, A., Howell, A. D., Moore, C. F., Ta, T. L., Hoener, M. C., Sabino, V., & Cottone, P. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.233 · Cited by 84 · see citing works
Stice, E. M., & Yokum, S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4365-15.2016 · Cited by 80 · see citing works
Cornier, M., Legget, K. T., Thomas, E. A., Bechtell, J. L., Eichman, L. C., Bessesen, D. H., & Tregellas, J. R. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.01.002 · Cited by 76 · see citing works
Food cue reactivity: Neurobiological and behavioral underpinnings
Kanoski, S. E., & Boutelle, K. N. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09724-x · Cited by 78 · see citing works
Is obesity related to enhanced neural reactivity to visual food cues? A review and meta-analysis
Morys, F., García‐García, I., & Dagher, A. (2020) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsaa113 · Cited by 71 · see citing works
Geliebter, A., Benson, L., Pantazatos, S. P., Joy Hirsch, C., & Carnell, S. (2015) · Appetite · doi:10.1016/j.appet.2015.08.009 · Cited by 68 · see citing works
Boutelle, K. N., Knatz, S., Carlson, J., Bergmann, K., & Peterson, C. B. (2017) · Cognitive and Behavioral Practice · doi:10.1016/j.cbpra.2016.08.003 · Cited by 60 · see citing works
Boutelle, K. N., Manzano, M. A., & Eichen, D. M. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113018 · Cited by 61 · see citing works
Meng, X., Huang, D., Ao, H., Wang, X., & Gao, X. (2020) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2020.02.004 · Cited by 62 · see citing works
Functional connectivity in obesity during reward processing
García‐García, I., Jurado, M. Á., Garolera, M., Segura, B., Marqués‐Iturria, I., Pueyo, R., Vernet‐Vernet, M., Palacios, M. J. S., Sala‐Llonch, R., Ariza, M., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.10.035 · Cited by 61 · see citing works
The Effects of Experimental Manipulation of Sleep Duration on Neural Response to Food Cues
Demos, K. E., Sweet, L. H., Hart, C. N., McCaffery, J. M., Williams, S. E., Mailloux, K. A., Trautvetter, J., Owens, M. M., & Wing, R. R. (2017) · Sleep · doi:10.1093/sleep/zsx125 · Cited by 57 · see citing works
Plessow, F., Marengi, D. A., Perry, S. K., Felicione, J. M., Franklin, R., Holmes, T. M., Holsen, L. M., Makris, N., Deckersbach, T., & Lawson, E. A. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.226 · Cited by 57 · see citing works
Adise, S., Geier, C. F., Roberts, N., White, C. N., & Keller, K. (2018) · Appetite · doi:10.1016/j.appet.2018.06.014 · Cited by 57 · see citing works
Neuroscience of Compulsive Eating Behavior
Moore, C. F., Sabino, V., Koob, G. F., & Cottone, P. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00469 · Cited by 56 · see citing works
Opel, N., Redlich, R., Grotegerd, D., Dohm, K., Haupenthal, C., Heindel, W. L., Kugel, H., Arolt, V., & Dannlowski, U. (2015) · Human Brain Mapping · doi:10.1002/hbm.22773 · Cited by 56 · see citing works
Li, G., Ji, G., Hu, Y., Liu, L., Jin, Q., Zhang, W., Liu, L., Wang, Y., Zhao, J., von Deneen, K. M., et al. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.10.022 · Cited by 50 · see citing works
Is the Brain a Key Player in Glucose Regulation and Development of Type 2 Diabetes?
Lundqvist, M., Almby, K. E., Abrahamsson, N., & Eriksson, J. W. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00457 · Cited by 49 · see citing works
Lyu, Z., & Jackson, T. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00188 · Cited by 49 · see citing works
Kennedy, J. T., & Dimitropoulos, A. (2014) · Appetite · doi:10.1016/j.appet.2013.12.017 · Cited by 46 · see citing works
Yunker, A. G., Alves, J. M., LUO, S. H., ANGELO, B. C., DEFENDIS, A. W., Pickering, T. A., Monterosso, J. R., & Page, K. A. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.26313 · Cited by 46 · see citing works
Nutritional Health Considerations for Persons with Spinal Cord Injury
Bigford, G. E., & Nash, M. S. (2017) · Topics in Spinal Cord Injury Rehabilitation · doi:10.1310/sci2303-188 · Cited by 47 · see citing works
Zheng, L., Miao, M., & Gan, Y. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104721 · Cited by 41 · see citing works
Hamza, E. A., Tindle, R., Pawlak, S., Bedewy, D. A., & Moustafa, A. A. (2024) · Reviews in the Neurosciences · doi:10.1515/revneuro-2023-0163 · Cited by 45 · see citing works
Food portion size and energy density evoke different patterns of brain activation in children
English, L., Fearnbach, S. N., Wilson, S. J., Fisher, J. O., Savage, J. S., Rolls, B. J., & Keller, K. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.136903 · Cited by 40 · see citing works
Li, G., Hu, Y., Zhang, W., Ding, Y., Wang, Y., Wang, J., He, Y., Lv, G., von Deneen, K. M., Zhao, Y., et al. (2020) · Addiction Biology · doi:10.1111/adb.12974 · Cited by 40 · see citing works
Zhang, P., Wu, G., Yu, F., Liu, Y., Li, M., Zheng, W., Ding, H., Li, X.-S., Wang, H., Jin, M., et al. (2020) · Obesity · doi:10.1002/oby.22839 · Cited by 35 · see citing works
Verdejo‐Román, J., Fornito, A., Soriano‐Mas, C., Vilar‐López, R., & Verdejo‐García, A. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.11.011 · Cited by 36 · see citing works
Harding, I. H., Andrews, Z. B., Mata, F., Orlandea, S., Martínez-Zalacaín, I., Soriano-Mas, C., Stice, E., & Verdejo-Garcia, A. (2018) · International Journal of Obesity · doi:10.1038/ijo.2017.237 · Cited by 31 · see citing works
Wagner, L., Veit, R., Fritsche, L., Häring, H., Fritsche, A., Birkenfeld, A. L., Heni, M., Preissl, H. T., & Kullmann, S. (2022) · International Journal of Obesity · doi:10.1038/s41366-022-01167-3 · Cited by 32 · see citing works
Neuropeptide-Y alters VTA dopamine neuron activity through both pre- and postsynaptic mechanisms
West, K. S., & Roseberry, A. G. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00879.2016 · Cited by 32 · see citing works
English, L., Fearnbach, S. N., Lasschuijt, M. P., Schlegel, A., Anderson, K. E., Harris, S., Wilson, S. J., Fisher, J. O., Savage, J. S., Rolls, B. J., et al. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.126 · Cited by 29 · see citing works
Central mechanisms in sympathetic nervous dysregulation in obesity
Patel, M., Braun, J., Lambert, G. W., Kameneva, T., Keatch, C., & Lambert, É. (2023) · Journal of Neurophysiology · doi:10.1152/jn.00254.2023 · Cited by 33 · see citing works
General Habit Propensity Relates to the Sensation Seeking Subdomain of Impulsivity But Not Obesity
Dietrich, A., de Wit, S., & Horstmann, A. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00213 · Cited by 29 · see citing works
Neural Correlates to Food-Related Behavior in Normal-Weight and Overweight/Obese Participants
Ho, A., Kennedy, J. T., & Dimitropoulos, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045403 · Cited by 28 · see citing works
Fearnbach, S. N., English, L., Lasschuijt, M. P., Wilson, S. J., Savage, J. S., Fisher, J. O., Rolls, B. J., & Keller, K. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.03.007 · Cited by 27 · see citing works
The obese brain as a heritable phenotype: a combined morphometry and twin study
Weise, C. M., Piaggi, P., Reinhardt, M., Chen, K., Savage, C. R., Krakoff, J. A., & Pleger, B. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.222 · Cited by 27 · see citing works
Brain imaging demonstrates a reduced neural impact of eating in obesity
Puzziferri, N., Zigman, J. M., Thomas, B. P., Mihalakos, P., Gallagher, R., Lutter, M. L., Carmody, T. J., Lu, H., & Tamminga, C. A. (2016) · Obesity · doi:10.1002/oby.21424 · Cited by 27 · see citing works
Effects of Anxiety on Caloric Intake and Satiety-Related Brain Activation in Women and Men
Mestre, Z., Melhorn, S. J., Askren, M. K., Tyagi, V., Gatenby, C., Young, L., Mehta, S. H., Webb, M. F., Grabowski, T. J., & Schur, E. A. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000299 · Cited by 26 · see citing works
Disgust proneness and associated neural substrates in obesity
Watkins, T. J., Iorio, C., Olatunji, B. O., Benningfield, M. M., Blackford, J. U., Dietrich, M. S., Bhatia, M. C., Theiss, J. D., Salomon, R. M., Niswender, K. D., et al. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv129 · Cited by 26 · see citing works
The Use of Functional Magnetic Resonance Imaging in the Study of Appetite and Obesity
Neseliler, S., Han, J.-E., & Dagher, A. (2017) · CRC Press eBooks · doi:10.1201/9781315120171-6 · Cited by 24 · see citing works
Perceptual Characterization of the Macronutrient Picture System (MaPS) for Food Image fMRI
King, J. L., Fearnbach, S. N., Ramakrishnapillai, S., Shankpal, P., Geiselman, P. J., Martin, C. K., Murray, K. B., Hicks, J. L., McClernon, F. J., Apolzan, J. W., et al. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.00017 · Cited by 25 · see citing works
Stice, E. M., & Yokum, S. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.08.035 · Cited by 25 · see citing works
LUO, S. H., ANGELO, B. C., Chow, T., Monterosso, J. R., Thompson, P. M., Xiang, A. H., & Page, K. A. (2020) · Diabetes Care · doi:10.2337/dc20-3006 · Cited by 25 · see citing works
Keller, K., English, L., Fearnbach, S. N., Lasschuijt, M. P., Anderson, K. E., Bermudez, M., Fisher, J. O., Rolls, B. J., & Wilson, S. J. (2018) · Appetite · doi:10.1016/j.appet.2018.01.027 · Cited by 26 · see citing works
Celeghin, A., Palermo, S., Giampaolo, R., Fini, G. D., Gandino, G., & Civilotti, C. (2023) · Brain Sciences · doi:10.3390/brainsci13030465 · Cited by 24 · see citing works
Trace Amine Associated Receptor 1 (TAAR1) Modulation of Food Reward
Moore, C. F., Sabino, V., & Cottone, P. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00129 · Cited by 24 · see citing works
Neural Food Reward Processing in Successful and Unsuccessful Weight Maintenance
Simon, J. J., Becker, A., Sinno, M. H., Skunde, M., Bendszus, M., Preissl, H. T., Enck, P., Herzog, W., & Friederich, H. (2018) · Obesity · doi:10.1002/oby.22165 · Cited by 23 · see citing works
Belfort‐DeAguiar, R., Seo, D., Lacadie, C., Naik, S., Schmidt, C., Lam, W., Hwang, J. J., Constable, R. T., Sinha, R., & Sherwin, R. S. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00335.2017 · Cited by 22 · see citing works
Yeung, A. W. K., & Wong, N. S. M. (2020) · Nutrients · doi:10.3390/nu12103010 · Cited by 21 · see citing works
Exercise-related changes in between-network connectivity in overweight/obese adults
Legget, K. T., Wylie, K. P., Cornier, M., Melanson, E. L., Paschall, C. J., & Tregellas, J. R. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.02.031 · Cited by 22 · see citing works
Nock, N. L., Dimitropoulos, A., Tkach, J. A., Frasure, H. E., & vonGruenigen, V. (2012) · BMC Neuroscience · doi:10.1186/1471-2202-13-74 · Cited by 21 · see citing works
Tan, Z., Hu, Y., Ji, G., Li, G., Ding, Y., Zhang, W., Wang, J., Jia, Z., Zhang, L., Li, H., et al. (2022) · Brain Topography · doi:10.1007/s10548-022-00906-z · Cited by 20 · see citing works
Nock, N. L., Dimitropoulos, A., Rao, S. M., Flask, C. A., Schluchter, M., Zanotti, K. M., Rose, P. G., Kirwan, J. P., & Alberts, J. L. (2014) · Contemporary Clinical Trials · doi:10.1016/j.cct.2014.08.008 · Cited by 20 · see citing works
How task demands shape brain responses to visual food cues
Pohl, T. M., Tempelmann, C., & Noesselt, T. (2017) · Human Brain Mapping · doi:10.1002/hbm.23560 · Cited by 20 · see citing works
Sensory cue reactivity: Sensitization in alcohol use disorder and obesity
Agarwal, K., Manza, P., Leggio, L., Livinski, A. A., Volkow, N. D., & Joseph, P. V. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.014 · Cited by 19 · see citing works
Ventral frontal satiation-mediated responses to food aromas in obese and normal-weight women
Eiler, W. J. A., Džemidžić, M., Case, K. R., Armstrong, C. L. H., Mattes, R. D., Cyders, M. A., Considine, R. V., & Kareken, D. A. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.080788 · Cited by 19 · see citing works
To What Extent Memory Could Contribute to Impaired Food Valuation and Choices in Obesity?
Zhang, Z., & Coppin, G. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.02523 · Cited by 16 · see citing works
Vugt, D. A. V., Krzemien, A. A., Alsaadi, H., Frank, T. C., & Reid, R. L. (2014) · Brain Research · doi:10.1016/j.brainres.2014.02.037 · Cited by 17 · see citing works
Wang, H., Chen, Y., Li, X., Wang, J., Zhou, Y., & Zhou, C. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00400 · Cited by 17 · see citing works
Zapparoli, L., Devoto, F., Giannini, G., Zonca, S., Gallo, F., & Paulesu, E. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103179 · Cited by 16 · see citing works
Neural Responsivity to Food Cues in Patients With Unmedicated First-Episode Psychosis
Borgan, F., O’Daly, O., Hoang, K., Veronese, M., Withers, D. J., Batterham, R. L., & Howes, O. D. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2018.6893 · Cited by 16 · see citing works
Kim, J., Lam, W., Wang, Q., Parikh, L., Elshafie, A., RANGEL, E. S., Schmidt, C., Li, F., Hwang, J. J., & Belfort‐DeAguiar, R. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00240 · Cited by 16 · see citing works
Shorter-lived neural taste representations in obese compared to lean individuals
Hardikar, S., Wallroth, R., Villringer, A., & Ohla, K. (2018) · Scientific Reports · doi:10.1038/s41598-018-28847-3 · Cited by 16 · see citing works
Thrifty-Eating Behavior Phenotype at the Food Court – Programming Goes Beyond Food Preferences
Molle, R. D., Filho, E. J. D. M., Minuzzi, L., Machado, T. D., Reis, R. S., Rodrigues, D. M., Mucellini, A. B., Franco, A. R., Buchweitz, A., Toazza, R., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.882532 · Cited by 14 · see citing works
More complex than you might think: Neural representations of food reward value in obesity
Pimpini, L., Kochs, S., Franssen, S., van den Hurk, J., Valente, G., Roebroeck, A. F., Jansen, A. T. M., & Roefs, A. (2022) · Appetite · doi:10.1016/j.appet.2022.106164 · Cited by 16 · see citing works
Dong, D., Wang, Y., Long, Z., Jackson, T., Chang, X., Zhou, F., & Chen, H. (2021) · Nutrients · doi:10.3390/nu13093221 · Cited by 14 · see citing works
What Twin Studies Tell Us About Brain Responses to Food Cues
Schur, E. A., & Carnell, S. (2017) · Current Obesity Reports · doi:10.1007/s13679-017-0282-7 · Cited by 13 · see citing works
Brain function predictors and outcome of weight loss and weight loss maintenance
Szabo‐Reed, A. N., Breslin, F. J., Lynch, A. M., Patrician, T. M., Martin, L. E., Lepping, R. J., Powell, J. N., Yeh, H., Befort, C. A., Sullivan, D. K., et al. (2014) · Contemporary Clinical Trials · doi:10.1016/j.cct.2014.12.008 · Cited by 13 · see citing works
Altered food liking in depression is driven by macronutrient composition
Thurn, L., Schulz, C., Borgmann, D., Klaus, J., Ellinger, S., Walter, M., & Kroemer, N. B. (2025) · Psychological Medicine · doi:10.1017/s0033291724003581 · Cited by 12 · see citing works
Devoto, F., Coricelli, C., Paulesu, E., & Zapparoli, L. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.954523 · Cited by 12 · see citing works
No evidence for an association between obesity and milkshake liking
Wall, K. M., Farruggia, M. C., Perszyk, E. E., Kanyamibwa, A., Fromm, S. P., Davis, X. S., Dalenberg, J. R., DiFeliceantonio, A. G., & Small, D. M. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-0583-x · Cited by 12 · see citing works
Reduced Neural Satiety Responses in Women Affected by Obesity
Gobbi, S., Weber, S. C., Graf, G., Hinz, D., Asarian, L., Geary, N., Leeners, B., Hare, T. A., & Tobler, P. N. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.07.022 · Cited by 11 · see citing works
Reinhardt, M., Parigi, A., Chen, K., Reiman, E. M., Thiyyagura, P., Krakoff, J. A., Hohenadel, M. G., Le, D. S. N. T., & Weise, C. M. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.75 · Cited by 11 · see citing works
Practical strategies to manage obesity in type 2 diabetes
Rodbard, H. W., Barnard-Kelly, K. D., Pfeiffer, A. F. H., Mauersberger, C., Schnell, O., & Giorgino, F. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15556 · Cited by 10 · see citing works
Vartanian, M., Jahanitabesh, A., Christensen, J. F., Staub, H., Jensen, D. E. A., Villringer, A., & Witte, A. V. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106301 · Cited by 9 · see citing works
- Authors
- Dimitropoulos, A., Tkach, J., Ho, A., & Kennedy, J.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Dimitropoulos, Anastasia
- Venue
- Appetite
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 58
- Issue
- 1
- Pages
- 303-312
- ISSN
- 0195-6663 (ISSN-L)
- PMC
- PMC3264811
- OpenAlex
- W1995809875
- Cited by
- 151
- References
- 44
- Citations by year
- 2025: 9 · 2024: 5 · 2023: 8 · 2022: 14 · 2021: 7 · 2020: 16 · 2019: 10 · 2018: 15 · 2017: 13 · 2016: 19 · 2015: 7 · 2014: 14 · 2013: 7 · 2012: 7
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Appetite (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r03hd058766-02)
- National Center for Research Resources (UL1RR024989)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R03 HD058766, R03HD058766-01)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- obesity, food cues, high-calorie foods, reward processing, lateral orbitofrontal cortex, caudate nucleus, anterior cingulate cortex, hunger, overweight adults
- MeSH terms
- Adolescent, Adult, Brain, Energy Intake, Cues, Eating, Female, Food, Humans, Hunger, Magnetic Resonance Imaging, Male, Obesity, Reward, Cluster Analysis, Young Adult
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