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Apamin administration impact on miR-219 and miR-155-3p expression in cuprizone induced multiple sclerosis model

Gholami, Samira, Mirian, Mina, Eftekhari, Seyed Mehdi, Aliomrani, Mehdi·2020·Molecular Biology Reports
DOI 10.1007/s11033-020-05959-6
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Abstract

Multiple sclerosis (MS) is a chronic debilitating disease that attacks the central nervous system. This study aims to investigate miR-219 and miR-155-3p expression levels involved in the myelination process following the administration of apamin peptide in the model of multiple sclerosis disease. Forty-four 8 week C57BL/6 male mice (22 ± 5 g) randomly divided into six groups. Apamin (100 µg/kg/BW) was administered intraperitoneally as a co-treatment during phase I (demyelination) or post-treatment phase II (remyelination) twice a week in cuprizone induced MS model. At the end of study myelin content and microRNA expression levels were measured with LFB staining and quantitative Real-Time PCR method, respectively. It was observed that the intended microRNAs were dysregulated during the different phases of disease induction. After 6 weeks of cuprizone exposure, miR-219 downregulated in phase I in comparison with the negative control. On the other hand, the apamin co-treatment significantly inhibit the miR-155-3p upregulation during the phase I as compared with the cuprizone group (p < 0.0001). Apamin has more impact on the miR155-3p reduction in phase I than miR-219 elevation in phase II. It could be considered as a therapeutic option for decreasing plaque formation during the exacerbation phase of the MS disease. Apamin has more impact on the miR155-3p reduction in phase I than miR-219 elevation in phase II. It could be considered as a therapeutic option for decreasing plaque…

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Metadata

Authors
Gholami, S., Mirian, M., Eftekhari, S. M., & Aliomrani, M.
Venue
Molecular Biology Reports
Publisher
Springer Science and Business Media LLC
Published
2020-11
Volume
47
Issue
11
Pages
9013-9019
ISSN
  • 0301-4851
  • 1573-4978
DOI
10.1007/s11033-020-05959-6
Cited by
16
References
3
Language
en
Licence
Funders
Isfahan University of Medical Sciences (297134)

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