Cited by 333Cholinesterase and Neurodegenerative DiseasesMedicinal Plants and NeuroprotectionPhytochemicals and Antioxidant Activities

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Comparative Study on the Inhibitory Effect of Caffeic and Chlorogenic Acids on Key Enzymes Linked to Alzheimer’s Disease and Some Pro-oxidant Induced Oxidative Stress in Rats’ Brain-In Vitro

Oboh, Ganiyu, Agunloye, Odunayo M., Akinyemi, Ayodele J., Ademiluyi, Adedayo O., Adefegha, Stephen A.·2013·Neurochemical Research

DOI 10.1007/s11064-012-0935-6

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Abstract

This study sought to investigate and compare the interaction of caffeic acid and chlorogenic acid on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and some pro-oxidants (FeSO(4), sodium nitroprusside and quinolinic acid) induced oxidative stress in rat brain in vitro. The result revealed that caffeic acid and chlorogenic acid inhibited AChE and BChE activities in dose-dependent manner; however, caffeic acid had a higher inhibitory effect on AChE and BChE activities than chlorogenic acid. Combination of the phenolic acids inhibited AChE and BChE activities antagonistically. Furthermore, pro-oxidants such as, FeSO(4), sodium nitroprusside and quinolinic acid caused increase in the malondialdehyde (MDA) contents of the brain which was significantly decreased dose-dependently by the phenolic acids. Inhibition of AChE and BChE activities slows down acetylcholine and butyrylcholine breakdown in the brain. Therefore, one possible mechanism through which the phenolic acids exert their neuroprotective properties is by inhibiting AChE and BChE activities as well as preventing oxidative stress-induced neurodegeneration. However, esterification of caffeic acid with quinic acid producing chlorogenic acid affects these neuroprotective properties.

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Authors: Oboh, G., Agunloye, O. M., Akinyemi, A. J., Ademiluyi, A. O., & Adefegha, S. A.
Affiliations: Federal University of Technology (NG)
Corresponding author: Oboh, Ganiyu
Akinyemi, Ayodele J.
ORCID: Oboh, Ganiyu
Agunloye, Odunayo M.
Akinyemi, Ayodele J.
Ademiluyi, Adedayo O.
Adefegha, Stephen A.
Venue: Neurochemical Research
Publisher: Springer Science and Business Media LLC
Published: 2012-11-27
Volume: 38
Issue: 2
Pages: 413-419
ISSN: 0364-3190 (ISSN-L)
1573-6903
DOI: 10.1007/s11064-012-0935-6
OpenAlex: W1973733191
Cited by: 333
References: 42
Citations by year: 2026: 12 · 2025: 19 · 2024: 38 · 2023: 39 · 2022: 43 · 2021: 32 · 2020: 37 · 2019: 19 · 2018: 20 · 2017: 25 · 2016: 21 · 2015: 17 · 2014: 7 · 2013: 4
FWCI: 6.57
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Neurochemical Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords: caffeic acid, chlorogenic acid, phenolic acids, acetylcholinesterase inhibition, butyrylcholinesterase inhibition, Alzheimer's disease, oxidative stress, pro-oxidants, malondialdehyde, neuroprotection, quinolinic acid, sodium nitroprusside, iron sulfate, brain
MeSH terms: Acetylcholinesterase, Alzheimer Disease, Animals, Brain, Butyrylcholinesterase, Caffeic Acids, Chlorogenic Acid, Cholinesterase Inhibitors, Male, Rats, Wistar, Reactive Oxygen Species, Oxidative Stress, Rats

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Comparative Study on the Inhibitory Effect of Caffeic and Chlorogenic Acids on Key Enzymes Linked to Alzheimer’s Disease and Some Pro-oxidant Induced Oxidative Stress in Rats’ Brain-In Vitro

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