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Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

Ohkawa, H., Ohishi, N., & Yagi, K. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90738-3 · Cited by 29,746

A new and rapid colorimetric determination of acetylcholinesterase activity

Ellman, G. L., Courtney, K. D., Andres, V., & Featherstone, R. M. (1961) · Biochemical Pharmacology · doi:10.1016/0006-2952(61)90145-9 · Cited by 27,221

Antioxidant activity applying an improved ABTS radical cation decolorization assay

Re, R., Pellegrini, N., Proteggente, A. R., Pannala, A. S., Yang, M. H., & Rice-Evans, C. A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00315-3 · Cited by 26,986

Structure-antioxidant activity relationships of flavonoids and phenolic acids

Rice-Evans, C. A., Miller, N. J., & Paganga, G. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02227-9 · Cited by 9,085

Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress

Butterfield, D. A., & Lauderback, C. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00794-3 · Cited by 1,013

Chlorogenic Acid and Caffeic Acid Are Absorbed in Humans

Olthof, M. R., Katan, M. B., & Hollman, P. C. H. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.1.66 · Cited by 975

Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS

Stone, T. W., & Perkins, M. N. (1981) · European Journal of Pharmacology · doi:10.1016/0014-2999(81)90587-2 · Cited by 751

The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal

Ferreira, A., Proença, C., Serralheiro, M. L. M., & Araújo, M. E. M. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.04.010 · Cited by 480

Alzheimer’s disease pathogenesis and therapeutic interventions

Parihar, M. S., & Hemnani, T. (2004) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2003.12.007 · Cited by 441

Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice

Kwon, S.-H., Lee, H.-K., Kim, J.-A., Hong, S.-I., Kim, H.-C., Jo, T.-H., Park, Y.-I., Lee, C.-K., Kim, Y.-B., Lee, S.-Y., et al. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.09.001 · Cited by 437

Adding New Scientific Evidences on the Pharmaceutical Properties of Pelargonium quercetorum Agnew Extracts by Using In Vitro and In Silico Approaches

Chiavaroli, A., Libero, M. L., Simone, S. C. D., Acquaviva, A., Nilofar, N., Recinella, L., Leone, S., Brunetti, L., Cicia, D., Izzo, A. A., et al. (2023) · Plants · doi:10.3390/plants12051132 · Cited by 35

Evaluation of Sacha Inchi (Plukenetia volubilis L.) By-Products as Valuable and Sustainable Sources of Health Benefits

Kittibunchakul, S., Hudthagosol, C., Sanporkha, P., Sapwarobol, S., Temviriyanukul, P., & Suttisansanee, U. (2022) · Horticulturae · doi:10.3390/horticulturae8040344 · Cited by 35

Establishment of a Rapid Micropropagation System for Kaempferia parviflora Wall. Ex Baker: Phytochemical Analysis of Leaf Extracts and Evaluation of Biological Activities

Park, H.-Y., Kim, K. S., Ak, G., Zengin, G., Cziáky, Z., Jekő, J., Kathalingam, A., Song, K., Kim, D.-H., & Sivanesan, I. (2021) · Plants · doi:10.3390/plants10040698 · Cited by 39

Comprehensive Review of Nutraceuticals against Cognitive Decline Associated with Alzheimer’s Disease

Reza-Zaldívar, E. E., & Jacobo‐Velázquez, D. A. (2023) · ACS Omega · doi:10.1021/acsomega.3c04855 · Cited by 39

Dietary supplementation with fermented legumes modulate hyperglycemia and acetylcholinesterase activities in Streptozotocin-induced diabetes

Ademiluyi, A. O., Oboh, G., Boligon, A. A., & Athayde, M. L. (2015) · Pathophysiology · doi:10.1016/j.pathophys.2015.08.003 · Cited by 34

UPLC-Orbitrap HRMS metabolic profiling of Cymbopogon citratus cultivated in Egypt; neuroprotective effect against AlCl3-induced neurotoxicity in rats

Madi, Y. F., Choucry, M. A., El‐Marasy, S. A., Meselhy, M. R., & El-Kashoury, E.-S. A. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112930 · Cited by 33

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Gevrenova, R., Zengin, G., Sinan, K. I., Zheleva‐Dimitrova, D., Balabanova, V., Kolmayer, M., Voynikov, Y., & Joubert, O. (2022) · Plants · doi:10.3390/plants12010022 · Cited by 33

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Budryn, G., Grzelczyk, J., Jaśkiewicz, A., Żyżelewicz, D., Pérez‐Sánchez, H., & Cerón‐Carrasco, J. P. (2018) · Food Research International · doi:10.1016/j.foodres.2018.04.041 · Cited by 34

Anti‐cholinesterase and antioxidant properties of alkaloid and phenolic‐rich extracts from pawpaw (Carica papaya) leaf: A comparative study

Adedayo, B. C., Oyeleye, S. I., Okeke, B. M., & Oboh, G. (2020) · Flavour and Fragrance Journal · doi:10.1002/ffj.3615 · Cited by 33

GC-MS Metabolic Profile and α-Glucosidase-, α-Amylase-, Lipase-, and Acetylcholinesterase-Inhibitory Activities of Eight Peach Varieties

Mihaylova, D. S., Desseva, I., Popova, A. T., Dincheva, I. N., Vrancheva, R. Z., Lante, A., & Krastanov, A. I. (2021) · Molecules · doi:10.3390/molecules26144183 · Cited by 32

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Barut, E. N., Barut, B., Engin, S., Yıldırım, S., Yaşar, A., Türkiş, S., Özel, A., & Sezen, F. S. (2017) · Turkish Journal of Biochemistry · doi:10.1515/tjb-2017-0084 · Cited by 31

Comparing the Neuroprotective Effects of Caffeic Acid in Rat Cortical Slices and Caenorhabditis elegans: Involvement of Nrf2 and SKN-1 Signaling Pathways

Colonnello, A., Aguilera, G., Rubio-López, L. C., Robles-Bañuelos, B., Rangel‐López, E., Cortez-Núñez, S., Evaristo-Priego, Y., Silva‐Palacios, A., Galván‐Arzate, S., García‐Contreras, R., et al. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-00133-8 · Cited by 31

Phytochemicals and In Vitro Bioactivities of Aqueous Ethanolic Extracts from Common Vegetables in Thai Food

Suttisansanee, U., Thiyajai, P., Chalermchaiwat, P., Wongwathanarat, K., Pruesapan, K., Charoenkiatkul, S., & Temviriyanukul, P. (2021) · Plants · doi:10.3390/plants10081563 · Cited by 36

Evidence for anti-inflammatory effects and modulation of neurotransmitter metabolism by Salvia officinalis L.

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Potential implications of polyphenolic compounds in neurodegenerative diseases

Shi, R., Gao, D., Stoika, R. S., Liu, K., Attila Gabor, S. I. K., & Jin, M. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2155106 · Cited by 33

Metabolomics Analysis of Different Tissues of Lonicera japonica Thunb. Based on Liquid Chromatography with Mass Spectrometry

Wang, Y., Li, L., Ji, W., Liu, S., Fan, J., Lu, H., & Wang, X. D. (2023) · Metabolites · doi:10.3390/metabo13020186 · Cited by 29

Chlorogenic acid alters the voltage-gated potassium channel currents of trigeminal ganglion neurons

Zhang, Y., Lu, X.-W., Song, N., Kou, L., Wu, M.-K., Liu, F., Wang, H., & Shen, J. (2014) · International Journal of Oral Science · doi:10.1038/ijos.2014.58 · Cited by 29

Neuroprotective Potential of Tamarillo (Cyphomandra betacea) Epicarp Extracts Obtained by Sustainable Extraction Process

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Evaluation of the chemical constituents, antioxidant and enzyme inhibitory activities of six Yemeni green coffee beans varieties

Ali, A. M. A., Yagi, S. M. A., Qahtan, A. A., Alatar, A. A., Angeloni, S., Maggi, F., Caprioli, G., Abdel-Salam, E. M., Sinan, K. I., & Zengin, G. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.101552 · Cited by 29

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Cholinesterase inhibitory activity, antioxidant properties, and phytochemical composition ofChlorococcumsp. extracts

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Phenolic content, antioxidant and enzyme inhibitory capacity of two Trametes species

Zengin, G., Karanfil, A., Uren, M. C., Kocak, M. S., Sarıkürkçü, C., Güngör, H., Picot, C. M. N., & Mahomoodally, M. F. (2016) · RSC Advances · doi:10.1039/c6ra09991b · Cited by 27

Antioxidant activity, acetylcholinesterase inhibitory potential and phytochemical analysis of Sarcocephalus latifolius Sm. bark used in traditional medicine in Sudan

Osama, A., Awadelkarim, S., & Ali, A. A. A. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-1772-6 · Cited by 28

Comprehensive bioactivity and chemical characterization of the endemic plant Scorzonera hieraciifolia Hayek extracts: A promising source of bioactive compounds

Dall’Acqua, S., Ak, G., Sut, S., Zengin, G., Yıldıztugay, E., Mahomoodally, M. F., Sinan, K. I., & Lobine, D. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109371 · Cited by 27

Blueberry ( Vaccinium virgatum ) Leaf Extracts Protect Against Aβ-Induced Cytotoxicity and Cognitive Impairment

Jeong, H. R., Jo, Y. N., Jeong, J. H., Kim, H. J., Kim, M.-J., & Heo, H. J. (2013) · Journal of Medicinal Food · doi:10.1089/jmf.2013.2881 · Cited by 26

Chromatographic Fingerprint Analysis, Acetylcholinesterase Inhibitory Properties and Antioxidant Activities of Redflower Ragleaf (C rassocephalum Crepidioides) Extract

Adefegha, S. A., Oboh, G., Molehin, O. R., Saliu, J. A., Athayde, M. L., & Boligon, A. A. (2015) · Journal of Food Biochemistry · doi:10.1111/jfbc.12200 · Cited by 26

Green and roasted coffee extracts as antioxidants in βTC3 cells with induced oxidative stress and lipid accumulation inhibitors in 3T3L1 cells, and their bioactivity in rats fed high fat diet

Budryn, G., Zakłos‐Szyda, M., Zaczyńska, D., Żyżelewicz, D., Grzelczyk, J., Zduńczyk, Z., & Juśkiewicz, J. (2017) · European Food Research and Technology · doi:10.1007/s00217-017-2843-0 · Cited by 26

Antioxidant, antimicrobial and neuroprotective effects of Octaviania asterosperma in vitro

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Antioxidant and cognitive-enhancing activities of Arctium lappa L. roots in Aβ1-42-induced mouse model

Kwon, Y. K., Choi, S. J., Kim, C. R., Kim, J. K., Kim, Y., Choi, J. H., Song, S.-W., Kim, C., Park, G. G., Park, C., et al. (2016) · Applied Biological Chemistry · doi:10.1007/s13765-016-0195-2 · Cited by 26

Fluted pumpkin ( Telfairia occidentalis ) seed modulates some markers of erectile function in isolated rat’s corpus cavernosum: Influence of polyphenol and amino acid constituents

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Optimizing health benefits of walnut (Juglans regia L.) agricultural by-products: Impact of maceration and Soxhlet extraction methods on phytochemical composition, enzyme inhibition, antioxidant, antimicrobial, and cytotoxic activities

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In vitro multimodal-effect of Trichilia catigua A. Juss. (Meliaceae) bark aqueous extract in CNS targets

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Caffeic acid improves memory impairment and brain glucose metabolism via ameliorating cerebral insulin and leptin signaling pathways in high-fat diet-induced hyperinsulinemic rats

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Morus alba fruit diet ameliorates cognitive deficit in mouse model of streptozotocin-induced memory impairment

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Selected Micronutrients in Cognitive Decline Prevention and Therapy

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Neuroprotective effects of some seaweeds against Zn – induced neuronal damage in HT-22 cells via modulation of redox imbalance, inhibition of apoptosis and acetylcholinesterase activity

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Quantification of Major Bioactive Constituents, Antioxidant Activity, and Enzyme Inhibitory Effects of Whole Coffee Cherries (Coffea arabica) and Their Extracts

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Zengin, G., Ak, G., Ceylan, R., Uysal, Ş., Llorent-Martínez, E. J., Simone, S. C. D., Rapino, M., Acquaviva, A., Libero, M. L., Chiavaroli, A., et al. (2022) · Plants · doi:10.3390/plants11020233 · Cited by 23

Sources for developing new medicinal products: biochemical investigations on alcoholic extracts obtained from aerial parts of some Romanian Amaryllidaceae species

Benedec, D., Oniga, I., Hanganu, D., Vlase, A.-M., Pușcaș, C., Silaghi-Dumitrescu, R. L., Duma, M. N., Tiperciuc, B., Vârban, R., & Vlase, L. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2292-8 · Cited by 23

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Sorghum stem extract modulates Na+/K+-ATPase, ecto-5′-nucleotidase, and acetylcholinesterase activities

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Phenolic profile, enzyme inhibition and antioxidant activities and bioinformatics analysis of leaf and stem bark of Ficus sycomorus L.

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Anticholinesterase and Antioxidative Properties of Aqueous Extract of Cola acuminata Seed In Vitro

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Neuroprotective Effect of Chlorogenic Acids against Alzheimer’s Disease

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In vitro anticholinergic and antiglycaemic properties of frost-hardy Actinidia fruit extracts and their polyphenol profile, L-ascorbic acid content and antioxidant capacity

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Regulation of chlorogenic acid, flavonoid, and iridoid biosynthesis by histone H3K4 and H3K9 methylation in Lonicera japonica

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Effects of chlorogenic acid on adenine nucleotides hydrolyzing enzyme activities and expression in platelets of rats experimentally demyelinated with ethidium bromide

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Modulatory effects of stonebreaker (Phyllanthus amarus) and bitter gourd (Momordica charantia) on enzymes linked with cardiac function in heart tissue of doxorubicin-stressed rats

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Coffee induces vascular endothelial growth factor (VEGF) expression in human neuroblastama SH-SY5Y cells

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