Effects of Ashwagandha (Roots of Withania somnifera) on Neurodegenerative Diseases

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

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Regeneration beyond the glial scar

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Glial inhibition of CNS axon regeneration

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Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

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Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes

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Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

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LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms

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Neuropathology of Alzheimer's Disease

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GDNF signalling through the Ret receptor tyrosine kinase

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Functional receptor for GDNF encoded by the c-ret proto-oncogene

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Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review.

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Regeneration of adult axons in white matter tracts of the central nervous system

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The validity of scopolamine as a pharmacological model for cognitive impairment: A review of animal behavioral studies

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Amyloid β-Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

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Ayurvedic Drugs and Their Plant Sources

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DEGRADATION OF GINSENOSIDES IN HUMANS AFTER ORAL ADMINISTRATION

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Withania somnifera: an Indian ginseng

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<i>Withania somnifera</i> reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver

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Neuritic regeneration and synaptic reconstruction induced by withanolide A

Kuboyama, T., Tohda, C., & Komatsu, K. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706122 · Cited by 339 · see citing works

The morphological phenotype of β-amyloid plaques and associated neuritic changes in Alzheimer’s disease

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Studies on the Development and Behavior of the Dystrophic Growth Cone, the Hallmark of Regeneration Failure, in anIn VitroModel of the Glial Scar and after Spinal Cord Injury

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The Low Density Lipoprotein Receptor-related Protein (LRP) Is a Novel β-Secretase (BACE1) Substrate

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Molecular insight in the multifunctional activities of Withaferin A

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Neuroprotective effects of Withania somnifera on 6-hydroxydopamine induced Parkinsonism in rats

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Axonal degeneration in Alzheimer's disease: When signaling abnormalities meet the axonal transport system

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Withanolide Derivatives from the Roots of Withania somnifera and Their Neurite Outgrowth Activities.

Zhao, J., Nakamura, N., Hattori, M., Kuboyama, T., Tohda, C., & Komatsu, K. (2002) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.50.760 · Cited by 194 · see citing works

Protective Role of Ashwagandha Leaf Extract and Its Component Withanone on Scopolamine-Induced Changes in the Brain and Brain-Derived Cells

Konar, A., Shah, N., Singh, R., Saxena, N., Kaul, S. C., Wadhwa, R., & Thakur, M. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027265 · Cited by 193 · see citing works

Selective Killing of Cancer Cells by Leaf Extract of Ashwagandha: Identification of a Tumor-Inhibitory Factor and the First Molecular Insights to Its Effect

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Withanoside IV and its active metabolite, sominone, attenuate Aβ(25–35)‐induced neurodegeneration

Kuboyama, T., Tohda, C., & Komatsu, K. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04664.x · Cited by 171 · see citing works

Spinal Cord Injury Elicits Expression of Keratan Sulfate Proteoglycans by Macrophages, Reactive Microglia, and Oligodendrocyte Progenitors

Jones, L. L., & Tuszynski, M. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04611.2002 · Cited by 163 · see citing works

Withania somnifera root extract improves catecholamines and physiological abnormalities seen in a Parkinson's disease model mouse

Rajasankar, S., Manivasagam, T., Venkatachalam, S., Prakash, S., Muthusamy, R., Krishnamurti, A., & Surendran, S. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.08.003 · Cited by 161 · see citing works

Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha

Kuboyama, T., Tohda, C., Zhao, J., Nakamura, N., Hattori, M., & Komatsu, K. (2002) · Neuroreport · doi:10.1097/00001756-200210070-00005 · Cited by 146 · see citing works

Ashwagandha leaf extract: A potential agent in treating oxidative damage and physiological abnormalities seen in a mouse model of Parkinson's disease

Rajasankar, S., Manivasagam, T., & Surendran, S. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.02.044 · Cited by 140 · see citing works

Molecular Targets and Mechanisms of Cancer Prevention and Treatment by Withaferin A, A Naturally Occurring Steroidal Lactone

Vyas, A. R., & Singh, S. V. (2013) · The AAPS Journal · doi:10.1208/s12248-013-9531-1 · Cited by 132 · see citing works

Antitumor and Radiosensitizing Effects of Withaferin a on Mouse Ehrlich Ascites Carcinoma in vivo

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Neuroprotective role of Withania somnifera root extract in maneb-paraquat induced mouse model of parkinsonism

Prakash, J., Yadav, S. K., Chouhan, S., & Singh, S. P. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1005-4 · Cited by 128 · see citing works

Differential Activities of the Two Closely Related Withanolides, Withaferin A and Withanone: Bioinformatics and Experimental Evidences

Vaishnavi, K. S., Saxena, N., Shah, N., Singh, R., Manjunath, K., Uthayakumar, M., Kanaujia, S. P., Kaul, S. C., Sekar, K., & Wadhwa, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044419 · Cited by 128 · see citing works

Possible Neuroprotective Effect of <i>Withania somnifera</i> Root Extract Against 3-Nitropropionic Acid-Induced Behavioral, Biochemical, and Mitochondrial Dysfunction in an Animal Model of Huntington's Disease

Kumar, P., & Kumar, A. (2009) · Journal of Medicinal Food · doi:10.1089/jmf.2008.0028 · Cited by 120 · see citing works

The neuroprotective effect of Withania somnifera root extract in MPTP-intoxicated mice: An analysis of behavioral and biochemical varibles

Sankar, S. R., Manivasagam, T., Krishnamurti, A., & Ramanathan, M. (2007) · Cellular & Molecular Biology Letters · doi:10.2478/s11658-007-0015-0 · Cited by 119 · see citing works

Ashwagandha (Withania somnifera) Reverses β-Amyloid1-42 Induced Toxicity in Human Neuronal Cells: Implications in HIV-Associated Neurocognitive Disorders (HAND)

Kurapati, K. R. V., Atluri, V., Samikkannu, T., & Nair, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077624 · Cited by 117 · see citing works

Dendrite extension by methanol extract of Ashwagandha (roots of Withania somnifera) in SK-N-SH cells

Tohda, C., Kuboyama, T., & Komatsu, K. (2000) · Neuroreport · doi:10.1097/00001756-200006260-00035 · Cited by 109 · see citing works

Acute and Sub‐Acute Oral Toxicity Assessment of the Hydroalcoholic Extract of Withania somnifera Roots in Wistar Rats

Prabu, P. C., Panchapakesan, S., & Raj, C. D. (2012) · Phytotherapy Research · doi:10.1002/ptr.4854 · Cited by 104 · see citing works

Intestinal bacterial hydrolysis is indispensable to absorption of 18β-glycyrrhetic acid after oral administration of glycyrrhizin in rats

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Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase

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Keratan Sulfate Restricts Neural Plasticity after Spinal Cord Injury

Imagama, S., Sakamoto, K., Tauchi, R., Shinjo, R., Ohgomori, T., Ito, Z., Zhang, H. M., Nishida, Y., Asami, N., Takeshita, S., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5120-10.2011 · Cited by 98 · see citing works

Withanolide A and Asiatic Acid Modulate Multiple Targets Associated with Amyloid-β Precursor Protein Processing and Amyloid-β Protein Clearance

Patil, S. P., Maki, S., Khedkar, S. A., Rigby, A. C., & Chan, C. (2010) · Journal of Natural Products · doi:10.1021/np900633j · Cited by 91 · see citing works

Withania Somnifera(Ashwagandha), a Rejuvenating Herbal Drug Which Enhances Survival During Stress (an Adaptogen)

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Differential gene expression of scopolamine-treated rat hippocampus-application of cDNA microarray technology

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Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and Presenilin

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Sominone enhances neurite outgrowth and spatial memory mediated by the neurotrophic factor receptor, RET

Tohda, C., & Joyashiki, E. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00313.x · Cited by 62 · see citing works

Toxicity of Withania Somnifera Root Extract in Rats and Mice

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A novel compound, denosomin, ameliorates spinal cord injury via axonal growth associated with astrocyte‐secreted vimentin

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Synthesis of Sominone and Its Derivatives Based on an RCM Strategy: Discovery of A Novel Anti-Alzheimer’s Disease Medicine Candidate “Denosomin”

Matsuya, Y., Yamakawa, Y.-I., Tohda, C., Teshigawara, K., Yamada, M., & Nemoto, H. (2009) · Organic Letters · doi:10.1021/ol901553w · Cited by 38 · see citing works

Sominone Improves Memory Impairments and Increases Axonal Density in Alzheimer's Disease Model Mice, 5XFAD

Joyashiki, E., Matsuya, Y., & Tohda, C. (2011) · International Journal of Neuroscience · doi:10.3109/00207454.2010.541571 · Cited by 37 · see citing works

Scientific basis for the anti-dementia drugs of constituents from Ashwagandha (Withania somnifera)(Chemical & Pharmacological study)

Tohda, C., Komatsu, K., & Kuboyama, T. (2005) · Institutional Repositories DataBase (IRDB) · Cited by 14 · see citing works

Withanoside IV improves hindlimb function by facilitating axonal growth and increase in peripheral nervous system myelin level after spinal cord injury

Nakayama, N., & Tohda, C. (2007) · Neuroscience Research · doi:10.1016/j.neures.2007.02.014 · Cited by 14 · see citing works

Pharmacologic overview of Withania somnifera, the Indian Ginseng

Dar, N. J., Hamid, A., & Ahmad, M. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2012-1 · Cited by 391 · see citing works

Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects

Paul, S., Chakraborty, S., Anand, U., Dey, S., Nandy, S., Ghorai, M., Saha, S. C., Patil, M. T., Kandimalla, R., Proćków, J., et al. (2021) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2021.112175 · Cited by 306 · see citing works

Effects of Withania somnifera (Ashwagandha) on Stress and the Stress- Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia

Speers, A. B., Cabey, K., Soumyanath, A., & Wright, K. M. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210712151556 · Cited by 242 · see citing works

Efficacy and Safety of Ashwagandha ( <i>Withania somnifera</i> (L.) <i>Dunal</i> ) Root Extract in Improving Memory and Cognitive Functions

Choudhary, D., Bhattacharyya, S., & Bose, S. (2017) · Journal of Dietary Supplements · doi:10.1080/19390211.2017.1284970 · Cited by 215 · see citing works

Dysfunction of the Microbiota-Gut-Brain Axis in Neurodegenerative Disease: The Promise of Therapeutic Modulation With Prebiotics, Medicinal Herbs, Probiotics, and Synbiotics

Peterson, C. T. (2020) · Journal of Evidence-Based Integrative Medicine · doi:10.1177/2515690x20957225 · Cited by 160 · see citing works

Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study

Salve, J., Pate, S., Debnath, K., & Langade, D. (2019) · Cureus · doi:10.7759/cureus.6466 · Cited by 150 · see citing works

Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspects

Mandlik, D. S., & Namdeo, A. G. (2020) · Journal of Dietary Supplements · doi:10.1080/19390211.2020.1741484 · Cited by 149 · see citing works

Ayurvedic Medicine for the Treatment of Dementia: Mechanistic Aspects

Farooqui, A. A., Farooqui, T., Madan, A., Ong, J. H.-J., & Ong, W. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/2481076 · Cited by 143 · see citing works

Ashwagandha in brain disorders: A review of recent developments

Zahiruddin, S., Basist, P., Parveen, A., Parveen, R., Khan, W., Gaurav, G., & Ahmad, S. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112876 · Cited by 150 · see citing works

Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology

Panossian, A., Seo, E.-J., & Efferth, T. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.09.204 · Cited by 127 · see citing works

Neurodegenerative diseases and Withania somnifera (L.): An update

Dar, N. J., & Ahmad, M. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112769 · Cited by 123 · see citing works

Anticancer activities ofWithania somnifera: Current research, formulations, and future perspectives

Rai, M., Jogee, P. S., Agarkar, G., & dos Santos, C. A. (2015) · Pharmaceutical Biology · doi:10.3109/13880209.2015.1027778 · Cited by 121 · see citing works

Role of Withania somnifera (Ashwagandha) in the management of male infertility

Sengupta, P., Agarwal, A. K., Pogrebetskaya, M., Roychoudhury, S., Durairajanayagam, D., & Henkel, R. (2017) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2017.11.007 · Cited by 120 · see citing works

An updated review on phytochemistry and molecular targets of Withania somnifera (L.) Dunal (Ashwagandha)

Bashir, A., Nabi, M., Tabassum, N., Afzal, S., & Ayoub, M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1049334 · Cited by 103 · see citing works

Withania somnifera and Its Withanolides Attenuate Oxidative and Inflammatory Responses and Up-Regulate Antioxidant Responses in BV-2 Microglial Cells

Sun, G. Y., Li, R., Cui, J., Hannink, M., Gu, Z., Fritsche, K. L., Lubahn, D. B., & Simonyi, A. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-016-8411-0 · Cited by 95 · see citing works

Investigating 11 Withanosides and Withanolides by UHPLC–PDA and Mass Fragmentation Studies from Ashwagandha ( Withania somnifera )

Girme, A., Saste, G., Pawar, S., Balasubramaniam, A. K., Musande, K., Darji, B., Satti, N. K., Verma, M. K., Anand, R., Singh, R., et al. (2020) · ACS Omega · doi:10.1021/acsomega.0c03266 · Cited by 78 · see citing works

Direct evidence for GABAergic activity of Withania somnifera on mammalian ionotropic GABAA and GABAρ receptors

Candelario, M., Cuellar, E., Reyes‐Ruiz, J. M., Darabedian, N., Zhou, F., Miledi, R., Russo‐Neustadt, A. A., & Limón, A. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.05.058 · Cited by 78 · see citing works

Review on anticancerous therapeutic potential of Withania somnifera (L.) Dunal

Singh, N., Yadav, S. S., Rao, A. S., Nandal, A., Kumar, S., Ganaie, S. A., & Narasihman, B. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113704 · Cited by 77 · see citing works

Role of Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives

Das, R. C., Rauf, A., Akhter, S., Islam, M. N., Emran, T. B., Mitra, S., Khan, I. N., & Mubarak, M. S. (2021) · Molecules · doi:10.3390/molecules26123696 · Cited by 79 · see citing works

A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults

Tiwari, S., Gupta, S. K., & Pathak, A. K. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.113929 · Cited by 64 · see citing works

Protective effects of Withania somnifera extract in SOD1G93A mouse model of amyotrophic lateral sclerosis

Dutta, K., Patel, P., & Julien, J.-P. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.08.008 · Cited by 56 · see citing works

Cancer Metabolism as a Therapeutic Target and Review of Interventions

Halma, M. T. J., Tuszyński, J. A., & Marik, P. E. (2023) · Nutrients · doi:10.3390/nu15194245 · Cited by 55 · see citing works

Effects of Ashwagandha (Withania somnifera) on VO2max: A Systematic Review and Meta-Analysis

Pérez‐Gómez, J., Villafaina, S., Adsuar, J. C., Merellano-Navarro, E., & Collado‐Mateo, D. (2020) · Nutrients · doi:10.3390/nu12041119 · Cited by 69 · see citing works

Effect of an ashwagandha ( Withania Somnifera ) root extract on climacteric symptoms in women during perimenopause: A randomized, double‐blind , placebo‐controlled study

Gopal, S., Ajgaonkar, A., Kanchi, P., Kaundinya, A. P., Thakare, V., Chauhan, S., & Langade, D. (2021) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.15030 · Cited by 53 · see citing works

Recent Advancements in Extraction Techniques of Ashwagandha ( Withania somnifera ) with Insights on Phytochemicals, Structural Significance, Pharmacology, and Current Trends in Food Applications

Shinde, S., Balasubramaniam, A. K., Mulay, V. P., Saste, G., Girme, A., & Hingorani, L. (2023) · ACS Omega · doi:10.1021/acsomega.3c03491 · Cited by 53 · see citing works

Effects of anti-inflammatory and adaptogenic herbal extracts on gene expression of eicosanoids signaling pathways in isolated brain cells

Panossian, A. G., Seo, E., & Efferth, T. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.152881 · Cited by 53 · see citing works

Withania somnifera Reverses Transactive Response DNA Binding Protein 43 Proteinopathy in a Mouse Model of Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration

Dutta, K., Patel, P., Rahimian, R., Phaneuf, D., & Julien, J. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0499-2 · Cited by 51 · see citing works

M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera

Konar, A., Gupta, R., Shukla, R. K., Maloney, B., Khanna, V. K., Wadhwa, R., Lahiri, D. K., & Thakur, M. K. (2019) · Scientific Reports · doi:10.1038/s41598-019-48238-6 · Cited by 53 · see citing works

Anti-amyloidogenic and anti-apoptotic effect of α-bisabolol against Aβ induced neurotoxicity in PC12 cells

Shanmuganathan, B., Suryanarayanan, V., Sathya, S., Narenkumar, M., Singh, S. K., Kandasamy, R., & Devi, K. P. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.10.017 · Cited by 49 · see citing works

Computational investigation of phytochemicals from Withania somnifera (Indian ginseng/ashwagandha) as plausible inhibitors of GluN2B-containing NMDA receptors

Ahmad, I., Kumar, D., & Patel, H. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2021.1905553 · Cited by 49 · see citing works

Super Critical Fluid Extracted Fatty Acids from Withania somnifera Seeds Repair Psoriasis-Like Skin Lesions and Attenuate Pro-Inflammatory Cytokines (TNF-α and IL-6) Release

Balkrishna, A., Nain, P., Chauhan, A., Sharma, N., Gupta, A., Ranjan, R., & Varshney, A. (2020) · Biomolecules · doi:10.3390/biom10020185 · Cited by 48 · see citing works

Neuroprotection with Bacopa monnieri–A review of experimental evidence

Shalini, V. T., Sajjanar, N. J., & Sriranjini, J. S. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06236-w · Cited by 51 · see citing works

Withaferin A protects against high-fat diet-induced obesity via attenuation of oxidative stress, inflammation, and insulin resistance

Abu Bakar, M. H., Azmi, M. N., Shariff, K. A., & Tan, J. S. (2019) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-018-2920-2 · Cited by 47 · see citing works

Novel Methods to Generate Active Ingredients-Enriched Ashwagandha Leaves and Extracts

Kaul, S. C., Ishida, Y., Tamura, K., Wada, T., Iitsuka, T., Garg, S., Kim, M., Gao, R., Nakai, S., Okamoto, Y., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166945 · Cited by 45 · see citing works

Nootropic potential of Ashwagandha leaves: Beyond traditional root extracts

Wadhwa, R., Konar, A., & Kaul, S. C. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.09.001 · Cited by 43 · see citing works

Therapeutic Potential of Different Natural Products for the Treatment of Alzheimer’s Disease

Chakraborty, B., Mukerjee, N., Maitra, S., Zehravi, M., Mukherjee, D., Ghosh, A., Massoud, E. E. S., & Rahman, M. H. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6873874 · Cited by 42 · see citing works

Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease

Wang, S., Kong, X., Chen, Z., Wang, G., Zhang, J., & Wang, J. (2022) · Molecules · doi:10.3390/molecules27134175 · Cited by 36 · see citing works

Authentication of the market samples of Ashwagandha by DNA barcoding reveals that powders are significantly more adulterated than roots

Amritha, N., Bhooma, V., & Parani, M. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112725 · Cited by 35 · see citing works

Withaferin A Induces Heat Shock Response and Ameliorates Disease Progression in a Mouse Model of Huntington’s Disease

Joshi, T., Kumar, V., Kaznacheyeva, E. V., & Jana, N. R. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02397-8 · Cited by 34 · see citing works

Withania somnifera - a magic plant targeting multiple pathways in cancer related inflammation

Kumar, P., Sharma, R., & Garg, N. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154137 · Cited by 37 · see citing works

Functional and Morphological Correlates in the Drosophila LRRK2 loss-of-function Model of Parkinson’s Disease: Drug Effects of Withania somnifera (Dunal) Administration

Rose, F. D., Marotta, R., Poddighe, S., Talani, G., Catelani, T., Setzu, M. D., Solla, P., Marrosu, F., Sanna, E., Kasture, S. B., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146140 · Cited by 31 · see citing works

Combined Ubisol-Q10 and Ashwagandha Root Extract Target Multiple Biochemical Mechanisms and Reduces Neurodegeneration in a Paraquat-Induced Rat Model of Parkinson’s Disease

Vegh, C., Wear, D., Okaj, I., Huggard, R., Culmone, L., Eren, Ş., Cohen, J. S., Rishi, A. K., & Pandey, S. (2021) · Antioxidants · doi:10.3390/antiox10040563 · Cited by 29 · see citing works

Emerging Vistas for the Nutraceutical Withania somnifera in Inflammaging

Basudkar, V., Gujrati, G., Ajgaonkar, S., Gandhi, M., Mehta, D. S., & Nair, S. (2024) · Pharmaceuticals · doi:10.3390/ph17050597 · Cited by 31 · see citing works

Effect of Ashwagandha Withanolides on Muscle Cell Differentiation

Wang, J., Zhang, H., Kaul, A., Li, K., Priyandoko, D., Kaul, S. C., & Wadhwa, R. (2021) · Biomolecules · doi:10.3390/biom11101454 · Cited by 30 · see citing works

Withaferin A alleviates traumatic brain injury induced secondary brain injury via suppressing apoptosis in endothelia cells and modulating activation in the microglia

Zhou, Z., Xiang, W., Jiang, Y., Tian, N., Wei, Z., Wen, X., Wang, W., Liao, W., Xia, X., Li, Q., et al. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.172988 · Cited by 25 · see citing works

Phytochemical Genomics of Ashwagandha

Sangwan, N. S., Tripathi, S., Srivastava, Y., Mishra, B., & Pandey, N. (2017) · Springer eBooks · doi:10.1007/978-3-319-59192-6_1 · Cited by 25 · see citing works

Complementary and alternative medicine for treating amyotrophic lateral sclerosis: a narrative review

Cai, M., & Yang, E. J. (2019) · Integrative Medicine Research · doi:10.1016/j.imr.2019.08.003 · Cited by 24 · see citing works

Network pharmacological evaluation of Withania somnifera bioactive phytochemicals for identifying novel potential inhibitors against neurodegenerative disorder

Pahal, S., Gupta, A., Choudhary, P., Chaudhary, A., & Singh, S. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2021.1951355 · Cited by 24 · see citing works

Withania somnifera root powder protects againist post-traumatic stress disorder-induced memory impairment

Alzoubi, K. H., Hilo, A. S. A., Al-Balas, Q. A., El‐Salem, K., El‐Elimat, T., & Alali, F. Q. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-04915-3 · Cited by 22 · see citing works

Differential effects of phytotherapic preparations in the hSOD1 Drosophila melanogaster model of ALS

Rose, F. D., Marotta, R., Talani, G., Catelani, T., Solari, P., Poddighe, S., Borghero, G., Marrosu, F., Sanna, E., Kasture, S. B., et al. (2017) · Scientific Reports · doi:10.1038/srep41059 · Cited by 22 · see citing works

Nature’s Derivative(s) as Alternative Anti-Alzheimer’s Disease Treatments

Sharma, A., & Kumar, Y. (2019) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-190137 · Cited by 20 · see citing works

Withania somnifera Extract Protects Model Neurons from In Vitro Traumatic Injury

Saykally, J. N., Hatic, H., Keeley, K. L., Jain, S. C., Ravindranath, V., & Citron, B. A. (2017) · Cell Transplantation · doi:10.1177/0963689717714320 · Cited by 24 · see citing works

Solid Lipid Nanoparticles Containing Morin: Preparation, Characterization, and Ex Vivo Permeation Studies

Gaetano, F. D., Celesti, C., Paladini, G., Venuti, V., Cristiano, M. C., Paolino, D., Iannazzo, D., Strano, V., Gueli, A. M., Tommasini, S., et al. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061605 · Cited by 19 · see citing works

Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson’s Disease

Singla, R. K., Agarwal, T., He, X., & Shen, B. (2020) · Current Drug Targets · doi:10.2174/1389450121999201013155202 · Cited by 19 · see citing works

The standardized Withania somnifera Dunal root extract alters basal and morphine-induced opioid receptor gene expression changes in neuroblastoma cells

Caputi, F. F., Acquas, E., Kasture, S. B., Ruiu, S., Candeletti, S., & Romualdi, P. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-2065-9 · Cited by 19 · see citing works

Liquid chromatography-mass spectrometry quantification of phytochemicals in Withania somnifera using data-dependent acquisition, multiple-reaction-monitoring, and parallel-reaction-monitoring with an inclusion list

Marney, L. C., Choi, J., Magaña, A. A., Yang, L., Techen, N., Alam, M. N., Brandes, M. S., Soumyanath, A., Stevens, J. F., & Maier, C. S. (2024) · Frontiers in Chemistry · doi:10.3389/fchem.2024.1373535 · Cited by 16 · see citing works

Withania somnifera (Ashwagandha) Improves Spatial Memory, Anxiety and Depressive-like Behavior in the 5xFAD Mouse Model of Alzheimer’s Disease

Gladen-Kolarsky, N., Monestime, O., Bollen, M., Choi, J., Yang, L., Magaña, A. A., Maier, C. S., Soumyanath, A., & Gray, N. E. (2024) · Antioxidants · doi:10.3390/antiox13101164 · Cited by 16 · see citing works

Rosiglitazone Ameliorates Spinal Cord Injury via Inhibiting Mitophagy and Inflammation of Neural Stem Cells

Meng, Q., Chen, Z., Gao, Q., Hu, L., Li, Q., Li, S., Cui, L., Feng, Z., Zhang, X., Cui, S., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5583512 · Cited by 15 · see citing works

Over the Counter Supplements for Memory: A Review of Available Evidence

Hersant, H., He, S., Maliha, P., & Grossberg, G. T. (2023) · CNS Drugs · doi:10.1007/s40263-023-01031-6 · Cited by 16 · see citing works

Spinocerebellar ataxia: Functional analysis of the stomatognathic system

Ferreira, B., Palinkas, M., Gonçalves, L. M. N., da Silva, G., Arnoni, V. W., Regalo, I. H., de Vasconcelos, P. B., Junior, W., Hallak, J. E. C., Regalo, S. C. H., et al. (2019) · Medicina oral, patología oral y cirugía bucal · doi:10.4317/medoral.22839 · Cited by 14 · see citing works

Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary Tumors

Singh, K. B., Hahm, E., Kim, S., & Singh, S. V. (2022) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-22-0193 · Cited by 13 · see citing works

Triphala inhibits alpha-synuclein fibrillization and their interaction study by NMR provides insights into the self-association of the protein

Bopardikar, M., Bhattacharya, A., Kakita, V. M. R., Rachineni, K., Borde, L. C., Choudhary, S., Ainavarapu, S. R. K., & Hosur, R. V. (2019) · RSC Advances · doi:10.1039/c9ra05551g · Cited by 13 · see citing works

Phytopharmacology of Ashwagandha as an Anti-Diabetic Herb

Kumar, V., Dey, A., & Chatterjee, S. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-59192-6_2 · Cited by 12 · see citing works

Withaferin-A Protects the Nigral Dopamine Neuron and Recovers Motor Activity in Aged Rats

Banu, M. R., Ibrahim, M., Prabhu, K., & Rajasankar, S. (2019) · Cells Tissues Organs · doi:10.1159/000505183 · Cited by 12 · see citing works

Endophytic fungi: a potential source for drugs against central nervous system disorders

Pant, A., & Vasundhara, M. (2023) · Brazilian Journal of Microbiology · doi:10.1007/s42770-023-00997-1 · Cited by 10 · see citing works

A Comprehensive Review of Therapeutic Compounds from Plants forNeurodegenerative Diseases

Panneerselvam, D. S., Kanakaraja, A., Sakthivelu, M., Gopinath, S. C. B., & Pachaiappan, R. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673272435231204072922 · Cited by 10 · see citing works

Anti-amnesic effects of withaferin A, a steroidal lactone isolated from Withania adpressa, on scopolamine-induced memory impairment in mice

Bakrim, W. B., Bouzidi, L. E., Manouze, H., Hafsa, J., Sobeh, M., Ba-M’hamed, S., Bekkouche, K., & Kouisni, L. (2021) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2021.103529 · Cited by 10 · see citing works

Viscosalactone B, a natural LSD1 inhibitor, inhibits proliferation in vitro and in vivo against prostate cancer cells

Yan, G., Zhang, H., Li, Y., Miao, G., Liu, X., & Lv, Q. (2023) · Investigational New Drugs · doi:10.1007/s10637-023-01330-1 · Cited by 9 · see citing works

Role of Withania somnifera (Ashwagandha) in the Treatment of Neurological Disorders

Sharma, S. (2022) · Current Nutrition & Food Science · doi:10.2174/1573401318666220415084108 · Cited by 8 · see citing works

Identification of natural inhibitor against L1 β-lactamase present in Stenotrophomonas maltophilia

Sreenithya, K. H., Jade, D., Harrison, M. A., & Sugumar, S. (2022) · Journal of Molecular Modeling · doi:10.1007/s00894-022-05336-z · Cited by 8 · see citing works

The Effect of Withania somnifera Extract on Drug Resistant Strains of Escherichia coli

Bokaeian, M., Fakheri, B. A., Nejad, N. M., Zarei, H., Saeidi, S., & Mohasseli, T. (2015) · International Journal of Infection · doi:10.17795/iji-23036 · Cited by 8 · see citing works

Neuroprotective Effect of Withaferin Derivatives toward MPP+ and 6-OHDA Toxicity to Dopaminergic Neurons

Parrales, V., Arcile, G., Laserre, L., Normant, S., Goff, G. L., Noble, C. D. C., Ouazzani, J., Callizot, N., Haı̈k, S., Rabhi, C., et al. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00655 · Cited by 7 · see citing works

In silico evaluations of phytochemicals from Withania somnifera exhibiting anticancer activity against NAD[P]H-quinone oxidoreductase

Jahagirdar, S., Kumar, H. V. A., Bhat, S. S., Poddar, A., Chattaraj, P. K., Ahmad, S. F., & Prasad, S. K. (2024) · Human & Experimental Toxicology · doi:10.1177/09603271241291399 · Cited by 7 · see citing works

Riluzole Promotes Neurite Growth in Rats after Spinal Cord Injury through the GSK-3β/CRMP-2 Pathway

Xu, S., Wu, Q., Zhang, W., Liu, T., Zhang, Y., Zhang, W., Zhang, Y., & Chen, X. (2022) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b21-00693 · Cited by 7 · see citing works

Identification of Withanolide G as a Potential Inhibitor of Rho-associated Kinase-2 Catalytic Domain to Confer Neuroprotection in Ischemic Stroke

Sinha, A. K., Dahiya, K., & Kumar, G. (2022) · Letters in Drug Design & Discovery · doi:10.2174/1570180819666220512170331 · Cited by 6 · see citing works

Alzheimer’s Disease: Perspective on Therapeutic Options and Recent Hallmarks in Clinical Research

MOLLY, B. A., Seethamraju, S. M., & Nori, L. P. (2021) · International Journal Of Pharmaceutical Research And Allied Sciences · doi:10.51847/vic6sagcyq · Cited by 6 · see citing works

Nanoformulated herbal bioactives for the treatment of neurodegenerative disorders

Sajadimajd, S., Moradi, S. Z., Akbari, V., Aghaz, F., & Farzaei, M. H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824385-5.00008-x · Cited by 6 · see citing works

The Antioxidative Effects of Picein and Its Neuroprotective Potential: A Review of the Literature

Elyasi, L., Rosenholm, J. M., Jesmi, F., & Jahanshahi, M. (2022) · Molecules · doi:10.3390/molecules27196189 · Cited by 6 · see citing works

Insights on therapeutic approaches of natural anti-Alzheimer's agents in the management of Alzheimer's disease: A future perspective

Mahajan, K. D., Sharma, S., Gautam, R. K., Goyal, R., Mishra, D. K., & Singla, R. K. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241296557 · Cited by 6 · see citing works

Neuroactive herbal agents for cognitive dysfunction

Awathale, S. N., Dhoble, L. R., Itankar, P. R., Raut, N. A., & Kokare, D. M. (2021) · Studies in natural products chemistry · doi:10.1016/b978-0-12-819489-8.00002-8 · Cited by 5 · see citing works

Therapeutic Effects of Withania somnifera: An Overview with Special Focus on Alzheimer’s Disease and Infertility among Youth

Saini, D., Srivastava, M., Vaid, S., & Kesharwani, V. (2022) · Springer eBooks · doi:10.1007/978-981-19-2507-8_14 · Cited by 5 · see citing works

Exploring the neuro-ameliorative propensity of Withania somnifera—Indian ginseng

Muralidhara, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-19084-1.00012-0 · Cited by 5 · see citing works

Indian Traditional Herbs and Alzheimer’s Disease: Integrating Ethnobotany and Phytotherapy

Malik, J., & Choudhary, S. (2021) · Springer eBooks · doi:10.1007/978-981-15-8127-4_50 · Cited by 5 · see citing works

Ashwagandha

Ross, S. M. (2023) · Holistic Nursing Practice · doi:10.1097/hnp.0000000000000607 · Cited by 5 · see citing works

Molecular and therapeutic insights into Withania somnifera (Ashwagandha) for cognition and neuroprotection

Shukla, S. D. (2025) · Academia Biology · doi:10.20935/acadbiol7925 · Cited by 4 · see citing works

Effects of Withania somnifera (L.) Dunal (Ashwagandha) on cognitive and physical function in adults: a systematic review and meta-analysis

Zhu, X., Zeng, Q., Lei, Y., & Xu, D. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1799467 · Cited by 4 · see citing works

A Comprehensive Scientific Claims on Ethnobotany, Phytochemical Pharmacological and Toxicology of Withania somnifera (L.) Dunal

Hussain, M. S., Alqahtani, S. S., Ahmad, S., & Iqbal, M. R. (2023) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v13i3.6003 · Cited by 6 · see citing works

Potential Treatment Strategies of Dementia With Ayurvedic Medicines

Farooqui, A. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816347-4.00009-x · Cited by 4 · see citing works

Herbal medicine used to treat andrological problems: Asia and Indian subcontinent: Withania somnifera, Panax ginseng, Centella asiatica

Sengupta, P., Durairajanayagam, D., & Agarwal, A. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-815565-3.00015-1 · Cited by 4 · see citing works

Exploring the Therapeutic Potential: Bioactive Molecules and Dietary Interventions in Multiple Sclerosis Management

Tancreda, G., Ravera, S., & Panfoli, I. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46060335 · Cited by 4 · see citing works

Clinical applications of Ashwagandha plant in depression and anxiety

Güllü, H., & Kıroğlu, O. (2024) · Çukurova medical journal (Online)/Çukurova medical journal · doi:10.17826/cumj.1460207 · Cited by 4 · see citing works

Natural products as anti-Alzheimer's drugs

Veer, B., Geetanjali, G., & Singh, R. (2020) · Studies in natural products chemistry · doi:10.1016/b978-0-12-817907-9.00006-4 · Cited by 3 · see citing works

Withania somnifera a journey from traditionalrejuvenator to anti-SARS-CoV-2 remedy

Ashokkumar, K., Pandian, A., Baskar, M., Karthik, M. N., Murugan, M., Semwal, R. B., & Semwal, D. K. (2023) · Herba Polonica · doi:10.5604/01.3001.0053.7210 · Cited by 4 · see citing works

Ayurveda: Ayurvedic herbs against neurological disorders: are they golden nuggets?

Muralidhara, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-19084-1.00022-3 · Cited by 2 · see citing works

Investigation into Efficacy and Mechanisms of Neuroprotection of Ashwagandha Root Extract and Water-Soluble Coenzyme Q10 in a Transgenic Mouse Model of Alzheimer’s Disease

Vegh, C., Walach, G., Dube, K., Dobson, B., Talukdar, R., Wear, D., Jayawardena, H., Dufault, K., Culmone, L., Srikantha, S., et al. (2025) · Nutrients · doi:10.3390/nu17162701 · Cited by 2 · see citing works

Anti-Inflammatory and Neuroprotective Effects of a Novel Water-Soluble Formulation of Coenzyme-Q10 and Ashwagandha Root Extract in a Paraquat-Induced Rat Model of Parkinson’s Disease

Vegh, C., Walach, G., Dube, K., Malakoti-Negad, N. J., Wear, D., Jayawardena, H., Patel, M. B., Polsinelli, A., Eren, Ş., Cohen, J. S., et al. (2026) · Biomedicine Hub · doi:10.1159/000550968 · Cited by 2 · see citing works

Life Experience Matters: Enrichment and Stress Can Influence the Likelihood of Developing Alzheimer’s Disease via Gut Microbiome

Torraville, S. E., Flynn, C. M., Kendall, T. L., & Yuan, Q. (2023) · Biomedicines · doi:10.3390/biomedicines11071884 · Cited by 2 · see citing works

A Review Study on Herbal Nutraceuticals: A Leading Edge in the Treatment of Neurological Disorders with the Help of Medicinal Plants

Kabra, S., Priya, T. S., Basu, T., Bashir, T., & Sachdeva, M. (2024) · Journal of Natural Remedies · doi:10.18311/jnr/2024/36026 · Cited by 2 · see citing works

Enhancing amyloid beta inhibition and disintegration by natural compounds: A study utilizing spectroscopy, microscopy and cell biology

Pariary, R., Shome, G., Dutta, T., Roy, A., Misra, A. K., Jana, K., Rastogi, S., Senapati, D., Mandal, A. K., & Bhunia, A. (2024) · Biophysical Chemistry · doi:10.1016/j.bpc.2024.107291 · Cited by 2 · see citing works

Ashwagandha for Brain Health: Experimental Evidence for Its Neuroregenerative Activities

Wadhwa, R., Kalra, R. S., Chaudhary, A., & Kaul, S. C. (2017) · Springer eBooks · doi:10.1007/978-3-319-59192-6_14 · Cited by 2 · see citing works

Neurodegenerative diseases and Withania somnifera (L.): An update

Dar, N. J., & Ahmad, M. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112769 · Cited by 123 · see citing works

Role of Withania somnifera (Ashwagandha) in Neuronal Health

Sinha, A. K., Dilnashin, H., Birla, H., & Kumar, G. (2022) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815050868122010016 · Cited by 1 · see citing works

Impact of Withania Somnifera (Ashwagandha) and Sesamum Indicum (Sesame Seeds) in Improving Neurodegenerative Diseases

Nafees, S., Kaur, R., Shukla, S., & Kaur, J. (2024) · CRC Press eBooks · doi:10.1201/9781003392941-6 · Cited by 1 · see citing works

Overcoming Several Neurodegenerative Diseases by Traditional Medicines

Tohda, C. (2008) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.128.1159 · Cited by 18 · see citing works

PHARMACOLOGICAL EFFECTS OF ASHWAGANDHA (WITHANIA SOMNIFERA) ON NEURODEGENERATIVE DISEASE(ALZHEIMER’S DISEASE)Preprint

Edwin, E. (2021) · doi:10.17605/osf.io/p96bd