Screening of Toll-Like Receptors Expression in Multiple System Atrophy Brains

A new mathematical model for relative quantification in real-time RT-PCR

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Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

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Toll-like receptors in innate immunity

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Second consensus statement on the diagnosis of multiple system atrophy

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Inflammation in neurodegenerative diseases

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Aggregated α‐synuclein activates microglia: a process leading to disease progression in Parkinson's disease

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Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs

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Differential Expression and Regulation of Toll-Like Receptors (TLR) in Human Leukocytes: Selective Expression of TLR3 in Dendritic Cells

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Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

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Microglia and neuroinflammation: a pathological perspective

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Broad Expression of Toll-Like Receptors in the Human Central Nervous System

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Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

Lee, H.-J., Suk, J.-E., Patrick, C., Bae, E.-J., Cho, J.-H., Rho, S., Hwang, D., Masliah, E., & Lee, S.-J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.081125 · Cited by 877 · see citing works

Glial reactions in Parkinson's disease

McGeer, P. L., & McGeer, E. G. (2008) · Movement Disorders · doi:10.1002/mds.21751 · Cited by 701 · see citing works

Toll‐like receptor 4 is required for α‐synuclein dependent activation of microglia and astroglia

Fellner, L., Irschick, R., Schanda, K., Reindl, M., Klimaschewski, L., Poewe, W., Wenning, G. K., & Stefanova, N. (2013) · Glia · doi:10.1002/glia.22437 · Cited by 697 · see citing works

Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits

Tang, S.-C., Arumugam, T. V., Xu, X., Cheng, A., Mughal, M. R., Jo, D. G., Lathia, J. D., Siler, D. A., Chigurupati, S., Ouyang, X., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702553104 · Cited by 672 · see citing works

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial Activation

Reed-Geaghan, E. G., Savage, J. C., Hise, A. G., & Landreth, G. E. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3158-09.2009 · Cited by 591 · see citing works

Role of the Toll-Like Receptor 4 in Neuroinflammation in Alzheimer’s Disease

Walter, S., Letiembre, M., Liu, Y., Heine, H., Penke, B., Hao, W., Bode, B., Manietta, N., Walter, J., Schulz-Schüffer, W., et al. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000110455 · Cited by 543 · see citing works

Role of toll-like receptor signalling in A uptake and clearance

Tahara, K., Kim, H.-D., Jin, J.-J., Maxwell, J. A., Li, L., & Fukuchi, K.-I. (2006) · Brain · doi:10.1093/brain/awl249 · Cited by 493 · see citing works

Multiple system atrophy

Wenning, G. K., Colosimo, C., Geser, F., & Poewe, W. H. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00662-8 · Cited by 467 · see citing works

Toll-Like Receptors in Neurodegeneration

Okun, E., Griffioen, K., Lathia, J., Tang, S.-C., Mattson, M., & Arumugam, T. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.09.001 · Cited by 459 · see citing works

Glia: Initiators and progressors of pathology in Parkinson's disease

Halliday, G. M., & Stevens, C. H. (2011) · Movement Disorders · doi:10.1002/mds.23455 · Cited by 423 · see citing works

Cultured astrocytes express toll‐like receptors for bacterial products

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Proposed neuropathological criteria for the <i>post mortem</i> diagnosis of multiple system atrophy

Trojanowski, J. Q., Revesz, T., & the Neuropathology Working Group on MSA (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00907.x · Cited by 349 · see citing works

Toll-like receptors and the host defense against microbial pathogens: bringing specificity to the innate-immune system

Netea, M. G., van der Graaf, C. A. A., van der Meer, J. W. M., & Kullberg, B. J. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.1103543 · Cited by 311 · see citing works

Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons

Stefanova, N., Fellner, L., Reindl, M., Masliah, E., Poewe, W., & Wenning, G. K. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.04.013 · Cited by 272 · see citing works

Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein

Watson, M. B., Richter, F., Lee, S., Gabby, L. C., Wu, J. E., Masliah, E., Effros, R. B., & Chesselet, M. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.06.025 · Cited by 241 · see citing works

Screening of innate immune receptors in neurodegenerative diseases: A similar pattern

Letiembre, M., Liu, Y., Walter, S., Hao, W., Pfander, T., Wrede, A., Schulz-Schaeffer, W., & Fassbender, K. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.08.018 · Cited by 228 · see citing works

α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia

Klegeris, A., Pelech, S., Giasson, B. I., Maguire, J., Zhang, H., McGeer, E. G., & McGeer, P. L. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.11.013 · Cited by 227 · see citing works

Microglial activation mediates neurodegeneration related to oligodendroglial α‐synucleinopathy: Implications for multiple system atrophy

Stefanova, N., Reindl, M., Neumann, M., Kahle, P. J., Poewe, W. H., & Wenning, G. K. (2007) · Movement Disorders · doi:10.1002/mds.21671 · Cited by 217 · see citing works

Activation of Toll-like Receptor 2 on Microglia Promotes Cell Uptake of Alzheimer Disease-associated Amyloid β Peptide

Chen, K., Iribarren, P., Hu, J., Chen, J., Gong, W., Cho, E. H., Lockett, S., Dunlop, N. M., & Wang, J. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508125200 · Cited by 214 · see citing works

α-Synuclein Alters Toll-Like Receptor Expression

Béraud, D., Twomey, M. A., Bloom, B., Mittereder, A., Ton, V., Neitzke, K., Chasovskikh, S., Mhyre, T. R., & Maguire‐Zeiss, K. A. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00080 · Cited by 199 · see citing works

Innate immune receptor expression in normal brain aging

Letiembre, M., Hao, W., Liu, Y., Walter, S., Mihaljevic, I., Rivest, S., Hartmann, T., & Fassbender, K. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.01.004 · Cited by 175 · see citing works

Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts

Fellner, L., Jellinger, K. A., Wenning, G. K., & Stefanova, N. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0833-z · Cited by 162 · see citing works

Mutant α-Synuclein Overexpression Mediates Early Proinflammatory Activity

Su, X., Federoff, H. J., & Maguire-Zeiss, K. A. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9053-x · Cited by 145 · see citing works

Papp–Lantos inclusions and the pathogenesis of multiple system atrophy: an update

Jellinger, K. A., & Lantos, P. L. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0672-3 · Cited by 144 · see citing works

Accumulation of phosphorylated a-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy

Nishie, M., Mori, F., Fujiwara, H., Hasegawa, M., Yoshimoto, M., Iwatsubo, T., Takahashi, H., & Wakabayashi, K. (2004) · Acta Neuropathologica · doi:10.1007/s00401-003-0811-1 · Cited by 119 · see citing works

The role of ?-synuclein in the pathogenesis of multiple system atrophy

Wenning, G. K., & Jellinger, K. A. (2005) · Acta Neuropathologica · doi:10.1007/s00401-004-0935-y · Cited by 117 · see citing works

Multiple System Atrophy

Wenning, G. K., & Braune, S. (2001) · CNS Drugs · doi:10.2165/00023210-200115110-00003 · Cited by 102 · see citing works

Glial Innate Immunity Generated by Non-Aggregated Alpha-Synuclein in Mouse: Differences between Wild-type and Parkinson's Disease-Linked Mutants

Roodveldt, C., Labrador‐Garrido, A., González‐Rey, E., Fernández-Montesinos, R., Caro, M., Lachaud, C. C., Waudby, C. A., Delgado, M., Dobson, C. M., & Pozo, D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013481 · Cited by 99 · see citing works

Roles of IL-18 in Basophils and Mast Cells

Yoshimoto, T., & Nakanishi, K. (2006) · Allergology International · doi:10.2332/allergolint.55.105 · Cited by 76 · see citing works

CpG‐containing oligodeoxynucleotide promotes microglial cell uptake of amyloid β 1–42 peptide by up‐regulating the expression of the G‐protein‐coupled receptor mFPR2

Iribarren, P., Chen, K., Hu, J., Gong, W., Cho, E. H., Lockert, S., Uranchimeg, B., & Wang, J. M. (2005) · The FASEB Journal · doi:10.1096/fj.05-4578fje · Cited by 73 · see citing works

Protein Aggregation Mechanisms in Synucleinopathies: Commonalities and Differences

Beyer, K., & Ariza, A. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181587d64 · Cited by 72 · see citing works

The Role of Glia in Alpha-Synucleinopathies

Fellner, L., & Stefanova, N. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8340-3 · Cited by 68 · see citing works

Toll-Like Receptors in Neurodegeneration

Owens, T. (2009) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-00549-7_6 · Cited by 62 · see citing works

Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α -Synucleinopathies

Sekiyama, K., Sugama, S., Fujita, M., Sekigawa, A., Takamatsu, Y., Waragai, M., Takenouchi, T., & Hashimoto, M. (2012) · Parkinson s Disease · doi:10.1155/2012/271732 · Cited by 48 · see citing works

Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets

Gao, C., Jiang, J., Tan, Y., & Chen, S. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01588-0 · Cited by 1,616 · see citing works

Role of Microglia TLRs in Neurodegeneration

Fiebich, B. L., Batista, C. R. A., Saliba, S. W., Yousif, N. M., & de Oliveira, A. C. P. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00329 · Cited by 291 · see citing works

Exogenous α-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes

Rannikko, E. H., Weber, S. S., & Kahle, P. J. (2015) · BMC Neuroscience · doi:10.1186/s12868-015-0192-0 · Cited by 185 · see citing works

Toll-like receptor expression in the blood and brain of patients and a mouse model of Parkinson's disease

Drouin-Ouellet, J., St-Amour, I., Saint-Pierre, M., Lamontagne-Proulx, J., Kriz, J., Barker, R. A., & Cicchetti, F. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu103 · Cited by 153 · see citing works

Toll-like receptors and their therapeutic potential in Parkinson’s disease and α-synucleinopathies

Kouli, A., Horne, C. B., & Williams-Gray, C. H. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.06.042 · Cited by 143 · see citing works

Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation

Vieira, B. D. M., Radford, R. A., Chung, R. S., Guillemin, G. J., & Pountney, D. L. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00437 · Cited by 93 · see citing works

Changes in total cell numbers of the basal ganglia in patients with multiple system atrophy — A stereological study

Salvesen, L., Ullerup, B. H., Sunay, F. B., Brudek, T., Løkkegaard, A., Agander, T. K., Winge, K., & Pakkenberg, B. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.11.008 · Cited by 85 · see citing works

Translational therapies for multiple system atrophy: Bottlenecks and future directions

Stefanova, N. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2017.09.016 · Cited by 12 · see citing works

Neurochemistry of Childhood Anxiety Disorders

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Monitoring 5HT Metabolism in the Brain of the Freely Moving Rat

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Nerve growth factor‐induced changes in neural cell adhesion molecule (N‐CAM) in PC12 cells.

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Sections on Neurochemistry and Child Neurology

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STUDIES ON THE METABOLIC EFFECTS OF A SUBSTANCE FOUND IN PERIPHERAL NERVE

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