The HDL lipidome is widely remodeled by fast food versus Mediterranean diet in 4 days
Open accessAbstract
Introduction HDL is associated with increased longevity and protection from multiple chronic diseases. The major HDL protein ApoA-I has a half-life of about 4 days, however, the effects of diet on the composition of HDL particles at this time scale have not been studied.Objectives The objective of this study is to investigate the short term dietary effect on HDL lipidomic composition.Methods In this randomized order cross-over study, ten healthy subjects consumed a Mediterranean (Med) and a fast food (FF) diet for 4 days, with a 4-day wash-out between treatments. Lipidomic composition was analyzed in isolated HDL fractions by an untargeted LC-MS method with 15 internal standards.Results HDL phosphatidylethanolamine (PE) content was increased by FF diet, and 41 out of 170 lipid species were differentially affected by diet. Saturated fatty acids (FAs) and odd chain FA were enriched after FF diet, while very-long chain FA and unsaturated FA were enriched after Med diet. The composition of phosphatidylcholine (PC), triacylglycerol (TG) and cholesteryl ester (CE) were significantly altered to reflect the FA composition of the diet whereas the composition of sphingomyelin (SM) and ceramides were generally unaffected.Conclusion Results from this study indicate that the HDL lipidome is widely remodeled within 4 days of diet change and that certain lipid classes are more sensitive markers of diet whereas other lipid classes are better indicators of non-dietary factors.
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Short-term adherence to the Mediterranean diet versus a fast food diet achieved a change of HDL lipidome towards a healthier HDL status, highlighting the cardioprotective effect of the Mediterranean diet.
“Furthermore, a study on the effect of a short-term adherence to MD versus fast food (FF) diet was able to achieve a change of HDL lipidome towards a healthier HDL status, further highlighting the cardioprotective effect of MD [52].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [52]
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Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing
Gantenbein, K. V., & Kanaka-Gantenbein, C. (2021) · Nutrients · doi:10.3390/nu13061951 · Cited by 288 · see citing works
Zhu, C., Sawrey-Kubicek, L., Beals, E., Rhodes, C. H., Houts, H. E., Sacchi, R., & Zivkovic, A. M. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.03.005 · Cited by 153 · see citing works
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- Authors
- Zhu, C., Sawrey-Kubicek, L., Beals, E., Hughes, R. L., Rhodes, C. H., Sacchi, R., & Zivkovic, A. M.
- Affiliations
- University of California, Davis (US)
- Corresponding author
- Zivkovic, Angela M.
- Venue
- Metabolomics
- Published
- 2019-08
- Volume
- 15
- Issue
- 8
- Pages
- 114-114
- ISSN
- 1573-3882 (ISSN-L)
- 1573-3890
- OpenAlex
- W2968555033
- Cited by
- 40
- References
- 46
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 7 · 2023: 5 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 1
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- green
- escholarship.org
- Locations
- Metabolomics (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- West Coast Metabolomics Center, University of California, Davis (DK097154)
- UC Davis Clinical and Translational Sciences Center Pilot Grant Program (UL1 TR001860)
- UC Davis Hellman Fellowship (NA)
- USDA National Institute of Food and Agriculture, Hatch Project (CA-D-NUT-2242-H)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Keywords
- fast food diet, Mediterranean diet, HDL particle composition, phosphatidylethanolamine, saturated fatty acids, odd-chain fatty acids, very long chain fatty acids, unsaturated fatty acids, phosphatidylcholine, triglycerides, cholesterol esters, sphingomyelin, ceramide, apolipoprotein A-I
- MeSH terms
- Lipidomics, Adolescent, Adult, Female, Humans, Lipoproteins, HDL, Male, Pilot Projects, Cross-Over Studies, Diet, Mediterranean, Young Adult, Fast Foods, Healthy Volunteers
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