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Cited by 77

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Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults

Toth, Luca, Czigler, Andras, Hegedus, Emoke, Komaromy, Hedvig, Amrein, Krisztina, Czeiter, Endre, Yabluchanskiy, Andriy, Koller, Akos, Orsi, Gergely, Perlaki, Gabor, Schwarcz, Attila, Buki, Andras, Ungvari, Zoltan, Toth, Peter J.·2022·GeroScience
DOI 10.1007/s11357-022-00623-2
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Abstract

Impairment of moment-to-moment adjustment of cerebral blood flow (CBF) to the increased oxygen and energy requirements of active brain regions via neurovascular coupling (NVC) contributes to the genesis of age-related cognitive impairment. Aging is associated with marked deficiency in the vasoprotective hormone insulin-like growth factor-1 (IGF-1). Preclinical studies on animal models of aging suggest that circulating IGF-1 deficiency is causally linked to impairment of NVC responses. The present study was designed to test the hypotheses that decreases in circulating IGF-1 levels in older adults also predict the magnitude of age-related decline of NVC responses. In a single-center cross-sectional study, we enrolled healthy young ( n = 31, 11 female, 20 male, mean age: 28.4 + / − 4.2 years) and aged volunteers ( n = 32, 18 female, 14 male, mean age: 67.9 + / − 4.1 years). Serum IGF-1 level, basal CBF (phase contrast magnetic resonance imaging (MRI)), and NVC responses during the trail making task (with transcranial Doppler sonography) were assessed. We found that circulating IGF-1 levels were significantly decreased with age and associated with decreased basal CBF. Age-related decline in IGF-1 levels predicted the magnitude of age-related decline in NVC responses. In conclusion, our study provides additional evidence in support of the concept that age-related circulating IGF-1 deficiency contributes to neurovascular aging, impairing CBF and functional hyperemia in older adults.

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Cited by

Metadata

Authors
Toth, L., Czigler, A., Hegedus, E., Komaromy, H., Amrein, K., Czeiter, E., Yabluchanskiy, A., Koller, A., Orsi, G., Perlaki, G., Schwarcz, A., Buki, A., Ungvari, Z., & Toth, P. J.
ORCID
Toth, Peter J.
Venue
GeroScience
Publisher
Springer Science and Business Media LLC
Published
2022-07-23
Volume
44
Issue
6
Pages
2771-2783
ISSN
  • 2509-2715
  • 2509-2723
DOI
10.1007/s11357-022-00623-2
Cited by
77
References
9
Language
en
Licence
Funders
  • Nemzeti Kutatási, Fejlesztési és Innovaciós Alap (NKFI-FK123798, NKFI-K 134555, TKP2021-EGA-16, TKP2021-NKTA-47, TKP2021-NVA)
  • Magyar Tudományos Akadémia
  • National Institute on Aging (RF1AG072295, R01AG055395, R01AG068295; K01-AG073614)
  • National Institute of Neurological Disorders and Stroke (R01NS100782)
  • National Cancer Center (R01CA255840)
  • Cellular and Molecular GeroScience (P20GM125528)
  • University of Pécs

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