Cited by 148Neuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune RegulationAlzheimer's disease research and treatments

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Amyloid-β-Induced Astrocytic Phagocytosis is Mediated by CD36, CD47 and RAGE

Jones, Raasay S., Minogue, Aedín M., Connor, Thomas J., Lynch, Marina A.·2013·Journal of Neuroimmune Pharmacology

DOI 10.1007/s11481-012-9427-3

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Abstract

Astrocytes, the most numerous glial cell in the brain, have multiple functions and are key to maintenance of homeostasis in the central nervous system. Microglia are the resident immunocompetent cells in the brain and share several functions with macrophages, including their phagocytic ability. Indeed microglia are the resident phagocytes in the brain and express numerous cell surface proteins which act to enable receptor-mediated phagocytosis. However recent evidence suggests that astrocytes express some genes which permit phagocytosis of phosphatidylserine-decorated cells and this probably explains sporadic reports in the literature which suggest that astrocytes become phagocytic following brain trauma. Here we examined the potential of astrocytes to phagocytose fluorescently-labelled latex beads and amyloid-β (Aβ) and report that they competently engulf both in a manner that relies on actin polymerization since it was inhibited by cytochalasin D. The data indicate that incubation of cultured astrocytes or microglia with Aβ increased phagocytosis and markers of activation of both cell types. Aβ was found to markedly increase expression of the putative Aβ-binding receptors CD36 and CD47 in astrocytes, while it decreased expression of the receptor for advanced glycation endproducts (RAGE). It is demonstrated that blocking these receptors using a neutralizing antibody attenuated Aβ-induced phagocytosis of latex beads by astrocytes. Interestingly blocking these receptors also decreased uptake of beads even in the absence of Aβ. Here we demonstrate that astrocytes are competent phagocytes and are capable of engulfing Aβ.

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“In addition, individual neutralization of CD36, CD47, or RAGE in astrocytes partially inhibits their phagocytic capability (Jones et al., 2013).”
The synthetic steroid tibolone exerts sex-specific regulation of astrocyte phagocytosis under basal conditions and after an inflammatory challenge
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“[81] R.”
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BackgroundInfluential
Ammonia induces amyloidogenesis in astrocytes by promoting amyloid precursor protein translocation into the endoplasmic reticulum
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“We detected significant transcriptional enrichment of phagocytosis-associated TAM family members Tyro3 and Axl , complement factor C4b , and the scavenger receptor Cd36 in our within-retina comparison (Jones et al., 2013; Konishi et al., 2022).”

Authors: Jones, R. S., Minogue, A. M., Connor, T. J., & Lynch, M. A.
Affiliations: Trinity College Dublin (IE)
Corresponding author: Minogue, Aedín M.
ORCID: Lynch, Marina A.
Venue: Journal of Neuroimmune Pharmacology
Publisher: Springer Science and Business Media LLC
Published: 2012-12-14
Volume: 8
Issue: 1
Pages: 301-311
ISSN: 1557-1890 (ISSN-L)
1557-1904
DOI: 10.1007/s11481-012-9427-3
OpenAlex: W2036955747
Cited by: 147
References: 46
Citations by year: 2026: 6 · 2025: 9 · 2024: 10 · 2023: 9 · 2022: 13 · 2021: 19 · 2020: 17 · 2019: 6 · 2018: 7 · 2017: 15 · 2016: 12 · 2015: 7 · 2014: 15 · 2013: 2
FWCI: 3.86
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Neuroimmune Pharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Health Research Board
Science Foundation Ireland
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: amyloid-beta, astrocytes, phagocytosis, CD36, CD47, RAGE, actin polymerization, microglia, receptor-mediated phagocytosis, receptor antagonists, neuroinflammation
MeSH terms: Receptor for Advanced Glycation End Products, Animals, Animals, Newborn, Astrocytes, Cell Survival, Flow Cytometry, Fluorescent Dyes, Glial Fibrillary Acidic Protein, L-Lactate Dehydrogenase, Microspheres, Phagocytosis, Receptors, Immunologic, RNA, Messenger, Amyloid beta-Peptides, Fluorescein-5-isothiocyanate, Rats, Wistar, Microglia, CD36 Antigens, Excitatory Amino Acid Transporter 2, CD11b Antigen, Rats, CD47 Antigen

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Amyloid-β-Induced Astrocytic Phagocytosis is Mediated by CD36, CD47 and RAGE

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