Cited by 93Gut microbiota and healthBariatric Surgery and OutcomesGastrointestinal motility and disorders

The gut microbiota as a mediator of metabolic benefits after bariatric surgery

Anhê, Fernando F., Varin, Thibault V., Schertzer, Jonathan D., Marette, André·2017·Canadian Journal of Diabetes

Abstract

Bariatric surgery is based on major anatomic rearrangements in the gastrointestinal tract that coincide with functional and taxonomic changes in gut microbial communities. These alterations in gut anatomy and in the microbiota are associated with early resolution of obesity-related impairment of glycemic control and are marked weight loss in the long term. Moreover, altered bile acid metabolism has been implicated in the control of energy homeostasis, emerging as a pivotal orchestrator in the gut microbiota-mediated effects of bariatric surgery. In this review, we summarize the growing body of evidence linking changes in the gut microbiota to the metabolic benefits of bariatric surgery and discuss the potential mechanisms involved.

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Crossref · 10.1016/j.jcjd.2017.02.002

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Authors
Anhê, F. F., Varin, T. V., Schertzer, J. D., & Marette, A.
Affiliations
  • Institut universitaire de cardiologie et de pneumologie de Québec (CA)
  • Université Laval (CA)
  • McMaster University (CA)
Corresponding author
Marette, André
Venue
Canadian Journal of Diabetes
Publisher
Elsevier BV
Published
2017-08
Volume
41
Issue
4
Pages
439-447
ISSN
1499-2671 (ISSN-L)
OpenAlex
W2617406638
Cited by
93
References
116
Citations by year
2026: 3 · 2025: 3 · 2024: 10 · 2023: 10 · 2022: 13 · 2021: 13 · 2020: 11 · 2019: 16 · 2018: 7 · 2017: 6
FWCI
1.02
Type
journal article
Language
en
Open access
closed
Locations
  • Canadian Journal of Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
bariatric surgery, gut microbiota, obesity, bile acid metabolism, glycemic control, weight loss, energy homeostasis, metabolic benefits
MeSH terms
Gastrointestinal Microbiome, Humans, Obesity, Gastrointestinal Tract, Bariatric Surgery

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