Cited by 815Fatty Acid Research and HealthLipid metabolism and biosynthesisAdipose Tissue and Metabolism

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Evidence that the trans‐10,cis‐12 isomer of conjugated linoleic acid induces body composition changes in mice

Park, Yeonhwa, Storkson, Jayne M., Albright, Karen J., Liu, Wei, Pariza, Michael W.·1999·Lipids

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Abstract

We investigated the effects of conjugated linoleic acid (CLA) preparations, which were enriched for the cis-9,trans-11 CLA isomer or the trans-10,cis-12 CLA isomer, on body composition in mice. Body composition changes (reduced body fat, enhanced body water, enhanced body protein, and enhanced body ash) were associated with feeding the trans-10,cis-12 CLA isomer. In cultured 3T3-L1 adipocytes, the trans-10,cis-12 isomer reduced lipoprotein lipase activity, intracellular triacylglycerol and glycerol, and enhanced glycerol release into the medium. By contrast, the cis-9,trans-11 and trans-9,trans-11 CLA isomers did not affect these biochemical activities. We conclude that CLA-associated body composition change results from feeding the trans-10,cis-12 isomer.

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Authors: Park, Y., Storkson, J. M., Albright, K. J., Liu, W., & Pariza, M. W.
Affiliations: University of Wisconsin–Madison (US)
Corresponding author: Pariza, Michael W.
ORCID: Park, Yeonhwa
Albright, Karen J.
Liu, Wei
Venue: Lipids
Publisher: Wiley
Published: 1999-03
Volume: 34
Issue: 3
Pages: 235-241
ISSN: 0024-4201 (ISSN-L)
1558-9307
DOI: 10.1007/s11745-999-0358-8
OpenAlex: W2057643905
Cited by: 815
References: 16
Citations by year: 2026: 4 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 13 · 2019: 8 · 2018: 5 · 2017: 18 · 2016: 18 · 2015: 16 · 2014: 14 · 2013: 28 · 2012: 35
FWCI: 49.28
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Lipids (publishedVersion)
PubMed (publishedVersion)
ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion)
Funders: Wisconsin Alumni Research Foundation
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: conjugated linoleic acid, body composition, adipocytes, lipoprotein lipase, triglycerides, glycerol release, fat deposition, dietary fatty acids
MeSH terms: Animals, Body Composition, Body Weight, Dose-Response Relationship, Drug, Female, Isomerism, Linoleic Acids, Lipoprotein Lipase, Male, Mice, Inbred ICR, Triglycerides, 3T3 Cells, Adipocytes, Mice

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Evidence that the trans‐10,cis‐12 isomer of conjugated linoleic acid induces body composition changes in mice

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