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Evidence that the trans‐10,cis‐12 isomer of conjugated linoleic acid induces body composition changes in mice
Abstract
We investigated the effects of conjugated linoleic acid (CLA) preparations, which were enriched for the cis-9,trans-11 CLA isomer or the trans-10,cis-12 CLA isomer, on body composition in mice. Body composition changes (reduced body fat, enhanced body water, enhanced body protein, and enhanced body ash) were associated with feeding the trans-10,cis-12 CLA isomer. In cultured 3T3-L1 adipocytes, the trans-10,cis-12 isomer reduced lipoprotein lipase activity, intracellular triacylglycerol and glycerol, and enhanced glycerol release into the medium. By contrast, the cis-9,trans-11 and trans-9,trans-11 CLA isomers did not affect these biochemical activities. We conclude that CLA-associated body composition change results from feeding the trans-10,cis-12 isomer.
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“Moreover, despite compelling evidence that CLA supplementation can influence body composition in rodent models [134,135], human data are more modest [[136], [137], [138]].”
From Nutritional Considerations for the Vegan Athlete (2023) · cites this paper as [135]
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Haug, A., Sjögren, P., Hølland, N., Müller, H., Kjos, N. P., Taugbøl, O., Fjerdingby, N., Biong, A. S., Selmer-Olsen, E., & Harstad, O. M. (2008) · Lipids in Health and Disease · doi:10.1186/1476-511x-7-31 · Cited by 17
Body Compositional Changes and Growth Alteration in Chicks from Hens Fed Conjugated Linoleic Acid
Leone, V., Worzalla, S. P., & Cook, M. E. (2009) · Lipids · doi:10.1007/s11745-009-3287-5 · Cited by 16
Accorsi, M. F., Leão, B. C. S., Rocha-Frigoni, N. A. S., Perri, S., & Mingoti, G. Z. (2015) · Zygote · doi:10.1017/s0967199415000428 · Cited by 16
EFFECTS OF CONJUGATED LINOLEIC ACID ISOMERS ON SERUM TUMOR NECROSIS FACTOR-A CONCENTRATION IN MICE
Park, Y., Yang, M., STORKSON, J. M., ALBRIGHT, K. J., Liu, W., Cook, M. E., & Pariza, M. W. (2007) · Journal of Food Biochemistry · doi:10.1111/j.1745-4514.2007.00110.x · Cited by 16
Self-citationInfluence of a fiber mixture on serum and liver lipids and on fecal fat excretion in rats
Kritchevsky, D., & Tepper, S. A. (2005) · Nutrition Research · doi:10.1016/j.nutres.2005.02.001 · Cited by 16
Dugan, M. E. R., Aalhus, J. L., Rolland, D. C., & Jeremiah, L. E. (2003) · Canadian Journal of Animal Science · doi:10.4141/a02-115 · Cited by 16
Metadata
- Authors
- Park, Y., Storkson, J. M., Albright, K. J., Liu, W., & Pariza, M. W.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Pariza, Michael W.
- Venue
- Lipids
- Publisher
- Wiley
- Published
- 1999-03
- Volume
- 34
- Issue
- 3
- Pages
- 235-241
- ISSN
- 0024-4201 (ISSN-L)
- 1558-9307
- OpenAlex
- W2057643905
- Cited by
- 815
- References
- 16
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 13 · 2019: 8 · 2018: 5 · 2017: 18 · 2016: 18 · 2015: 16 · 2014: 14 · 2013: 28 · 2012: 35
- FWCI
- 49.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lipids (publishedVersion)
- PubMed (publishedVersion)
- ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion)
- Funders
- Wisconsin Alumni Research Foundation
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- conjugated linoleic acid, body composition, adipocytes, lipoprotein lipase, triglycerides, glycerol release, fat deposition, dietary fatty acids
- MeSH terms
- Animals, Body Composition, Body Weight, Dose-Response Relationship, Drug, Female, Isomerism, Linoleic Acids, Lipoprotein Lipase, Male, Mice, Inbred ICR, Triglycerides, 3T3 Cells, Adipocytes, Mice
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