The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Evidence that the trans‐10,cis‐12 isomer of conjugated linoleic acid induces body composition changes in mice
Abstract
We investigated the effects of conjugated linoleic acid (CLA) preparations, which were enriched for the cis-9,trans-11 CLA isomer or the trans-10,cis-12 CLA isomer, on body composition in mice. Body composition changes (reduced body fat, enhanced body water, enhanced body protein, and enhanced body ash) were associated with feeding the trans-10,cis-12 CLA isomer. In cultured 3T3-L1 adipocytes, the trans-10,cis-12 isomer reduced lipoprotein lipase activity, intracellular triacylglycerol and glycerol, and enhanced glycerol release into the medium. By contrast, the cis-9,trans-11 and trans-9,trans-11 CLA isomers did not affect these biochemical activities. We conclude that CLA-associated body composition change results from feeding the trans-10,cis-12 isomer.
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“Moreover, despite compelling evidence that CLA supplementation can influence body composition in rodent models [134,135], human data are more modest [[136], [137], [138]].”
From Nutritional Considerations for the Vegan Athlete (2023) · cites this paper as [135]
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REGULATION OF CYTOSOLIC NADP + - DEPENDENT ISOCITRATE DEHYDROGENASE EXPRESSION
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Metadata
- Authors
- Park, Y., Storkson, J. M., Albright, K. J., Liu, W., & Pariza, M. W.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Pariza, Michael W.
- Venue
- Lipids
- Publisher
- Wiley
- Published
- 1999-03
- Volume
- 34
- Issue
- 3
- Pages
- 235-241
- ISSN
- 0024-4201 (ISSN-L)
- 1558-9307
- OpenAlex
- W2057643905
- Cited by
- 815
- References
- 16
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 13 · 2019: 8 · 2018: 5 · 2017: 18 · 2016: 18 · 2015: 16 · 2014: 14 · 2013: 28 · 2012: 35
- FWCI
- 49.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lipids (publishedVersion)
- PubMed (publishedVersion)
- ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion)
- Funders
- Wisconsin Alumni Research Foundation
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- conjugated linoleic acid, body composition, adipocytes, lipoprotein lipase, triglycerides, glycerol release, fat deposition, dietary fatty acids
- MeSH terms
- Animals, Body Composition, Body Weight, Dose-Response Relationship, Drug, Female, Isomerism, Linoleic Acids, Lipoprotein Lipase, Male, Mice, Inbred ICR, Triglycerides, 3T3 Cells, Adipocytes, Mice
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