Cited by 815Fatty Acid Research and HealthLipid metabolism and biosynthesisAdipose Tissue and Metabolism

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Evidence that the trans‐10,cis‐12 isomer of conjugated linoleic acid induces body composition changes in mice

Park, Yeonhwa, Storkson, Jayne M., Albright, Karen J., Liu, Wei, Pariza, Michael W.·1999·Lipids

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Abstract

We investigated the effects of conjugated linoleic acid (CLA) preparations, which were enriched for the cis-9,trans-11 CLA isomer or the trans-10,cis-12 CLA isomer, on body composition in mice. Body composition changes (reduced body fat, enhanced body water, enhanced body protein, and enhanced body ash) were associated with feeding the trans-10,cis-12 CLA isomer. In cultured 3T3-L1 adipocytes, the trans-10,cis-12 isomer reduced lipoprotein lipase activity, intracellular triacylglycerol and glycerol, and enhanced glycerol release into the medium. By contrast, the cis-9,trans-11 and trans-9,trans-11 CLA isomers did not affect these biochemical activities. We conclude that CLA-associated body composition change results from feeding the trans-10,cis-12 isomer.

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Effects of isomers of conjugated linoleic acid on porcine adipocyte growth and differentiation11This work is a publication of the USDA/ARS Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030-2600. This project has been funded in part with federal funds from the USDA/ARS under Cooperative Agreement No. 58-6250-6001. The contents of this publication do not necessarily reflect the views or policies of the USDA, nor does mention of trade names, commercial products, or organizations imply endorsement from the U.S. government.
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Self-citation

Authors: Park, Y., Storkson, J. M., Albright, K. J., Liu, W., & Pariza, M. W.
Affiliations: University of Wisconsin–Madison (US)
Corresponding author: Pariza, Michael W.
ORCID: Park, Yeonhwa
Albright, Karen J.
Liu, Wei
Venue: Lipids
Publisher: Wiley
Published: 1999-03
Volume: 34
Issue: 3
Pages: 235-241
ISSN: 0024-4201 (ISSN-L)
1558-9307
DOI: 10.1007/s11745-999-0358-8
OpenAlex: W2057643905
Cited by: 815
References: 16
Citations by year: 2026: 4 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 13 · 2019: 8 · 2018: 5 · 2017: 18 · 2016: 18 · 2015: 16 · 2014: 14 · 2013: 28 · 2012: 35
FWCI: 49.28
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Lipids (publishedVersion)
PubMed (publishedVersion)
ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion)
Funders: Wisconsin Alumni Research Foundation
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: conjugated linoleic acid, body composition, adipocytes, lipoprotein lipase, triglycerides, glycerol release, fat deposition, dietary fatty acids
MeSH terms: Animals, Body Composition, Body Weight, Dose-Response Relationship, Drug, Female, Isomerism, Linoleic Acids, Lipoprotein Lipase, Male, Mice, Inbred ICR, Triglycerides, 3T3 Cells, Adipocytes, Mice

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Evidence that the trans‐10,cis‐12 isomer of conjugated linoleic acid induces body composition changes in mice

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