Dietary fatty acids affect plasma markers of inflammation in healthy men fed controlled diets: a randomized crossover study
Open accessAbstract
Background The effect of individual dietary fatty acids on emerging risk factors for cardiovascular disease that are associated with subclinical inflammation is unknown.Objective The goal was to evaluate the role of dietary fat and specific fatty acids, especially trans fatty acids, in altering concentrations of markers of inflammation in humans fed controlled diets.Design In a randomized crossover design, 50 men consumed controlled diets for 5 wk that provided 15% of energy from protein, 39% of energy from fat, and 46% of energy from carbohydrate. Eight percent of fat or fatty acids was replaced across diets with the following: cholesterol, oleic acid, trans fatty acids (TFAs), stearic acid (STE), TFA+STE (4% of energy each), and 12:0-16:0 saturated fatty acids (LMP).Results Fibrinogen concentrations were higher after consumption of the diet enriched in stearic acid than after consumption of the carbohydrate diet. C-reactive protein concentrations were higher after consumption of the TFA diet than after consumption of the carbohydrate diet, but were not significantly different after consumption of the TFA and TFA+STE diets than after consumption of the LMP diet. Interleukin 6 concentrations were lower after consumption of the oleic acid diet than after consumption of the LMP, TFA, and STE diets. E-selectin concentrations were higher after consumption of the TFA diet than after consumption of the carbohydrate diet. Consumption of the TFA but not the TFA+STE diet resulted in higher E-selectin concentrations than did the LMP diet.Conclusions These data provide evidence that dietary fatty acids can modulate markers of inflammation. Although stearic acid minimally affects LDL cholesterol, it does appear to increase fibrinogen concentrations.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Vitamin D analogues selectively inhibit inducible cyclo-oxygenase-2, which could be viewed as an anti-inflammatory action.
“Vitamin D analogues selectively inhibit the inducible cyclo-oxygenase-2 (738) , which could be viewed as an anti-inflammatory action.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [738]
Cites
Ridker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H. (2000) · Circulation · doi:10.1161/01.cir.101.15.1767 · Cited by 2,429 · see citing works
Hwang, S., Ballantyne, C. M., Sharrett, A. R., Smith, L. C., DAVIS, C. E., Gotto, A. M., & Boerwinkle, E. (1997) · Circulation · doi:10.1161/01.cir.96.12.4219 · Cited by 1,340 · see citing works
Ridker, P. M., Glynn, R. J., & Hennekens, C. H. (1998) · Circulation · doi:10.1161/01.cir.97.20.2007 · Cited by 1,012 · see citing works
Plasma Concentration of C-Reactive Protein and Risk of Developing Peripheral Vascular Disease
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1998) · Circulation · doi:10.1161/01.cir.97.5.425 · Cited by 973 · see citing works
Self-citationMacy, E. M., Hayes, T. E., & Tracy, R. P. (1997) · Clinical Chemistry · doi:10.1093/clinchem/43.1.52 · Cited by 797 · see citing works
Self-citationNovel Clinical Markers of Vascular Wall Inflammation
Blake, G. J., & Ridker, P. M. (2001) · Circulation Research · doi:10.1161/hh2101.099270 · Cited by 754 · see citing works
Inflammatory bio‐markers and cardiovascular risk prediction
Blake, G., & Ridker, P. M. (2002) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2002.01019.x · Cited by 702 · see citing works
Liu, S., Manson, J. E., Buring, J. E., Stampfer, M. J., Willett, W. C., & Ridker, P. M. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.3.492 · Cited by 594 · see citing works
Circulating Cell Adhesion Molecules and Death in Patients With Coronary Artery Disease
Blankenberg, S., Rupprecht, H. J., Bickel, C., Peetz, D., Hafner, G., Tiret, L., Meyer, J., & for the AtheroGene Investigators (2001) · Circulation · doi:10.1161/hc3701.095949 · Cited by 593 · see citing works
Weight Loss Reduces C-Reactive Protein Levels in Obese Postmenopausal Women
Tchernof, A., Nolan, A., Sites, C. K., Ades, P. A., & Poehlman, E. T. (2002) · Circulation · doi:10.1161/hc0502.103331 · Cited by 541 · see citing works
Tracy, R. P., Psaty, B. M., Macy, E., Bovill, E. G., Cushman, M., Cornell, E. S., & Kuller, L. H. (1997) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.17.10.2167 · Cited by 539 · see citing works
Self-citationMalik, I. S., Danesh, J., Whincup, P. H., Bhatia, V. K., Papacosta, O., Walker, M., LENNON, L. T., Thomson, A. G., & Haskard, D. O. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06104-9 · Cited by 389 · see citing works
Trans-fatty acids intake and risk of myocardial infarction.
Ascherio, A., Hennekens, C. H., Buring, J. E., MASTER, C., Stampfer, M. J., & Willett, W. C. (1994) · Circulation · doi:10.1161/01.cir.89.1.94 · Cited by 369 · see citing works
Measuring Plasma Fibrinogen to Predict Stroke and Myocardial Infarction
Maresca, G., Blasio, A. D., Marchioli, R., & Minno, G. D. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.6.1368 · Cited by 305 · see citing works
Han, S. N., Leka, L. S., Lichtenstein, A. H., Ausman, L. M., Schaefer, E. J., & Meydani, S. N. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30151-6 · Cited by 263 · see citing works
Pradhan, A. D., Rifai, N., & Ridker, P. M. (2002) · Circulation · doi:10.1161/01.cir.0000025636.03561.ee · Cited by 229 · see citing works
Laimer, M. W., Ebenbichler, C. F., Kaser, S., Sandhofer, A., Weiß, H., Nehoda, H., Aigner, F., & Patsch, J. R. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0801970 · Cited by 191 · see citing works
Jenkins, D. J. A., Kendall, C. W. C., Connelly, P. W., Jackson, C. C., Parker, T. L., Faulkner, D. A., & Vidgen, E. (2002) · Metabolism · doi:10.1053/meta.2002.33352 · Cited by 156 · see citing works
Role of inflammatory biomarkers in prediction of coronary heart disease
Ridker, P. M. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06112-8 · Cited by 134 · see citing works
Dietary cis and trans monounsaturated and saturated FA and plasma lipids and lipoproteins in men
Judd, J. T., Baer, D. J., Clevidence, B. A., Kris‐Etherton, P. M., Muesing, R. A., & Iwane, M. K. (2002) · Lipids · doi:10.1007/s11745-002-0871-9 · Cited by 132 · see citing works
Self-citationBarinas‐Mitchell, E. (2001) · American Journal of Epidemiology · doi:10.1093/aje/153.11.1094 · Cited by 123 · see citing works
van der Bom, J. G., de Maat, M. P. M., Bots, M. L., Haverkate, F., de Jong, P. T. V. M., Albert Hofman, D., Kluft, C., & Grobbee, D. E. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.4.621 · Cited by 89 · see citing works
Geffken, D. F., Fg, K., Mh, K., Es, C., BOVILL, E. G., & Tracy, R. P. (1994) · PubMed · Cited by 58 · see citing works
Self-citationInfluence of dietary trans-fatty acids on swine lipoprotein composition and structure
Jackson, R. L., Morrisett, J. D., Pownall, H. J., et al. (1977) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41697-9 · Cited by 49 · see citing works
Bladbjerg, E., Tholstrup, T., Marckmann, P., et al. (1995) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1653757 · Cited by 37 · see citing works
Influence of Trans Unsaturated Fats on Experimental Atherosclerosis in Rabbits
Ruttenberg, H. D., Davidson, L. M., Little, N. A., et al. (1983) · Journal of Nutrition · doi:10.1093/jn/113.4.835 · Cited by 30 · see citing works
Trans fatty acid effects in experimental atherosclerosis.
Kritchevsky, D. (1982) · PubMed · Cited by 24 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Trans fatty acids and cardiovascular disease
Mozaffarian, D., Katan, M. B., Ascherio, A., Stampfer, M. J., & Willett, W. C. (2006) · New England Journal of Medicine · doi:10.1056/nejmra054035 · Cited by 1,752 · see citing works
de Souza, R. J., Mente, A., Maroleanu, A., Cozma, A. I., Ha, V., Kishibe, T., Uleryk, E., Budylowski, P., Schünemann, H., Beyene, J., et al. (2015) · BMJ · doi:10.1136/bmj.h3978 · Cited by 1,424 · see citing works
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
Diet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction
Fung, T. T., McCullough, M. L., Newby, P., Manson, J. E., Meigs, J. B., Rifai, N., Willett, W. C., & Hu, F. B. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.1.163 · Cited by 1,001 · see citing works
The Effects of Diet on Inflammation
Giugliano, D., Ceriello, A., & Esposito, K. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.03.052 · Cited by 842 · see citing works
Health effects of trans-fatty acids: experimental and observational evidence
Mozaffarian, D., Aro, A., & Willett, W. C. (2009) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602973 · Cited by 662 · see citing works
Saturated fat, carbohydrate, and cardiovascular disease
Siri-Tarino, P. W., Sun, Q., Hu, F. B., & Krauss, R. M. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26285 · Cited by 636 · see citing works
Lopez-Garcia, E., Schulze, M. B., Meigs, J. B., Manson, J. E., Rifai, N., Stampfer, M. J., Willett, W. C., & Hu, F. B. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.3.562 · Cited by 600 · see citing works
Micha, R., & Mozaffarian, D. (2010) · Lipids · doi:10.1007/s11745-010-3393-4 · Cited by 543 · see citing works
Inflammation and cardiovascular disease: From mechanisms to therapeutics
Alfaddagh, A., Martin, S. S., Leucker, T. M., Michos, E. D., Blaha, M. J., Lowenstein, C. J., Jones, S. R., & Toth, P. P. (2020) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2020.100130 · Cited by 473 · see citing works
Mozaffarian, D., & Clarke, R. (2009) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602976 · Cited by 410 · see citing works
Stote, K. S., Baer, D. J., Spears, K., Paul, D. R., Harris, G. K., Rumpler, W. V., Strycula, P., Najjar, S. S., Ferrucci, L., Ingram, D. K., et al. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.4.981 · Cited by 392 · see citing works
Self-citationTrans fatty acids: effects on metabolic syndrome, heart disease and diabetes
Micha, R., & Mozaffarian, D. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.79 · Cited by 290 · see citing works
van Dijk, S. J., Feskens, E. J., Bos, M. B., Hoelen, D. W., Heijligenberg, R., Bromhaar, M. G., de Groot, L. C., de Vries, J. H., Müller, M., & Afman, L. A. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27792 · Cited by 291 · see citing works
Johnson, G. H., & Fritsche, K. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2012.03.029 · Cited by 268 · see citing works
A prospective study of dietary fat consumption and endometriosis risk
Missmer, S. A., Chavarro, J. E., Malspeis, S., Bertone-Johnson, E. R., Hornstein, M. D., Spiegelman, D., Barbieri, R. L., Willett, W. C., & Hankinson, S. E. (2010) · Human Reproduction · doi:10.1093/humrep/deq044 · Cited by 251 · see citing works
Motard-Bélanger, A., Charest, A., Grenier, G., Paquin, P., Chouinard, Y., Lemieux, S., Couture, P., & Lamarche, B. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.3.593 · Cited by 204 · see citing works
Dietary fatty acid intakes and the risk of ovulatory infertility
Chavarro, J. E., Rich-Edwards, J. W., Rosner, B. A., & Willett, W. C. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.1.231 · Cited by 203 · see citing works
Targeting fatty acid metabolism to improve glucose metabolism
Stinkens, R., Goossens, G. H., Jocken, J. W. E., & Blaak, E. E. (2015) · Obesity Reviews · doi:10.1111/obr.12298 · Cited by 183 · see citing works
Nettleton, J. A., Diez-Roux, A., Jenny, N. S., Fitzpatrick, A. L., & Jacobs, D. R. (2008) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26429 · Cited by 184 · see citing works
Kalogeropoulos, N., Panagiotakos, D. B., Pitsavos, C., Chrysohoou, C., Rousinou, G., Toutouza, M., & Stefanadis, C. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.01.023 · Cited by 160 · see citing works
Poppitt, S. D., Keogh, G. F., Lithander, F. E., Wang, Y., Mulvey, T. B., Chan, Y.-K., McArdle, B. H., & Cooper, G. J. S. (2008) · Nutrition · doi:10.1016/j.nut.2007.12.012 · Cited by 112 · see citing works
Aronis, K. N., Khan, S. M., & Mantzoros, C. S. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.040576 · Cited by 64 · see citing works
Trans-fatty acids and nonlipid risk factors
Wallace, S. K., & Mozaffarian, D. (2009) · Current Atherosclerosis Reports · doi:10.1007/s11883-009-0064-0 · Cited by 53 · see citing works
Replacing Trans Fat: The Argument for Palm Oil with a Cautionary Note on Interesterification
Hayes, K. C., & Pronczuk, A. (2010) · Journal of the American College of Nutrition · doi:10.1080/07315724.2010.10719842 · Cited by 51 · see citing works
Curcumin Inhibits Age-Related Vascular Changes in Aged Mice Fed a High-Fat Diet
Takano, K., Tatebe, J., Washizawa, N., & Morita, T. (2018) · Nutrients · doi:10.3390/nu10101476 · Cited by 43 · see citing works
Higgins, L. J., & Rutledge, J. C. (2009) · Current Atherosclerosis Reports · doi:10.1007/s11883-009-0031-9 · Cited by 42 · see citing works
- Authors
- Baer, D. J., Judd, J. T., Clevidence, B. A., & Tracy, R. P.
- Affiliations
- Agricultural Research Service (US)
- University of Vermont (US)
- Corresponding author
- Baer, David J
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2004-06
- Volume
- 79
- Issue
- 6
- Pages
- 969-973
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2113969989
- Cited by
- 476
- References
- 27
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 14 · 2023: 20 · 2022: 18 · 2021: 24 · 2020: 27 · 2019: 17 · 2018: 15 · 2017: 18 · 2016: 26 · 2015: 30 · 2014: 16 · 2013: 23 · 2012: 22
- FWCI
- 19.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Nuts composition and effects
- Keywords
- dietary fatty acids, trans fatty acids, stearic acid, oleic acid, long-chain polyunsaturated fatty acids, inflammatory markers, fibrinogen, C-reactive protein, interleukin-6, E-selectin, cardiovascular risk factors, LDL cholesterol, saturated fatty acids, controlled diet
- MeSH terms
- Adult, Body Weight, Energy Intake, Cholesterol, Diet, Dietary Carbohydrates, Dietary Fats, Humans, Inflammation, Male, Middle Aged, Risk Factors, Body Mass Index, Cross-Over Studies, Trans Fatty Acids
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
