Cited by 156Gut microbiota and healthRheumatoid Arthritis Research and TherapiesOral microbiology and periodontitis research

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The Role of the Microbiome in Rheumatic Diseases

Yeoh, Nigel, Burton, Jeremy P., Suppiah, Praema, Reid, Gregor, Stebbings, Simon·2013·Current Rheumatology Reports

DOI 10.1007/s11926-012-0314-y

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Abstract

There is a growing understanding of the mechanisms by which the influence of the microbiota projects beyond sites of primary mucosal occupation to other human body systems. Bacteria present in the intestinal tract exert a profound effect on the host immune system, both locally and at distant sites. The oral cavity has its own characteristic microbiota, which concentrates in periodontal tissues and is in close association with a permeable epithelium. In this review we examine evidence which supports a role for the microbiome in the aetiology of rheumatic disease. We also discuss how changes in the composition of the microbiota, particularly within the gastrointestinal tract, may be affected by genetics, diet, and use of antimicrobial agents. Evidence is presented to support the theory that an altered microbiota is a factor in the initiation and perpetuation of inflammatory diseases, including rheumatoid arthritis (RA), spondyloarthritis (SpA), and inflammatory bowel disease (IBD). Mechanisms through which the microbiota may be involved in the pathogenesis of these diseases include altered epithelial and mucosal permeability, loss of immune tolerance to components of the indigenous microbiota, and trafficking of both activated immune cells and antigenic material to the joints. The potential to manipulate the microbiome, by application of probiotics and faecal microbial transplant (FMT), is now being investigated. Both approaches are in their infancy with regard to management of rheumatic disease but their potential is worthy of consideration, given the need for novel therapeutic approaches, and the emerging recognition of the importance of microbial interactions with human hosts.

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Authors: Yeoh, N., Burton, J. P., Suppiah, P., Reid, G., & Stebbings, S.
Affiliations: University of Otago (NZ)
Western University (CA)
Corresponding author: Stebbings, Simon
ORCID: Burton, Jeremy P.
Reid, Gregor
Stebbings, Simon
Venue: Current Rheumatology Reports
Publisher: Springer Science and Business Media LLC
Published: 2013-02-03
Volume: 15
Issue: 3
Pages: 314-314
ISSN: 1523-3774 (ISSN-L)
1534-6307
DOI: 10.1007/s11926-012-0314-y
OpenAlex: W2095223297
Cited by: 155
References: 135
Citations by year: 2026: 4 · 2025: 6 · 2024: 10 · 2023: 9 · 2022: 11 · 2021: 12 · 2020: 15 · 2019: 10 · 2018: 14 · 2017: 8 · 2016: 16 · 2015: 15 · 2014: 18 · 2013: 7
FWCI: 1.75
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Current Rheumatology Reports (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: microbiome, rheumatic diseases, rheumatoid arthritis, spondyloarthritis, inflammatory bowel disease, gut microbiota, oral microbiota, periodontal microbiota, mucosal permeability, immune tolerance, immune cell trafficking, probiotics, fecal microbiota transplantation, diet, antimicrobial agents, etiology
MeSH terms: Anti-Bacterial Agents, Diet, Humans, Immune Tolerance, Mouth, Obesity, Rheumatic Diseases, Probiotics, Gastrointestinal Tract, Metagenome

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