Fecal microbiota transplantation broadening its application beyond intestinal disorders
Open accessAbstract
Intestinal dysbiosis is now known to be a complication in a myriad of diseases. Fecal microbiota transplantation (FMT), as a microbiota-target therapy, is arguably very effective for curing Clostridium difficile infection and has good outcomes in other intestinal diseases. New insights have raised an interest in FMT for the management of extra-intestinal disorders associated with gut microbiota. This review shows that it is an exciting time in the burgeoning science of FMT application in previously unexpected areas, including metabolic diseases, neuropsychiatric disorders, autoimmune diseases, allergic disorders, and tumors. A randomized controlled trial was conducted on FMT in metabolic syndrome by infusing microbiota from lean donors or from self-collected feces, with the resultant findings showing that the lean donor feces group displayed increased insulin sensitivity, along with increased levels of butyrate-producing intestinal microbiota. Case reports of FMT have also shown favorable outcomes in Parkinson's disease, multiple sclerosis, myoclonus dystonia, chronic fatigue syndrome, and idiopathic thrombocytopenic purpura. FMT is a promising approach in the manipulation of the intestinal microbiota and has potential applications in a variety of extra-intestinal conditions associated with intestinal dysbiosis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
FMT has been explored as a therapeutic strategy for a wide range of neurological disorders, including multiple sclerosis, epilepsy, ASD, Tourette syndrome, diabetic neuropathy, AD and PD, with promising preclinical and clinical data.
“Following the successful use of FMT in the treatment of refractory or recurrent Clostridium difficile infection, several studies have been conducted to explore FMT as a therapeutic strategy for a wide range of neurological disorders, including multiple sclerosis, epilepsy, ASD, Tourette syndrome, diabetic neuropathy, AD and PD, with promising preclinical and clinical data [30,465,466,467,468].”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [468]
Case reports and animal models have revealed probable therapeutic effects of FMT in patients with severe multiple sclerosis, autism, multidrug-resistant organisms infections, and multiple organ dysfunction in critical patients.
“Several case reports and animal models have also revealed the probable therapeutic effects of FMT in patients with severe multiple sclerosis, 41 autism, 42 multidrug-resistant organisms (MDRO) infections, 43 and multiple organ dysfunction in critical patients.44”
From Fecal microbiota transplantation: Review and update (2019) · cites this paper as [41]
Cites
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815 · see citing works
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762 · see citing works
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597 · see citing works
Hay fever, hygiene, and household size.
Strachan, D. P. (1989) · BMJ · doi:10.1136/bmj.299.6710.1259 · Cited by 5,054 · see citing works
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029 · see citing works
Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386 · see citing works
Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182 · see citing works
Induction of Colonic Regulatory T Cells by Indigenous <i>Clostridium</i> Species
Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752 · see citing works
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,402 · see citing works
Vrieze, A., Van Nood, E., Holleman, F., Salojärvi, J., Kootte, R. S., Bartelsman, J. F. W. M., Dallinga–Thie, G. M., Ackermans, M. T., Serlie, M. J., Oozeer, R., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.031 · Cited by 2,913 · see citing works
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910 · see citing works
Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718 · see citing works
Microbiota and SCFA in lean and overweight healthy subjects
Schwiertz, A., Taras, D., Schäfer, K., Beijer, S., Bos, N. A., Donus, C., & Hardt, P. D. (2010) · Obesity · doi:10.1038/oby.2009.167 · Cited by 2,457 · see citing works
MICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT
Savage, D. C. (1977) · Annual Review of Microbiology · doi:10.1146/annurev.mi.31.100177.000543 · Cited by 2,436 · see citing works
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
Scher, J. U., Sczesnak, A., Longman, R. S., Segata, N., Ubeda, C., Bielski, C., Rostron, T., Cerundolo, V., Pamer, E. G., Abramson, S. B., et al. (2013) · eLife · doi:10.7554/elife.01202 · Cited by 2,047 · see citing works
Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function
Olszak, T., An, D., Zeissig, S., Vera, M. P., Richter, J., Franke, A., Glickman, J. N., Siebert, R., Baron, R. M., Kasper, D. L., et al. (2012) · Science · doi:10.1126/science.1219328 · Cited by 1,661 · see citing works
Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections
Surawicz, C. M., Brandt, L. J., Binion, D. G., Ananthakrishnan, A. N., Curry, S. R., Gilligan, P. H., McFarland, L. V., Mellow, M., & Zuckerbraun, B. S. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.4 · Cited by 1,645 · see citing works
The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
Round, J. L., Lee, S. M., Li, J., Tran, G., Jabri, B., Chatila, T. A., & Mazmanian, S. K. (2011) · Science · doi:10.1126/science.1206095 · Cited by 1,604 · see citing works
Clostridium difficile--more difficult than ever.
Kelly, C. P., & Lamont, J. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0707500 · Cited by 1,386 · see citing works
Gut Microbiota and Metabolic Endotoxemia in Young Obese Mexican Subjects
Radilla-Vázquez, R. B., Parra‐Rojas, I., Martínez-Hernández, N. E., Márquez‐Sandoval, F., Illades‐Aguiar, B., & Castro-Alarcón, N. (2016) · Obesity Facts · doi:10.1159/000442479 · Cited by 1,200 · see citing works
Gough, E., Shaikh, H., & Manges, A. R. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir632 · Cited by 1,003 · see citing works
Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice
Le Roy, T., Llopis, M., Lepage, P., Bruneau, A., Rabot, S., Bevilacqua, C., Martin, P., Philippe, C., Walker, F., Bado, A., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303816 · Cited by 1,001 · see citing works
(1958) · PubMed · Cited by 978 · see citing works
Interactions Between the Intestinal Microbiome and Liver Diseases
Schnabl, B., & Brenner, D. A. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.020 · Cited by 971 · see citing works
Human Gut Microbiome and Risk for Colorectal Cancer
Ahn, J., Sinha, R., Pei, Z., Dominianni, C., Wu, J., Shi, J., Goedert, J. J., Hayes, R. B., & Yang, L. (2013) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djt300 · Cited by 947 · see citing works
Murphy, E. F., Cotter, P. D., Healy, S., Marques, T. M., O’Sullivan, Ó., Fouhy, F., Clarke, S. F., O’Toole, P. W., Quigley, E. M. M., Stanton, C., et al. (2010) · Gut · doi:10.1136/gut.2010.215665 · Cited by 942 · see citing works
Armougom, F., Henry, M., Vialettes, B., Raccah, D., & Raoult, D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007125 · Cited by 905 · see citing works
Gut microbiome, obesity, and metabolic dysfunction
Tilg, H., & Kaser, A. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58109 · Cited by 860 · see citing works
The gut microbiota and obesity: from correlation to causality
Zhao, L. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3089 · Cited by 847 · see citing works
Bäckhed, F., Fraser, C. M., Ringel, Y., Sanders, M. E., Sartor, R. B., Sherman, P. M., Versalovic, J., Young, V., & Finlay, B. B. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.10.012 · Cited by 836 · see citing works
The Changing Epidemiology of Clostridium difficile Infections
Freeman, J., Bauer, M. P., Baines, S. D., Corver, J., Fawley, W. N., Goorhuis, A., Kuijper, E. J., & Wilcox, M. H. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00082-09 · Cited by 825 · see citing works
Greenblum, S., Turnbaugh, P. J., & Borenstein, E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116053109 · Cited by 821 · see citing works
The role of microbiome in central nervous system disorders
Wang, Y., & Kasper, L. H. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.015 · Cited by 803 · see citing works
Gastrointestinal Microflora Studies in Late‐Onset Autism
Finegold, S. M., Molitoris, D., Song, Y., Liu, C., Vaisanen, M., Bolte, E., McTeague, M., Sandler, R., Wexler, H., Marlowe, E. M., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/341914 · Cited by 742 · see citing works
Hamilton, M. J., Weingarden, A. R., Sadowsky, M. J., & Khoruts, A. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.482 · Cited by 738 · see citing works
Fecal microbiota transplantation and emerging applications
Borody, T. J., & Khoruts, A. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.244 · Cited by 677 · see citing works
Khoruts, A., Dicksved, J., Jansson, J. K., & Sadowsky, M. J. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181c87e02 · Cited by 649 · see citing works
Should we standardize the 1,700-year-old fecal microbiota transplantation?
Zhang, F., Luo, W., Shi, Y., Fan, Z., & Ji, G. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.251 · Cited by 619 · see citing works
Collins, S. M., & Bercik, P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.075 · Cited by 612 · see citing works
Rabot, S., Membrez, M., Bruneau, A., Gérard, P., Harach, T., Moser, M., Raymond, F., Mansourian, R., & Chou, C. J. (2010) · The FASEB Journal · doi:10.1096/fj.10-164921 · Cited by 610 · see citing works
Rabot, S., Membrez, M., Bruneau, A., Gérard, P., Harach, T., Moser, M., Raymond, F., Mansourian, R., & Chou, C. J. (2010) · The FASEB Journal · doi:10.1096/fj.10.164921 · Cited by 610 · see citing works
Wang, Z., Tang, W. H. W., Buffa, J. A., Fu, X., Britt, E. B., Koeth, R. A., Levison, B. S., Fan, Y., Wu, Y., & Hazen, S. L. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu002 · Cited by 559 · see citing works
Real-Time PCR Quantitation of Clostridia in Feces of Autistic Children
Song, Y., Liu, C., & Finegold, S. M. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.11.6459-6465.2004 · Cited by 556 · see citing works
Parks, B. W., Nam, E., Org, E., Kostem, E., Norheim, F., Hui, S. T., Pan, C., Civelek, M., Rau, C. D., Bennett, B. J., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.007 · Cited by 544 · see citing works
Colonization of the Human Gut by <i>E. coli</i> and Colorectal Cancer Risk
Bonnet, M., Buc, E., Sauvanet, P., Darcha, C., Dubois, D., Pereira, B., Déchelotte, P., Bonnet, R., Pezet, D., & Darfeuille-Michaud, A. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1343 · Cited by 475 · see citing works
The role of the gut microbiota in nonalcoholic fatty liver disease
Abu-Shanab, A., & Quigley, E. M. M. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.172 · Cited by 457 · see citing works
Insulin Resistance in Nonalcoholic Fatty Liver Disease
Bugianesi, E., Moscatiello, S., Ciaravella, M. F., & Marchesini, G. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210791208875 · Cited by 446 · see citing works
Dysregulation of Allergic Airway Inflammation in the Absence of Microbial Colonization
Herbst, T., Sichelstiel, A., Schär, C., Yadava, K., Bürki, K., Cahenzli, J., McCoy, K., Marsland, B. J., & Harris, N. L. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201010-1574oc · Cited by 440 · see citing works
Interaction Between Obesity and the Gut Microbiota: Relevance in Nutrition
Delzenne, N. M., & Cani, P. D. (2011) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-072610-145146 · Cited by 409 · see citing works
The ‘microflora hypothesis’ of allergic diseases
Noverr, M. C., & Huffnagle, G. B. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2005.02379.x · Cited by 394 · see citing works
Zoetendal, E. G., Vaughan, E. E., & de Vos, W. M. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05056.x · Cited by 390 · see citing works
The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus
Kootte, R. S., Vrieze, A., Holleman, F., Dallinga‐Thie, G. M., Zoetendal, E. G., de Vos, W. M., Groen, A. K., Hoekstra, J. B. L., Stroes, E. S. G., & Nieuwdorp, M. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01483.x · Cited by 348 · see citing works
Fecal microbiota transplantation: past, present and future
Aroniadis, O. C., & Brandt, L. J. (2013) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32835a4b3e · Cited by 336 · see citing works
Angelberger, S., Reinisch, W., Makristathis, A., Lichtenberger, C., Dejaco, C., Papay, P., Novacek, G., Trauner, M., Loy, A., & Berry, D. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.257 · Cited by 330 · see citing works
Kunde, S., Pham, A., Bonczyk, S., Crumb, T., Duba, M., Conrad, H., Cloney, D., & Kugathasan, S. (2013) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e318292fa0d · Cited by 314 · see citing works
Systematic review: faecal microbiota transplantation in the management of inflammatory bowel disease
Anderson, J. E., Edney, R. J., & Whelan, K. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2012.05220.x · Cited by 313 · see citing works
Probiotics in pregnant women to prevent allergic disease: a randomized, double-blind trial
Dotterud, C. K., Storrø, O., Johnsen, R., & Øien, T. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.09889.x · Cited by 296 · see citing works
The impact of nutrition on the human microbiome
Flint, H. J. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00499.x · Cited by 291 · see citing works
Fecal Microbiota Transplantation: Indications, Methods, Evidence, and Future Directions
Borody, T. J., Paramsothy, S., & Agrawal, G. (2013) · Current Gastroenterology Reports · doi:10.1007/s11894-013-0337-1 · Cited by 275 · see citing works
Use of Antibiotics during Pregnancy Increases the Risk of Asthma in Early Childhood
Stensballe, L. G., Simonsen, J., Jensen, S. M., Bønnelykke, K., & Bisgaard, H. F. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2012.09.049 · Cited by 248 · see citing works
Potential mechanisms for the emerging link between obesity and increased intestinal permeability
Teixeira, T. F. S., Collado, M. C., Ferreira, C. L. D. L. F., Bressan, J., & Pelúzio, M. D. C. G. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.07.003 · Cited by 242 · see citing works
Fox, J. G., Feng, Y., Theve, E. J., Raczynski, A. R., Fiala, J. L. A., Doernte, A. L., Williams, M. V., McFaline‐Figueroa, J. L., Essigmann, J. M., Schauer, D. B., et al. (2009) · Gut · doi:10.1136/gut.2009.183749 · Cited by 238 · see citing works
A Clinician's Primer on the Role of the Microbiome in Human Health and Disease
Khanna, S., & Tosh, P. K. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.10.011 · Cited by 231 · see citing works
Borody, T. J., George, L., Andrews, P., Brandl, S., Noonan, S., Cole, P., Hyland, L., Morgan, A., Maysey, J., & Moore‐Jones, D. (1989) · Medical Journal of Australia · doi:10.5694/j.1326-5377.1989.tb136704.x · Cited by 221 · see citing works
De Leon, L. M., Watson, J. B., & Kelly, C. R. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.04.045 · Cited by 215 · see citing works
Frémont, M., Coomans, D. H., Massart, S., & Meirleir, K. D. (2013) · Anaerobe · doi:10.1016/j.anaerobe.2013.06.002 · Cited by 208 · see citing works
Association of Streptococcus bovis Bacteremia With Colonic Neoplasia and Extracolonic Malignancy
Gold, J. S. (2004) · Archives of Surgery · doi:10.1001/archsurg.139.7.760 · Cited by 202 · see citing works
Therapeutic modulation of intestinal dysbiosis
Walker, A. W., & Lawley, T. D. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.09.008 · Cited by 197 · see citing works
Life style risks of Parkinson?s disease: Association between decreased water intake and constipation
Ueki, A., & Otsuka, M. (2004) · Journal of Neurology · doi:10.1007/s00415-004-1706-3 · Cited by 190 · see citing works
Rao, V. P., Poutahidis, T., Ge, Z., Nambiar, P. R., Boussahmain, C., Wang, Y. Y., Horwitz, B. H., Fox, J. G., & Erdman, S. E. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0558 · Cited by 185 · see citing works
Fuentes, S., van Nood, E., Tims, S., Jong, I. H., ter Braak, C. J. F., Keller, J. J., Zoetendal, E. G., & de Vos, W. M. (2014) · The ISME Journal · doi:10.1038/ismej.2014.13 · Cited by 174 · see citing works
Szymula, A., Rosenthal, J., Szczerba, B. M., Bagavant, H., Fu, S. M., & Deshmukh, U. S. (2014) · Clinical Immunology · doi:10.1016/j.clim.2014.02.004 · Cited by 166 · see citing works
The Role of the Microbiome in Rheumatic Diseases
Yeoh, N., Burton, J. P., Suppiah, P., Reid, G., & Stebbings, S. (2013) · Current Rheumatology Reports · doi:10.1007/s11926-012-0314-y · Cited by 155 · see citing works
Fecal Microbiota Transplantation (FMT) in Multiple Sclerosis (MS): 942
Borody, T., Leis, S., Campbell, J., Torres, M., & Nowak, A. (2011) · American Journal of Gastroenterology · doi:10.14309/00000434-201110002-00942 · Cited by 149 · see citing works
Fecal Microbiota Transplantation
Borody, T. J., & Campbell, J. (2012) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2012.08.008 · Cited by 140 · see citing works
The role of microbes and autoimmunity in the pathogenesis of neuropsychiatric illness
Hornig, M. (2013) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32836208de · Cited by 138 · see citing works
Clinical Use of Probiotics in Pediatric Allergy (cuppa): A World Allergy Organization Position Paper
Fiocchi, A. G., Burks, W. A., Bahna, S. L., Bielory, L., Boyle, R. J., Cocco, R. R., Dreborg, S. K. G., Goodman, R. E., Kuitunen, M., Haahtela, T., et al. (2012) · World Allergy Organization Journal · doi:10.1097/wox.0b013e3182784ee0 · Cited by 133 · see citing works
Kyriakidis, N. C., Kapsogeorgou, E. K., & Tzioufas, A. G. (2013) · Journal of Autoimmunity · doi:10.1016/j.jaut.2013.11.001 · Cited by 132 · see citing works
Tuohy, K. M., Fava, F., & Viola, R. (2014) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113003911 · Cited by 124 · see citing works
The Physiological Relevance of the Intestinal Microbiota - Contributions to Human Health
Tappenden, K. A., & Deutsch, A. S. (2007) · Journal of the American College of Nutrition · doi:10.1080/07315724.2007.10719647 · Cited by 123 · see citing works
Fecal microbiota transplantation for severe enterocolonic fistulizing Crohn’s disease
Zhang, F. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i41.7213 · Cited by 118 · see citing works
Malabsorption and cerebral dysfunction: A multivariate and comparative study of autistic children
Goodwin, M. S., Goodwin, T. C., & Cowen, M. A. (1971) · Journal of Autism and Developmental Disorders · doi:10.1007/bf01537742 · Cited by 116 · see citing works
State of the art; microbiology in health and disease. Intestinal bacterial flora in autism
Finegold, S. M. (2011) · Anaerobe · doi:10.1016/j.anaerobe.2011.03.007 · Cited by 116 · see citing works
Jang, S.-O., Kim, H., Kim, Y., Kang, M., Kwon, J., Seo, J., Kim, H. Y., Kim, B., Yu, J., & Hong, S. (2012) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2012.4.3.150 · Cited by 111 · see citing works
Udayappan, S. D., Hartstra, A. V., Dallinga‐Thie, G. M., & Nieuwdorp, M. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12293 · Cited by 101 · see citing works
Yamamoto, M. L., Maier, I., Dang, A. T., Berry, D., Liu, J., Ruegger, P. M., Yang, J.-I., Soto, P. A., Presley, L. L., Reliene, R., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0022 · Cited by 93 · see citing works
Fecal microbiota transplantation: facts and controversies
van Nood, E., Speelman, P., Nieuwdorp, M., & Keller, J. (2014) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000024 · Cited by 92 · see citing works
Kao, D. H., Hotte, N., Gillevet, P. M., & Madsen, K. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000131 · Cited by 86 · see citing works
Rao, V. P., Poutahidis, T., Ge, Z., Nambiar, P. R., Horwitz, B. H., Fox, J. G., & Erdman, S. E. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3445 · Cited by 81 · see citing works
Breast Cancer: Should Gastrointestinal Bacteria Be on Our Radar Screen?
Rao, V. P., Poutahidis, T., Fox, J. G., & Erdman, S. E. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3468 · Cited by 77 · see citing works
The impact of gut microbes in allergic diseases
Russell, S., & Finlay, B. B. (2012) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3283573017 · Cited by 74 · see citing works
Hohmann, E. L., Ananthakrishnan, A. N., & Deshpande, V. (2014) · New England Journal of Medicine · doi:10.1056/nejmcpc1400842 · Cited by 74 · see citing works
Reversal of Idiopathic Thrombocytopenic Purpura [ITP] with Fecal Microbiota Transplantation [FMT]
Borody, T. J., Campbell, J., Torres, M., Nowak, A. K., & Leis, S. (2011) · The American Journal of Gastroenterology · doi:10.14309/00000434-201110002-00941 · Cited by 74 · see citing works
Ultrastructural changes in enterocytes in subjects with Hashimoto’s thyroiditis: Figure 1
Sasso, F. C., Carbonara, O., Torella, R., Mezzogiorno, A., Esposito, V., deMagistris, L., Secondulfo, M., Carratu’, R., Iafusco, D., & Cartenì, M. (2004) · Gut · doi:10.1136/gut.2004.047498 · Cited by 67 · see citing works
Early fish introduction and neonatal antibiotics affect the risk of asthma into school age
Goksör, E., Alm, B., Pettersson, R., Möllborg, P., Erdes, L., Åberg, N., & Wennergren, G. (2013) · Pediatric Allergy and Immunology · doi:10.1111/pai.12078 · Cited by 66 · see citing works
Faecal transplant eases symptoms of Parkinson's disease
Ananthaswamy, A. (2011) · The New Scientist · doi:10.1016/s0262-4079(11)60124-3 · Cited by 55 · see citing works
Relationship Between Thyroid Autoimmunity and Yersinia Enterocolitica Antibodies
Çorapçıoğlu, D., Gedik, V. T., Kıyan, M., Yilmaz, A. E., Emral, R., Kamel, N., & Erdoğan, G. (2002) · Thyroid · doi:10.1089/105072502320288483 · Cited by 53 · see citing works
RecurrentClostridium difficileinfections: The importance of the intestinal microbiota
Terrier, M.-C. Z. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i23.7416 · Cited by 51 · see citing works
Schabussová, I., Hufnagl, K., Tang, M. L. K., Hoflehner, E., Wagner, A., Loupal, G., Nutten, S., Zuercher, A. W., Mercenier, A., & Wiedermann, U. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040271 · Cited by 47 · see citing works
A patient with severe Crohn's colitis responds to Faecal Microbiota Transplantation
Gordon, H., & Harbord, M. (2013) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2013.10.007 · Cited by 45 · see citing works
Menéndez, A., Gómez, J. M. F., Caminal‐Montero, L., Díaz-López, J. B., Cabezas‐Rodríguez, I., & Mozo, L. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/832789 · Cited by 44 · see citing works
Does the gut microbiota trigger Hashimoto's thyroiditis?
Mori, K., Nakagawa, Y., & Ozaki, H. (2012) · PubMed · Cited by 42 · see citing works
Microbial Translocation and Cardiometabolic Risk Factors in HIV Infection
Trøseid, M., Manner, I. W., Pedersen, K. K., Haissman, J. M., Kvale, D., & Nielsen, S. D. (2014) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2013.0280 · Cited by 41 · see citing works
Strieder, T. G. A., Wenzel, B. E., Prummel, M. F., Tijssen, J. G. P., & Wiersinga, W. M. (2003) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2003.02139.x · Cited by 40 · see citing works
Restoring the gut microbiome for the treatment of inflammatory bowel diseases
Allegretti, J. R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i13.3468 · Cited by 40 · see citing works
Bugs & us: the role of the gut in autoimmunity.
Luckey, D. H., Gomez, A. M., Murray, J. A., White, B. A., & Taneja, V. (2013) · Europe PMC (PubMed Central) · Cited by 40 · see citing works
The GI microbiome and its role in Chronic Fatigue Syndrome: A summary of bacteriotherapy
Borody, T. J., Nowak, A., & Finlayson, S. (2012) · Journal of the Australasian College of Nutritional and Environmental Medicine · Cited by 39 · see citing works
Early fish introduction and neonatal antibiotics affect the risk of asthma into school age
Goksör, E., Alm, B., Petterson, R., Möllborg, P., Erdes, L., Åberg, N., & Wennergren, G. (2013) · European Respiratory Journal · doi:10.1183/13993003/erj.42.suppl_57.p1629 · Cited by 36 · see citing works
A case for antibiotic perturbation of the microbiota leading to allergy development
Reynolds, L. A., & Finlay, B. B. (2013) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2013.851603 · Cited by 29 · see citing works
Faecal microbiota transplantation for Clostridium difficile infection
Dodin, M., & Katz, D. E. (2013) · International Journal of Clinical Practice · doi:10.1111/ijcp.12320 · Cited by 27 · see citing works
Effraimidis, G., Tijssen, J. G. P., Strieder, T. G. A., & Wiersinga, W. M. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04399.x · Cited by 25 · see citing works
Microbial functionality in the human intestinal tract
Salonen, A. (2009) · Frontiers in bioscience · doi:10.2741/3436 · Cited by 23 · see citing works
Myoclonus-dystonia Affected by GI Microbiota?
Borody, T. J., Rosen, D., Torres, M., Campbell, J., & Nowak, A. (2011) · The American Journal of Gastroenterology · doi:10.14309/00000434-201110002-00940 · Cited by 16 · see citing works
How Do Microbes Shape Animal Development?
Pennisi, E. (2013) · Science · doi:10.1126/science.340.6137.1159 · Cited by 15 · see citing works
Is Crohn’s Disease Ready for Fecal Microbiota Transplantation?
Borody, T. J., Finlayson, S., & Paramsothy, S. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000155 · Cited by 10 · see citing works
Guseo, A. (2012) · Orvosi Hetilap · doi:10.1556/oh.2012.29461 · Cited by 4 · see citing works
Abdollahi‐Roodsaz, S., Rogier, R., Ederveen, T., Wopereis, H., Oozeer, R., Koenders, M. I., & van den Berg, W. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-205124.203 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Rivière, A., Selak, M., Lantin, D., Leroy, F., & Vuyst, L. D. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00979 · Cited by 1,746 · see citing works
The Gut Microbiota and Alzheimer’s Disease
Jiang, C., Li, G., Huang, P., Liu, Z., & Zhao, B. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161141 · Cited by 852 · see citing works
“Anarguablyeffectivetherapyfortreat-ingpatientswith Clostridium difficile infection [71, 72] (for review, see [72]), FMT has also shown favorable outcomes in extra-intestinal diseases associated with intestinal dysbiosis (for review, see [73, 74]).”
Long-term benefit of microbiota transfer therapy on autism symptoms and gut microbiota
Kang, D.-W., Adams, J. B., Coleman, D. M., Pollard, E. L., Maldonado, J., McDonough-Means, S., Caporaso, J. G., & Krajmalnik-Brown, R. (2019) · Scientific Reports · doi:10.1038/s41598-019-42183-0 · Cited by 749 · see citing works
Shen, Z.-H., Zhu, C.-X., Quan, Y.-S., Yang, Z.-Y., Wu, S., Luo, W.-W., Tan, B., & Wang, X.-Y. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i1.5 · Cited by 646 · see citing works
Fecal microbiota transplantation: Review and update
Wang, J.-W., Kuo, C.-H., Kuo, F.-C., Wang, Y.-K., Hsu, W.-H., Yu, F.-J., Hu, H.-M., Hsu, P.-I., Wang, J.-Y., & Wu, D.-C. (2019) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2018.08.011 · Cited by 576 · see citing works
Brain-Gut-Microbiota Axis in Parkinson’s Disease
Mulak, A. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i37.10609 · Cited by 583 · see citing works
Gut microbiota: A player in aging and a target for anti-aging intervention
Vaiserman, A. M., Koliada, A. K., & Marotta, F. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.01.001 · Cited by 465 · see citing works
Regulation of life span by the gut microbiota in the short-lived African turquoise killifish
Smith, P., Willemsen, D., Popkes, M., Metge, F., Gandiwa, E., Reichard, M., & Valenzano, D. R. (2017) · eLife · doi:10.7554/elife.27014 · Cited by 423 · see citing works
“, 2016) and have been proposed to treat obesity, metabolic syndrome and even neurodegenerative diseases (Marotz and Zarrinpar, 2016; Xu et al., 2015), the application of this methodology as an anti-aging intervention has not been explored to date.”
BackgroundMicrobes and mental health: A review
Rieder, R., Wisniewski, P. J., Alderman, B. L., & Campbell, S. C. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.01.016 · Cited by 429 · see citing works
“Although there is currently insufficient research involving the potential efficacy of FMT in depression, emerging evidence supports its use in patients with Parkinson’s disease, multiple sclerosis, and autism (Xu et al., 2015).”
BackgroundSystematic Review: Adverse Events of Fecal Microbiota Transplantation
Wang, S., Xu, M., Wang, W., Cao, X., Piao, M., Khan, S., Yan, F., Cao, H., & Wang, B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161174 · Cited by 410 · see citing works
“Perturbations in the gut microbiota have been associated with conditions as diverse as gastrointestinal diseases and even systemic disorders [46].”
Self-citationPain regulation by gut microbiota: molecular mechanisms and therapeutic potential
Guo, R., Chen, L., Xing, C., & Liu, T. (2019) · British Journal of Anaesthesia · doi:10.1016/j.bja.2019.07.026 · Cited by 416 · see citing works
Mizuno, S., Masaoka, T., Naganuma, M., Kishimoto, T., Kitazawa, M., Kurokawa, S., Nakashima, M., Takeshita, K., Suda, W., Mimura, M., et al. (2017) · Digestion · doi:10.1159/000471919 · Cited by 395 · see citing works
Calabrese, V., Santoro, A., Monti, D., Crupi, R., Di Paola, R., Latteri, S., Cuzzocrea, S., Zappia, M., Giordano, J., Calabrese, E. J., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.10.379 · Cited by 356 · see citing works
“Importantly, several research findings suggest that direct modulation of gut microbiome may be applied both in treating particular age-related disorders [101], but also can be a promising therapeutic option to combat the aging process per se [102,103].”
BackgroundConnecting the immune system, systemic chronic inflammation and the gut microbiome: the role of sex
Rizzetto, L., Fava, F., Tuohy, K. M., & Selmi, C. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.05.008 · Cited by 331 · see citing works
Faecal microbiota transplantation protects against radiation‐induced toxicity
Cui, M., Xiao, H., Li, Y., Zhou, L., Zhao, S., Luo, D., Zheng, Q., Dong, J., Zhao, Y., Zhang, X., et al. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201606932 · Cited by 327 · see citing works
“…of a human’s enteric microbiota to improve the quality of life in patients with inflammatory bowel disease (Moayyedi et al, 2015; Wei et al, 2015), non-alcoholic fatty liver disease (Le Roy et al, 2013), metabolic syndrome (Vrieze et al, 2012) and neuropsychiatric disorders (Xu et al, 2015).”
BackgroundFecal microbiota transplantation in cancer management: Current status and perspectives
Chen, D., Wu, J., Jin, D., Wang, B., & Cao, H. (2018) · International Journal of Cancer · doi:10.1002/ijc.32003 · Cited by 330 · see citing works
“Moreover, accumulating data indicate that FMT proves beneficial for the treatment of inflammatory bowel diseases and intractable functional constipation, etc.(21,22) In addition, the observed intestinal dysbiosis in cancer leads to increasing interests in the potential of FMT for the management of cancer.”
BackgroundFecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives
Choi, H. H., & Cho, Y.-S. (2016) · Clinical Endoscopy · doi:10.5946/ce.2015.117 · Cited by 318 · see citing works
“There are preliminary reports on the use of FMT therapy in a wide range of disorders including Parkinson’s disease, fibromyalgia, chronic fatigue syndrome, myoclonus dystonia, multiple sclerosis, obesity, insulin resistance, metabolic syndrome, and childhood regressive autism (Table 1).(2) Vrieze et al.”
BackgroundRecent developments in understanding the role of the gut microbiota in brain health and disease
Sherwin, E., Dinan, T. G., & Cryan, J. F. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13416 · Cited by 338 · see citing works
Microbes, immunity, and behavior: psychoneuroimmunology meets the microbiome
Dinan, T. G., & Cryan, J. F. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.103 · Cited by 246 · see citing works
Microbiota and Thyroid Interaction in Health and Disease
Fröhlich, E., & Wahl, R. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.05.008 · Cited by 233 · see citing works
Recurrent Clostridium difficile Infection: Risk Factors, Treatment, and Prevention
Song, J. H., & Kim, Y. S. (2018) · Gut and Liver · doi:10.5009/gnl18071 · Cited by 223 · see citing works
“Another potential problem of FMT is that changes in gut microbiota can affect various extraintestinal disorders, such as metabolic, neuropsychiatric, autoimmune, and tumorous disorders.(68)”
BackgroundChang, C.-W., Lee, H., Li, L.-H., Chiau, J. C., Wang, T.-E., Chuang, W.-H., Chen, M., Wang, H.-Y., Shih, S., Liu, C.-Y., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020386 · Cited by 205 · see citing works
“Because feces act as mediators between the donor and the recipient, FMT has the potential to transmit occult infections, even when donor screening is performed stringently [16,17].”
InfluentialRole of Gut Microbiome in Autism Spectrum Disorder and Its Therapeutic Regulation
Taniya, M. A., Chung, H.-J., Al Mamun, A., Alam, S., Aziz, M. A., Emon, N. U., Islam, M. M., Hong, S.-T. S., Podder, B. R., Ara Mimi, A., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.915701 · Cited by 207 · see citing works
“…of the donor and recipient should further define specific strains, better pathways, and regimens to provide optimum supplements and treatment in this particular population (Gondalia et al., 2012; Sanders et al., 2013; Xu, 2015; Li et al., 2019; Nitschke et al., 2020; Yadav and Chauhan, 2021).”
BackgroundSundman, M., Chen, N., Subbian, V., & Chou, Y. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.05.009 · Cited by 200 · see citing works
The Gut Microbiota in Multiple Sclerosis: An Overview of Clinical Trials
Schepici, G., Silvestro, S., Bramanti, P., & Mazzon, E. (2019) · Cell Transplantation · doi:10.1177/0963689719873890 · Cited by 187 · see citing works
Frailty, Cognitive Decline, Neurodegenerative Diseases and Nutrition Interventions
Gómez-Gómez, M. E., & Zapico, S. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112842 · Cited by 186 · see citing works
“The symptoms of constipation in patients with PD begin about ten years before the onset of motor function deterioration and these symptoms can be treated with antibiotics, thus, it is assumed that this disease could originate in the intestine [131].”
BackgroundMicrobiota-gut brain axis involvement in neuropsychiatric disorders
Iannone, L. F., Preda, A., Blottière, H. M., Clarke, G., Albani, D., Belcastro, V., Carotenuto, M., Cattaneo, A., Citraro, R., Ferraris, C., et al. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1638763 · Cited by 177 · see citing works
Green, J. E., Davis, J. A., Berk, M., Hair, C., Loughman, A., Castle, D. J., Athan, E., Nierenberg, A. A., Cryan, J. F., Jacka, F. N., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1854640 · Cited by 163 · see citing works
Gut Microbiota, Endocrine-Disrupting Chemicals, and the Diabetes Epidemic
Velmurugan, G., Ramprasath, T., Mithieux, G., Swaminathan, K., & Ramasamy, S. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.05.001 · Cited by 159 · see citing works
“What is the efficacy of microbiomebased therapeutic approaches for diabetes, and how long do benefits persist following treatment? What are the ethical, societal, economic, and health implications of therapeutic approaches such as fecal transplantation? clinical trials for diabetes therapy are currently in progress [7…”
BackgroundChu, F., Shi, M., Lang, Y., Shen, D., Jin, T., Zhu, J., & Cui, L. (2018) · Mediators of Inflammation · doi:10.1155/2018/8168717 · Cited by 159 · see citing works
“The results of clinical trials have shown that FMT can improve the walking ability in MS and alleviate autistic behavior as well as improve the neurological symptoms of PD [171, 174].”
Fecal Microbiota Transplantation and Its Usage in Neuropsychiatric Disorders
Evrensel, A., & Ceylan, M. E. (2016) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2016.14.3.231 · Cited by 150 · see citing works
Correlation between human gut microbiome and diseases
Madhogaria, B., Bhowmik, P., & Kundu, A. (2022) · Infectious Medicine · doi:10.1016/j.imj.2022.08.004 · Cited by 164 · see citing works
“Case reports and animal models demonstrated the effectiveness of FMT against an array of differ-ent disorders like metabolic disorders, insulin sensitivity, multiple sclerosis, autism etc. [ 69 , 70 ].”
BackgroundLinking What We Eat to Our Mood: A Review of Diet, Dietary Antioxidants, and Depression
Huang, Q., Liu, H., Suzuki, K., Ma, S., & Liu, C. (2019) · Antioxidants · doi:10.3390/antiox8090376 · Cited by 144 · see citing works
“A fecal microbiota transplant has been applied in different disorders such as Clostridium difficile infection, irritable bowel syndrome, inflammatory bowel diseases, insulin resistance, multiple sclerosis, and idiopathic thrombocytopenic purpura [77].”
BackgroundFecal microbiota transplantation associated with 10 years of stability in a patient with SPMS
Makkawi, S., Camara-Lemarroy, C. R., & Metz, L. M. (2018) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000459 · Cited by 144 · see citing works
“Because of progressive symptom worsening, and stable MRI, this suggested a diagnosis of SPMS.”
BackgroundInfluentialGut microbiota restoration through fecal microbiota transplantation: a new atopic dermatitis therapy
Kim, J., Kim, K., & Kim, W. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00627-6 · Cited by 130 · see citing works
Brugman, S., Ikeda‐Ohtsubo, W., Braber, S., Folkerts, G., Pieterse, C. M. J., & Bakker, P. A. H. M. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00080 · Cited by 127 · see citing works
Cerovic, M., Forloni, G., & Balducci, C. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00284 · Cited by 126 · see citing works
“Another strategy for modifying GM composition is fecal transplant, already successful for treating infections of Clostridium difficile (Xu et al., 2015), but there are only limited attempts to use it outside gastrointestinal diseases (Evrensel and Ceylan, 2016).”
BackgroundFecal microbiota transplant as a potential treatment for Parkinson's disease – A case series
Segal, A., Zlotnik, Y., Moyal-Atias, K., Abuhasira, R., & Ifergane, G. (2021) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2021.106791 · Cited by 124 · see citing works
Current progress of process integration for waste heat recovery in steel and iron industries
Inayat, A. (2023) · Fuel · doi:10.1016/j.fuel.2022.127237 · Cited by 114 · see citing works
Potential roles of gut microbiota and microbial metabolites in Parkinson’s disease
Zheng, S.-Y., Li, H.-X., Xu, R.-C., Miao, W.-T., Dai, M.-Y., Ding, S.-T., & Liu, H.-D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101347 · Cited by 101 · see citing works
Wang, W., Lin, L., Du, Y., Song, Y., Peng, X., Chen, X., & Yang, C. J. (2019) · Nature Communications · doi:10.1038/s41467-019-09267-x · Cited by 101 · see citing works
Metabolome of human gut microbiome is predictive of host dysbiosis
Larsen, P. E., & Dai, Y. D. (2015) · GigaScience · doi:10.1186/s13742-015-0084-3 · Cited by 98 · see citing works
“Clostridium difficile infections [34, 35].”
Eltokhi, A., Janmaat, I. E., Genedi, M., Haarman, B. C. M., & Sommer, I. E. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24616 · Cited by 100 · see citing works
Integrative Analysis of Fecal Metagenomics and Metabolomics in Colorectal Cancer
Clos‐Garcia, M., García‐Etxebarria, K., Alonso, C., Iruarrizaga‐Lejarreta, M., D’Amato, M., Crespo, A., Iglesias, Á., Cubiella, J., Bujanda, L., & Falcón‐Pérez, J. M. (2020) · Cancers · doi:10.2139/ssrn.3520024 · Cited by 98 · see citing works
The gut microbiota and inflammatory bowel disease
Goto, Y., Kurashima, Y., & Kiyono, H. (2015) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000192 · Cited by 96 · see citing works
“Indeed, FMT has recently shown beneficial effects in cases of multiple sclerosis and Parkinson’s disease [84].”
BackgroundProtection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis
Li, K., Wei, S., Hu, L., Yin, X., Mai, Y., Jiang, C., Peng, X., Cao, X., Huang, Z., Zhou, H., et al. (2020) · Mediators of Inflammation · doi:10.1155/2020/2058272 · Cited by 92 · see citing works
“Some case reports suggest that FMT may help improve symptoms of epilepsy and Parkinson’s disease [21, 22].”
BackgroundStandardized Preparation for Fecal Microbiota Transplantation in Pigs
Hu, J. P., Chen, L., Tang, Y., Xie, C., Xu, B., Shi, M. Y., Zheng, W., Zhou, S., Wang, X., Liu, L., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01328 · Cited by 90 · see citing works
“, 2013; Barton, 2014), which destroy the normal community structure of intestinal microbiota and lead to the emergence of multidrug-resistant microorganisms in the intestine (Laxminarayan et al., 2013; Xu et al., 2015).”
BackgroundBabaie, F., Hasankhani, M., Mohammadi, H., Safarzadeh, E., Rezaiemanesh, A., Salimi, R., Baradaran, B., & Babaloo, Z. (2018) · Immunology Letters · doi:10.1016/j.imlet.2018.01.014 · Cited by 90 · see citing works
Zhao, H., Li, M., Liu, L., Li, D., Zhao, L., Wu, Z., Zhou, M., Jia, L., & Yang, F. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123241 · Cited by 89 · see citing works
Varesi, A., Campagnoli, L. I. M., Fahmideh, F., Pierella, E., Romeo, M., Ricevuti, G., Nicoletta, M., Chirumbolo, S., & Pascale, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012289 · Cited by 88 · see citing works
Engen, P. A., Zaferiou, A. M., Rasmussen, H. E., Naqib, A. D., Green, S. J., Fogg, L., Forsyth, C. B., Raeisi, S., Hamaker, B. R., & Keshavarzian, A. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00978 · Cited by 89 · see citing works
Tywanek, E., Michalak, A., Świrska, J., & Zwolak, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094703 · Cited by 88 · see citing works
“Fecal microbiota transplantation (FMT) is proved to be useful not only in intestinal disorders, but also in metabolic syndrome or in selected immunological diseases [91].”
BackgroundThe gut microbiome and microbial translocation in multiple sclerosis
Mirza, A., & Mao‐Draayer, Y. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.03.001 · Cited by 86 · see citing works
Jayakumar, S., & Loomba, R. S. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15314 · Cited by 88 · see citing works
The heart-gut axis: new target for atherosclerosis and congestive heart failure therapy
Forkosh, E., & Ilan, Y. (2019) · Open Heart · doi:10.1136/openhrt-2018-000993 · Cited by 82 · see citing works
Regulation of the serotonin transporter in the pathogenesis of irritable bowel syndrome
Jin, D., Cao, H., Xu, M., Wang, S.-N., Wang, Y., Yan, F., & Wang, B. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i36.8137 · Cited by 82 · see citing works
Self-citationStable core virome despite variable microbiome after fecal transfer
Broecker, F., Russo, G., Klumpp, J., & Moelling, K. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1265196 · Cited by 79 · see citing works
“difficile infection (rCDI) that may soon be applied to other dysbiotic gastrointestinal conditions including inflammatory bowel disease (IBD) and obesity.(1,2)”
BackgroundFecal Microbiota Transplantation in Inflammatory Bowel Disease
Boicean, A., Bîrluțiu, V., Ichim, C., Anderco, P., & Bîrsan, S. (2023) · Biomedicines · doi:10.3390/biomedicines11041016 · Cited by 83 · see citing works
“There are different bacterial communities in the proximal and distal intestine, with most intestinal microbes being hosted by the colon, which plays a critical role in health and illness [10].”
BackgroundThe Human Gut Microbiome in Health and Disease
Jovel, J., Dieleman, L. A., Kao, D. H., Mason, A. L., & Wine, E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-102268-9.00010-0 · Cited by 78 · see citing works
The gut microbiota and endometriosis: From pathogenesis to diagnosis and treatment
Qin, R., Tian, G., Liu, J., & Cao, L. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1069557 · Cited by 77 · see citing works
“, may provide new ideas for the clinical treatment of endometriosis (Xu et al., 2015).”
BackgroundMcCormack, U. M. M., Curião, T., Wilkinson, T., Metzler-Zebeli, B. U., Reyer, H., Ryan, T., Díaz, J. A. C., Crispie, F., Cotter, P. D., Creevey, C. J., et al. (2018) · mSystems · doi:10.1128/msystems.00134-17 · Cited by 75 · see citing works
“It is also under investigation for the treatment of enteric infections and inflammatory bowel disorders (14), as well as metabolic and autoimmune diseases (15).”
Gut microbiota in autoimmunity: potential for clinical applications
Kim, D.-H., Yoo, S., & Kim, W. (2016) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0796-7 · Cited by 72 · see citing works
Beyond the Gut: The intratumoral microbiome's influence on tumorigenesis and treatment response
Zhang, H., Fu, L., Leiliang, X., Qu, C., Wu, W., Wen, R., Huang, N., He, Q., Cheng, Q., Liu, G., et al. (2024) · 癌症：英文版 · doi:10.1002/cac2.12597 · Cited by 71 · see citing works
A Possible Role of Intestinal Microbiota in the Pathogenesis of Ankylosing Spondylitis
Yang, L., Wang, L., Wang, X., Xian, C. J., & Lü, H. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122126 · Cited by 69 · see citing works
“The possible mechanism of FMT is to restore a normal intestinal microbiome and regulate the immune homeostasis of recipient [137].”
BackgroundLorente-Picón, M., & Laguna, A. (2021) · Biomolecules · doi:10.3390/biom11030433 · Cited by 69 · see citing works
The Association between Gut Microbiota and Osteoarthritis: Does the Disease Begin in the Gut?
Ramires, L. C., Santos, G. S., Ramires, R. P., da Fonseca, L. F., Jeyaraman, M., Muthu, S., Lana, A. V. S. D., Azzini, G. O. M., Smith, C. S., & Lana, J. F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031494 · Cited by 69 · see citing works
“Although further studies are still needed, FMT appears to be broadening its application well beyond local intestinal perturbations, serving as a potential therapeutic intervention for other complications such as metabolic syndrome, neuropsychiatric disorders, autoimmune conditions, allergic diseases, and even specific…”
BackgroundRole of the microbiome and its metabolites in ankylosing spondylitis
Song, Z., Yuan, D., & Zhang, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1010572 · Cited by 68 · see citing works
The Microbiome and Sustainable Healthcare
Dietert, R. R., & Dietert, J. M. (2015) · Healthcare · doi:10.3390/healthcare3010100 · Cited by 67 · see citing works
“These include metabolic, neurological and immune-associated disorders [200].”
BackgroundFlux, M. C., & Lowry, C. A. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104578 · Cited by 68 · see citing works
Varesi, A., Deumer, U.-S., Ananth, S. V., & Ricevuti, G. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10215077 · Cited by 62 · see citing works
Gut microbiota impact on stroke outcome: Fad or fact?
Winek, K., Meisel, A., & Dirnagl, U. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16636890 · Cited by 59 · see citing works
Desselberger, U. (2018) · Pathogens · doi:10.3390/pathogens7030057 · Cited by 55 · see citing works
Non-alcoholic fatty liver diseases: from role of gut microbiota to microbial-based therapies
Leylabadlo, H. E., Ghotaslou, R., Kafil, H. S., Feizabadi, M. M., Moaddab, S. Y., Farajnia, S., Sheykhsaran, E., Sanaie, S., Shanehbandi, D., & Baghi, H. B. (2019) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-019-03746-1 · Cited by 56 · see citing works
Gut Microbiota and IL-17A: Physiological and Pathological Responses
Douzandeh-Mobarrez, B., & Kariminik, A. (2017) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-017-9329-z · Cited by 58 · see citing works
“system-related diseases, obesity, and diabetes [1, 5, 10].”
BackgroundThe Use of Fecal Microbiome Transplant in Treating Human Diseases: Too Early for Poop?
Ser, H., Letchumanan, V., Goh, B. H., Wong, S. H., & Lee, L. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.519836 · Cited by 57 · see citing works
“Even though no one was able to explain such a “treatment” method at the time, scientists are now witnessing major progress in science, particularly in the drug discovery sector, using a stool to rehabilitate the gut microbiome of patients (Brandt, 2012; Xu et al., 2015; Gaines and Alverdy, 2017).”
BackgroundKang, Y., & Cai, Y. (2017) · Journal of Hospital Infection · doi:10.1016/j.jhin.2017.04.007 · Cited by 53 · see citing works
Dohlman, A. B., & Shen, X. (2019) · Experimental Biology and Medicine · doi:10.1177/1535370219836771 · Cited by 49 · see citing works
Li, X., Feng, X., Jiang, Z., & Jiang, Z. (2021) · Gut Pathogens · doi:10.1186/s13099-021-00420-w · Cited by 54 · see citing works
“According to the above mechanisms, studies have shown that faecal microbiota transplantation and probiotics may represent adjuvant therapies for PD [26, 27].”
BackgroundOral, Nasal, and Gut Microbiota in Parkinson’s Disease
Li, Z., Lu, G., Luo, E., Wu, B., Li, Z., Guo, J., Xia, Z., Zheng, C., Su, Q., Zeng, Y., et al. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2021.10.011 · Cited by 52 · see citing works
Gut microbiome and multiple sclerosis: New insights and perspective
Amini, M. E., Shomali, N., Bakhshi, A., Rezaei, S., Hemmatzadeh, M., Hosseinzadeh, R., Eslami, S., Babaie, F., Aslani, S., Torkamandi, S., et al. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107024 · Cited by 53 · see citing works
Jarett, J. K., Carlson, A., Serao, M. C. R., Strickland, J., Serfilippi, L. M., & Ganz, H. H. (2019) · PeerJ · doi:10.7717/peerj.7661 · Cited by 53 · see citing works
Microbial modulation of the gut microbiome for treating autoimmune diseases
Balakrishnan, B., & Taneja, V. (2018) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2018.1517044 · Cited by 51 · see citing works
“There are no studies showing that FMT results in a complete remission of autoimmune disease, even though there is strong evidence to a relationship between dysbiosis and autoimmunity [38,45].”
BackgroundMicrobiota of the gastrointestinal tract: Friend or foe?
Senchukova, M. A. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i1.19 · Cited by 55 · see citing works
Stripling, J. T., & Rodríguez, M. (2018) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2018.08.010 · Cited by 50 · see citing works
Ma, L., Liwen, Z., Jianguo, S., Dai, J., Ding, F., Yin, Z., Wu, C., & Jianping, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.728723 · Cited by 48 · see citing works
Fecal microbiota transplantation: a novel strategy for treating Alzheimer’s disease
Xiang, W., Xiang, H., Wang, J., Jiang, Y., Pan, C., Ji, B.-J., & Zhang, A. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1281233 · Cited by 48 · see citing works
Obesity-Associated Colorectal Cancer
Gonzalez-Gutierrez, L., Motiño, O., Barriuso, D., de la Puente-Aldea, J., Alvarez-Frutos, L., Kroemer, G., Palacios, R., & Senovilla, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168836 · Cited by 51 · see citing works
“On the other hand, chemotherapy can result in dysbiosis [388].”
BackgroundXu, F., Li, N., Wang, C., Xing, H., Chen, D., & Wei, Y. (2021) · BMC Gastroenterology · doi:10.1186/s12876-021-01630-x · Cited by 48 · see citing works
“The etiology of SIBO is lie on the exceeding growth of bacterial, especially harmful ones, in small intestine, the dysbiosis of small intestinal microbiota would result in typical SIBO symptoms, this paves the possibility of curing SIBO by treatment which could modulate human gut microbiota [37, 38].”
BackgroundSpinal cord injury and the human microbiome: beyond the brain–gut axis
Wallace, D. J., Sayre, N. L., Patterson, T. T., Nicholson, S. E., Hilton, D. L., & Grandhi, R. (2019) · Neurosurgical FOCUS · doi:10.3171/2018.12.focus18206 · Cited by 47 · see citing works
Is adolescence the missing developmental link in Microbiome–Gut–Brain axis communication?
Flannery, J., Callaghan, B. L., Sharpton, T. J., Fisher, P. A., & Pfeifer, J. H. (2019) · Developmental Psychobiology · doi:10.1002/dev.21821 · Cited by 46 · see citing works
Can the gastrointestinal microbiota be modulated by dietary fibre to treat obesity?
Davis, H. C. (2017) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-017-1686-9 · Cited by 44 · see citing works
The Pivotal Role of the Gut Microbiome in Colorectal Cancer
Siddiqui, R., Boghossian, A., Alharbi, A. M., Alfahemi, H. H., & Khan, N. A. (2022) · Biology · doi:10.3390/biology11111642 · Cited by 43 · see citing works
“Various studies were conducted on the capability of probiotics to inhibit tumorigenesis and their ability to reduce the toxicity of cancer-related therapy [62].”
BackgroundMethodMicrobiota in Irritable Bowel Syndrome and Endometriosis: Birds of a Feather Flock Together—A Review
Salmeri, N., Sinagra, E., Dolci, C., Buzzaccarini, G., Sozzi, G., Sutera, M., Candiani, M., Ungaro, F., Massimino, L., Danese, S., et al. (2023) · Microorganisms · doi:10.3390/microorganisms11082089 · Cited by 43 · see citing works
Thomann, A., Mak, J. W. Y., Zhang, J., Wüstenberg, T., Ebert, M. P., Sung, J. J. �., Bernstein, C. N., Reindl, W., & Ng, S. C. (2020) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15787 · Cited by 44 · see citing works
Prescott, S. L., Millstein, R. A., Katzman, M. A., & Logan, A. C. (2016) · International Journal of Biodiversity · doi:10.1155/2016/2718275 · Cited by 45 · see citing works
“Preliminary studies have begun to evaluate its usefulness in neurological conditions, including multiple sclerosis and Parkinson’s disease [204].”
Gut Microbiota and Endometriosis: Exploring the Relationship and Therapeutic Implications
Xholli, A., Cremonini, F., Perugi, I., Londero, A. P., & Cagnacci, A. (2023) · Pharmaceuticals · doi:10.3390/ph16121696 · Cited by 49 · see citing works
“The regulation of gut microbiota can be achieved through several strategies, such as using antibiotics, fecal bacteria transplantation, probiotics, and dietary interventions with specific nutrients [83–86].”
BackgroundFaecal Transplantation, Pro- and Prebiotics in Parkinson’s Disease; Hope or Hype?
van Laar, T., Boertien, J. M., & Herranz, A. H. (2019) · Journal of Parkinson s Disease · doi:10.3233/jpd-191802 · Cited by 42 · see citing works
Bacteriotherapy for inflammatory bowel disease
Yoshimatsu, Y., Mikami, Y., & Kanai∥, T. (2021) · Inflammation and Regeneration · doi:10.1186/s41232-020-00153-4 · Cited by 40 · see citing works
Kenneth, M. J., Tsai, H., Fang, C., Hussain, B., Chiu, Y., & Hsu, B. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.12.015 · Cited by 41 · see citing works
“However, administration of FMT restored the abundance of these phyla, indicating that FMT may have the clinical potential to restore chemotherapy-induced gut dysbiosis [145].”
BackgroundZhang, X., Gu, S., You, L., Xu, Y., Zhou, D., Chen, Y., Ren, Y., Jiang, H., Li, Y., Lv, L., et al. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01550 · Cited by 38 · see citing works
“Importantly, probiotic supplementation or fecal microbiome transplantation has been shown to be clinically beneficial to patients with autoimmune diseases (Xu et al., 2015; Uusitalo et al., 2016; Kouchaki et al., 2017).”
Background
- Authors
- Xu, M.-Q.
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2015
- Volume
- 21
- Issue
- 1
- Pages
- 102
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC4284325
- OpenAlex
- W2085818382
- Cited by
- 231
- References
- 119
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 10 · 2023: 22 · 2022: 19 · 2021: 27 · 2020: 15 · 2019: 34 · 2018: 25 · 2017: 28 · 2016: 21 · 2015: 7
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- World Journal of Gastroenterology
- Funders
- National Natural Science Foundation of China (81470796, 81070283, 81300272)
- Specialized Research Fund for the Doctoral Program of Higher Education of China
- Tianjin Research Program of Application Foundation and Advanced Technology of China
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- fecal microbiota transplantation, gut dysbiosis, metabolic syndrome, neuropsychiatric disorders, autoimmune disease, allergic diseases, cancer, Parkinson's disease, multiple sclerosis, idiopathic thrombocytopenic purpura, chronic fatigue syndrome, myoclonus-dystonia, insulin sensitivity, butyrate-producing bacteria, Clostridium difficile infection
- MeSH terms
- Animals, Biological Therapy, Feces, Humans, Intestinal Diseases, Intestines, Treatment Outcome, Host-Pathogen Interactions, Microbiota, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
