Cited by 135Psoriasis: Treatment and PathogenesisDermatology and Skin DiseasesGut microbiota and health

The role of the skin and gut microbiome in psoriatic disease

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Yan, Di, Issa, Naiem, Afifi, Ladan, Jeon, Caleb, Chang, Hsin-Wen, Liao, Wilson·2017·Current Dermatology Reports

Abstract

Purpose To understand the changes in the microbiome in psoriatic disease, we conducted a systematic review of studies comparing the skin and gut microbiota in psoriatic individuals and healthy controls.Findings Our review of studies pertaining to the cutaneous microbiome showed a trend towards an increased relative abundance of Streptococcus and a decreased level of Propionibacterium in psoriasis patients compared to controls. In the gut microbiome, the ratio of Firmicutes and Bacteroidetes was perturbed in psoriatic individuals compared to healthy controls. Actinobacteria was also relatively underrepresented in psoriasis patients relative to healthy individuals.Summary Although the field of the psoriatic microbiome is relatively new, these first studies reveal interesting differences in microbiome composition that may be associated with the development of psoriatic comorbidities and serve as novel therapeutic targets.

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Authors
Yan, D., Issa, N., Afifi, L., Jeon, C., Chang, H.-W., & Liao, W.
Affiliations
  • University of California, San Francisco (US)
  • Georgetown University (US)
Corresponding author
Yan, Di
Venue
Current Dermatology Reports
Published
2017-04-22
Volume
6
Issue
2
Pages
94-103
ISSN
2162-4933 (ISSN-L)
OpenAlex
W2606499437
Cited by
135
References
72
Citations by year
2026: 8 · 2025: 10 · 2024: 20 · 2023: 18 · 2022: 15 · 2021: 22 · 2020: 13 · 2019: 18 · 2018: 9 · 2017: 2
FWCI
5.20
Type
journal article
Language
en
Open access
Locations
  • Current Dermatology Reports (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
National Psoriasis Foundation Translational Research Award (NIH R01 AR065174, NIH U01 AI119125)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
psoriasis, psoriatic arthritis, skin microbiome, gut microbiota, Streptococcus, Propionibacterium, Firmicutes, Bacteroidetes, actinobacteria, dysbiosis, therapeutic target

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