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Cited by 47Phytochemicals and Medicinal PlantsAdipokines, Inflammation, and Metabolic DiseasesNatural Antidiabetic Agents Studies

Withaferin A protects against high-fat diet-induced obesity via attenuation of oxidative stress, inflammation, and insulin resistance

Abu Bakar, Mohamad Hafizi, Azmi, Mohamad Nurul, Shariff, Khairul Anuar, Tan, Joo Shun·2019·Applied Biochemistry and Biotechnology
DOI 10.1007/s12010-018-2920-2
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Abstract

Withaferin A (WA), a bioactive constituent derived from Withania somnifera plant, has been shown to exhibit many qualifying properties in attenuating several metabolic diseases. The current investigation sought to elucidate the protective mechanisms of WA (1.25 mg/kg/day) on pre-existing obese mice mediated by high-fat diet (HFD) for 12 weeks. Following dietary administration of WA, significant metabolic improvements in hepatic insulin sensitivity, adipocytokines with enhanced glucose tolerance were observed. The hepatic oxidative functions of obese mice treated with WA were improved via augmented antioxidant enzyme activities. The levels of serum pro-inflammatory cytokines and hepatic mRNA expressions of toll-like receptor (TLR4), nuclear factor κB (NF-κB), tumor necrosis factor-α (TNF-α), chemokine (C-C motif) ligand-receptor, and cyclooxygenase 2 (COX2) in HFD-induced obese mice were reduced. Mechanistically, WA increased hepatic mRNA expression of peroxisome proliferator-activated receptors (PPARs), cluster of differentiation 36 (CD36), fatty acid synthase (FAS), carnitine palmitoyltransferase 1 (CPT1), glucokinase (GCK), phosphofructokinase (PFK), and phosphoenolpyruvate carboxykinase (PCK1) that were associated with enhanced lipid and glucose metabolism. Taken together, these results indicate that WA exhibits protective effects against HFD-induced obesity through attenuation of hepatic inflammation, oxidative stress, and insulin resistance in mice.

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Crossref · 10.1007/s12010-018-2920-2

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  • Withaferin A protects against high-fat-induced obesity in mice.

    “withaferin A (withanolide A; Figure 15) protects against high-fat-induced obesity in mice [216].”

    From Ecdysteroids (2021) · cites this paper as [216]

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Authors
Abu Bakar, M. H., Azmi, M. N., Shariff, K. A., & Tan, J. S.
Affiliations
Universiti Sains Malaysia (MY)
ORCID
Venue
Applied Biochemistry and Biotechnology
Publisher
Springer Science and Business Media LLC
Published
2018-11-12
Volume
188
Issue
1
Pages
241-259
ISSN
  • 0273-2289 (ISSN-L)
  • 1559-0291
DOI
10.1007/s12010-018-2920-2
OpenAlex
W2901733517
Cited by
47
References
60
Citations by year
2026: 3 · 2025: 4 · 2024: 7 · 2023: 7 · 2022: 4 · 2021: 8 · 2020: 9 · 2019: 5
FWCI
7.55
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Applied Biochemistry and Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Universiti Sains Malaysia (304/PTEKIND/6313329, 304/PKIMIA/6313330)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords
withaferin A, Withania somnifera, high-fat diet-induced obesity, hepatic insulin resistance, oxidative stress, liver inflammation, TLR4, NF-κB signaling, adipokines, glucose tolerance, lipid metabolism, glucose metabolism, peroxisome proliferator-activated receptors, CD36, fatty acid synthase, carnitine palmitoyltransferase 1, glucokinase, phosphoenolpyruvate carboxykinase, antioxidant enzymes, TNF-α, cyclooxygenase-2
MeSH terms
Animals, Blood Glucose, Body Weight, Enzyme-Linked Immunosorbent Assay, Fatty Liver, Feeding Behavior, Inflammation, Insulin Resistance, Male, Mice, Inbred C57BL, Obesity, RNA, Messenger, Cytokines, Oxidative Stress, Inflammation Mediators, Lipid Metabolism, Mice, Withanolides, Diet, High-Fat

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