The DOI matches its Crossref record, with a small difference in title or year; 205 of the 205 references it cites were found in a registry or an index.
Immunology of Aging: the Birth of Inflammaging
Open accessAbstract
The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an evolutionary or rather a revolutionary conceptualization of the immune changes in response to a lifelong stress. This conceptualization permitted to consider the lifelong proinflammatory process as an adaptation which could eventually lead to either beneficial or detrimental consequences. This dichotomy is influenced by both the genetics and the environment. Depending on which way prevails in an individual, the outcome may be healthy longevity or pathological aging burdened with aging-related diseases. The concept of inflammaging has also revealed the complex, systemic nature of aging. Thus, this conceptualization opens the way to consider age-related processes in their complexity, meaning that not only the process but also all counter-processes should be considered. It has also opened the way to add new concepts to the original one, leading to better understanding of the nature of inflammaging and of aging itself. Finally, it showed the way towards potential multimodal interventions involving a holistic approach to optimize the aging process towards a healthy longevity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“A relationship between aging and chronic, low-grade inflammation exists, in which a term called “inflammaging” arose, coined by Dr. Franceschi in the year 2000 (38). With this, proinflammatory cytokines are notably increased, including immune cells infiltrating WAT (38).”
From Metabolic impact of endogenously produced estrogens by adipose tissue in females and males across the lifespan (2025) · cites this paper as [38]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358
Self-citationThe proximal origin of SARS-CoV-2
Andersen, K. G., Rambaut, A., Lipkin, W. I., Holmes, E. C., & Garry, R. F. (2020) · Nature Medicine · doi:10.1038/s41591-020-0820-9 · Cited by 5,081
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891
Self-citationInflammaging: a new immune–metabolic viewpoint for age-related diseases
Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0059-4 · Cited by 3,586
Self-citationDNA methylation-based biomarkers and the epigenetic clock theory of ageing
Horvath, S., & Raj, K. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0004-3 · Cited by 3,095
mTOR at the nexus of nutrition, growth, ageing and disease
Liu, G. Y., & Sabatini, D. M. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0199-y · Cited by 2,737
Defining trained immunity and its role in health and disease
Netea, M. G., Domínguez-Andrés, J., Barreiro, L. B., Chavakis, T., Divangahi, M., Fuchs, E., Joosten, L. A. B., van der Meer, J. W. M., Mhlanga, M. M., Mulder, W. J. M., et al. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-0285-6 · Cited by 2,690
Pathogen Recognition by the Innate Immune System
Kumar, H., Kawai, T., & Akira, S. (2011) · International Reviews of Immunology · doi:10.3109/08830185.2010.529976 · Cited by 2,368
Flagged first, then by citations
Research works printed but not linked: 4
- Ottaviani E, Franceschi C (1997) The invertebrate phagocytic immunocyte: clues to a common evolution of immune and neuroendocrine systems. Immunol Today 18(4):169–174. https://doi.org/10.1016/s0167-5699(97)84663-4 · DOI
- Ong SM, Hadadi E, Dang TM, Yeap WH, Tan CT, Ng TP, Larbi A, Wong SC (2018) The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence. Cell Death Dis 9(3):266. https://doi.org/10.1038/s41419-018-0327-1 · DOI · Paper page
- Bektas A, Schurman SH, Sen R, Ferrucci L (2017) Human T cell immunosenescence and inflammation in aging. J Leukoc Biol 102(4):977–988. https://doi.org/10.1189/jlb.3RI0716-335R · DOI
- Janac S, Clarke B, Gems D (2017) Aging: natural or disease? A view from medical textbooks. In: Vaiserman AM (ed) Anti-aging drugs: from basic research to clinical practice. Royal Society of Chemistry, Cambridge (UK), p 2017
Cited by
Sorted by citations
Items 201–300 of 465
Blichfeldt‐Eckhardt, M. R., Varnum, C., Lauridsen, J. T., Rasmussen, L. E., Mortensen, W. C. P., Jensen, H. I., Vægter, H. B., & Lambertsen, K. L. (2024) · Bone and Joint Research · doi:10.1302/2046-3758.1312.bjr-2024-0103.r1 · Cited by 8
Wang, Y., Zhang, Q., Liao, H., Lu, X., Cong, J., Liu, Z., Liu, Q., Deng, C., Cheng, Y., Shu, P., et al. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e42730 · Cited by 6
Catalogna, M., Saporta, N., Nathansohn-Levi, B., Tamir, T., Shahaf, A., Molcho, S., Erlich, S., Shelly, S., & Amedi, A. (2025) · npj Digital Medicine · doi:10.1038/s41746-025-01765-1 · Cited by 7
Arikawa, A. Y., Waterman, A., Mishra, S. P., Labyak, C. A., Williams, C., Chaudhari, D. S., Shukla, R., Kumar, V., Masternak, M. M., Holland, P., et al. (2025) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.06.026 · Cited by 6
Haines, D. D., Rose, S. A., Cowan, F. M., Mahmoud, F. F., Rizvanov, A. A., & Tósaki, Á. (2025) · Biomolecules · doi:10.3390/biom15111501 · Cited by 7
Marinescu, A., Machado, V., Pagano, G., Muelhardt, N. M., Kustermann, T., Mracsko, E. Z., Brockmann, K., Shariati, N., Anzures‐Cabrera, J., & Zinnhardt, B. (2025) · Movement Disorders · doi:10.1002/mds.70103 · Cited by 6
Yang, J., Wang, D., Dong, X., Huo, H., Tao, R., Zhang, Y., Wang, Z., Wang, L., & Zhi, N. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01646-x · Cited by 6
Cytomegalovirus at the crossroads of immunosenescence and oncogenesis
Bouezzedine, F., Baba, R. E., Morot-Bizot, S., Diab‐Assaf, M., & Herbein, G. (2023) · Exploration of Immunology · doi:10.37349/ei.2023.00086 · Cited by 7
Santos, C. A. F., Nardy, A., Gomez, R. J., Silva, B. R., Monteiro, F. R., Rossi, M. N., do Amaral, J. B., Paixão, V., Vaisberg, M. W., Amirato, G. R., et al. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21111425 · Cited by 6
Changes in senescence markers after a weight loss intervention in older adults with obesity
Lynch, D. H., Petersen, C. L., Stewart, D. A., Justice, J. N., Batchek, D. J., Sumner, S., McRitchie, S., & Batsis, J. A. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2024.105685 · Cited by 6
Inflammatory Biomarkers and Tinnitus in Older Adults
Okamura, L. S. T., Marchiori, L. L. D. M., Ciquinato, D. S. D. A., Teixeira, D. D. C., Marchiori, G. D. M., Branco, B. H. M., & Poli‐Frederico, R. C. (2024) · Noise and Health · doi:10.4103/nah.nah_39_23 · Cited by 7
Catalogna, M., Somerville, Y., Saporta, N., Nathansohn-Levi, B., Shelly, S., Edry, L., Zagoory‐Sharon, O., Feldman, R., & Amedi, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-91457-3 · Cited by 9
Wang, Y., Zhu, W., Zhang, T., Liu, Q., Zou, M., Xie, Y., Wang, M., Wang, T. S., Pang, Y., Jing, T., et al. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.138273 · Cited by 6
Krüger, P., Schroll, M., Fenzl, F. Q., Hartinger, R., Lederer, E.-M., Görlach, A., Gordon, L. B., Cavalcante, P., Iacomino, N., Rathkolb, B., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104849 · Cited by 6
Chen, L., Lin, A., Luo, P., & Miao, K. (2025) · Nano Research · doi:10.26599/nr.2025.94907609 · Cited by 6
Granic, A., Martin-Ruiz, C. M., Rimmer, L., Dodds, R. M., Robinson, L. A., Spyridopoulos, I., Kirkwood, T. B. L., von Zglinicki, T., & Sayer, A. A. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111739 · Cited by 7
Tomas‐Grau, R. H., Maldonado-Galdeano, C., López, M. A., Pingitore, E. V., Aznar, P., Alcorta, M. E., Vélez, E. M. D. M., Stagnetto, A., Soliz-Santander, S. E., Ávila, C. L., et al. (2022) · Aging · doi:10.18632/aging.204299 · Cited by 5
GROWTH HORMONE, IMMUNOSENESCENCE AND VACCINATION FAILURE IN THE ELDERLY
Belizário, J. E., & Garay-Malpartida, M. (2023) · Clinical Immunology Communications · doi:10.1016/j.clicom.2023.02.005 · Cited by 7
Inter-organ Crosstalk and the Effect on the Aging Process in Obesity
Armutçu, F., & Özen, O. A. (2023) · Current Aging Science · doi:10.2174/1874609816666230223110458 · Cited by 6
Advanced biomaterial strategies for overcoming age-associated wound healing impairments
Dores, R., Rodrigues, T., Carvalho, D. S., Batista, E., Kozak, M., Blanco‐Elices, C., Fernandes, H., & Bimbo, L. M. (2025) · APL Bioengineering · doi:10.1063/5.0251889 · Cited by 5
Miceli, G., Ciaccio, A. M., Cuffaro, M., Profita, M., & Tuttolomondo, A. (2025) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2025.2575449 · Cited by 6
Natural killer cells: gatekeepers of healthy aging in longevity medicine
Yang, J. Y., Tu, D. T., Liao, J.-C., & Lee, O. K. (2026) · Inflammation and Regeneration · doi:10.1186/s41232-026-00414-8 · Cited by 5
Jo, H.-G., Baek, C. Y., Hwang, Y., Baek, E., Park, C., Song, H. S., & Lee, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179594 · Cited by 5
Increased magnesium intake does not mitigate MAFLD risk associated with magnesium deficiency
Peng, H., Zhao, M., Zhang, Y., Guo, Y., & Zhao, A. (2024) · Scientific Reports · doi:10.1038/s41598-024-82203-2 · Cited by 5
Repetitive Overuse Injury Causes Entheseal Damage and Palmar Muscle Fibrosis in Older Rats
Patel, P. R., Tamas, I. P., Bas, M. V. D., Kegg, A., Hilliard, B. A., Lambi, A. G., Popoff, S. N., & Barbe, M. F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413546 · Cited by 5
Zheng, Q., Li, Z., Li, Z., Zheng, Q., & Xu, W. (2025) · PLoS ONE · doi:10.1371/journal.pone.0318311 · Cited by 5
Admission lymphopenia predicts risk of pneumonia and AKI in hospitalized burn injuries
Nguyễn, N., Galet, C., Kurjatko, A., & McGonagill, P. W. (2025) · Burns · doi:10.1016/j.burns.2025.107581 · Cited by 5
Inflammaging is minimal among forager-horticulturalists in the Bolivian Amazon
Aronoff, J. E., Jenkins, C. L., García, A. R., Koebele, S. V., Ghafoor, S., Woolard, K. L., Charifson, M., Suarez, I. M., Rodríguez, D. E., Beheim, B., et al. (2025) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2025.1111 · Cited by 7
Self-citationGuidelines for the management of acquired hemophilia A in elderly patients
Windyga, J., Baran, B., Odnoczko, E., & Grodzicki, T. K. (2021) · Journal of Transfusion Medicine · doi:10.5603/jtm.2021.0010 · Cited by 5
The role of immune aging in Giant Cell Arteritis
Harkins, P., Cowley, S., Harrington, R., Kane, D. J., & Conway, R. P. (2023) · Aging Pathobiology and Therapeutics · doi:10.31491/apt.2023.09.119 · Cited by 5
Paola, A. D., Marrapodi, M. M., Pota, E., Cante, R. C., Rana, D., Giliberti, G., Feo, G. D., Ahmed, S., Roberti, D., Nigro, R., et al. (2024) · Cancers · doi:10.3390/cancers16040714 · Cited by 5
The influence of aging and the microbiome in multiple sclerosis and other neurologic diseases
Fettig, N. M., Pu, A., Osborne, L. C., & Gommerman, J. L. (2024) · Immunological Reviews · doi:10.1111/imr.13361 · Cited by 7
Associations between inflammation and striatal dopamine D2-receptor availability in aging
Crine, V., Papenberg, G., Johansson, J. J., Boraxbekk, C., Wåhlin, A., Lindenberger, U., Lövdén, M., Riklund, K., Bäckman, L., Nyberg, L. H., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03355-0 · Cited by 5
Fisher, A., Fisher, L., & Srikusalanukul, W. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13133969 · Cited by 5
Dennis, C. J., He, A. Z., Krishnaraj, A., Quan, A., Teoh, H., Connelly, K. A., Hess, D. A., & Verma, S. (2026) · Circulation Research · doi:10.1161/circresaha.126.327425 · Cited by 4
Senolytic Vaccines from the Central and Peripheral Tolerance Perspective
Vasilieva, M., Shatalova, R. O., Matveeva, K. S., Shindyapin, V. V., Minskaia, E., Ivanov, R. A., & Shevyrev, D. (2024) · Vaccines · doi:10.3390/vaccines12121389 · Cited by 5
The telomere connection between aging and cancer: The burden of replication stress and dysfunction
Boccardi, V., & Marano, L. (2025) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2025.112026 · Cited by 5
Jana, R., & Sarma, J. D. (2025) · Biogerontology · doi:10.1007/s10522-025-10213-2 · Cited by 4
The Small Intestinal Microbiota and the Gut–Brain Axis in Parkinson’s Disease: A Narrative Review
Carrossa, G., Misenti, V., Faggin, S., Giron, M. C., & Antonini, A. (2025) · Biomedicines · doi:10.3390/biomedicines13071769 · Cited by 4
The various pathological roles of oxidized LDL in diseases
Babakr, A. T. (2025) · Obesity Medicine · doi:10.1016/j.obmed.2025.100646 · Cited by 4
Potential dietary geroprotectors and their impact on key mechanisms of aging
Moskalev, A., & Veselova, O. M. (2025) · Biogerontology · doi:10.1007/s10522-025-10355-3 · Cited by 4
A versatile platform for sequential glyco-, phospho-, and proteomics with multi-PTMs integration
Dong, X., Xiong, F., Du, G., Yang, Y., Chen, C., Cui, Y., Ding, X., Li, X., Shen, Y., & Liang, X. (2026) · Nature Communications · doi:10.1038/s41467-025-68270-7 · Cited by 6
Cellular senescence: mechanisms and clinical implications
Михайловна, М. А., Pashenkov, M. V., & Pinegin, B. V. (2024) · Immunologiya · doi:10.33029/1816-2134-2024-45-2-221-234 · Cited by 10
Changes in Innate Immunity and Microbiome in Different Aging Phenotypes
Gankovskaya, L. V., Свитич, О. А., Поддубиков, А. В., Владиславовна, Б. В., Хасанова, Е. М., & Gorodishchenskaya, S. V. (2024) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-024-06244-3 · Cited by 4
Xiang, X., Feng, Y., Li, H., Li, W., Li, J., Xia, Z., Pang, H., & Wang, Z. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112702 · Cited by 4
Sobotkova, T., Hugo, J., Salavec, M., Kojanová, M., Tichý, M., Nečas, M., Machovcová, A., Cetkovsky, M., Kysilka, Z., Tivadar, S., et al. (2025) · International Journal of Dermatology · doi:10.1111/ijd.17814 · Cited by 4
Living a longer life: unique lessons from the naked mole‐rat blood system
Andersson, R., & Florian, M. C. (2022) · The EMBO Journal · doi:10.15252/embj.2022111759 · Cited by 4
Demir, A. B. (2023) · Current Molecular Biology Reports · doi:10.1007/s40610-023-00153-6 · Cited by 4
Tobacco exposure, but not aging, shifts the frequency of peripheral blood B cell subpopulations
Pinto, T. N. C., da Silva, C. C. B. M., Carvalho‐Pinto, R. M., Duarte, A. J. D. S., Benard, G., & Fernandes, J. R. (2023) · GeroScience · doi:10.1007/s11357-023-01051-6 · Cited by 5
Guan, C.-Y., Zhang, D., Sun, X., Ma, X., & Xia, H. (2024) · Stem Cells and Development · doi:10.1089/scd.2023.0290 · Cited by 4
Hernández-Orozco, S., Uthamacumaran, A., Hernández-Quiroz, F., Saeb‐Parsy, K., & Zenil, H. (2026) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2026.111628 · Cited by 3
Telomere length as a biomarker in multiple sclerosis
Piedrabuena, M. A., Correale, J. D., Farez, M., Murúa, S. R., Canyazo, C. M., Fiol, M. P., Marrodán, M., & Ysrraelit, M. C. (2024) · Multiple Sclerosis Journal · doi:10.1177/13524585241273054 · Cited by 4
Appetite loss as a clinical marker of loss of function during ageing
Lu, W., Sánchez‐Sánchez, J. L., & Barreto, P. D. S. (2025) · Proceedings of The Nutrition Society · doi:10.1017/s0029665125101778 · Cited by 3
Bone Loss and TLR4 Signals Contribute Independently to B Lineage Aging
Baker, E., Montecino‐Rodriguez, E., Xu, S., Tetradis, S., Rouault, A., Estrada, O. I., & Dorshkind, K. A. (2025) · Aging Cell · doi:10.1111/acel.70267 · Cited by 3
Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
Guo, J., Lei, L., Jin, Y., Su, L., Cui, S., & Shi, L. (2026) · Advanced Science · doi:10.1002/advs.202521776 · Cited by 3
Age-related disease: Immune system
de Punder, K., & Karabatsiakis, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15500-0.00004-9 · Cited by 3
Bonnefous, H., Teulière, J., Lapointe, F., Lopez, P., & Bapteste, E. P. (2024) · GeroScience · doi:10.1007/s11357-024-01234-9 · Cited by 5
Effects of Plant Meristem-Cell-Based Cosmetics on Menopausal Skin: Clinical Data and Mechanisms
Korkina, L., Kharaeva, Z., Shokarova, A., Barokova, E., Mayer, W., Trakhtman, I., Dal Toso, R., & De Luca, C. (2024) · Biomolecules · doi:10.3390/biom14091176 · Cited by 3
Role of microbiota in the GUT-SKIN AXIS responses to outdoor stressors
Ferrara, F., & Valacchi, G. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.11.003 · Cited by 6
Intestinal Microbiota and Aging in People with HIV—What We Know and What We Don’t
Islam, S. M. S., Singh, S. T., Keshavarzian, A., & Abdel‐Mohsen, M. (2024) · Current HIV/AIDS Reports · doi:10.1007/s11904-024-00717-w · Cited by 4
HIV and Inflamm-Aging: How Do We Reach the Summit of Healthy Aging?
Sheets, K. M., & Baker, J. V. (2024) · PubMed Central · Cited by 3
Brito‐de‐Sousa, J. P., Lima-Silva, M. L., da Costa-Rocha, I. A., Campi‐Azevedo, A. C., Mambrini, J. V. D. M., Faria, A. M. C., Lima‐Costa, M. F., Peixoto, S. V., Teixeira‐Carvalho, A., Torres, K., et al. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112700 · Cited by 3
Ahn, E., Kim, S., Park, S., Kim, S., Kim, H., Lee, H., Kim, H., Song, E., Hwang, K.-A., Ahn, T., et al. (2025) · Cancers · doi:10.3390/cancers17071251 · Cited by 3
The systemic costs of hematopoietic stem cell aging
Puri, G., & Blanc, R. S. (2025) · Development · doi:10.1242/dev.205103 · Cited by 3
Melatonin as a Chronobiotic and Cytoprotector in Healthy Aging
Cardinali, D. P., Pandi-Perumal, S. R., & Brown, G. M. (2023) · Healthy ageing and longevity · doi:10.1007/978-3-031-22468-3_14 · Cited by 3
The roles of stress‐induced premature senescence and Akt/ FoxO1 signaling in periapical lesions
Liu, Q., Li, S., Tang, T., & Wu, Y. (2023) · Oral Diseases · doi:10.1111/odi.14703 · Cited by 3
From Genesis to Old Age: Exploring the Immune System One Cell at a Time with Flow Cytometry
Larbi, A. (2024) · Biomedicines · doi:10.3390/biomedicines12071469 · Cited by 4
Self-citationFeltes, B. C. (2025) · Biogerontology · doi:10.1007/s10522-025-10243-w · Cited by 3
Inflammaging and Immunosenescence
Fülöp, T., Pawelec, G., Cohen, A. A., Legault, V., Hirokawa, K., Larbi, A., Khalil, A., Franceschi, C., & Witkowski, J. M. (2024) · Springer eBooks · doi:10.1007/978-3-031-57361-3_10 · Cited by 2
Self-citationImpact of senescence in impaired wound healing
Méndez-Valdés, G., Rojas-Solé, C., Lillo‐Moya, J., & Rodrigo, R. (2024) · Advances in biogerontology · doi:10.1016/bs.abger.2024.05.004 · Cited by 2
Zhou, A., Ye, Q., Wei, Y., & Li, W. (2025) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.2778 · Cited by 2
Liu, M.-L., Liu, P., Chao, L. K., Yang, T.-J., Li, L.-H., Weng, Y., Sommano, S. R., Unpaprom, Y., Ramaraj, R., Ho, C., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115419 · Cited by 2
Le, C., Lewis, M., Harris, C., Berger, L., Chavez-Iglesias, E., Morse, L. M., Sucher, A., Roy, R., Olshen, A. B., Hammer, M. J., et al. (2025) · Cancer Medicine · doi:10.1002/cam4.71067 · Cited by 2
Νάκα, Ό., Chatzidou, P., Sarafidou, K., & Anastassiadou, V. (2025) · Archives of Gerontology and Geriatrics Plus · doi:10.1016/j.aggp.2025.100192 · Cited by 2
Alfhili, M. A., Alazmi, S. A., & Alsughayyir, J. (2025) · International Journal of General Medicine · doi:10.2147/ijgm.s537039 · Cited by 2
Barbe, M. F., Lambi, A. G., Harris, M. Y., Patel, P. R., Tamas, I. P., McGonagle, E. R., Bas, M. V. D., Kalicharan, B. A., Holt-Bright, L. T., Popoff, S. N., et al. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1500795 · Cited by 3
Advancing nanotheranostics for neuro-immunological disorders: current status and future prospects
Rai, S., Nair, A., Saleem, Z., Ray, S. K., Kanwar, J. R., & Mukherjee, S. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.08.051 · Cited by 2
Ageing, Nutrition, and Infection: The Forgotten Triad
Worku, D. A. (2025) · British Journal of Hospital Medicine · doi:10.12968/hmed.2024.0873 · Cited by 3
Inflammaging and the sex-frailty paradox
Arosio, B., Salafia, G., Ferri, E., Mari, D., Tobaldini, E., Vitale, G., & Montano, N. (2025) · Aging Clinical and Experimental Research · doi:10.1007/s40520-025-03181-7 · Cited by 2
Balneotherapy as a potential immunomodulator in inflammaging
Alp, A., Ellergezen, P. H., & Ercan, İ. (2025) · Clinical Rheumatology · doi:10.1007/s10067-025-07708-1 · Cited by 2
Hong, Y. (2025) · The FASEB Journal · doi:10.1096/fj.202503032r · Cited by 1
Kaur, S., Abhisheka, N. S., & Singh, L. (2025) · Journal of Food Science and Technology · doi:10.1007/s13197-025-06514-6 · Cited by 2
Ciortea, I., Vaștag, E., Fira-Mlădinescu, C., Crișan, A. F., Wellmann, N., Trușculescu, A. A., Bertici, N. S., Trăilă, D., Oancea, C. I., & Firă-Mladinescu, O. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm15010180 · Cited by 2
Molecular time machines unleashed: small-molecule-driven reprogramming to reverse the senescence
Tang, C., Zhang, Z., Yang, C., Li, L., Li, J., Cheng, X., Zhou, W., Lin, Y., Zeng, L., & Zhang, L. (2025) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szaf069 · Cited by 2
Aging Reshapes γ/δ T‐Cell Immunity Through a Type I Interferon–Foxo1 Axis
Durand, A., Porte, S., Xing, E., Wu, C., Bon, A. L., Auffray, C., Lucas, B., & Martin, B. (2026) · Aging Cell · doi:10.1111/acel.70389 · Cited by 2
Vitamin D and Older Adults: To Supplement or Not to Supplement?
Mourelatou, N. G., Rebelos, E., Hughes, M., Kounatidis, D. C., & Jude, E. B. (2026) · Drugs & Aging · doi:10.1007/s40266-025-01277-3 · Cited by 2
Interleukin-6 in Natural and Pathophysiological Kidney Aging
Mutig, K., Singh, P. B., & Lebedeva, S. V. (2026) · Cells · doi:10.3390/cells15030225 · Cited by 2
Сергеевич, В. М., Pospelova, M. L., Nikolaeva, A. E., Krasnikova, V. V., Makhanova, A. M., Fionik, O. V., Samochernykh, K. A., Alekseeva, T., Combs, S. E., & Shevtsov, M. A. (2026) · Current Oncology · doi:10.3390/curroncol33020121 · Cited by 2
Wu, Y., 叶兵, Zhao, T., & Lu, P. (2026) · Clinical Interventions in Aging · doi:10.2147/cia.s576360 · Cited by 2
Targeting immunosenescence in lung diseases: mechanistic insights and clinical interventions
Zhang, Y., Yu, X., Li, P., Ouyang, Y., Zhu, L., & Luo, F. (2026) · BMC Medicine · doi:10.1186/s12916-026-04833-9 · Cited by 2
Ultra-Processed Foods and Chronic Kidney Disease: Is Inflammaging the Missing Link?
Kounatidis, D. C., Evangelopoulos, A. A., Dimitriou, K., & Vallianou, N. G. (2026) · Biomolecules · doi:10.3390/biom16050660 · Cited by 3
Jiang, F., Dong, B., Wang, Y., & Xiong, Y. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27104322 · Cited by 2
Skin aging: Mechanistic insights and targeted therapeutic strategies
Beaziz, J., Avallone, G., Langer, K., DUCA, E. D., Navrazhina, K., He, H., & Guttman‐Yassky, E. (2026) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2026.05.015 · Cited by 3
Harris, C., Nisar, M. A., Amamoo, R., Patel, R., Martin, P. M., Jadeja, R. N., & Thounaojam, M. C. (2026) · Experimental Eye Research · doi:10.1016/j.exer.2026.111094 · Cited by 3
Decoding the tumor-aging axis: from bench to clinical
Wang, Y., Lv, G., Gao, X., Zheng, J. H., Huang, J., & Wang, Z. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1823423 · Cited by 2
Rose, A., Muthukumarasamy, K. M., Dasari, H., Gaudreau, P., & Hiram, R. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103266 · Cited by 2
Polidori, M. C., Ferrucci, L., & Franceschi, C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823761-8.00012-4 · Cited by 2
Self-citationPattern of Post COVID Fatigue in Elderly Patients
Gaber, T. A. (2023) · Advances in Rehabilitation Science and Practice · doi:10.1177/27536351231194561 · Cited by 2
Immune system rejuvenation—approaches and real achievements
Pishel, I. (2023) · Exploration of Immunology · doi:10.37349/ei.2023.00105 · Cited by 2
Zrzavy, T., Rieder, K., Wuketich, V., Thalhammer, R., Haslacher, H., Altmann, P., Kornek, B., Krajnc, N., Monschein, T., Schmied, C., et al. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1388941 · Cited by 2
Metadata
- Authors
- Fulop, T., Larbi, A., Pawelec, G., Khalil, A., Cohen, A. A., Hirokawa, K., Witkowski, J. M., & Franceschi, C.
- Affiliations
- Agency for Science, Technology and Research (SG)
- Health Sciences North (CA)
- Université de Sherbrooke (CA)
- Tokyo Medical and Dental University (JP)
- Gdańsk Medical University (PL)
- N. I. Lobachevsky State University of Nizhny Novgorod (RU)
- Venue
- Clinical Reviews in Allergy & Immunology
- Published
- 2021-09-18
- Volume
- 64
- Issue
- 2
- Pages
- 109-122
- ISSN
- 1080-0549 (ISSN-L)
- 1559-0267
- PMC
- PMC8449217
- OpenAlex
- W3201542050
- Cited by
- 464
- References
- 205
- Citations by year
- 2026: 104 · 2025: 131 · 2024: 111 · 2023: 63 · 2022: 52 · 2021: 2
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Clinical Reviews in Allergy & Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- cihr (106634 and PJT-162366)
- fonds de recherche du québec-société et culture
- krajowy naukowy osrodek wiodacy
- a*star
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- inflammaging, immunosenescence, aging, low-grade inflammation, healthy longevity, age-related diseases, genetic and environmental factors, multimodal intervention
- MeSH terms
- Aging, Female, Humans, Inflammation, Longevity, Pregnancy, Parturition
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
