Decrease in TSH levels after lactose restriction in Hashimoto's thyroiditis patients with lactose intolerance

Asik, Mehmet; Gunes, Fahri; Binnetoglu, Emine; Eroglu, Mustafa; Bozkurt, Neslihan; Sen, Hacer; Akbal, Erdem; Bakar, Coskun; Beyazit, Yavuz; Ukinc, Kubilay

doi:10.1007/s12020-013-0065-1

Cited by 59Thyroid Disorders and TreatmentsDigestive system and related healthThyroid and Parathyroid Surgery

Decrease in TSH levels after lactose restriction in Hashimoto's thyroiditis patients with lactose intolerance

Asik, Mehmet, Gunes, Fahri, Binnetoglu, Emine, Eroglu, Mustafa, Bozkurt, Neslihan, Sen, Hacer, Akbal, Erdem, Bakar, Coskun +2 more·2014·Endocrine

DOI 10.1007/s12020-013-0065-1

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Abstract

We aimed to evaluate the prevalence of lactose intolerance (LI) in patients with Hashimoto's thyroiditis(HT) and the effects of lactose restriction on thyroid function in these patients. Eighty-three HT patients taking L-thyroxine (LT4) were enrolled, and lactose tolerance tests were performed on all patients. Lactose intolerance was diagnosed in 75.9 % of the patients with HT. Thirty-eight patients with LI were started on a lactose-restricted diet for 8 weeks. Thirty-eight patients with LI (30 euthyroid and 8 with subclinical hypothyroidism), and 12 patients without LI were included in the final analysis. The level of TSH significantly decreased in the euthyroid and subclinical hypothyroid patients with LI [from 2.06 ± 1.02 to 1.51 ±1.1 IU/mL and from 5.45 ± 0.74 to 2.25 ± 1.88 IU/mL,respectively (both P<0.05)]. However, the level of TSH in patients without LI did not change significantly over the 8 weeks (P>0.05). Lactose intolerance occurs at a high frequency in HT patients. Lactose restriction leads to decreased levels of TSH, and LI should be considered in hypothyroid patients who require increasing LT4 doses,have irregular TSH levels and are resistant to LT4 treatment.

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In hypothyroid patients with lactose intolerance, a lactose-free diet lowers TSH.
“Seventy-six percent of hypothyroid patients show lactose intolerance, a lowered TSH was observed when such patients are provided a lactose-free diet (Asik et al., 2014).”
From Thyroid disorders and gastrointestinal dysmotility: an old association (2024) · cites this paper as Asik et al., 2014
Treatment for food sensitivities/intolerances improves malabsorption of thyroid medication.
“Malabsorption of thyroid medication has also been improved with treatment for food sensitivities/intolerances (Asik et al., 2014).”
From Thyroid disorders and gastrointestinal dysmotility: an old association (2024) · cites this paper as Asik et al., 2014
Seventy-six percent of hypothyroid patients show lactose intolerance.
“Seventy-six percent of hypothyroid patients show lactose intolerance, a lowered TSH was observed when such patients are provided a lactose-free diet (Asik et al., 2014).”
From Thyroid disorders and gastrointestinal dysmotility: an old association (2024) · cites this paper as Asik et al., 2014
In patients with celiac disease, intestinal parasitosis, or other intestinal dysfunctions, TSH concentrations remained elevated even after treatment with increased doses.
“In patients with celiac disease, intestinal parasitosis, or other intestinal dysfunctions, TSH concentrations remained elevated, even after treatment with increased doses (19, 23–26).”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [25]
Lactose intolerance and celiac disease are among the most frequent intestinal diseases responsible for malabsorption and may both impair intestinal absorption of drugs and nutrients via hydrolysis and complexation.
“In addition to surgery, lactose intolerance and celiac disease are among the most frequent intestinal diseases responsible for malabsorption. They may both impair intestinal absorption of drugs and nutrients via hydrolysis and complexation (25, 26, 55).”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [25]

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Authors: Asik, M., Gunes, F., Binnetoglu, E., Eroglu, M., Bozkurt, N., Sen, H., Akbal, E., Bakar, C., Beyazit, Y., & Ukinc, K.
Affiliations: Çanakkale Onsekiz Mart Üniversitesi (TR)
ORCID: Akbal, Erdem
Venue: Endocrine
Publisher: Springer Science and Business Media LLC
Published: 2013-09-28
Volume: 46
Issue: 2
Pages: 279-284
ISSN: 0969-711X (ISSN-L)
1355-008X
1559-0100
DOI: 10.1007/s12020-013-0065-1
OpenAlex: W2082937613
Cited by: 58
References: 25
Citations by year: 2026: 2 · 2025: 4 · 2024: 10 · 2023: 4 · 2022: 8 · 2021: 8 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 2
FWCI: 2.36
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Endocrine (publishedVersion)
PubMed (publishedVersion)
Çanakkale Onsekiz Mart University AVESIS (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Digestive system and related health
Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Keywords: Hashimoto's thyroiditis, lactose intolerance, thyroid-stimulating hormone, thyroid function, subclinical hypothyroidism, levothyroxine, dietary intervention
MeSH terms: Adult, Diet, Female, Humans, Lactose Intolerance, Lactose Tolerance Test, Male, Middle Aged, Thyrotropin, Treatment Outcome, Hashimoto Disease

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Decrease in TSH levels after lactose restriction in Hashimoto's thyroiditis patients with lactose intolerance

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