Cited by 800Antioxidant Activity and Oxidative StressRedox biology and oxidative stressParkinson's Disease Mechanisms and Treatments

The DOI matches its Crossref record; 282 of the 282 references it cites were found in a registry or an index.

Oxidative Stress in Neurodegenerative Diseases

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Niedzielska, Ewa, Smaga, Irena, Gawlik, Maciej, Moniczewski, Andrzej, Stankowicz, Piotr, Pera, Joanna, Filip, Małgorzata·2016·Molecular Neurobiology

DOI 10.1007/s12035-015-9337-5PMC PMC4937091

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Abstract

The pathophysiologies of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD), are far from being fully explained. Oxidative stress (OS) has been proposed as one factor that plays a potential role in the pathogenesis of neurodegenerative disorders. Clinical and preclinical studies indicate that neurodegenerative diseases are characterized by higher levels of OS biomarkers and by lower levels of antioxidant defense biomarkers in the brain and peripheral tissues. In this article, we review the current knowledge regarding the involvement of OS in neurodegenerative diseases, based on clinical trials and animal studies. In addition, we analyze the effects of the drug-induced modulation of oxidative balance, and we explore pharmacotherapeutic strategies for OS reduction.

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Fig. 1 Generation of reactive species (based on [280–283])CC BY · PubMed Central

Fig. 2 Source of radical and OS biomarkers. 8-OHA 2,8-hydroxyadenine, HNE 4-hydroxynonenal, 5-OHC 5-hydroxycytosine, 5-OHU 5-hydroxyuracil, 8-OHdG 8-hydroxy-2′-deoxyguanosine, 8-OH-Gua 8-hydroxyguanine, AGEs advanced glycation end products, ALES advanced lipid peroxidation end products, AOPP advanced oxidation products, CTL creatol, COX cyclooxygenases, CYP cytochrome P450, ETC electron transport chain, F2-isoPs F2-isoprostanes, F4-NPs F 4-neuroprostanes, HETE hydroxyeicosatetraenoic acids, HODE hydroxyoctadecadienoic acid, HIF-1a hypoxia-inducible factor-1a, IsoF isofuran, LF lipofuscin, LOX lipoxygenases, Lyso PC lysophosphatidylcholines, MPO myeloperoxidase, NOX NADPH oxidases, NFS neurofuran, Opht A ophthalmic acid, GSSG oxidized glutathione, ox-LDL oxidized LDL, GSSG/GSH oxidized/reduced glutathione, Prxs peroxiredoxins, PC protein carbonyl, TBARS thiobarbituric acid reactive substances, TQ/TQH2 tocopherylquinone/tocopheryl hydroquinone, TAC total antioxidant capacity, Tyr tyrosines, UQ/UQH2 ubiquinone/ubiquinol, XO xanthine oxidaseCC BY · PubMed Central

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Authors: Niedzielska, E., Smaga, I., Gawlik, M., Moniczewski, A., Stankowicz, P., Pera, J., & Filip, M.
Affiliations: Jagiellonian University (PL)
Corresponding author: Filip, Małgorzata
ORCID: Niedzielska, Ewa
Smaga, Irena
Gawlik, Maciej
Moniczewski, Andrzej
Pera, Joanna
Filip, Małgorzata
Venue: Molecular Neurobiology
Publisher: Springer Science and Business Media LLC
Published: 2015-07-22
Volume: 53
Issue: 6
Pages: 4094-4125
ISSN: 0893-7648 (ISSN-L)
1559-1182
DOI: 10.1007/s12035-015-9337-5
PMC: PMC4937091
OpenAlex: W1032629512
Cited by: 800
References: 282
Citations by year: 2026: 40 · 2025: 90 · 2024: 103 · 2023: 80 · 2022: 88 · 2021: 103 · 2020: 92 · 2019: 78 · 2018: 60 · 2017: 39 · 2016: 19 · 2015: 4
FWCI: 4.33
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (unspecified)
Locations: Molecular Neurobiology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion, cc-by-nc-nd)
Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords: oxidative stress, neurodegenerative diseases, amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, antioxidant defense, oxidative stress biomarkers
MeSH terms: Animals, Antioxidants, Clinical Trials as Topic, Humans, Biomarkers, Oxidative Stress, Neurodegenerative Diseases

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