The DOI matches its Crossref record; 282 of the 282 references it cites were found in a registry or an index.
Oxidative Stress in Neurodegenerative Diseases
Open accessAbstract
The pathophysiologies of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD), are far from being fully explained. Oxidative stress (OS) has been proposed as one factor that plays a potential role in the pathogenesis of neurodegenerative disorders. Clinical and preclinical studies indicate that neurodegenerative diseases are characterized by higher levels of OS biomarkers and by lower levels of antioxidant defense biomarkers in the brain and peripheral tissues. In this article, we review the current knowledge regarding the involvement of OS in neurodegenerative diseases, based on clinical trials and animal studies. In addition, we analyze the effects of the drug-induced modulation of oxidative balance, and we explore pharmacotherapeutic strategies for OS reduction.
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“ROS have been postulated to be the main cause of neurological deterioration, triggering pathologies such as AD, Parkinson’s disease (PD), and Huntington’s disease (HD) [72,116,124].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [124]
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Metadata
- Authors
- Niedzielska, E., Smaga, I., Gawlik, M., Moniczewski, A., Stankowicz, P., Pera, J., & Filip, M.
- Affiliations
- Jagiellonian University (PL)
- Corresponding author
- Filip, Małgorzata
- Venue
- Molecular Neurobiology
- Published
- 2015-07-22
- Volume
- 53
- Issue
- 6
- Pages
- 4094-4125
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- PMC
- PMC4937091
- OpenAlex
- W1032629512
- Cited by
- 800
- References
- 282
- Citations by year
- 2026: 40 · 2025: 90 · 2024: 103 · 2023: 80 · 2022: 88 · 2021: 103 · 2020: 92 · 2019: 78 · 2018: 60 · 2017: 39 · 2016: 19 · 2015: 4
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Molecular Neurobiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion, cc-by-nc-nd)
- Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
- Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- oxidative stress, neurodegenerative diseases, amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, antioxidant defense, oxidative stress biomarkers
- MeSH terms
- Animals, Antioxidants, Clinical Trials as Topic, Humans, Biomarkers, Oxidative Stress, Neurodegenerative Diseases
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