Oxidative Stress in Neurodegenerative Diseases

The Ferric Reducing Ability of Plasma (FRAP) as a Measure of “Antioxidant Power”: The FRAP Assay

Benzie, I. F. F., & Strain, J. (1996) · Analytical Biochemistry · doi:10.1006/abio.1996.0292 · Cited by 23,027

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989

Nitric oxide synthases: regulation and function

Forstermann, U., & Sessa, W. C. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr304 · Cited by 4,409

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

Betarbet, R. S., Sherer, T., MacKenzie, G. M., Garcia‐Osuna, M., Panov, A. V., & Greenamyre, J. T. (2000) · Nature Neuroscience · doi:10.1038/81834 · Cited by 3,770

Frequency Dependence of Signal Power and Spatial Reach of the Local Field Potential

Leski, S., Lindén, H., Tetzlaff, T., Pettersen, K. H., & Einevoll, G. T. (2013) · PubMed · doi:10.18154/rwth-conv-084442 · Cited by 3,667

Advances in metal-induced oxidative stress and human disease

Jomová, K., & Valko, M. (2011) · Toxicology · doi:10.1016/j.tox.2011.03.001 · Cited by 3,280

Postsynaptic Supersensitivity after 6‐Hydroxy‐dopamine Induced Degeneration of the Nigro‐striatal Dopamine System

Ungerstedt, U. (1971) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.1971.tb11000.x · Cited by 1,920

Oxidative Stress, Prooxidants, and Antioxidants: The Interplay

Rahal, A., Kumar, A., Singh, V., Yadav, B., Tiwari, R., Chakraborty, S., & Dhama, K. (2014) · BioMed Research International · doi:10.1155/2014/761264 · Cited by 1,806

Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease

Dexter, D. T., Carter, C. J., Wells, F. R., Javoy-Agid, F., Agid, Y., Lees, A. J., Jenner, P. G., & MARSDEN, C. D. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09133.x · Cited by 1,397

Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains

Riederer, P., Sofic, E., Rausch, W., Schmidt, B., Reynolds, G. P., Jellinger, K., & Youdim, M. B. H. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09150.x · Cited by 1,383

The role of glutathione-S-transferase in anti-cancer drug resistance

Townsend, D. M., & Tew, K. D. (2003) · Oncogene · doi:10.1038/sj.onc.1206940 · Cited by 1,353

Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems

Lü, J., Lin, P. H., Yao, Q. C., & Chen, C. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00897.x · Cited by 1,331

Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions

Lushchak, V. I. (2012) · Journal of Amino Acids · doi:10.1155/2012/736837 · Cited by 1,266

Effects of Tocopherol and Deprenyl on the Progression of Disability in Early Parkinson's Disease

The Parkinson Study Group (1993) · New England Journal of Medicine · doi:10.1056/nejm199301213280305 · Cited by 1,222

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

Sian, J., Dexter, D. T., Lees, A. J., Daniel, S., Agid, Y., Javoy‐Agid, F., Jenner, P., & Marsden, C. D. (1994) · Annals of Neurology · doi:10.1002/ana.410360305 · Cited by 1,161

Reactive oxygen species: from health to disease

Brieger, K., Schiavone, S., Miller Jr., F. J., & Krause, K.-H. (2012) · Swiss Medical Weekly · doi:10.4414/smw.2012.13659 · Cited by 1,133

Oxidative damage to mitochondrial DNA is increased in Alzheimer’s disease

Mecocci, P., MacGarvey, U., & Beal, M. F. (1994) · Annals of Neurology · doi:10.1002/ana.410360510 · Cited by 1,037

Effects of Coenzyme Q10 in Early Parkinson Disease: Evidence of Slowing of the Functional Decline

Shults, C. W. (2002) · Archives of Neurology · doi:10.1001/archneur.59.10.1541 · Cited by 984

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.

Yoritaka, A., Hattori, N., Uchida, K., Tanaka, M., Stadtman, E. R., & Mizuno, Y. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.2696 · Cited by 981

Mechanism of Oxidative Stress in Neurodegeneration

Gandhi, S., & Abramov, A. Y. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/428010 · Cited by 964

Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

Langston, J. W., Forno, L. S., Rebert, C. S., & Irwin, I. (1984) · Brain Research · doi:10.1016/0006-8993(84)90777-7 · Cited by 922

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

Li, X., Fang, P., Mai, J., Choi, E. T., Wang, H., & Yang, X. (2013) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-6-19 · Cited by 860

Oxidative DNA Damage in the Parkinsonian Brain: An Apparent Selective Increase in 8‐Hydroxyguanine Levels in Substantia Nigra

Alam, Z. I., Jenner, A., Daniel, S. E., Lees, A. J., Cairns, N., Marsden, C. D., Jenner, P., & Halliwell, B. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69031196.x · Cited by 845

Biological markers of oxidative stress: Applications to cardiovascular research and practice

Ho, E. C., Galougahi, K. K., Liu, C., Bhindi, R., & Figtree, G. A. (2013) · Redox Biology · doi:10.1016/j.redox.2013.07.006 · Cited by 835

Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease: A Randomized Trial

Quinn, J. F., Raman, R., Thomas, R. G., Yurko-Mauro, K., Nelson, E. B., Van Dyck, C., Galvin, J. E., Emond, J., Jack, C. R., Weiner, M., et al. (2010) · JAMA · doi:10.1001/jama.2010.1510 · Cited by 764

Parkinson's disease: A disorder due to nigral glutathione deficiency?

Perry, T. L., Godin, D. V., & Hansen, S. (1982) · Neuroscience Letters · doi:10.1016/0304-3940(82)90390-1 · Cited by 753

ω-3 Fatty Acid Treatment in 174 Patients With Mild to Moderate Alzheimer Disease: OmegAD Study: A Randomized Double-blind Trial

Freund-Levi, Y., Eriksdotter-Jönhagen, M., Cederholm, T., Basun, H., Faxén-Irving, G., Garlind, A., Vedin, I., Vessby, B., Wahlund, L.-O., & Palmblad, J. (2006) · Archives of Neurology · doi:10.1001/archneur.63.10.1402 · Cited by 751

Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis

Klivenyi, P., Ferrante, R. J., Matthews, R. T., Bogdanov, M. B., Klein, A. M., Andreassen, O. A., Mueller, G., Wermer, M., Kaddurah-Daouk, R., & Beal, M. F. (1999) · Nature Medicine · doi:10.1038/6568 · Cited by 682

Animal models of Alzheimer's disease and frontotemporal dementia

Götz, J., & Ittner, L. M. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2420 · Cited by 676

Oxidative stress in ALS: Key role in motor neuron injury and therapeutic target

Barber, S. C., & Shaw, P. J. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.11.018 · Cited by 647

Benefit of vitamin E, riluzole, and gababapentin in a transgenic model of familial amyotrophic lateral sclerosis

Gurney, M. E., Cutting, F. B., Zhai, P., Doble, A., Taylor, C. P., Andrus, P. K., & Hall, E. D. (1996) · Annals of Neurology · doi:10.1002/ana.410390203 · Cited by 647

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

Devos, D., Moreau, C., Devedjian, J. C., Kluza, J., Pétrault, M., Laloux, C., Jonneaux, A., Ryckewaert, G., Garçon, G., Rouaix, N., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5593 · Cited by 641

Parkinson's Disease Is Associated with Oxidative Damage to Cytoplasmic DNA and RNA in Substantia Nigra Neurons

Zhang, J., Perry, G. L., Smith, M. A., Robertson, D., Olson, S. J., Graham, D. G., & Montine, T. J. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65396-5 · Cited by 639

Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease: The TEAM-AD VA Cooperative Randomized Trial

Dysken, M. W., Sano, M., Asthana, S., Vertrees, J. E., Pallaki, M., Llorente, M., Love, S., Schellenberg, G. D., McCarten, J. R., Malphurs, J., et al. (2014) · JAMA · doi:10.1001/jama.2013.282834 · Cited by 628

Protein aggregation in amyotrophic lateral sclerosis

Blokhuis, A. M., Groen, E. J. N., Koppers, M., van den Berg, L. H., & Pasterkamp, R. J. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1125-6 · Cited by 607

Oxidative stress in the progression of Alzheimer disease in the frontal cortex

Ansari, M. A., & Scheff, S. W. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181cb5af4 · Cited by 605

Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease

Baum, L., Lam, C. W. K., Cheung, S. K. K., Kwok, T. C. Y., Lui, V. W.-C., Tsoh, J., LAM, L. C. W., Leung, V., Hui, E., Ng, C., et al. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318160862c · Cited by 602

Are Reactive Oxygen Species Always Detrimental to Pathogens?

Paiva, C. N., & Bozza, M. T. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5447 · Cited by 577

Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

Ringman, J. M., Frautschy, S. A., Teng, E., Begum, A. N., Bardens, J., Beigi, M., Gylys, K. H., Badmaev, V., Heath, D. D., Apostolova, L. G., et al. (2012) · Alzheimer s Research & Therapy · doi:10.1186/alzrt146 · Cited by 559

A Reevaluation of the Duration of Survival after the Onset of Dementia

Wolfson, C. M., Wolfson, D. B., Asgharian, M., M’lan, C. E., Østbye, T., Rockwood, K. J., & Hogan, D. B. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104123441501 · Cited by 553

A Generalised Increase in Protein Carbonyls in the Brain in Parkinson's but Not Incidental Lewy Body Disease

Alam, Z. I., Daniel, S. E., Lees, A. J., Marsden, D. C., Jenner, P. G., & Halliwell, B. B. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69031326.x · Cited by 547

Protein Nitration in Parkinsonʼs Disease

Good, P. F., Hsu, A., Werner, P., Perl, D. P., & Olanow, C. W. (1998) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199804000-00006 · Cited by 540

Reaction of superoxide with nitric oxide to form peroxonitrite in alkaline aqueous solution

Blough, N. V., & Zafiriou, O. C. (1985) · Inorganic Chemistry · doi:10.1021/ic00216a003 · Cited by 525

Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats.

Lannert, H., & Hoyer, S. (1998) · Behavioral Neuroscience · doi:10.1037/0735-7044.112.5.1199 · Cited by 525

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

Turner, B. J., & Talbot, K. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.01.001 · Cited by 524

Oxidative Stress and Neurodegenerative Disorders

Li, J., Wuliji, O., Li, W., Jiang, Z.-G., & Ghanbari, H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141224438 · Cited by 520

Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease

Marcus, D. L., Thomas, C., Rodriguez, C., Simberkoff, K., Tsai, J. S., Strafaci, J. A., & Freedman, M. L. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6750 · Cited by 513

Amyotrophic Lateral Sclerosis-Associated SOD1 Mutant Proteins Bind and Aggregate with Bcl-2 in Spinal Cord Mitochondria

Pasinelli, P., Belford, M. E., Lennon, N. J., Bacskai, B. J., Hyman, B. T., Trotti, D., & Brown, R. H. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.021 · Cited by 506

Classic and New Animal Models of Parkinson's Disease

Blesa, J., Phani, S., Jackson-Lewis, V. R., & Przedborski, S. (2012) · BioMed Research International · doi:10.1155/2012/845618 · Cited by 502

Comparative antioxidant capacities of phenolic compounds measured by various tests

Tabart, J., Kevers, C., Pincemail, J., Defraigne, J.-O., & Dommès, J. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.08.013 · Cited by 496

Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis

Vargas, M. R., Johnson, D. A., Sirkis, D. W., Messing, A., & Johnson, J. A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4099-08.2008 · Cited by 479

A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease

The NINDS NET-PD Investigators (2006) · Neurology · doi:10.1212/01.wnl.0000201252.57661.e1 · Cited by 453

Histological Evidence of Protein Aggregation in Mutant SOD1 Transgenic Mice and in Amyotrophic Lateral Sclerosis Neural Tissues

Watanabe, M., Dykes‐Hoberg, M., Culotta, V., Price, D. L., Wong, P. C., & Rothstein, J. D. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0443 · Cited by 447

ROS and Brain Diseases: The Good, the Bad, and the Ugly

Popa-Wagner, A., Mitran, S., Sivanesan, S., Chang, E., & Buga, A.-M. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/963520 · Cited by 427

A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease

The Parkinson Study Group QE3 Investigators, Beal, M. F., Oakes, D., Shoulson, I., Henchcliffe, C., Galpern, W. R., Haas, R., Juncos, J. L., Nutt, J. G., Voss, T., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.131 · Cited by 410

Reactive oxygen species: Destroyers or messengers?

Bartosz, G. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.11.009 · Cited by 386

Antioxidants for Alzheimer Disease: A Randomized Clinical Trial With Cerebrospinal Fluid Biomarker Measures

Galasko, D. R., Peskind, E., Clark, C. M., Quinn, J. F., Ringman, J. M., Jicha, G. A., Cotman, C., Cottrell, B., Montine, T. J., Thomas, R. G., et al. (2012) · Archives of Neurology · doi:10.1001/archneurol.2012.85 · Cited by 377

Creatine and Cyclocreatine Attenuate MPTP Neurotoxicity

Matthews, R. T., Ferrante, R. J., Klivènyi, P., Yang, L., Klein, A., Mueller, G., Kaddurah-Daouk, R. F., & Beal, M. F. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7049 · Cited by 374

Dysregulation of Glutathione Homeostasis in Neurodegenerative Diseases

Johnson, W. M., Wilson‐Delfosse, A. L., & Mieyal, J. J. (2012) · Nutrients · doi:10.3390/nu4101399 · Cited by 367

Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients

Perry, T. L., & Yong, V. W. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90320-4 · Cited by 362

Oxidative damage to macromolecules in human Parkinson disease and the rotenone model

Sanders, L. H., & Greenamyre, J. T. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.003 · Cited by 360

Mitochondrial metabolism of reactive oxygen species

Venditti, P., Stefano, L. D., & Meo, S. D. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.01.008 · Cited by 359

Monomeric Cu,Zn-superoxide Dismutase Is a Common Misfolding Intermediate in the Oxidation Models of Sporadic and Familial Amyotrophic Lateral Sclerosis

Rakhit, R., Crow, J. P., Lepock, J. R., Kondejewski, L. H., Cashman, N. R., & Chakrabartty, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313295200 · Cited by 345

Genetics of amyotrophic lateral sclerosis: an update

Chen, S., Sayana, P., Zhang, X., & Le, W. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-28 · Cited by 344

Is SOD1 loss of function involved in amyotrophic lateral sclerosis?

Saccon, R. A., Bunton-Stasyshyn, R. K. A., Fisher, E., & Fratta, P. (2013) · Brain · doi:10.1093/brain/awt097 · Cited by 339

Novel Antibodies Reveal Inclusions Containing Non-Native SOD1 in Sporadic ALS Patients

Forsberg, K., Jonsson, P. A., Andersen, P. M., Bergemalm, D., Graffmo, K. S., Hultdin, M., Jacobsson, J., Rosquist, R., Marklund, S. L., & Brännström, T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011552 · Cited by 338

Role of Oxidative Stress in the Progression of Alzheimer's Disease

Rukhsana Sultana, A., & Butterfield, D. A. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1222 · Cited by 336

Increased oxidative damage to DNA in ALS patients

Bogdanov, M. B., Brown, R. H., Matson, W. R., Smart, R. J., Hayden, D. L., O’Donnell, H. C., Beal, M. F., & Cudkowicz, M. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00349-x · Cited by 334

Advanced glycation end products and neurodegenerative diseases: Mechanisms and perspective

Li, J., Liu, D., Sun, L., Lu, Y., & Zhang, Z. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.02.018 · Cited by 326

Increased iron‐related MRI contrast in the substantia nigra in Parkinson's disease

Gorell, J. M., Ordidge, R. J., Brown, G. G., Deniau, J.-C., Buderer, N. M. F., & Helpern, J. A. (1995) · Neurology · doi:10.1212/wnl.45.6.1138 · Cited by 324

Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics

Mailloux, R. J., McBride, S., & Harper, M. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.09.001 · Cited by 308

Redox imbalance in Parkinson's disease

Chinta, S. J., & Andersen, J. K. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.02.005 · Cited by 303

Glutathione peroxidase activity in Parkinson's disease brain

Kish, S. J., Morito, C. L. H., & Hornykiewicz, O. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90078-3 · Cited by 303

Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy

Kikuchi, A., Takeda, A., Onodera, H., Kimpara, T., Hisanaga, K., Sato, N., Nunomura, A., Castellani, R. J., Perry, G. L., Smith, M. A., et al. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0466 · Cited by 296

Decreased plasma antioxidants in patients with Alzheimer's disease

Kim, T., Pae, C., Yoon, S.-J., Jang, W., Lee, N. J., Kim, J.-J., Lee, S., Lee, C., Paik, I.-H., & Lee, C. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1469 · Cited by 293

Increased DNA Oxidation and Decreased Levels of Repair Products in Alzheimer's Disease Ventricular CSF

Lovell, M. A., Gabbita, S. P., & Markesbery, W. R. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720771.x · Cited by 292

Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer’s disease

Chonpathompikunlert, P., Wattanathorn, J., & Muchimapura, S. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.12.009 · Cited by 292

A Randomized Placebo-Controlled Pilot Trial of Omega-3 Fatty Acids and Alpha Lipoic Acid in Alzheimer's Disease

Shinto, L., Quinn, J., Montine, T., Dodge, H. H., Woodward, W., Baldauf-Wagner, S., Waichunas, D., Bumgarner, L., Bourdette, D., Silbert, L., et al. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-130722 · Cited by 288

Reduced oxidative damage in ALS by high‐dose enteral melatonin treatment

Weishaupt, J. H., Bartels, C., Pölking, E., Dietrich, J., Rohde, G., Pöeggeler, B., Mertens, N., Sperling, S., Bohn, M., Huether, G., et al. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00377.x · Cited by 284

Amount and type of alcohol and risk of dementia

Truelsen, T. C., Thudium, D., & Grønbæk, M. (2002) · Neurology · doi:10.1212/01.wnl.0000031421.50369.e7 · Cited by 283

A randomized sequential trial of creatine in amyotrophic lateral sclerosis

Groeneveld, G. J., Veldink, J. H., van der Tweel, I., Kalmijn, S., Beijer, C., de Visser, M., Wokke, J. H. J., Franssen, H., & van den Berg, L. H. (2003) · Annals of Neurology · doi:10.1002/ana.10554 · Cited by 283

Role of oxidative stress in paraquat‐induced dopaminergic cell degeneration

McCormack, A. L., Atienza, J. G., Johnston, L. C., Andersen, J. K., Vu, S., & Monte, D. A. D. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03088.x · Cited by 282

Effects of natural antioxidants in neurodegenerative disease

Albarracín, S. L., Stab, B., Casas, Z., Sutachan, J. J., Samudio, I. J., González, J., Gonzalo, L., Capani, F., Morales, L., & Barreto, G. E. (2012) · Nutritional Neuroscience · doi:10.1179/1476830511y.0000000028 · Cited by 276

Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease

Lovell, M. A., Xie, C., & Markesbery, W. R. (1998) · Neurology · doi:10.1212/wnl.51.6.1562 · Cited by 275

A double-blind, placebo-controlled randomized clinical trial of α-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis

Desnuelle, C., Dib, M., Garrel, C., & Favier, A. E. (2001) · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders · doi:10.1080/146608201300079364 · Cited by 266

Investigation of the therapeutic effects of edaravone, a free radical scavenger, on amyotrophic lateral sclerosis (Phase II study)

Yoshino, H., & Kimura, A. (2006) · Amyotrophic Lateral Sclerosis · doi:10.1080/17482960600881870 · Cited by 265

Wild‐type superoxide dismutase acquires binding and toxic properties of ALS‐linked mutant forms through oxidation

Ezzi, S. A., Urushitani, M., & Julien, J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04531.x · Cited by 263

Oxidative damage in Parkinson disease: Measurement using accurate biomarkers

Seet, R. C. S., Lee, J. C., Lim, E. C. H., Tan, J. J. H., Quek, A. M. L., Chong, W.-L., Looi, W. F., Huang, S.-H., Wang, H., Chan, Y., et al. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.11.026 · Cited by 255

Presence of 4‐hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis

Smith, R. G., Henry, Y. K., Mattson, M. P., & Appel, S. H. (1998) · Annals of Neurology · doi:10.1002/ana.410440419 · Cited by 254

Oxygen toxicity protecting enzymes in Parkinson's disease

Marttila, R. J., Lorentz, H., & Rinne, U. K. (1988) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(88)90108-6 · Cited by 249

Mitochondrial dysfunction in ALS

Cozzolino, M., & Carrì, M. T. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.06.003 · Cited by 249

Effect of Centella asiatica on cognition and oxidative stress in an intracerebroventricular streptozotocin model of Alzheimer's disease in rats

Veerendra Kumar, M., & Gupta, Y. (2003) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2003.03842.x · Cited by 249

Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people

DiSilvestro, R. A., Joseph, E., Zhao, S., & Bomser, J. A. (2012) · Nutrition Journal · doi:10.1186/1475-2891-11-79 · Cited by 244

An overview of the chemistry and biology of reactive aldehydes

Fritz, K. S., & Petersen, D. R. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.06.025 · Cited by 237

Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III

Kaufmann, P., Thompson, J. L. P., Levy, G., Buchsbaum, R., Shefner, J. M., Krivickas, L. S., Katz, J., Rollins, Y. D., Barohn, R. J., Jackson, C. E., et al. (2009) · Annals of Neurology · doi:10.1002/ana.21743 · Cited by 236

Plasma chain-breaking antioxidants in Alzheimer's disease, vascular dementia and Parkinson's disease

Foy, C. J. (1999) · QJM · doi:10.1093/qjmed/92.1.39 · Cited by 235

Increased Cerebral Glucose‐6‐Phosphate Dehydrogenase Activity in Alzheimer's Disease May Reflect Oxidative Stress

Martins, R. N., Harper, C. G., Stokes, G. B., & Masters, C. L. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb00615.x · Cited by 234

Messenger RNA Oxidation Occurs Early in Disease Pathogenesis and Promotes Motor Neuron Degeneration in ALS

Chang, Y., Kong, Q., Shan, X., Tian, G., Ilieva, H. S., Cleveland, D. W., Rothstein, J. D., Borchelt, D., Wong, P. C., & Lin, C.-L. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002849 · Cited by 232

Reactive oxygen species at phospholipid bilayers: Distribution, mobility and permeation

Cordeiro, R. M. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.09.016 · Cited by 228

Impaired Glutathione Synthesis in Neurodegeneration

Aoyama, K., & Nakaki, T. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141021021 · Cited by 226

Reactive oxygen species and reactive nitrogen species: Relevance to cyto(neuro)toxic events and neurologic disorders. An overview

Metodiewa, D., & Kośka, C. (1999) · Neurotoxicity Research · doi:10.1007/bf03033290 · Cited by 226

Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson’s disease in rats

Karuppagounder, S. S., Madathil, S. K., Pandey, M., Haobam, R., Rajamma, U., & Mohanakumar, K. P. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.032 · Cited by 225

Aberrant expression of NOS isoforms in Alzheimer’s disease is structurally related to nitrotyrosine formation

Lüth, H., Münch, G. W., & Arendt, T. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03280-8 · Cited by 223

N-acetylcysteine Boosts Brain and Blood Glutathione in Gaucher and Parkinson Diseases

Holmay, M. J., Terpstra, M., Coles, L. D., Mishra, U., Ahlskog, M., Öz, G., Cloyd, J. C., & Tuite, P. J. (2013) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e31829ae713 · Cited by 216

(E)-4-Hydroxy-2-Nonenal May be Involved in the Pathogenesis of Parkinson’s Disease

Selley, M. L. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00021-5 · Cited by 215

Evaluation of antioxidants: Scope, limitations and relevance of assays

Pinchuk, I., Shoval, H., Dotan, Y., & Lichtenberg, D. A. (2012) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2012.05.003 · Cited by 208

Lipid Peroxidation and Antioxidant Enzyme Activities in Vascular and Alzheimer Dementias

Casado, Á., López-Fernández, M. E., Casado, M. C., & de la Torre, R. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9453-3 · Cited by 207

Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice

Ito, H., Wate, R., Zhang, J., Ohnishi, S., Kaneko, S., Ito, H., Nakano, S., & Kusaka, H. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.07.017 · Cited by 205

Creatine supplementation in Parkinson disease: A placebo-controlled randomized pilot trial

Bender, A., Koch, W., Elstner, M., Schombacher, Y., Bender, J., Moeschl, M., Gekeler, F., Müller‐Myhsok, B., Gasser, T., Tatsch, K., et al. (2006) · Neurology · doi:10.1212/01.wnl.0000238518.34389.12 · Cited by 205

Randomized, Double-blind, Placebo-Controlled Trial on Symptomatic Effects of Coenzyme Q10 in Parkinson Disease

Storch, A. (2007) · Archives of Neurology · doi:10.1001/archneur.64.7.nct60005 · Cited by 205

Oxidative and nitrative protein modifications in Parkinson's disease

Danielson, S. R., & Andersen, J. K. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.03.005 · Cited by 204

Hydrogen in Drinking Water Reduces Dopaminergic Neuronal Loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Parkinson's Disease

Fujita, K., Seike, T., Yutsudo, N., Ohno, M., Yamada, H., Yamaguchi, H., Sakumi, K., Yamakawa, Y., Kido, M. A., Takaki, A., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007247 · Cited by 204

PS2APP Transgenic Mice, Coexpressing hPS2mut and hAPPswe, Show Age-Related Cognitive Deficits Associated with Discrete Brain Amyloid Deposition and Inflammation

Richards, J. G., Higgins, G. A., Ouagazzal, A., Ozmen, L., Kew, J. N. C., Bohrmann, B., Malherbe, P., Brockhaus, M., Loetscher, H., Czech, C., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-26-08989.2003 · Cited by 204

DATATOP: A decade of neuroprotective inquiry

Shoulson, I., & Parkinson Study Group (1998) · Annals of Neurology · doi:10.1002/ana.410440724 · Cited by 202

Additive neuroprotective effects of creatine and cyclooxygenase 2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis

Klivènyi, P., Kiaei, M., Gardian, G., Calingasan, N. Y., & Beal, M. F. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02160.x · Cited by 201

The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids

Liu, D., WEN, J., Liu, J., & Li, L. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.15.2318 · Cited by 199

Oxidative stress biomarkers in sporadic ALS

Mitsumoto, H., Santella, R. M., Liu, X., Bogdanov, M. B., Zipprich, J., Wu, H., Mahata, J., Kilty, M., Bednarz, K., Bell, D. A., et al. (2008) · Amyotrophic Lateral Sclerosis · doi:10.1080/17482960801933942 · Cited by 199

High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study

Graf, M., Ecker, D., Horowski, R., Krämer, B., Riederer, P. F., Gerlach, M., Hager, C., Ludolph, A. C., Krämer, B., Ecker, D., et al. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0220-1 · Cited by 192

Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms

Fan, Y., Hu, J., Li, J., Yang, Z., Xin, X., Wang, J., Ding, J., & Geng, M. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.10.063 · Cited by 188

Randomized, Double-Blind, Controlled Trial of Acetylcysteine in Amyotrophic Lateral Sclerosis

Louwerse, E. S., Weverling, G. J., Bossuyt, P. M., Meyjes, F. E. P., & de Jong, J. M. B. V. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540300031009 · Cited by 186

Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS

Zhang, W., Narayanan, M. V., & Friedlander, R. M. (2003) · Annals of Neurology · doi:10.1002/ana.10476 · Cited by 185

Effects of imperatorin on scopolamine-induced cognitive impairment and oxidative stress in mice

Budzyńska, B., Boguszewska‐Czubara, A., Kruk-Słomka, M., Skalicka‐Woźniak, K., Michalak, A., Musik, I., & Biała, G. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3728-6 · Cited by 184

β-Amyloid (1–42)-induced learning and memory deficits in mice: involvement of oxidative burdens in the hippocampus and cerebral cortex

Jhoo, J. H., Kim, H., Nabeshima, T., Yamada, K., Shin, E., Jhoo, W., Kim, W. K., Kang, K., Jo, S. A., & Woo, J. I. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.04.012 · Cited by 184

Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer’s disease, in APP23 transgenic mice and after experimental brain lesion in rat: Evidence for an induction by amyloid pathology

Lüth, H.-J., Holzer, M., Gärtner, U., Staufenbiel, M., & Arendt, T. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02758-5 · Cited by 183

Protein Nitration in a Mouse Model of Familial Amyotrophic Lateral Sclerosis

Casoni, F., Basso, M., Massignan, T., Gianazza, E., Cheroni, C., Salmona, M., Bendotti, C., & Bonetto, V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413111200 · Cited by 180

Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model

Jung, C., Rong, Y., Doctrow, S. R., Baudry, M., Malfroy, B., & Xu, Z. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01784-0 · Cited by 177

A Pilot Clinical Trial of Creatine and Minocycline in Early Parkinson Disease

Ninds Net-Pd Investigators (2008) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e3181342f32 · Cited by 174

Reduced intravenous glutathione in the treatment of early parkinson's disease

Sechi, G., Deledda, M. G., Bua, G., Satta, W. M., Deiana, G. A., Pes, G. M., & Rosati, G. (1996) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(96)00103-0 · Cited by 173

Free copper, ferroxidase and SOD1 activities, lipid peroxidation and NO(x) content in the CSF. A different marker profile in four neurodegenerative diseases

Boll, M.-C., Alcaraz-Zubeldia, M., Montes, S., & Rios, C. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9610-3 · Cited by 173

Elevated “Hydroxyl Radical” Generation In Vivo in an Animal Model of Amyotrophic Lateral Sclerosis

Bogdanov, M. B., Ramos, L. E., Xu, Z., & Beal, M. F. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71031321.x · Cited by 172

Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative Stress

Puchchakayala, G. R., Akina, S., & Thati, M. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/974013 · Cited by 171

Protective Effect of Lycopene on Oxidative Stress and Cognitive Decline in Rotenone Induced Model of Parkinson’s Disease

Kaur, H., Chauhan, S., & Sandhir, R. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0469-3 · Cited by 171

Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

Castellani, R. J., Perry, G. L., Siedlak, S. L., Nunomura, A., Shimohama, S., Zhang, J., Montine, T. J., Sayre, L. M., & Smith, M. A. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02514-9 · Cited by 169

Genetics of sporadic amyotrophic lateral sclerosis

Schymick, J. C., Talbot, K., & Traynor, B. J. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm215 · Cited by 167

Depletion of reduced glutathione enhances motor neuron degeneration in vitro and in vivo

Chi, L., Ke, Y., Luo, C. T., Gozal, D., & Liu, R. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.09.064 · Cited by 167

Melatonin or silymarin reduces maneb‐ and paraquat‐induced Parkinson’s disease phenotype in the mouse

Singhal, N. K., Srivastava, G., Patel, D. K., Jain, S. K., & Singh, M. P. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00819.x · Cited by 166

Naringenin ameliorates Alzheimer’s disease (AD)-type neurodegeneration with cognitive impairment (AD-TNDCI) caused by the intracerebroventricular-streptozotocin in rat model

Khan, M. B., Khan, M. M., Khan, A., Ahmed, M. E., Ishrat, T., Tabassum, R., Vaibhav, K., Ahmad, A., & Islam, F. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.07.025 · Cited by 165

Rodent models of amyotrophic lateral sclerosis

McGoldrick, P., Joyce, P. I., Fisher, E., & Greensmith, L. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.03.012 · Cited by 162

Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer's disease

Zheng, F., Qin, C., Chang, Y. S., & Zhang, J. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.014 · Cited by 156

Idebenone treatment fails to slow cognitive decline in Alzheimer’s disease

Thal, L. J., Grundman, M., Berg, J., Ernstrom, K., Margolin, R., Pfeiffer, E., Weiner, M. F., Zamrini, E., & Thomas, R. G. (2003) · Neurology · doi:10.1212/01.wnl.0000096376.03678.c1 · Cited by 156

Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice

Saxena, G., Singh, S. P., Agrawal, R., & Nath, C. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.12.009 · Cited by 155

DATATOP: a decade of neuroprotective inquiry. Parkinson Study Group. Deprenyl And Tocopherol Antioxidative Therapy Of Parkinsonism.

Shoulson, I. (1998) · PubMed · Cited by 154

Isoprostanes and Neuroprostanes as Biomarkers of Oxidative Stress in Neurodegenerative Diseases

Miller, E. D., Morel, A., Saso, L., & Saluk, J. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/572491 · Cited by 154

Oxidative stress-induced posttranslational modifications of alpha-synuclein: Specific modification of alpha-synuclein by 4-hydroxy-2-nonenal increases dopaminergic toxicity

Xiang, W., Schlachetzki, J. C. M., Helling, S., Bussmann, J., Berlinghof, M., Schäffer, T. E., Marcus, K., Winkler, J., Klucken, J., & Becker, C. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2013.01.004 · Cited by 152

Ginkgo biloba affords dose‐dependent protection against 6‐hydroxydopamine‐induced parkinsonism in rats: neurobehavioural, neurochemical and immunohistochemical evidences

Ahmad, M., Saleem, S., Ahmad, A. S., Yousuf, S., Ansari, M. A., Khan, M. B., Ishrat, T., Chaturvedi, R. K., Agrawal, A. K., & Islam, F. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03000.x · Cited by 150

Oxidative stress and metal content in blood and cerebrospinal fluid of amyotrophic lateral sclerosis patients with and without a Cu, Zn-superoxide dismutase mutation

Ihara, Y., Nobukuni, K., Takata, H., & Hayabara, T. (2005) · Neurological Research · doi:10.1179/016164105x18430 · Cited by 148

Evaluation of Markers of Oxidative Stress, Antioxidant Function and Astrocytic Proliferation in the Striatum and Frontal Cortex of Parkinson’s Disease Brains

Mythri, R. B., Venkateshappa, C., Harish, G., Mahadevan, A., Muthane, U. B., Yasha, T. C., Bharath, M. M. S., & Shankar, S. K. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0471-9 · Cited by 148

Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice—a model of familial amyotrophic lateral sclerosis

Poon, H. F., Hensley, K., Thongboonkerd, V., Merchant, M. L., Lynn, B. C., Pierce, W. M. J., Klein, J. B., Calabrese, V., & Butterfield, D. A. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.03.030 · Cited by 148

Memantine reduces oxidative damage and enhances long-term recognition memory in aged rats

Dias, C. P., de Lima, M. N. M., Presti-Torres, J., Dornelles, A. D. S., Garcia, V. A., Scalco, F. S., Guimarães, M. R., Constantino, L. D. S., Budni, P., Dal‐Pizzol, F., et al. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.03.018 · Cited by 146

Electrons, life and the evolution of Earth's oxygen cycle

Falkowski, P. G., & Godfrey, L. V. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0054 · Cited by 144

Glial activation and post-synaptic neurotoxicity: The key events in Streptozotocin (ICV) induced memory impairment in rats

Rai, S., Kamat, P. K., Nath, C., & Shukla, R. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.035 · Cited by 141

Acetyl-l-carnitine and α-lipoic acid affect rotenone-induced damage in nigral dopaminergic neurons of rat brain, implication for Parkinson's disease therapy

Zaitone, S. A., Abo–Elmatty, D. M., & Shaalan, A. A. M. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.09.002 · Cited by 141

Intake of polyunsaturated fatty acids and vitamin E reduces the risk of developing amyotrophic lateral sclerosis

Veldink, J. H., Kalmijn, S., Groeneveld, G. J., Wunderink, W., Koster, A., de Vries, J. H. M., van der Luyt, J., Wokke, J. H. J., & van den Berg, L. H. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.083378 · Cited by 139

Glutathione homeostasis in response to exercise training and nutritional supplements

Sen, C. K. (1999) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006910011048 · Cited by 137

Manganese porphyrin given at symptom onset markedly extends survival of ALS mice

Crow, J. P., Calingasan, N. Y., Chen, J., Hill, J. L., & Beal, M. F. (2005) · Annals of Neurology · doi:10.1002/ana.20552 · Cited by 136

Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis

Zhang, Y., Cook, A., Kim, J., Baranov, S. V., Jiang, J., Smith, K., Cormier, K., Bennett, E., Browser, R. P., Day, A. L., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.03.008 · Cited by 134

S-allyl cysteine attenuates oxidative stress associated cognitive impairment and neurodegeneration in mouse model of streptozotocin-induced experimental dementia of Alzheimer's type

Javed, H., Khan, M. M., Khan, A., Vaibhav, K., Ahmad, A., Khuwaja, G., Ahmed, M. E., Raza, S. S., Ashafaq, M., Tabassum, R., et al. (2011) · Brain Research · doi:10.1016/j.brainres.2011.02.072 · Cited by 133

Animal models of Alzheimer disease: historical pitfalls and a path forward

Cavanaugh, S. E. (2014) · ALTEX · doi:10.14573/altex.1310071 · Cited by 132

Oxidative stress as a common pathway to chronic tubulointerstitial injury in kidney allografts

Djamali, A. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00037.2007 · Cited by 131

Levels of reduced and oxidized coenzymeQ-10 and 8-hydroxy-2′-deoxyguanosine in the cerebrospinal fluid of patients with living Parkinson's disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process

Isobe, C., Abe, T., & Terayama, Y. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.11.065 · Cited by 130

Urinary 8-hydroxydeoxyguanosine levels as a biomarker for progression of Parkinson disease

Sato, S., Mizuno, Y., & Hattori, N. (2005) · Neurology · doi:10.1212/01.wnl.0000154597.24838.6b · Cited by 124

Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson’s disease

Ghosh, A., Kanthasamy, A., Joseph, J., Anantharam, V., Srivastava, P., Dranka, B. P., Kalyanaraman, B., & Kanthasamy, A. G. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-241 · Cited by 124

Flavonoids in Atherosclerosis: An Overview of Their Mechanisms of Action

Siasos, G., Tousoulis, D., Tsigkou, V., et al. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320210003 · Cited by 124

Motor cortex glutathione deficit in ALS measured in vivo with the J-editing technique

Weiduschat, N., Mao, X., Hupf, J. C., et al. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.04.020 · Cited by 118

In parkinsonian substantia nigra, α-synuclein is modified by acrolein, a lipid-peroxidation product, and accumulates in the dopamine neurons with inhibition of proteasome activity

Shamoto‐Nagai, M., Maruyama, W., Hashizume, Y., Yoshida, M., Osawa, T., Riederer, P. F., & Naoi, M. (2007) · Journal of Neural Transmission · doi:10.1007/s00702-007-0789-2 · Cited by 118

Skeletal muscle properties in a transgenic mouse model for amyotrophic lateral sclerosis: effects of creatine treatment

Derave, W., Bosch, L. V. D., Lemmens, G., Eijnde, B. O., Robberecht, W., & Hespel, P. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00041-x · Cited by 116

Melatonin protects against oxidative stress caused by 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine in the mouse nigrostriatum

Thomas, B., & Mohanakumar, K. P. (2003) · Journal of Pineal Research · doi:10.1046/j.1600-079x.2003.00096.x · Cited by 115

Protein Levels and Activity of Some Antioxidant Enzymes in Hippocampus of Subjects with Amnestic Mild Cognitive Impairment

Rukhsana Sultana, A., Piroddi, M., Galli, F., & Butterfield, D. A. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9593-0 · Cited by 115

Hesperidin Alleviates Cognitive Impairment, Mitochondrial Dysfunction and Oxidative Stress in a Mouse Model of Alzheimer’s Disease

Wang, D., Liu, L., Zhu, X., Wu, W., & Wang, Y. (2014) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0098-x · Cited by 114

Protection of DFP-induced oxidative damage and neurodegeneration by antioxidants and NMDA receptor antagonist

Zaja‐Milatovic, S., Gupta, R. C., Aschner, M., & Milatović, D. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.07.006 · Cited by 111

Characterization of Detergent-Insoluble Proteins in ALS Indicates a Causal Link between Nitrative Stress and Aggregation in Pathogenesis

Basso, M., Samengo, G., Nardo, G., Massignan, T., D’Alessandro, G., Tartari, S., Cantoni, L., Marino, M., Cheroni, C., Biasi, S. D., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008130 · Cited by 111

The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer’s disease

Duffy, A. M., & Hölscher, C. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.10.045 · Cited by 109

Effect of quercetin and desferrioxamine on 6-hydroxydopamine (6-OHDA) induced neurotoxicity in striatum of rats

Haleagrahara, N., Siew, C. J., & Ponnusamy, K. (2013) · The Journal of Toxicological Sciences · doi:10.2131/jts.38.25 · Cited by 108

Cerebral blood flow regulation by nitric oxide in neurological disorders

Toda, N., Ayajiki, K., & Okamura, T. (2009) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y09-048 · Cited by 108

Oxidant–antioxidant imbalance in the erythrocytes of sporadic amyotrophic lateral sclerosis patients correlates with the progression of disease

Babu, G. N., Kumar, A., Chandra, R., et al. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.01.009 · Cited by 107

Different Patterns of Oxidized Lipid Products in Plasma and Urine of Dengue Fever, Stroke, and Parkinson's Disease Patients: Cautions in the Use of Biomarkers of Oxidative Stress

Lee, J. C., Seet, R. C. S., Huang, S. H., Long, L. H., & Halliwell, B. B. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2179 · Cited by 106

Vitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 transgenic and wild-type mice

Harrison, F. E., Hosseini, A. H., McDonald, M. P., & May, J. M. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.06.006 · Cited by 103

Alzheimer’s disease treated patients showed different patterns for oxidative stress and inflammation markers

Gubandru, M., Margina, D. M., Tsitsimpikou, C., Goutzourelas, N., Tsarouhas, K., Ilie, M., Tsatsakis, A. M., & Kouretas, D. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.07.013 · Cited by 102

Neuronal and Vascular Oxidative Stress in Alzheimers Disease

Massaad, C. A. (2011) · Current Neuropharmacology · doi:10.2174/157015911798376244 · Cited by 102

Effect of One-Year Vitamin C- and E-Supplementation on Cerebrospinal Fluid Oxidation Parameters and Clinical Course in Alzheimer’s Disease

Arlt, S., Müller‐Thomsen, T., Beisiegel†, U., & Kontush, A. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0860-8 · Cited by 100

PPAR-α agonist fenofibrate protects against the damaging effects of MPTP in a rat model of Parkinson's disease

Barbiero, J. K., Santiago, R. M., Tonin, F. S., Boschen, S. L., da Silva, L. M., Werner, M. F. D. P., Cunha, C. D., Lima, M. M. S., & Vital, M. A. B. F. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.02.009 · Cited by 97

Early memory deficits precede plaque deposition in APPswe/PS1dE9 mice: Involvement of oxidative stress and cholinergic dysfunction

Zhang, W., Bai, M., Ye, X., Hao, J., Liu, L., Mao, N., Su, C., Miao, J., & Li, Z. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.01.023 · Cited by 97

Toxin-Induced and Genetic Animal Models of Parkinson's Disease

Hisahara, S., & Shimohama, S. (2010) · Parkinson s Disease · doi:10.4061/2011/951709 · Cited by 95

Evaluation of Antioxidants, Protein, and Lipid Oxidation Products in Blood from Sporadic Amiotrophic Lateral Sclerosis Patients

Oteiza, P. I., Uchitel, O. D., Carrasquedo, F., Dubrovski, A. L., Roma, J. C., & Fraga, C. G. (1997) · Neurochemical Research · doi:10.1023/a:1027384432715 · Cited by 93

Oxidative stress indicators are elevated in de novo Parkinson's disease patients.

Ilic, T. V., Jovanovic, M., Jovicic, A., & Tomovic, M. (1999) · PubMed · Cited by 92

Melatonin protects against MPTP/MPP + ‐induced mitochondrial DNA oxidative damage in vivo and in vitro

Chen, L., Gao, Y., Li, X., Shen, D., & Sun, F. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00209.x · Cited by 92

An Orally Active Catalytic Metalloporphyrin Protects against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine NeurotoxicityIn Vivo

Liang, L., Huang, J., Fulton, R. E., Day, B. J., & Patel, M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0019-07.2007 · Cited by 91

Isofurans, but not F2‐isoprostanes, are increased in the substantia nigra of patients with Parkinson's disease and with dementia with Lewy body disease

Fessel, J. P., Hulette, C., Powell, S. Z.-E., Roberts, L. J., & Zhang, J. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01709.x · Cited by 90

No evidence for systemic oxidant stress in Parkinson's or Alzheimer's disease

Ahlskog, J. E., Uitti, R. J., Low, P. A., Tyce, G. M., Nickander, K. K., Petersen, R. C., & Kokmen, E. (1995) · Movement Disorders · doi:10.1002/mds.870100507 · Cited by 90

Okadaic acid (ICV) induced memory impairment in rats: a suitable experimental model to test anti-dementia activity.

Kamat, P. K., Tota, S., Saxena, G., Shukla, R., & Nath, C. (2010) · Brain Research · doi:10.1016/j.brainres.2009.10.064 · Cited by 88

Cerebrospinal fluid concentrations of N-acetylcysteine after oral administration in Parkinson's disease

Katz, M., Won, S. J., Park, Y. H., Orr, A., Jones, D. P., Swanson, R. A., & Glass, G. A. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.02.020 · Cited by 87

Oxidative stress and dopamine depletion in an intrastriatal 6-hydroxydopamine model of Parkinson’s disease

Smith, M. P., & Cass, W. A. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.10.004 · Cited by 86

Redox Regulation in Amyotrophic Lateral Sclerosis

Parakh, S., Spencer, D. M. S., Halloran, M. A., Soo, K. Y., & Atkin, J. D. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/408681 · Cited by 85

Ameliorative effect of Sida cordifolia in rotenone induced oxidative stress model of Parkinson's disease

Khurana, N., & Gajbhiye, A. (2013) · NeuroToxicology · doi:10.1016/j.neuro.2013.08.005 · Cited by 84

Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper-binding abilities

Tokuda, E., Okawa, E., Watanabe, S., Ono, S.-I., & Marklund, S. L. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.01.001 · Cited by 83

Progression of dopaminergic depletion in a model of MPTP-induced Parkinsonism in non-human primates. An 18F-DOPA and 11C-DTBZ PET study

Blesa, J., Carlos Juri, C., Collantes, M., et al. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.03.006 · Cited by 82

Oxidative stress in Alzheimer's disease: Primary villain or physiological by-product?

Sutherland, G. T., Chami, B., Youssef, P., & Witting, P. K. (2013) · Redox Report · doi:10.1179/1351000213y.0000000052 · Cited by 80

Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease

Siedlak, S. L., Casadesús, G., Webber, K. M., Pappolla, M. A., Atwood, C., Smith, M. A., & Perry, G. L. (2009) · Free Radical Research · doi:10.1080/10715760802644694 · Cited by 79

Lifestyle, oxidative stress, and antioxidants: Back and forth in the pathophysiology of chronic diseases

Sharifi-Rad, M., Anil Kumar, N. V., Zucca, P., Varoni, E. M., Dini, L., Panzarini, E., Rajkovic, J., Tsouh Fokou, P. V., Azzini, E., Peluso, I., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00694 · Cited by 1,971

Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies

Bhatti, J. S., Bhatti, G. K., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.010 · Cited by 1,655

Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease

Ngo, V., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11122345 · Cited by 1,130

Ageing, age-related diseases and oxidative stress: What to do next?

Luo, J., Mills, K., le Cessie, S., Noordam, R., & van Heemst, D. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100982 · Cited by 581

ALS clinical trials review: 20 years of failure. Are we any closer to registering a new treatment?

Petrov, D., Mansfield, C., Moussy, A., & Hermine, O. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00068 · Cited by 451

Genetics of Amyotrophic Lateral Sclerosis

Gorodenker, J., & Levy, L. M. (2014) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3831 · Cited by 4

Phosphorylated TDP-43 aggregates in peripheral motor nerves of patients with amyotrophic lateral sclerosis

Riva, N., Gentile, F., Cerri, F., Gallia, F., Podini, P., Dina, G., Falzone, Y., Fazio, R., Lunetta, C., Calvo, A., et al. (2021) · Brain · doi:10.1093/brain/awab285 · Cited by 59

Negative results of a phase II study of hyperbaric oxygen therapy for amyotrophic lateral sclerosis

Steele, J., Zutshi, D., & Bradley, W. G. (2007) · Amyotrophic Lateral Sclerosis · doi:10.1080/17482960701547875 · Cited by 7

Diagnosis and Treatment of Amyotrophic Lateral Sclerosis

Yang, F. (2011) · Zhongguo quanke yixue

Amyotrophic Lateral Sclerosis Sera Applied to Cultured Motor Neurons

Horwich, M., Engel, W. K., & Chauvin, P. B. (1974) · Archives of Neurology · doi:10.1001/archneur.1974.00490340060015 · Cited by 39