A Review of the Functional and Anatomical Default Mode Network in Schizophrenia
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Schizophrenia is a severe mental disorder characterized by impaired perception, delusions, thought disorder, abnormal emotion regulation, altered motor function, and impaired drive. The default mode network (DMN), since it was first proposed in 2001, has become a central research theme in neuropsychiatric disorders, including schizophrenia. In this review, first we define the DMN and describe its functional activity, functional and anatomical connectivity, heritability, and inverse correlation with the task positive network. Second, we review empirical studies of the anatomical and functional DMN, and anti-correlation between DMN and the task positive network in schizophrenia. Finally, we review preliminary evidence about the relationship between antipsychotic medications and regulation of the DMN, review the role of DMN as a treatment biomarker for this disease, and consider the DMN effects of individualized therapies for schizophrenia.
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Abnormalities in the corpus callosum and interhemispheric connectivity are linked to many neurodevelopmental disorders, including ASD and SCZ.
“a wealth of evidence links abnormalities in the corpus callosum and interhemispheric connectivity (driven by callosal projection neurons) to many neurodevelopmental disorders, among them ASD and SCZ2,3,111,112.”
From CYFIP1 governs the development of cortical axons by modulating calcium availability (2025) · cites this paper as [3]
The section “Functional Connectivity in the DMN in Schizophrenia” reports abnormal connectivity in schizophrenia, supporting that part of the claim. The paper does not link those findings to corpus callosum abnormalities or interhemispheric connectivity; the retrieved mention of autism is a reference entry, not evidence for the claimed link across ASD and other disorders. No page numbers are available in our copy. (LLM, conf=0.83)
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- Authors
- Hu, M.-L., Zong, X.-F., Mann, J. J., Zheng, J.-J., Liao, Y.-H., Li, Z.-C., He, Y., Chen, X.-G., & Tang, J.-S.
- Affiliations
- New York State Psychiatric Institute (US)
- ORCID
- Mann, J. John
- Venue
- Neuroscience Bulletin
- Published
- 2016-12-19
- Volume
- 33
- Issue
- 1
- Pages
- 73-84
- ISSN
- 1995-8218 (ISSN-L)
- 1673-7067
- PMC
- PMC5567552
- OpenAlex
- W2565049982
- Cited by
- 331
- References
- 67
- Citations by year
- 2026: 20 · 2025: 48 · 2024: 43 · 2023: 46 · 2022: 47 · 2021: 38 · 2020: 36 · 2019: 27 · 2018: 19 · 2017: 6 · 2016: 1
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neuroscience Bulletin (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (973 Program, 81271484, 30900486, 81471361, 81371480)
- China Scholarship Council (201506370095)
- National Key Research and Development Program of China (2012CB517904)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- default mode network, schizophrenia, functional connectivity, structural connectivity, task-positive network, heritability, antipsychotic drugs, treatment biomarkers, personalized treatment, brain network dysfunction
- MeSH terms
- Brain, Humans, Models, Neurological, Schizophrenia
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