Increase in Cerebellar Neurotrophin-3 and Oxidative Stress Markers in Autism

Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study

Courchesne, E., Karns, C. M., Davis, H. R., Ziccardi, R., Carper, R. A., Tigue, Z. D., Chisum, H. J., Moses, P., Pierce, K., Lord, C., et al. (2001) · Neurology · doi:10.1212/wnl.57.2.245 · Cited by 1,487 · see citing works

Evidence of Brain Overgrowth in the First Year of Life in Autism

Courchesne, E. (2003) · JAMA · doi:10.1001/jama.290.3.337 · Cited by 1,120 · see citing works

Pesticides and oxidative stress: a review.

Abdollahi, M. R., Ranjbar, A., Shadnia, S., Nikfar, S., & Rezaie, A. R. (2004) · PubMed · Cited by 1,010 · see citing works

Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism

James, S. J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D. W., & Neubrander, J. A. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1611 · Cited by 955 · see citing works

Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism

James, S. J., Melnyk, S., Jernigan, S., Cleves, M. A., Halsted, C. H., Wong, D. H., Cutler, P., Bock, K., Boris, M., Bradstreet, J., et al. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30366 · Cited by 607 · see citing works

Lower Purkinje cell counts in the cerebella of four autistic subjects: initial findings of the UCLA-NSAC Autopsy Research Report

(1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.7.862 · Cited by 590 · see citing works

Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis

Ghosh, A., & Greenberg, M. E. (1995) · Neuron · doi:10.1016/0896-6273(95)90067-5 · Cited by 470 · see citing works

Autism spectrum disorders in relation to distribution of hazardous air pollutants in the San Francisco Bay Area

Windham, G. C., Zhang, L., Gunier, R., Croen, L. A., & Grether, J. K. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.9120 · Cited by 424 · see citing works

Cholinergic Activity in Autism: Abnormalities in the Cerebral Cortex and Basal Forebrain

Perry, E. K., Lee, M., Martin-Ruiz, C. M., COURT, J. A., Volsen, S. G., Merrit, J., Folly, E. A., Iversen, P. E., Bauman, M. L., Perry, R. H., et al. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.7.1058 · Cited by 390 · see citing works

The Contribution of Neuropathologic Studies to the Understanding of Autism

Kemper, T. L., & Bauman, M. L. (1993) · Neurologic Clinics · doi:10.1016/s0733-8619(18)30176-2 · Cited by 373 · see citing works

Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: pathophysiological implications

Yip, J., Soghomonian, J.-J., & Blatt, G. J. (2007) · Acta Neuropathologica · doi:10.1007/s00401-006-0176-3 · Cited by 303 · see citing works

Increased DNA Oxidation and Decreased Levels of Repair Products in Alzheimer's Disease Ventricular CSF

Lovell, M. A., Gabbita, S. P., & Markesbery, W. R. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720771.x · Cited by 291 · see citing works

Cerebellar Purkinje Cells are Reduced in a Subpopulation of Autistic Brains: A Stereological Experiment Using Calbindin-D28k

Whitney, E. R., Kemper, T. L., Bauman, M. L., Rosene, D. L., & Blatt, G. J. (2008) · The Cerebellum · doi:10.1007/s12311-008-0043-y · Cited by 268 · see citing works

Protein Oxidation and Lipid Peroxidation in Brain of Subjects with Alzheimer's Disease: Insights into Mechanism of Neurodegeneration from Redox Proteomics

Rukhsana Sultana, A., Marzia Perluigi, A., & Butterfield, D. A. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.2021 · Cited by 259 · see citing works

Increased excretion of a lipid peroxidation biomarker in autism

Ming, X., Stein, T. P., Brimacombe, M., Johnson, W. G., Lambert, G. H., & Wagner, G. C. (2005) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.06.002 · Cited by 236 · see citing works

Increased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autism

Zoroğlu, S. S., Armutçu, F., Özen, Ş., Gürel, A., Sivaslı, E., Yetkin, O., & Meram, İ. (2004) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-004-0456-7 · Cited by 235 · see citing works

Insight into the pathophysiology of restless legs syndrome

Earley, C. J., Allen, R. P., Beard, J. L., & Connor, J. R. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20001201)62:5 · Cited by 216 · see citing works

8-Hydroxydeoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage

Helbock, H. J., Beckman, K. B., & Ames, B. N. (1999) · Methods in Enzymology · doi:10.1016/s0076-6879(99)00123-8 · Cited by 215 · see citing works

Axonal growth and fasciculation linked to differential expression of BDNF and NT3 receptors in developing cerebellar granule cells

Segal, R. A., Pomeroy, S. L., & Stiles, C. D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-07-04970.1995 · Cited by 212 · see citing works

Investigation of antioxidant enzymes in children with autistic disorder

Yorbık, Ö., Sayal, A., Akay, C., Akbiyik, D. I., & Söhmen, T. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2002.0439 · Cited by 207 · see citing works

Genetic susceptibility to the respiratory effects of air pollution

Yang, I. A., Fong, K. M., Zimmerman, P. V., Holgate, S. T., & Holloway, J. W. (2008) · Thorax · doi:10.1136/thx.2007.079426 · Cited by 184 · see citing works

Granule Neuron Regulation of Purkinje Cell Development: Striking a Balance Between Neurotrophin and Glutamate Signaling

Morrison, M. E., & Mason, C. A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-10-03563.1998 · Cited by 172 · see citing works

Mercury and autism: accelerating evidence?

Mutter, J., Naumann, J., Schneider, R., Walach, H., & Haley, B. E. (2005) · PubMed · Cited by 172 · see citing works

Neuroanatomic Imaging in Autism

Courchesne, E. (1991) · PEDIATRICS · doi:10.1542/peds.87.5.781 · Cited by 170 · see citing works

Proximity to point sources of environmental mercury release as a predictor of autism prevalence

Palmer, R. F., Stephen Blanchard, B., & Wood, R. G. (2008) · Health & Place · doi:10.1016/j.healthplace.2008.02.001 · Cited by 147 · see citing works

Selected neurotrophins, neuropeptides, and cytokines: developmental trajectory and concentrations in neonatal blood of children with autism or Down syndrome

Nelson, P. G., Kuddo, T., Song, E. Y., Dambrosia, J. M., Kohler, S. J., Satyanarayana, G., VanDunk, C., Grether, J. K., & Nelson, K. B. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.10.003 · Cited by 144 · see citing works

Barhl1Regulates Migration and Survival of Cerebellar Granule Cells by Controlling Expression of the Neurotrophin-3 Gene

Li, S., Qiu, F., Xu, A., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4444-03.2004 · Cited by 126 · see citing works

Paraoxonase gene variants are associated with autism in North America, but not in Italy: possible regional specificity in gene–environment interactions

D'Amelio, M., Ricci, I., Sacco, R., Liu, X., D'Agruma, L., Muscarella, L. A., Guarnieri, V, Militerni, R., Bravaccio, C., Elia, M., et al. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001714 · Cited by 125 · see citing works

Lead-induced increase in antioxidant enzymes and lipid peroxidation products in developing rat brain

Bokara, K. K., Brown, E. T., McCormick, R., Yallapragada, P. R., Rajanna, S., & Rajanna, B. (2007) · BioMetals · doi:10.1007/s10534-007-9088-5 · Cited by 125 · see citing works

Evidence of host-virus co-evolution in tetranucleotide usage patterns of bacteriophages and eukaryotic viruses

Pride, D. T., Wassenaar, T. M., Ghose, C., & Blaser, M. J. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-8 · Cited by 124 · see citing works

Urinary 8-hydroxydeoxyguanosine levels as a biomarker for progression of Parkinson disease

Sato, S., Mizuno, Y., & Hattori, N. (2005) · Neurology · doi:10.1212/01.wnl.0000154597.24838.6b · Cited by 124 · see citing works

Genetically Encoding Protein Oxidative Damage

Neumann, H., Hazen, J. L., Weinstein, J. R., Mehl, R. A., & Chin, J. W. (2008) · Journal of the American Chemical Society · doi:10.1021/ja710100d · Cited by 122 · see citing works

Disrupting effects of hydroxy-polychlorinated biphenyl (PCB) congeners on neuronal development of cerebellar Purkinje cells: A possible causal factor for developmental brain disorders?

Kimura‐Kuroda, J., Nagata, I., & Kuroda, Y. (2007) · Chemosphere · doi:10.1016/j.chemosphere.2006.05.137 · Cited by 116 · see citing works

Evidence for Oxidative DNA Damage in the Hippocampus of Elderly Patients With Chronic Schizophrenia

Nishioka, N., & Arnold, S. E. (2004) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200403000-00008 · Cited by 114 · see citing works

Differential patterns of nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 mRNA and protein levels in developing regions of rat brain

Das, K. P., Chao, S., White, L. D., Haines, W. T., Harry, G. J., Tilson, H. A., & Barone, S. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00011-2 · Cited by 106 · see citing works

Oxidative Stress in Autism: Elevated Cerebellar 3-nitrotyrosine Levels

Sajdel, E. M., Lipiński, B., Windom, H., AUDHYA, T. K., & McGinnis, W. R. (2008) · American journal of biochemistry & biotechnology/American journal of biochemistry and biotechnology · doi:10.3844/ajbbsp.2008.73.84 · Cited by 99 · see citing works

Analysis of case-parent trios at a locus with a deletion allele: association of GSTM1 with autism

Buyske, S. G., Williams, T. A., Mars, A. E., Stenroos, E. S., Ming, S. X., Wang, R., Sreenath, M., Factura, M. F., Reddy, C., Lambert, G. H., et al. (2006) · BMC Genetics · doi:10.1186/1471-2156-7-8 · Cited by 75 · see citing works

Increased urinary level of oxidized nucleosides in patients with mild-to-moderate Alzheimer's disease

Lee, S. H., Kim, I., & Chung, B. C. (2007) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2006.11.021 · Cited by 71 · see citing works

Polymorphisms in Xenobiotic Metabolism Genes and Autism

Serajee, F., Nabi, R., Zhong, H., & Huq, A. H. M. M. (2004) · Journal of Child Neurology · doi:10.1177/088307380401900603 · Cited by 60 · see citing works

Chronic exposure to ethanol alters neurotrophin content in the basal forebrain–cortex system in the mature rat: Effects on autocrine–paracrine mechanisms

Miller, M. W., & Mooney, S. M. (2004) · Journal of Neurobiology · doi:10.1002/neu.20059 · Cited by 57 · see citing works

Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 levels in human amniotic fluid

Marx, C. E., Vance, B. J., Jarskog, L. F., Chescheir, N. C., & Gilmore, J. H. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70113-4 · Cited by 53 · see citing works

Protein tyrosine nitration is triggered by nerve growth factor during neuronal differentiation of PC12 cells

Cappelletti, G. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00209-x · Cited by 50 · see citing works

Increased Rate of Head Growth During Infancy in Autism

Lainhart, J. E. (2003) · JAMA · doi:10.1001/jama.290.3.393 · Cited by 45 · see citing works

The evaluation of oxidative DNA damage in children with brain damage using 8-hydroxydeoxyguanosine levels

Fukuda, M., Yamauchi, H., Yamamoto, H., Aminaka, M., Murakami, H., Kamiyama, N., Miyamoto, Y., & Koitabashi, Y. (2007) · Brain and Development · doi:10.1016/j.braindev.2007.07.005 · Cited by 44 · see citing works

Stimulation of nerve growth factor expression in astrocytes by peroxynitrite.

Vargas, M. R., Pehar, M., Cassina, P., et al. (2005) · PubMed · Cited by 39 · see citing works

Amalgam: Eine Risikobewertung unter Berücksichtigung der neuen Literatur bis 2005

Mutter, J., Naumann, J., Walach, H., & Daschner, F. D. (2005) · Das Gesundheitswesen · doi:10.1055/s-2005-857962 · Cited by 35 · see citing works

Lead‐induced alterations of apoptosis and neurotrophic factor mRNA in the developing rat cortex, hippocampus, and cerebellum

Chao, S. L., Moss, J. M., & Harry, G. J. (2007) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.20191 · Cited by 35 · see citing works

Neurotrophin-3 Promotes Cell Death Induced in Cerebral Ischemia, Oxygen-Glucose Deprivation, and Oxidative Stress: Possible Involvement of Oxygen Free Radicals

Bates, B., Hirt, L., Thomas, S. S., et al. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0458 · Cited by 30 · see citing works

A pathogenetic model of autism involving Purkinje cell loss through anti-GAD antibodies

Rout, U. K., & Dhossche, D. M. (2008) · Medical Hypotheses · doi:10.1016/j.mehy.2007.11.012 · Cited by 29 · see citing works

Glutathione status in the blood and tissues of patients with virus-originated hepatocellular carcinoma

Lee, K., Tsai, S., Wang, S., et al. (2007) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2007.06.012 · Cited by 26 · see citing works

Neurotrophin-3, TNF-alpha and IL-6 relations in serum and cerebrospinal fluid of ischemic stroke patients.

Păsărică, D., Gheorghiu, M., Topârceanu, F., et al. (2007) · PubMed · Cited by 18 · see citing works

An Exploration of Possible Pre- and Postnatal Correlates of Autism: A Pilot Survey

Brown, G. E., Jones, S. D., MacKewn, A., & Plank, E. J. (2008) · Psychological Reports · doi:10.2466/pr0.102.1.273-282 · Cited by 10 · see citing works

Content of 8-Hydroxy-2-Deoxyguanosine in Steroid Receptor-Positive and Receptor-Negative Breast Cancer Cells

Берштейн, Л. М., Levina, V. V., Poroshina, T. E., et al. (2005) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-005-0419-7 · Cited by 5 · see citing works

Rita Levi-Montalcini: A brief biographic view of past and present studies on nerve growth factor

Aloe, L. (1999) · Microscopy Research and Technique · doi:10.1002/(sici)1097-0029(19990515/01)45:4/5 · Cited by 2 · see citing works

Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice

Tsai, P. T., Hull, C., Chu, Y., Greene-Colozzi, E., Sadowski, A. R., Leech, J. M., Steinberg, J., Crawley, J. N., Regehr, W. G., & Sahin, M. (2012) · Nature · doi:10.1038/nature11310 · Cited by 888 · see citing works

Consensus Paper: Pathological Role of the Cerebellum in Autism

Fatemi, S. H., Aldinger, K. A., Ashwood, P., Bauman, M. L., Blaha, C. D., Blatt, G. J., Chauhan, A., Chauhan, V., Dager, S. R., Dickson, P. E., et al. (2012) · The Cerebellum · doi:10.1007/s12311-012-0355-9 · Cited by 723 · see citing works

Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain

Rose, S., Melnyk, S., Pavliv, O., Bai, S., Nick, T. G., Frye, R. E., & James, S. J. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.61 · Cited by 480 · see citing works

The Emerging Picture of Autism Spectrum Disorder: Genetics and Pathology

Chen, J. A., Peñagarikano, O., Belgard, T. G., Swarup, V., & Geschwind, D. H. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040405 · Cited by 254 · see citing works

Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism

Smaga, I., Niedzielska, E., Gawlik, M., Moniczewski, A., Krzek, J., Przegaliński, E., Pera, J., & Filip, M. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2014.12.015 · Cited by 252 · see citing works

Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism

Melnyk, S., Fuchs, G. J., Schulz, E., Lopez, M., Kahler, S. G., Fussell, J. J., Bellando, J., Pavliv, O., Rose, S., Seidel, L., et al. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-011-1260-7 · Cited by 250 · see citing works

Brain region‐specific deficit in mitochondrial electron transport chain complexes in children with autism

Chauhan, A., Gu, F., Essa, M. M., Wegiel, J., Kaur, K., Brown, W. T., & Chauhan, V. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07189.x · Cited by 243 · see citing works

The neuropathology of autism: A systematic review of post-mortem studies of autism and related disorders

Fetit, R., Hillary, R. F., Price, D. J., & Lawrie, S. M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.07.014 · Cited by 148 · see citing works

The role of cerebellar circuitry alterations in the pathophysiology of autism spectrum disorders

Mosconi, M. W., Wang, Z., Schmitt, L. M., Tsai, P., & Sweeney, J. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00296 · Cited by 112 · see citing works

Cerebellar Oxidative DNA Damage and Altered DNA Methylation in the BTBR T+tf/J Mouse Model of Autism and Similarities with Human Post Mortem Cerebellum

Shpyleva, S., Ivanovsky, S., de Conti, A., Melnyk, S., Tryndyak, V., Beland, F. A., James, S. J., & Pogribny, I. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113712 · Cited by 83 · see citing works

Mitochondrial dysfunction in the gastrointestinal mucosa of children with autism: A blinded case-control study

Rose, S., Bennuri, S. C., Murray, K. F., Buie, T., Winter, H., & Frye, R. E. (2017) · PLOS ONE · doi:10.1371/journal.pone.0186377 · Cited by 82 · see citing works

Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum

James, S. J., Shpyleva, S., Melnyk, S., Pavliv, O., & Pogribny, I. P. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.87 · Cited by 79 · see citing works

Excessive astrocyte-derived neurotrophin-3 contributes to the abnormal neuronal dendritic development in a mouse model of fragile X syndrome.

Yang, Q., Feng, B., Zhang, K., Guo, Y.-Y., Liu, S.-B., Wu, Y.-M., Li, X.-Q., & Zhao, M.-G. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003172 · Cited by 59 · see citing works

Neuronal nucleus and cytoplasm volume deficit in children with autism and volume increase in adolescents and adults

Wegiel, J., Flory, M., Kuchna, I., Nowicki, K., Ma, S. Y., Imaki, H., Wegiel, J., Frackowiak, J., Kolecka, B. M., Wierzba-Bobrowicz, T., et al. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0183-5 · Cited by 47 · see citing works

Do Autism-Specific and General Developmental Screens Have Complementary Clinical Value?

STURNER, R. A., Bergmann, P. E., Howard, B. J., Bet, K., Stewart, L., & Attar, S. M. (2022) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-022-05541-y · Cited by 6 · see citing works

Brief Report: Learning About Autism: Is the Source of Autism Knowledge Associated with Differences in Autism Knowledge, Autism Identity, and Experiences of Stigma

Bury, S., Haschek, A., Wenzel, M., Spoor, J., & Hedley, D. (2022) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-022-05823-5 · Cited by 22 · see citing works

Which terms should be used to describe autism? Perspectives from the UK autism community

Kenny, L., Hattersley, C., Molins, B., Buckley, C., Povey, C., & Pellicano, E. (2016) · Autism · doi:10.1177/1362361315588200 · Cited by 1,941 · see citing works

Brief Report: Trends in U.S. National Autism Awareness from 2004 to 2014: The Impact of National Autism Awareness Month

DeVilbiss, E. A., & Lee, B. K. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-014-2160-4 · Cited by 46 · see citing works

The broad autism phenotype: A complementary strategy for molecular genetic studies of autism

(2001) · doi:10.1002/1096-8628(20010108)105:1