The Contribution of Neuropathologic Studies to the Understanding of Autism
Open accessAbstract
A review of the neuropathology of infantile autism shows abnormalities in the limbic forebrain and in cerebellar circuits. The role of the cerebellar lesions in the symptomatology of infantile autism is unknown. The cerebellar findings appear to date from a fetal stage of development with evidence for an ongoing process after birth. The timing of the findings in the limbic system is unknown. A postulated role for these findings in the limbic system in infantile autism is presented.
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Early assessments of the amygdala in ASD report decreased size and increased neuron density in the medial, central, and cortical nuclei.
“Early assessments of the amygdala in ASD report decreased size and increased neuron density in the medial, central, and cortical nuclei [23, 191]”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [191]
In young children with ASD, deep cerebellar nuclei and inferior olivary neurons appear enlarged, but with age these neurons become reduced in size.
“In young children with ASD, deep cerebellar nuclei and inferior olivary neurons appear enlarged, but with age these neurons become reduced in size [191].”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [191]
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- Authors
- Kemper, T. L., & Bauman, M. L.
- Affiliations
- City of Boston (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Kemper, Thomas L.
- ORCID
- Bauman, Margaret L.
- Venue
- Neurologic Clinics
- Publisher
- Elsevier BV
- Published
- 1993-02
- Volume
- 11
- Issue
- 1
- Pages
- 175-187
- ISSN
- 0733-8619 (ISSN-L)
- OpenAlex
- W2346906038
- Cited by
- 373
- References
- 24
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 19 · 2023: 10 · 2022: 7 · 2021: 14 · 2020: 8 · 2019: 4 · 2018: 9 · 2017: 7 · 2016: 14 · 2015: 15 · 2014: 14 · 2013: 18 · 2012: 24
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neurologic Clinics (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- infantile autism, neuropathology, limbic forebrain, cerebellar lesions, cerebellar circuits, fetal development, postnatal development, limbic system
- MeSH terms
- Adult, Autistic Disorder, Brain, Cerebellum, Child, Female, Humans, Limbic System, Male
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