The intestinal ecosystem in chronic functional constipation
Abstract
Chronic functional constipation is common in infants, and the bacterial composition of stools in this condition is not known. The study aims were to: (i) investigate the composition of the intestinal ecosystem in chronic functional constipation; (ii) establish whether the addition of the water‐holding agent calcium polycarbophil to the diet induces an improvement in constipation; and (iii) determine the composition of the intestinal ecosystem after the use of this agent. In total, 42 children (20F, 22M; mean age: 8.6 ± 2.9 y) were studied. Twenty‐eight children with functional chronic constipation without anatomical disorders were treated double‐blind in random sequence for 1 month with an oral preparation of calcium polycarbophil (0.62 g /twice daily) or placebo. Intestinal flora composition was evaluated by standard microbiological methods and biochemical assays on faecal samples collected before and after treatment. Fourteen healthy children were studied as controls. The results show that (i) the constipated children presented a significant increase in clostridia and bifidobacteria in faeces compared to healthy subjects–different species of clostridia and enterobacteriaceae were frequently isolated; no generalized overgrowth was observed; Clostridia outnumbered bacteroides and E. coli mean counts by 2–3log, while bacteroides and E. coli counts were similar (5‐6 log 10/g fresh faeces); these intestinal disturbances could be defined as a dysbiosis, i.e. a quantitative alteration in the relative proportions of certain intestinal bacterial species. (ii) Clinical resolution of constipation was achieved only in 43% of treated children and an improvement in 21% (one bowel movement every 2 d). (iii) Calcium polycarbophil treatment induced no significant changes in the composition of the intestinal ecosystem, nor in blood chemistry parameters.
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Intestinal microbiota is diverse among healthy individuals and sufferers of constipation.
“there is data showing that the intestinal microbiota is diverse among healthy individuals and sufferers of constipation [24,25].”
Cites
The Pharmacological Basis of Therapeutics
Faddis, M. O., Goodman, L., & Gilman, A. (1941) · AJN American Journal of Nursing · doi:10.2307/3414719 · Cited by 929 · see citing works
Normal Indigenous Intestinal Flora
Finegold, S. M., Sutter, V. L., & Mathisen, G. E. (1983) · Elsevier eBooks · doi:10.1016/b978-0-12-341280-5.50007-0 · Cited by 618 · see citing works
Kleessen, B., Sykura, B., Zunft, H. ‐., & Blaut, M. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.5.1397 · Cited by 586 · see citing works
Pediatric Gastrointestinal Disease
Walker, W. A. (2004) · Cited by 443 · see citing works
Intestinal microflora of Estonian and Swedish infants
Sepp, E., Julge, K., Vasar, M., Naaber, P., Björkstén, B., & Mikelsaar, M. (1997) · Acta Paediatrica · doi:10.1111/j.1651-2227.1997.tb15178.x · Cited by 416 · see citing works
Griffiths, L. A. (1975) · Biochemical Society Transactions · doi:10.1042/bst0030565a · Cited by 400 · see citing works
(1976) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(76)80265-9 · Cited by 395 · see citing works
Cummings, J. H., Hill, M. J., Bone, E., Branch, W. J., & Jenkins, D. J. A. (1979) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/32.10.2094 · Cited by 358 · see citing works
Biofeedback training in treatment of childhood constipation: a randomised controlled study
van der Plas, R. N., Benninga, M., Büller, H. A., Bossuyt, P. M., Akkermans, L. M. A., Redekop, K., & Taminiau, J. A. J. M. (1996) · The Lancet · doi:10.1016/s0140-6736(96)03206-0 · Cited by 214 · see citing works
(1997) · Springer eBooks · doi:10.1007/978-1-4615-4111-0 · Cited by 168 · see citing works
Lynn, R. B., & Friedman, L. S. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312233292608 · Cited by 139 · see citing works
Metabolic Activities of the Normal Colonic Flora
Macfarlane, G. T., & Gibson, G. R. (1994) · Springer series in applied biology · doi:10.1007/978-1-4471-3443-5_2 · Cited by 98 · see citing works
Eherer, A. J., Ana, C. A. S., Porter, J. L., et al. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90267-g · Cited by 81 · see citing works
Development of Intestinal Microbiota
Conway, P. L. (1997) · Springer eBooks · doi:10.1007/978-1-4757-0322-1_1 · Cited by 65 · see citing works
Midtvedt, T., Carlstedt‐Duke, B., Høverstad, T., et al. (1986) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1986.tb01300.x · Cited by 59 · see citing works
Ecological Effects of Antimicrobial Agents on the Human Intestinal Microflora
Nord, C. E., & Edlund, C. (1991) · Microbial Ecology in Health and Disease · doi:10.3109/08910609109140143 · Cited by 31 · see citing works
Ecological Effects of Antimicrobial Agents on the Human Intestinal Microflora
Nord, C. E., & Edlund, C. (1991) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v4i4.7658 · Cited by 29 · see citing works
Danhof, I. E. (1982) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/j.1875-9114.1982.tb03168.x · Cited by 20 · see citing works
Potential Complications in the Use of Wheat Bran for Constipation in Infancy
Zoppi, G., Gobio-Casali, L., Deganello, A., et al. (1982) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-198201010-00015 · Cited by 17 · see citing works
Self-citationThe Role of Eubacterium Species in Periodontal Disease and Other Oral Infections
Wade, W. G. (1996) · Microbial Ecology in Health and Disease · doi:10.1002/(sici)1234-987x(199611)9:6 · Cited by 14 · see citing works
Bacterial Faecal Flora in Healthy Women of Different Ages
Minelli, E. B., Benini, A., Beghini, A. M., Cerutti, R., & Nardo, G. (1993) · Microbial Ecology in Health and Disease · doi:10.3109/08910609309141561 · Cited by 13 · see citing works
Self-citationPOLYACRYLIC RESIN: EFFECTIVE HYDROPHILIC COLLOID FOR THE TREATMENT OF CONSTIPATION†
Grossman, A. J., Batterman, R. C., & Leifer, P. (1957) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1957.tb00044.x · Cited by 11 · see citing works
Minelli, E. B., Benini, A., Vicentini, L. M., Andreoli, E., Oselladore, M., & Cerutti, R. (1996) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v9i6.8391 · Cited by 10 · see citing works
Self-citationGorbach, S. L. (1969) · Gastroenterology · doi:10.1016/s0016-5085(19)33944-7 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
New evidences on the altered gut microbiota in autism spectrum disorders
Strati, F., Cavalieri, D., Albanese, D., De Felice, C., Donati, C., Hayek, J., Jousson, O., Leoncini, S., Renzi, D., Calabrò, A., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0242-1 · Cited by 1,040 · see citing works
Dimidi, E., Christodoulides, S., Scott, S. M., & Whelan, K. (2017) · Advances in Nutrition · doi:10.3945/an.116.014407 · Cited by 468 · see citing works
Parthasarathy, G., Chen, J., Chen, X., Chia, N., O'Connor, H. M., Wolf, P. G., Gaskins, H. R., & Bharucha, A. E. (2016) · Gastroenterology · doi:10.1053/j.gastro.2015.10.005 · Cited by 396 · see citing works
KHALIF, I., QUIGLEY, E., KONOVITCH, E., & MAXIMOVA, I. (2005) · Digestive and Liver Disease · doi:10.1016/j.dld.2005.06.008 · Cited by 382 · see citing works
Structural changes in the gut microbiome of constipated patients
Zhu, L., Liu, W., Alkhouri, R., Baker, R. D., Bard, J. E., Quigley, E. M., & Baker, S. S. (2014) · Physiological Genomics · doi:10.1152/physiolgenomics.00082.2014 · Cited by 381 · see citing works
Dimidi, E., Christodoulides, S., Fragkos, K. C., Scott, S. M., & Whelan, K. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.089151 · Cited by 316 · see citing works
Koebnick, C., Wagner, I., Leitzmann, P., Stern, U., & Zunft, H. F. (2003) · Canadian Journal of Gastroenterology · doi:10.1155/2003/654907 · Cited by 288 · see citing works
Coccorullo, P., Strisciuglio, C., Martinelli, M., Miele, E., Greco, L., & Staiano, A. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.04.066 · Cited by 209 · see citing works
Pijpers, M. A. M., Tabbers, M. M., Benninga, M. A., & Berger, M. Y. (2008) · Archives of Disease in Childhood · doi:10.1136/adc.2007.127233 · Cited by 187 · see citing works
Role of gut microbiota in functional constipation
Zhang, S., Wang, R., Li, D., Zhao, L., & Zhu, L. (2021) · Gastroenterology Report · doi:10.1093/gastro/goab035 · Cited by 175 · see citing works
Mancabelli, L., Milani, C., Lugli, G. A., Turroni, F., Mangifesta, M., Viappiani, A., Ticinesi, A., Nouvenne, A., Meschi, T., van Sinderen, D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10663-w · Cited by 182 · see citing works
Kim, S.-E., Choi, S. C., Park, K. S., Park, M. I., Shin, J. E., Lee, T. H., Jung, K. W., Koo, H. S., & Myung, S.-J. (2015) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14048 · Cited by 180 · see citing works
Banaszkiewicz, A., & Szajewska, H. (2005) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.10.022 · Cited by 150 · see citing works
Guerra, P. V. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i34.3916 · Cited by 106 · see citing works
Magro, D. O., de Oliveira, L. M. R., Bernasconi, I., de Souza Ruela, M., Credidio, L., Barcelos, I. K., Leal, R. F., Ayrizono, M. D. L. S., Fagundes, J. J., Teixeira, L. D. B., et al. (2014) · Nutrition Journal · doi:10.1186/1475-2891-13-75 · Cited by 105 · see citing works
Alteration of gut microbiota and efficacy of probiotics in functional constipation
Choi, C. H., & Chang, S. K. (2015) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14142 · Cited by 76 · see citing works
Bacillus coagulans Unique IS2 in Constipation: A Double-Blind, Placebo-Controlled Study
Madempudi, R. S., Neelamraju, J., Ahire, J. J., Gupta, S. K., & Shukla, V. K. (2020) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-019-09542-9 · Cited by 60 · see citing works
Turan, İ., Dedeli, Ö., Bor, S., & İlter, T. (2014) · Turkish Journal of Gastroenterology · doi:10.5152/tjg.2014.6990 · Cited by 56 · see citing works
Kang, D.-W., DiBaise, J. K., Ilhan, Z. E., Crowell, M. D., Rideout, J. R., Caporaso, J. G., Rittmann, B. E., & Krajmalnik-Brown, R. (2015) · Anaerobe · doi:10.1016/j.anaerobe.2015.01.005 · Cited by 55 · see citing works
Huang, L. S., Kong, C., Gao, R. Y., Yan, X., Yu, H. J., Wen, B., Zhu, Q., Shen, T. Y., Sun, Z. L., & Qin, H. L. (2018) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-017-3149-7 · Cited by 42 · see citing works
Zhang, T., Han, Y., Wang, J., Hou, D., Deng, H., Deng, Y. L., & Song, Z. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00176 · Cited by 38 · see citing works
Effects of bread yeast cell wall beta-glucans on mice with loperamide-induced constipation
Chen, Z., Lin, S., Jiang, Y., Liu, L., Jiang, J., Chen, S., Tong, Y., & Wang, P. (2019) · Journal of Medicinal Food · doi:10.1089/jmf.2019.4407 · Cited by 34 · see citing works
- Authors
- Zoppi, G., Cinquetti, M., Luciano, A., Benini, A., Muner, A., & Minelli, E. B.
- Affiliations
- University of Verona (IT)
- Venue
- Acta Paediatrica
- Publisher
- Wiley
- Published
- 1998-08
- Volume
- 87
- Issue
- 8
- Pages
- 836-841
- ISSN
- 0365-1436 (ISSN-L)
- 0803-5253
- 1651-2227
- OpenAlex
- W2073837934
- Cited by
- 169
- References
- 24
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 11 · 2023: 11 · 2022: 18 · 2021: 11 · 2020: 14 · 2019: 10 · 2018: 11 · 2017: 12 · 2016: 10 · 2015: 6 · 2014: 10 · 2013: 2 · 2012: 4
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Paediatrica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- chronic functional constipation, gut microbiota, dysbiosis, Clostridia, Bifidobacterium, Enterobacteriaceae, Bacteroides
- MeSH terms
- Acrylic Resins, Adolescent, Blood Chemical Analysis, Cathartics, Child, Child, Preschool, Chronic Disease, Constipation, Double-Blind Method, Feces, Female, Humans, Hydrogen-Ion Concentration, Male, Statistics, Nonparametric
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